Schmid Lab

Our objective is to translate new concepts of aerosol research, biotechnology and physics into technological advances facilitating the development of novel inhaled drugs for the treatment of lung diseases.

Lung health and immunity by Lin Yang HI_Website-News-images_BSIC2023_Winner_Main-Image

How can we improve aerosolized drug delivery to the lung in both preclinical (cells, animal models) and clinical (human) settings?
How can we determine both dose and bioactivity of the pulmonary drug dose in real-time?
Can physiologically more realistic cell-based drug screening methods improve the predictive power of these tests for the efficacy of novel drugs in clinical settings?
How can inhaled drugs be targeted specifically to the site of interest (e.g. bronchial or alveolar region or specific cell types depending on disease type)?

We aim to design and validate systems for aerosolized drug delivery to pulmonary cells (in vitro) and to mouse models of disease (in vivo). Furthermore, methods for (real-time) in vivo monitoring of both delivered and bioactive pulmonary drug dose are developed. Our mini-lung-fibrosis-model for example may change the way we can imitate the processes in the lung during inhalation therapy.

Also, the ALICE-CLOUD technology was introduced which combines ease-of-handling with rapid, efficient and accurate delivery of aerosolized drugs to cells cultured at air-liquid interface conditions. This technology may pave the way for screening of inhalable drugs under physiologically more relevant and thus clinically more predictive conditions than the currently used submerged cell culture systems.

Picture right: Aeorosole distribution in the lung under microscope.

Dr. Marion Blayac

Scientist

Dr. Ashesh Chakraborty

Scientist

Penghang Chen

PhD Student

Anna Fuchs

Biologisch Technische Assistentin

Christina Gabriel

PhD

Dr. Alberto Hidalgo

Scientist

Andreas Schröppel

IT, Engineer

Marleen Stremlau

PhD Student

Magdalena Weiß

PhD Student

Dr. Lin Yang

Postdoctoral Fellow

Rittersberger, R. ; Covini, C. ; Kalgudde Gopal, S. ; Kumar, P. ; Voß, F. ; Martin, J. ; Deuter, F.M. ; Koslowski, G. ; Dabbars, A. ; Salcher, S. ; Blayac, M. ; Römisch, J. ; Murányi, A. ; Knoch, J. ; Yildirim, A.Ö. ; Conlon, T.M. ; Schmid, O. ; Hammerschmidt, S.I. ; Schindowski, K.

Inhalative polyclonal immunoglobulin G for the prevention of respiratory infections: A comprehensive in vitro assessment.

Liu, Q. ; Yang, L. ; Li, C. ; Han, L. ; Wilmot, J. ; Yang, G. ; Leinardi, R. ; Zhou, Q. ; Schröppel, A. ; Kutschke, D. ; Secklehner, J. ; Yildirim, A.Ö. ; Huaux, F. ; Zeuschner, D. ; Carlin, L.M. ; Sperandio, M. ; Schmid, O. ; Stöger, T. ; Rehberg, M.

Alveolar macrophages initiate the spatially targeted recruitment of neutrophils after nanoparticle inhalation.

Voss, C. ; Han, L. ; Ansari, M. ; Strunz, M. ; Haefner, V. ; Angelidis, I. ; Mayr, C.H. ; Berthing, T. ; Zhou, Q. ; Günther, E. ; Huzain, O. ; Schmid, O. ; Vogel, U. ; Schniering, J. ; Gaedcke, S. ; Theis, F.J. ; Schiller, H.B. ; Stöger, T.

Toward a ToxAtlas of carbon-based nanomaterials: Single-cell RNA sequencing reveals initiating cell circuits in pulmonary inflammation.

Stone, V. ; Moschini, E. ; Murphy, F. ; Hunt, N. ; Blosi, M. ; Hristozov, D. ; Johnston, H. ; Stenton, F. ; Mikolajczyk, A. ; Oomen, A.G. ; Schmid, O. ; Tsiliki, G. ; Brunelli, A. ; Badetti, E. ; Vogel, U. ; Gajewicz-Skretna, A. ; Wohlleben, W.

Minimising data needs to support the safer design of multicomponent nanomaterials – Application of grouping.

Kecorius, S. ; Madueno, L. ; Birmili, W. ; Löndahl, J. ; Plauškaite, K. ; Byčenkiene, S. ; Lovrić, M. ; Petric, V. ; Carranza-García, M. ; Jiménez-Navarro, M.J. ; Martínez-Ballesteros, M. ; Weiss, M. ; Schmid, O. ; Cyrys, J. ; Peters, A. ; Kecorius, G.

Urban pollution impact assessment in six lithuanian cities with a focus on road traffic emissions - integrated framework for environmental health studies.

Dekkers, S. ; Adam, V. ; Battista, V.D. ; Haase, A. ; Prinz, J. ; Nagel, G. ; Fransman, W. ; Persson, M. ; Suarez-Merino, B. ; Wohlleben, W. ; Schmid, O. ; Someren, E.v.

Safe‐and‐sustainable‐by‐design approach and decision support system for advanced materials.

Adam, V. ; Di Battista, V. ; Testard, F. ; Persson, M. ; Persson, D. ; Gargouri, D. ; Filoramo, A. ; Grafström, R.C. ; Kohonen, P. ; Hongisto, V. ; Conolly, M. ; Navas, J.M. ; Skjolding, L.M. ; Gajewicz-Skretna, A. ; Danielsen, P.H. ; Vogel, U. ; Jensen, K.A. ; van Someren, E. ; Dekkers, S. ; Schmid, O. ; Wohlleben, W. ; Suarez Merino, B.

Decision support system for safe-and-sustainable-by-design advanced materials: Case study demonstration.

Wohlleben, W. ; Adam, V. ; Lledo, P.C. ; Dekkers, S. ; Durand, C. ; Haase, A. ; Soeteman-Hernandez, L.G. ; Livieri, A. ; Martel-Martin, S. ; Pizzol, L. ; Rollon, B.P. ; Prenner, S. ; Rein, C. ; Van Someren, E.J.W. ; Fransman, W. ; Zabeo, A. ; Rumbo, C. ; Schmid, O. ; Hristozov, D.

A suite of tools for safe-and-sustainable-by-design advanced materials from the EU projects DIAGONAL, HARMLESS and SUNSHINE.

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