About our Research
"The management and analysis of increasingly large amounts of research data is of enormous importance for the understanding of fundamental metabolic processes, their regulation and the subsequent development of innovative approaches to disease therapy."
The Bioinformatics team at the MCD develops informatics infrastructures for the management of data and performs gene function analysis, the analysis of high-throughput and omics data, the modeling of genetic and protein interaction networks, and of statistical data. We develop databases and software tools for data storage, data exchange and data visualization, and software to assist in the design of genome-wide gene editing experiments and the evaluation of RNA guide sequences for the CRISPR/Cas9 system. In addition, we work on the modeling of genetic interactions and extend regulatory networks by predicting genetic interactions using high-throughput gene expression data and in-silico promoter analysis based on sophisticated statistical analysis
PI of Bioinformatics
Dr. Jens HansenGroup Leader
Highlight PublicationsSee all
Primary cilia and SHH signaling impairments in human and mouse models of Parkinson's disease. Nat Commun. 2022 Aug 16;13(1):4819.
The conserved miR-8/miR-200 microRNA family and their role in invertebrate and vertebrate neurogenesis. Cell Tissue Res. 2015 Jan;359(1):161-77
Generation of targeted mouse mutants by embryo microinjection of TALENs. Nature Protocols 8(12), 2355-2379
Bioinformatics identification of modules of transcription factor binding sites in Alzheimer's disease-related genes by in silico promoter analysis and microarrays. Int. J. Alzheimers Dis. Published online 2011 April 26
The mammalian gene function resource: the international knockout mouse consortium. Mamm Genome. 23(9-10):580-6.