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Helmholtz Munich | Mara Catani
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Dr. Anika Böttcher

Group Leader Intestinal Stem Cell Research, Institute of Diabetes and Regeneration Research (IDR)

 

Dr. Anika Böttcher

Group Leader Intestinal Stem Cell Research, Institute of Diabetes and Regeneration Research (IDR)

 

Research focus and Academic Career

The main objective of Anika Böttcher and her team is to decipher the cellular and molecular mechanisms underlying stem cell lineage decisions in the gut. In particular, they want to understand how biomechanical signals regulate stem cell fate and cellular function. The ultimate goal is to use the knowledge to manipulate stem cell lineage decisions for obesity and diabetes therapy.

Anika is a cell and developmental biologist. She obtained her Diploma in Biology from the University of Jena, Germany and University of Lund, Sweden. She then joined Reinhard Fässler´s group at the Max-Planck Institute for Molecular Medicine in Munich for her PhD and studied the role of integrin signaling in kidney morphogenesis. Afterwards, Anika joined Heiko Lickert´s lab at Helmholtz Munich as a postdoc fellow to study the role of Wnt/Planar Cell Polarity signaling in the gut. Since 2016, Anika has been leading the group of Intestinal Stem Cell Research at IDR with the research focus on the regulation of enteroendocrine lineage formation from intestinal stem cells and subset specification in homeostatic conditions and diseased state.

Expertise

Cell BiologyDevelopmental BiologyStem Cell BiologyDiabetesObesityEndocrine CellsCell PolaritySingle Cell Genomics

Professional Career

From 2016

Head of the Group Intestinal stem cells research

Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, Germany 

2010 - 2016

Postdoctoral Fellow

Institute of Stem Cell Research and Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, Germany

2005 - 2010

PhD Student

Research Department “Molecular Medicine”, Max Planck Institute of Biochemistry, Germany

Honors and Awards

  • 2020-2024
    Transregional Collaborative Research Centre 127 “Biology of xenogeneic cell, tissue and organ transplantation” – from bench to bedside with Eckhard Wolf (LMU Munich)

  • 2018-2019
    Research fund from the German center for diabetes research (DZD)

  • 2010
    Max Planck Junior Research Award

  • 2010
    Rupert Timpl Award of the International Society for Matrix Biology

Helmholtz Munich | Mara Catani

Most important publications

PubMed

2020 Nat Metab 2, 192–209

Sachs, S., Bastidas-Ponce, A., Tritschler, S., Bakhti, M., Böttcher, A., Sánchez-Garrido, M.A., Tarquis-Medina, M., Kleinert, M., Fischer, K., Jall, S., Harger, A., Bader, E., Roscioni, S., Ussar, S., Feuchtinger, A., Yesildag, B., Neelakandhan, A., Jensen, C.B., Cornu, M., Yang, B., Finan, B., DiMarchi, R.D., Tschöp, M.H., Theis, F.J., Hofmann, S.M., Müller, T.D., Lickert, H

Targeted pharmacological therapy restores β-cell function for diabetes remission

Networks and Affiliations

DZD

DFG