Prevention

The young man at the doctor's office signs the documents.

In order to develop effective lifestyle intervention programs that are fully tailored to the individual needs of a person at risk of developing type 2 diabetes, more needs to be known about the mechanisms that determine the "response" or "non-response" to lifestyle intervention. This requires extremely accurate phenotyping and genotyping of individuals. With this in mind, the TULIP study (Tuebinger Lifestyle Intervention Program) was launched in 2003. The Germany-wide Prediabetes Lifestyle Intervention Study (PLIS), which has already been completed, aims to develop personalized prevention measures. In the IFIS study (Intermittent Fasting to Improve Insulin Secretion), we are investigating how intermittent fasting affects sugar metabolism in subtypes of prediabetes and diabetes. Gestational diabetes (PREG) is also being researched in several studies.

Diabetes concept with insulin, syringe, vials, pills, and stethoscope.

View clinical trial

The X-ray of the human brain closeup image

The aim of this study is to investigate the influence of the drug bromocriptine on weight loss in relation to the FTO genotype.

View clinical trial

Obesity overweight diabetes fitness abdomen adult background

doctor with glucometer and patient at hospital

View clinical trial

The BMBF funds a new project in the field of medical AI and systems medicine. The goal of the KI-DiabetesDetektion project is to integrate indication data from various sources in a knowledge graph and apply machine learning methods to improve the early stage detection of Diabetes.

Explore Project

Prof. Dr. Andreas Fritsche

Deputy Director

View profile

Dr. Andreas Vosseler

Scientist

Vazquez Arreola, E. ; Gong, Q. ; Hanson, R.L. ; Wang, J. ; Sandforth, L. ; He, S. ; Sandforth, A. ; Qian, X. ; Giacca, M. ; Bornstein, S.R. ; Fritsche, A. ; Stefan, N. ; Preissl, H. ; Gregg, E.W. ; Marx, N. ; Jumpertz von Schwartzenberg, R. ; Li, G. ; Birkenfeld, A.L.

Prediabetes remission and cardiovascular morbidity and mortality: Post-hoc analyses from the Diabetes Prevention Program Outcome study and the DaQing Diabetes Prevention Outcome study.

Wang, Y. ; Ram, J. ; Bianchi, C. ; Fiorentino, T.V. ; Kim, S.S. ; Kim, J. ; Ryang, S. ; Del Prato, S. ; Sesti, G. ; Sandforth, L. ; Preissl, H. ; Jumpertz von Schwartzenberg, R. ; Stefan, N. ; Fritsche, A. ; Ha, J. ; Birkenfeld, A.L. ; Bergman, M.

Superiority of 1 h plasma glucose vs fasting plasma glucose, 2 h plasma glucose and HbA_1c for the diagnosis of type 2 diabetes.

Sehgal, R. ; Haacke, N. ; Maguolo, A. ; Solari, F.A. ; Jähnert, M. ; Gottmann, P. ; Nilsson, E. ; Vaag, A. ; Fischer-Posovszky, P. ; Werberger, A. ; Birkenfeld, A.L. ; Fritsche, A. ; Häring, H.-U. ; Sickmann, A. ; Vogel, H. ; Ling, C. ; Ouni, M. ; Schürmann, A.

Adipose tissue-derived microRNAs as epigenetic modulators of type 2 diabetes.

Wang, Y. ; Sandforth, A. ; Jumpertz von Schwartzenberg, R. ; Ganslmeier, M. ; Cheng, Y. ; Sandforth, L. ; Katzenstein, S. ; Machann, J. ; Schick, F. ; Kantartzis, K. ; Preissl, H. ; Fritsche, A. ; Stefan, N. ; Bergman, M. ; Birkenfeld, A.L.

Lifestyle intervention is more effective in high 1-hour post-load glucose than in prediabetes for restoring β-cell function, reducing ectopic fat, and preventing type 2 diabetes.

Sandforth, A. ; Vazquez Arreola, E. ; Hanson, R.L. ; Wewer Albrechtsen, N.J. ; Holst, J.J. ; Ahrends, R. ; Coman, C. ; Gerst, F. ; Lorza-Gil, E. ; Cheng, Y. ; Sandforth, L. ; Katzenstein, S. ; Ganslmeier, M. ; Seissler, J. ; Hauner, H. ; Perakakis, N. ; Wagner, R. ; Machann, J. ; Schick, F. ; Peter, A. ; Lehmann, R. ; Weigert, C. ; Maurer, J. ; Preissl, H. ; Heni, M. ; Szendrödi, J. ; Kopf, S. ; Solimena, M. ; Schwarz, P. ; Blüher, M. ; Häring, H.-U. ; Hrabě de Angelis, M. ; Schürmann, A. ; Kabisch, S. ; Mai, K. ; Pfeiffer, A.F.H. ; Bornstein, S. ; Stumvoll, M. ; Roden, M. ; Stefan, N. ; Fritsche, A. ; Birkenfeld, A.L. ; Jumpertz von Schwartzenberg, R.

Prevention of type 2 diabetes through prediabetes remission without weight loss.

Wagner, R. ; Selvin, E. ; Sehgal, R. ; Prystupa, K. ; Misra, S. ; Fritsche, A. ; Heni, M.

Beyond glucose-rethinking prediabetes for precision prevention.

Goll, N. ; Wiechers, C. ; Zinke, K. ; Preissl, H. ; Fritsche, A. ; Hallschmid, M.

Influence of maternal metabolism on neonate eating behaviour.

Gallwitz, B. ; Aberle, J. ; Birkenfeld, A.L. ; Fritsche, A. ; Kellerer, M. ; Klein, H.H. ; Landgraf, R. ; Müller-Wieland, D. ; Müssig, K. ; Nauck, M.A. ; Siegel, E. ; Szendrödi, J. ; Wiesner, T.

Therapie des Typ-2-Diabetes.

Heni, M. ; Hummel, J. ; Fritsche, A. ; Peter, A.

Response to Xu and Gao: Robustness of butyrylcholinesterase associations with liver fat and insulin sensitivity.

Auchynnikava, V. ; Semeia, L. ; Sippel, K. ; Sbierski-Kind, J. ; Fritsche, A. ; Birkenfeld, A.L. ; Paluscke-Fröhlich, J. ; Wikström, A.K. ; Preissl, H.

Fetal heart rate variability in relation to maternal physical activity and metabolic health.

Prevention

Clinical Trials & Cohort Studies

German Study of gestational diabetes (PREG Study)

Dopamine Genetics

Intermittent Fasting to Improve Insulin Secretion (IFIS)

Prediabetes Lifestyle Intervention Study Follow Up (PLIS FU)

TUEDID study

We are Partner in the New Project on Early Stage Diabetes Detection

Scientists at Prevention

Recent Publications

Primary Investigators