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Insulin Signalling in Beta Cells

Our discovery of inceptor, a novel and druggable insulin inhibitory receptor, is a significant milestone for diabetes research as the scientific community celebrates 100 years of insulin and 50 years of insulin receptor discovery. The blocking of inceptor function leads to an increased sensitisation of the insulin signaling pathway in pancreatic beta cells. This might allow protection and regeneration of beta cells for diabetes remission.

Our discovery of inceptor, a novel and druggable insulin inhibitory receptor, is a significant milestone for diabetes research as the scientific community celebrates 100 years of insulin and 50 years of insulin receptor discovery. The blocking of inceptor function leads to an increased sensitisation of the insulin signaling pathway in pancreatic beta cells. This might allow protection and regeneration of beta cells for diabetes remission.

Who we are

Prisca Chapouton Portrait No. 2

Dr. Prisca Chapouton

Senior Scientist Insulin/IGF signalling

PhD student

Porträt Sara Bilekova

Sára Bileková

PhD student - Insulin/IGF signalling
Porträt Sheya Bhattacharya

Sreya Bhattacharya

PhD Student - Insulin/IGF signalling
Porträt Jin Feng

Jin Feng

PhD Student - Insulin/IGF signalling

Postdoc Insulin/IGF signalling

DR Alessandro Dema

Postdoc

Pei Xu

PhD Student - Insulin/IGF signalling

Leopold Schomann

PhD Student

Publications

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2021 Nature

Ansarullah, Jain C, Far FF, Homberg S, Wißmiller K, von Hahn FG, Raducanu A, Schirge S, Sterr M, Bilekova S, Siehler J, Wiener J, Oppenländer L, Morshedi A, Bastidas-Ponce A, Collden G, Irmler M, Beckers J, Feuchtinger A, Grzybek M, Ahlbrecht C, Feederle R, Plettenburg O, Müller TD, Meier M, Tschöp MH, Coskun Ü, Lickert H

Inceptor counteracts insulin signalling in β-cells to control glycaemia

Contact

Donna Thomson

Personal Assistant IDR-L / Office and Administrative Project Manager

Campus Neuherberg, building 3620, room 306b