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Helmholtz Munich - Winfried Meining

Zeidler Lab

Research Group Therapeutic Antibodies

Research Group Therapeutic Antibodies

About us

Tumor-specific monoclonal antibodies

Antibody-based therapy of cancer is one of the most important success stories of personalized medicine. Although the concept that antibodies could serve as 'magic bullets' in the treatment and detection of cancer has a long history, the number of available antibodies is still too small. A key challenge for the development of new therapeutic antibodies for the clinic is the identification of suitable and accessible target molecules on the surface of cancer cells. We pursue a proprietary approach for the generation and evaluation of novel antibodies with a potential for cancer treatment and detection.

Development of a new experimental therapy for Glioblastoma

Glioblastoma multiforme (GBM) is the most common and most aggressive type of brain cancer with a dismal prognosis. As a first translational project, we develop a new experimental immunotherapy for the treatment of glioblastoma. This approach is based on our antibody 6A10 that binds to an enzyme present on the surface of glioblastoma cells but not of normal brain. Equipped with a radioactive payload, the antibody will be injected into the hole that remains after surgical removal of the tumor. From there, the antibody will migrate into the surrounding brain tissue. If it encounters a residual cancer cell, it will bind to this cell and – hopefully – destroy it. Resident tumor cells that remained in the brain after surgery are the origin of recurrent disease, and our approach aims at significantly prolonging recurrence-free survival.

Spin-off company 'Eximmium'

We are actively pursuing the commercialization of our proprietary therapeutic antibody candidates. Eximmium will concentrate on the generation and pre-clinical validation of proprietary first-in-class antibodies. Currently, we are talking with various potential investors.

Group members

Markus Kellner

PhD, Postdoc

Marie-Sophie Gießelmann

BSc

Nina Hauser

BSc

Julia Hörmann

PhD student

Johannes Rößler

MSc, PhD student

Susanne Fackler

Biologist

Judith Dünzhofer

Technician

Publications

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2022 Scientific Article in Basic Research in Cardiology

Kogan, P.S. ; Wirth, F. ; Tomar, A. ; Darr, J. ; Teperino, R. ; Lahm, H. ; Dreßen, M. ; Puluca, N. ; Zhang, Z. ; Neb, I. ; Beck, N. ; Luzius, T. ; de la Osa de la Rosa, L. ; Gärtner, K. ; Hüls, C. ; Zeidler, R. ; Ramanujam, D. ; Engelhardt, S. ; Wenk, C. ; Holdt, L.M. ; Mononen, M. ; Sahara, M. ; Cleuziou, J. ; Hörer, J. ; Lange, R. ; Krane, M. ; Doppler, S.A.

Uncovering the molecular identity of cardiosphere-derived cells (CDCs) by single-cell RNA sequencing.

2020 Scientific Article in Molecular Therapy-Oncolytics

Slabik, C. ; Kalbarczyk, M. ; Danisch, S. ; Zeidler, R. ; Klawonn, F. ; Volk, V. ; Krönke, N. ; Feuerhake, F. ; Ferreira de Figueiredo, C. ; Blasczyk, R. ; Olbrich, H. ; Theobald, S.J. ; Schneider, A. ; Ganser, A. ; von Kaisenberg, C. ; Lienenklaus, S. ; Bleich, A. ; Hammerschmidt, W. ; Stripecke, R.

CAR-T cells targeting Epstein-Barr virus gp350 validated in a humanized mouse model of EBV infection and lymphoproliferative disease.

Zeidler Lab

Contact

Prof. Dr. Reinhard Zeidler

Research Group Leader