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Stefanie Winkler

Type 1 Diabetes Immunology

Our main research interest focusses on understanding the role of regulatory T cells in the development and progression of autoimmune diseases such as Type 1 Diabetes. To do so, we combine the analysis of human immune cells from different disease stages with mechanistic studies in murine and humanized in vivo models. We focus on the following research topics: We dissect key molecular mechanisms underlying regulatory T cell impairments in autoimmunity and investigate the heterogeneity, plasticity and functional specialization of regulatory T cells in metabolic tissues of diabetes. Our studies have the overarching goal to facilitate the future context-specific manipulation of regulatory T cells in (autoimmune) diabetes.

Our main research interest focusses on understanding the role of regulatory T cells in the development and progression of autoimmune diseases such as Type 1 Diabetes. To do so, we combine the analysis of human immune cells from different disease stages with mechanistic studies in murine and humanized in vivo models. We focus on the following research topics: We dissect key molecular mechanisms underlying regulatory T cell impairments in autoimmunity and investigate the heterogeneity, plasticity and functional specialization of regulatory T cells in metabolic tissues of diabetes. Our studies have the overarching goal to facilitate the future context-specific manipulation of regulatory T cells in (autoimmune) diabetes.

Our Main Research Topics

Martin Scherm / BioRender

Autoantigen-specific T cell and Treg responses

Helmholtz Munich | ©BioRender

Personalized immunological models of human disease

Helmholtz Munich | ©BioRender

Treg impairments during islet autoimmunity

Martin Scherm / BioRender

Next-generation miRNA targeting strategies

Helmholtz Munich | ©BioRender

Novel drug candidates to control T1D autoimmunity

Martin Scherm / BioRender

Immune-metabolic crosstalk in target tissues of diabetes

Who We Are

Dr. Isabelle Serr

Deputy Department Head

Dr. Maike Becker

Postdoc

Dr. Martin Scherm

Postdoc

Dr. Alexey Surnov

Postdoc

Daria Opaleva

Postdoc

Hannah Hipp

Postdoc

Laura Harrison

Scientific Coordinator

Anne-Katrin Pelak

Team Assistant

Franziska Schadl

Biology Lab Technician

Anne Helena Neubig

Doctoral Researcher

Till Johannsmann

Doctoral Researcher

Gianmarco Spata

Doctoral Researcher

Jana Rohde

Doctoral Researcher

Sandra Maria Dirschl

Doctoral Researcher

Emily Schardey

Doctoral Researcher

Anne-Marie Bührer

Doctoral Researcher

Michael Lauber

Scientist

Franc Hysenaj

Medical Doctoral Researcher

Aina Bonet

Scientific Coordinator

TDI Publications | Key Publications

More on PubMed

2017 Cell Metabolism

Kälin S, Becker M, Ott VB, Serr I, Hosp F, Mollah MMH, Keipert S, Lamp D, Rohner-Jeanrenaud F, Flynn VK, Scherm MG, Nascimento LFR, Gerlach K, Popp V, Dietzen S, Bopp T, Krishnamurthy P, Kaplan MH, Serrano M, Woods SC, Tripal P, Palmisano R, Jastroch M, Bluher M, Wolfrum C, Weigmann B, Ziegler AG, Mann M, Tschöp MH, Daniel C.

A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function

TDI Publications | Reviews

More on PubMed

Contact Us

Laura Harrison

Scientific Coordinator

Type 1 Diabetes Immunology (TDI) Helmholtz Diabetes Center (HDC) Heidemannstraße 1 80939 Munich