Helmholtz Diabetes Center Type 1 Diabetes Immunology
Our main research interest in Type 1 Diabetes Immunology (TDI) focuses on understanding the role of regulatory T cells in the development and progression of autoimmune diseases such as Type 1 Diabetes. To do so, we combine the analysis of human immune cells from different disease stages with mechanistic studies in murine and humanized in vivo models. We focus on the following research topics: We dissect key molecular mechanisms underlying regulatory T cell impairments in autoimmunity and investigate the heterogeneity, plasticity, and functional specialization of regulatory T cells in metabolic tissues of diabetes. Our studies have the overarching goal of facilitating the future context-specific manipulation of regulatory T cells in (autoimmune) diabetes.
Our main research interest in Type 1 Diabetes Immunology (TDI) focuses on understanding the role of regulatory T cells in the development and progression of autoimmune diseases such as Type 1 Diabetes. To do so, we combine the analysis of human immune cells from different disease stages with mechanistic studies in murine and humanized in vivo models. We focus on the following research topics: We dissect key molecular mechanisms underlying regulatory T cell impairments in autoimmunity and investigate the heterogeneity, plasticity, and functional specialization of regulatory T cells in metabolic tissues of diabetes. Our studies have the overarching goal of facilitating the future context-specific manipulation of regulatory T cells in (autoimmune) diabetes.
Leadership team
TDI Publications
Key Publications
More on PubMed2023 Cell Metabolism
2019 Nature Communications
miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes
2019 Molecular Metabolism
Short-term cold exposure supports human Treg induction in vivo
2018 Science Translational Medicine
miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes
2017 Cell Metabolism
A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function
2016 Proceedings of the National Academy of Sciences
2016 Nature Communications
Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice
2013 Nature Reviews Drug Discovery
2011 Journal of Experimental Medicine
2010 Proceedings of the National Academy of Sciences
2009 Journal of Experimental Medicine
TDI Publications
Reviews
More on PubMed2024 Cell Metabolism
2022 Molecular Metabolism
2021 Frontiers in Immunology
Antigen-Specific Treg Therapy in Type 1 Diabetes - Challenges and Opportunities
2021 Frontiers in Immunology
Advances in human immune system (HIS) mouse models for personalized Treg-based immunotherapies
2020 Frontiers in Endocrinology
miRNA-mediated immune regulation in islet autoimmunity and type 1 diabetes
2020 Current Diabetes Reports
miRNA Regulation of T Cells in Islet Autoimmunity and Type 1 Diabetes
2019 Molecular Metabolism
The role of T cell miRNAs for regulatory T cell induction in islet autoimmunity
2018 Frontiers in Immunology
Regulation of T follicular helper cells in islet autoimmunity
2017 European Journal of Immunology
Adipose-tissue regulatory T cells: Critical players in adipose-immune crosstalk
2016 Current Diabetes Reports