Type 1 Diabetes Immunology
Our main research interest focusses on understanding the role of regulatory T cells in the development and progression of autoimmune diseases such as Type 1 Diabetes. To do so, we combine the analysis of human immune cells from different disease stages with mechanistic studies in murine and humanized in vivo models. We focus on the following research topics: We dissect key molecular mechanisms underlying regulatory T cell impairments in autoimmunity and investigate the heterogeneity, plasticity and functional specialization of regulatory T cells in metabolic tissues of diabetes. Our studies have the overarching goal to facilitate the future context-specific manipulation of regulatory T cells in (autoimmune) diabetes.
Our main research interest focusses on understanding the role of regulatory T cells in the development and progression of autoimmune diseases such as Type 1 Diabetes. To do so, we combine the analysis of human immune cells from different disease stages with mechanistic studies in murine and humanized in vivo models. We focus on the following research topics: We dissect key molecular mechanisms underlying regulatory T cell impairments in autoimmunity and investigate the heterogeneity, plasticity and functional specialization of regulatory T cells in metabolic tissues of diabetes. Our studies have the overarching goal to facilitate the future context-specific manipulation of regulatory T cells in (autoimmune) diabetes.
Leadership team
TDI Publications | Key Publications
More on PubMed2023 Cell Metabolism
2019 Nature Communications
miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes
2019 Molecular Metabolism
Short-term cold exposure supports human Treg induction in vivo
2018 Science Translational Medicine
miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes
2017 Cell Metabolism
A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function
2016 Proceedings of the National Academy of Sciences
2016 Nature Communications
Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice
2013 Nature Reviews Drug Discovery
2011 Journal of Experimental Medicine
2010 Proceedings of the National Academy of Sciences
2009 Journal of Experimental Medicine
TDI Publications | Reviews
More on PubMed2024 Cell Metabolism
2022 Molecular Metabolism
2021 Frontiers in Immunology
Antigen-Specific Treg Therapy in Type 1 Diabetes - Challenges and Opportunities
2021 Frontiers in Immunology
Advances in human immune system (HIS) mouse models for personalized Treg-based immunotherapies
2020 Frontiers in Endocrinology
miRNA-mediated immune regulation in islet autoimmunity and type 1 diabetes
2020 Current Diabetes Reports
miRNA Regulation of T Cells in Islet Autoimmunity and Type 1 Diabetes
2019 Molecular Metabolism
The role of T cell miRNAs for regulatory T cell induction in islet autoimmunity
2018 Frontiers in Immunology
Regulation of T follicular helper cells in islet autoimmunity
2017 European Journal of Immunology
Adipose-tissue regulatory T cells: Critical players in adipose-immune crosstalk
2016 Current Diabetes Reports