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Antibodies destroy an infected cell by a virus, immun defense kill the infected cell
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Ebert Lab

Our lab is interested in the study of cell signaling pathways related to cell death and inflammation manipulated during host-pathogen interactions for novel therapeutic development.

 

Our lab is interested in the study of cell signaling pathways related to cell death and inflammation manipulated during host-pathogen interactions for novel therapeutic development.

 

About our research

Our research is focused on the characterization of host-pathogen interactions and the role of cell signaling and cell death during intracellular infections to identify novel host and virulence factors that manipulate the host to facilitate infection. Analysis and understanding of involved signaling pathways and factors allow us to identify novel potent therapeutic targets and strategies to fight infections. We aim to identify and design small molecule compounds that inhibit or eliminate these factors to support the control of infection, including chronic hepatitis B, SARS-CoV-2 and bunyavirus infection. Our work intersects with the fields of molecular virology, cell signaling, immunology and biochemistry and includes in vitro based cell culture assays and tools as well as in vivo infection models in BSL2 and BSL3 laboratories.

 

Our scientists at Ebert Lab

Porträt Gregor Ebert

Dr. Gregor Ebert

Gruppenleiter

Felix Esslinger

PhD Student
Porträt Le Phuoc Hoa

Dr. Phuoc Hoa Le

Wissenschaftler
Porträt Olga Polezhaeva

Olga Polezhaeva

Technician
Porträt Daniele Mistretta

Daniele Mistretta

Technician

Publications

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2024 Scientific Article in ACS applied materials & interfaces

Kohantorabi, M. ; Ugolotti, A. ; Sochor, B. ; Rössler, J. ; Wagstaffe, M. ; Meinhardt, A. ; Beck, E.E. ; Dolling, D.S. ; Garcia, M.B. ; Creutzburg, M. ; Keller, T.F. ; Schwartzkopf, M. ; Vayalil, S.K. ; Thuenauer, R. ; Guédez, G. ; Löw, C. ; Ebert, G. ; Protzer, U. ; Hammerschmidt, W. ; Zeidler, R. ; Roth, S.V. ; Di Valentin, C. ; Stierle, A. ; Noei, H.

Light-induced transformation of virus-like particles on TiO2.

2023 Scientific Article in Communications Biology

Reinke, P.Y.A. ; de Souza, E.E. ; Gunther, S. ; Falke, S. ; Lieske, J. ; Ewert, W. ; Loboda, J. ; Herrmann, A. ; Rahmani Mashhour, A. ; Karničar, K. ; Usenik, A. ; Lindič, N. ; Sekirnik, A. ; Botosso, V.F. ; Santelli, G.M.M. ; Kapronezai, J. ; de Araújo, M.V. ; Silva-Pereira, T.T. ; Filho, A.F.S. ; Tavares, M.S. ; Flórez-Álvarez, L. ; de Oliveira, D.B.L. ; Durigon, E.L. ; Giaretta, P.R. ; Heinemann, M.B. ; Hauser, M. ; Seychell, B. ; Böhler, H. ; Rut, W. ; Drag, M. ; Beck, T. ; Cox, R. ; Chapman, H.N. ; Betzel, C. ; Brehm, W. ; Hinrichs, W. ; Ebert, G. ; Latham, S.L. ; Guimarães, A.M.S. ; Turk, D. ; Wrenger, C. ; Meents, A.

Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections.

2023 Scientific Article in Nature Communications

Garnish, S.E. ; Martin, K.R. ; Kauppi, M. ; Jackson, V.E. ; Ambrose, R. ; Eng, V.V. ; Chiou, S. ; Meng, Y. ; Frank, D. ; Tovey Crutchfield, E.C. ; Patel, K.M. ; Jacobsen, A.V. ; Atkin-Smith, G.K. ; Di Rago, L. ; Doerflinger, M. ; Horne, C.R. ; Hall, C. ; Young, S.N. ; Cook, M. ; Athanasopoulos, V. ; Vinuesa, C.G. ; Lawlor, K.E. ; Wicks, I.P. ; Ebert, G. ; Ng, A.P. ; Slade, C.A. ; Pearson, J.S. ; Samson, A.L. ; Silke, J. ; Murphy, J.M. ; Hildebrand, J.M.

A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation.

Contact

Porträt Gregor Ebert

Dr. Gregor Ebert

Gruppenleiter