Ebert Lab
Our lab is interested in the study of cell signaling pathways related to cell death and inflammation manipulated during host-pathogen interactions for novel therapeutic development.
Our lab is interested in the study of cell signaling pathways related to cell death and inflammation manipulated during host-pathogen interactions for novel therapeutic development.
About our research
Our research is focused on the characterization of host-pathogen interactions and the role of cell signaling and cell death during intracellular infections to identify novel host and virulence factors that manipulate the host to facilitate infection. Analysis and understanding of involved signaling pathways and factors allow us to identify novel potent therapeutic targets and strategies to fight infections. We aim to identify and design small molecule compounds that inhibit or eliminate these factors to support the control of infection, including chronic hepatitis B, SARS-CoV-2 and bunyavirus infection. Our work intersects with the fields of molecular virology, cell signaling, immunology and biochemistry and includes in vitro based cell culture assays and tools as well as in vivo infection models in BSL2 and BSL3 laboratories.
Publications
Read more2024 Scientific Article in Nature Communications
Multi-omics characterization of the monkeypox virus infection.
2024 Scientific Article in ACS applied materials & interfaces
Light-induced transformation of virus-like particles on TiO2.
2024 Scientific Article in Journal of Medicinal Chemistry
Structural elucidation and antiviral activity of covalent cathepsin L inhibitors.
2024 Letter to the Editor in Cell Discovery
Engineered, nucleocytoplasmic shuttling Cas13d enables highly efficient cytosolic RNA targeting.
2024 Scientific Article in Virology
Major open questions in the hepatitis B and D field – Proceedings of the inaugural International emerging hepatitis B and hepatitis D researchers workshop.
2024 Scientific Article in Virology
Murine norovirus infection of macrophages induces intrinsic apoptosis as the major form of programmed cell death.
2023 Scientific Article in Communications Biology
Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections.
2023 Scientific Article in Nature Communications
A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation.
2023 Scientific Article in ACS applied materials & interfaces