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Nößner Lab

Research unit IMA-TCI studies the interaction of immunocytes with aberrant tissue cells in kidney liver and lung to provide new hypothesis for therapy improvement. Immune monitoring accompanying clinical trials shall identify new prognostic and predictive markers.

Research unit IMA-TCI studies the interaction of immunocytes with aberrant tissue cells in kidney liver and lung to provide new hypothesis for therapy improvement. Immune monitoring accompanying clinical trials shall identify new prognostic and predictive markers.

About our research

The focus of our research are immunocytes in peripheral blood and within tissue where they have to be active to maintain health and fight disease. We study killer cells in cancer patients. They are detected even in patients with advanced disease, thus, their activity is obviously not sufficient to destroy the cancer cells. We wish to understand the immune suppression and explore strategies to better activate the patients' immune system.  We use engineering approaches and means to change the tissue milieu to enable necessary immune reactivity. With our knowledge in flow cytometry and multiplex cytokine profiling we determine the features of those immunocytes, which can destroy the cancer cells. We work closely with clinicians and pharma, providing our knowledge for guidance to improve therapies and help patient selection for best therapeutic approach.

 

Our scientists at Nößner Lab

Prof. Dr. Elfriede Nößner

Group Leader

Publications

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2022 Scientific Article in Translational Lung Cancer Research

Käsmann, L. ; Taugner, J. ; Eze, C. ; Nieto, A. ; Pelikan, C. ; Floersch, B. ; Kenndoff, S. ; Hofer, T.P. ; Nößner, E. ; Schulz, C. ; Unterrainer, M. ; Tufman, A. ; Klauschen, F. ; Jung, A. ; Neumann, J. ; Kumbrink, J. ; Reinmuth, N. ; Bartenstein, P. ; Belka, C. ; Manapov, F.

Prospective evaluation of immunological, molecular-genetic, image-based and microbial analyses to characterize tumor response and control in patients with unresectable stage III NSCLC treated with concurrent chemoradiotherapy followed by consolidation therapy with durvalumab (PRECISION): Protocol for a prospective longitudinal biomarker study.

2021 Scientific Article in European Journal of Cancer

Issels, R.D. ; Nößner, E. ; Lindner, L.H. ; Schmidt, M. ; Albertsmeier, M. ; Blay, J.Y. ; Stutz, E. ; Xu, Y. ; Buecklein, V. ; Altendorf-Hofmann, A. ; Abdel-Rahman, S. ; Mansmann, U. ; von Bergwelt-Baildon, M. ; Knoesel, T.

Immune infiltrates in patients with localised high-risk soft tissue sarcoma treated with neoadjuvant chemotherapy without or with regional hyperthermia: A translational research program of the EORTC 62961-ESHO 95 randomised clinical trial.

2021 Scientific Article in Journal of Hepatology

Quitt, O. ; Luo, S. ; Meyer, M. ; Xie, Z. ; Golsaz-Shirazi, F. ; Loffredo-Verde, E. ; Festag, J. ; Bockmann, J.H. ; Zhao, L. ; Stadler, D. ; Chou, W.M. ; Tedjokusumo, R. ; Wettengel, J.M. ; Ko, C. ; Nößner, E. ; Bulbuc, N. ; Shokri, F. ; Lüttgau, S. ; Heikenwälder, M. ; Bohne, F. ; Moldenhauer, G. ; Momburg, F. ; Protzer, U.

T-cell engager antibodies enable T cells to control HBV infection and to target HBsAg-positive hepatoma in mice.

2021 Scientific Article in Scientific Reports

Esteve-Codina, A. ; Hofer, T.P. ; Burggraf, D. ; Heiss-Neumann, M.S. ; Gesierich, W. ; Boland, A. ; Olaso, R. ; Bihoreau, M.T. ; Deleuze, J.F. ; Möller, W. ; Schmid, O. ; Soler Artigas, M. ; Renner, K. ; Hohlfeld, J.M. ; Welte, T. ; Fuehner, T. ; Jerrentrup, L. ; Koczulla, A.R. ; Greulich, T. ; Prasse, A. ; Müller-Quernheim, J. ; Gupta, S. ; Brightling, C. ; Subramanian, D.R. ; Parr, D.G. ; Kolsum, U. ; Gupta, V. ; Barta, I. ; Döme, B. ; Strausz, J. ; Stendardo, M. ; Piattella, M. ; Boschetto, P. ; Korzybski, D. ; Gorecka, D. ; Nowinski, A. ; Dabad, M. ; Fernández-Callejo, M. ; Endesfelder, D. ; zu Castell, W. ; Hiemstra, P.S. ; Venge, P. ; Nößner, E. ; Griebel, T. ; Heath, S. ; Singh, D. ; Gut, I. ; Ziegler-Heitbrock, L.

Gender specific airway gene expression in COPD sub-phenotypes supports a role of mitochondria and of different types of leukocytes.

Contact

Prof. Dr. Elfriede Nößner

Group Leader