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Complex Diseases

We aim to decipher the molecular underpinnings of complex traits and the effect of environment and lifestyle on (epi-)genomic regulation.

We aim to decipher the molecular underpinnings of complex traits and the effect of environment and lifestyle on (epi-)genomic regulation.

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About our Research

Our research focuses on the molecular analysis of cardiometabolic traits. We combine state-of-the-art laboratory and statistical methods to study the complex interplay between molecular mechanisms, environment and lifestyle in the context of the onset and progression of disease. Identified loci are subjected to further functional characterization. We have particular experience in conducting high-throughput genotyping and genome-wide methylation projects.

 

People at Complex Diseases

Dr. Melanie Waldenberger

Senior Scientist, Head of Research Group 'Complex Diseases' View profile

Monica del Carmen Gomez Alonso

PhD Student

Pamela Matias Garcia

Postdoc

Nadine Lindemann

Technician

Ritika Sharma

PhD Student (visiting)

Dr. Julia Groth

Project Manager Biobanking

Liye Lai

PhD Student

Markéta Rynesova

Data Scientist

Dr. Thomas Delerue

Postdoc

Dr. Aayah Nounu

Postdoc

Current Projects

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Funded by BMBF

Dimension

Dietary induced methylome and transcriptome dynamics assessing nutrition impacts on cardiovascular and metabolic health

 

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Funded by DFG

Risk Prediction Score

Identification and validation of circulating sncRNAs causally associated with gallbladder cancer and development of a multifactorial risk prediction score

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Funded by DFG & CONACYT

Functional Characterization

Functional characterization of DNA methylation at the LGALS3BP and SREBF1 loci: molecular mechanisms linked to metabolic disorders

Funded by EU

ORCHESTRA

Connecting European Cohorts to Increase Common and Effective Response to SARS-CoV-2 Pandemic

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Orchestra
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Funded by DZHK

Shared Expertise

Epigenetic age acceleration and cardiometabolic health: a longitudinal investigation.

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DNA Methylation

Methylation of DNA is important to determine genomic structure and function. Disturbances in DNA methylation have been implicated in the development of a variety of pathologies. Improved mechanistic understanding of the genetic, environmental and lifestyle influences on DNA methylation is anticipated to provide new insights into the biological pathways that determine genome regulation, molecular phenotypes, and development of disease.

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Contact Head

Dr. Melanie Waldenberger

Senior Scientist, Head of Research Group 'Complex Diseases'

34/0307a