Henriette Uhlenhaut

Director of the Institute for Diabetes and Endocriology and W3 Professor, Chair for Metabolic Programming, Technical University of Munich (TUM)

Prof. Dr. Henriette Uhlenhaut

"Hormones control every second of every day of our lives! Here at IDE, we aim to harness the power of hormones to find novel therapeutic approaches for the treatment of metabolic and inflammatory disorders, and for healthier, longer lives."

Academic Career and Research Areas

Prof. Uhlenhaut's (*1977) research focuses on investigating gene regulatory mechanisms that mediate hormone responses. Latest genome-wide techniques are combined with preclinical models to find new therapeutic approaches for metabolic or inflammatory diseases (e.g. diabetes, asthma).

Prof. Uhlenhaut studied at the Technical University of Braunschweig and at Georgia Tech in Atlanta. She received her doctorate from EMBL in Heidelberg and, after postdoctoral research at the Salk Institute in San Diego and the MDC in Berlin, came to Helmholtz Zentrum München as group leader. She was also professor at the Gene Center of the LMU. In 2019, Prof. Uhlenhaut was appointed professor of 'Metabolic Programming' at the TUM.

Fields of Work and Expertise

Nuclear hormone receptors Transcription Chromatin Genomics Metabolism

Gene Regulation Inflammation Hormones Circadian Clocks Physiology

Professional Background

Since 2021

Director of the Institute for Diabetes and Endocrinology

Since 2019

W3 Professor at TUM School of Life Sciences, Chair for Metabolic Programming

2018 - 2019

W2 Professor LMU Gene Center

2013 - 2018

Emmy Noether group leader at HDC Helmholtz Munich

Honors and Awards

  • 2023 EJE Award of the European Society of Endocrinology
  • 2023 ERC GRACE
  • 2022 Science Prize from the city of Freising
  • 2019 Heinz-Maier-Leibnitz Prize of the DFG
  • 2015 Friedmund Neumann Prize of the Schering Foundation
  • 2014 ERC Starting Grant SILENCE

Highlight Publications

Sara Della Torre, Valeria Benedusi, Giovanna Pepe, Clara Meda, Nicoletta Rizzi, Nina Henriette Uhlenhaut, Adriana Maggi; 2021

Dietary essential amino acids restore liver metabolism in ovariectomized mice via hepatic estrogen receptor α

Franziska Greulich, Michael Wierer, Aikaterini Mechtidou, Omar Gonzalez-Garcia, N Henriette Uhlenhaut; 2021

The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers

Laura Escoter-Torres, Franziska Greulich, Fabiana Quagliarini, Michael Wierer, Nina Henriette Uhlenhaut; 2020

Anti-inflammatory functions of the glucocorticoid receptor require DNA binding

Fabiana Quagliarini, Ashfaq Ali Mir, Kinga Balazs, Michael Wierer, Kenneth Allen Dyar, Celine Jouffe, Konstantinos Makris, Johann Hawe, Matthias Heinig, Fabian Volker Filipp, Grant Daniel Barish, Nina Henriette Uhlenhaut; 2019

Cistromic Reprogramming of the Diurnal Glucocorticoid Hormone Response by High-Fat Diet

M Charlotte Hemmer, Michael Wierer, Kristina Schachtrup, Michael Downes, Norbert Hübner, Ronald M Evans, N Henriette Uhlenhaut; 2019

E47 modulates hepatic glucocorticoid action

Kenneth Allen Dyar, Michaël Jean Hubert, Ashfaq Ali Mir, Stefano Ciciliot, Dominik Lutter, Franziska Greulich, Fabiana Quagliarini, Maximilian Kleinert, Katrin Fischer, Thomas Oliver Eichmann, Lauren Emily Wright, Marcia Ivonne Peña Paz, Alberto Casarin, Vanessa Pertegato, Vanina Romanello, Mattia Albiero, Sara Mazzucco, Rosario Rizzuto, Leonardo Salviati, Gianni Biolo, Bert Blaauw, Stefano Schiaffino, N Henriette Uhlenhaut; 2018

Transcriptional programming of lipid and amino acid metabolism by the skeletal muscle circadian clock

Networks and Affiliations

German Center for Diabetes Research

Read more
Logo CRC Chromatin Dynamics

SFB 1064 - Chromatin Dynamics

Read more
SFB 205 Logo - Nebennierenforschung

TRR205 - Adrenal Gland

Read more
BATenergy CRC TRR333 Logo

TRR333 - BATenergy

Read more
Logo epigenetics@HelmholtzMunich

Epigenetics@HelmholtzMunich

Read more
Logo Technische Universität München

ZIEL - Institute for Food & Health

Read more
Logo Technische Universität München

TUM Metabolic Programming

Read more