Epigenetics @HelmholtzMunich
Dozens of researchers at Helmholtz Munich joined forces
to reveal the myriad of secrets of Epigenetics.
The Epigenetics@HelmholtzMunich Community Research consists of almost 30 labs from 17 Helmholtz Munich institutes, committed all to performing ground-breaking research in the field of epigenetics. These groups are pioneers in their respective disciplines, utilizing cutting edge techniques to answer the complex questions of today.
The topics studied by the community include: stem cells, cellular plasticity, metabolism, diabetes, computational biology, epidemiology, immunology, development and systems biology.
Dozens of researchers @Helmholtz Munich join forces to reveal the myriad of secrets of Epigenetics.
Learn more about us below.
Our Groups
Seminars & Events
Recent Publications
Back2025 Editorial in Current Opinion in Cell Biology Curr. Opin. Cell Biol. 95:102530 (2025)
Fukagawa, T. ; Torres-Padilla, M.E.
Exploring the cell nucleus: From chromosome structure to single-cell omics.
2025 Review in Current Opinion in Neurobiology Curr. Opin. Neurobiol. 93:103047 (2025)
Merino, F.L. ; Götz, M.
The role of moonlighting proteins in neurogenesis.
In: (The Thirteenth International Conference on Learning Representations (ICLR 2025 Spotlight)). 2025. accepted
Hetzel, L. ; Sommer, J. ; Rieck, B. ; Theis, F.J. ; Günnemann, S.
MAGNet: Motif-agnostic generation of molecules from scaffolds.
In:. International Conference on Learning Representations, ICLR, 2025. accepted
Uscidda, T. ; Eyring, L. ; Roth, K. ; Theis, F.J. ; Akata, Z. ; Cuturi, M.C.
Disentangled representation learning with the gromov-monge gap.
Lecture Notes in Computer Science In: (International Conference on Research in Computational Molecular Biology). 2025. 285-289 (Lect. Notes Comput. Sc. ; 15647 LNBI)
Inecik, K. ; Kara, A. ; Rose, A. ; Haniffa, M. ; Theis, F.J.
TarDis: Achieving robust and structured disentanglement of multiple covariates.
Lecture Notes in Computer Science In: (29th RECOMB 2025). 2025. 345-348 (Lect. Notes Comput. Sc. ; 15647 LNBI)
Litinetskaya, A. ; Schulman, M. ; Curion, F. ; Szalata, A. ; Omidi, A. ; Lotfollahi, M. ; Theis, F.J.
Integration and querying of multimodal single-cell data with PoE-VAE.
Papargyriou, A. ; Richter, T. ; Luecken, M. ; Theis, F.J. ; Reichert, M.
Single cell transcriptomic analysis of epithelial and mesenchymal tumour cells.
In: (The Thirteenth International Conference on Learning Representations, ICLR 2025). 2025. accepted
Palma, A. ; Richter, T. ; Zhang, H. ; Lubetzk, M. ; Tong, A. ; Dittadi, A. ; Theis, F.J.
Multi-modal and multi-attribute generation of single cells with CFGen.
2025 Nature metabolism Nat. Metab., DOI: 10.1038/s42255-025-01308-8 (2025)
Gutgesell, R.M. ; Khalil, A. ; Liskiewicz, A. ; Maity-Kumar, G. ; Novikoff, A. ; Grandl, G. ; Liskiewicz, D. ; Coupland, C. ; Karaoglu, Ö.E. ; Akindehin, S.E. ; Castelino, R.L. ; Curion, F. ; Liu, X. ; García-Cáceres, C. ; Cebrian Serrano, A. ; Douros, J.D. ; Knerr, P.J. ; Finan, B. ; DiMarchi, R.D. ; Sloop, K.W. ; Samms, R.J. ; Theis, F.J. ; Tschöp, M.H. ; Müller, T.D.
Publisher Correction: GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice.
2025 Scientific Article in Nature Genetics Nat. Genet. 57, 1201–1212 (2025)
Xu, Q. ; Halle, L. ; Hediyeh-Zadeh, S. ; Kuijs, M. ; Riedweg, R. ; Kilik, U. ; Recaldin, T. ; Yu, Q. ; Rall, I. ; Frum, T. ; Adam, L. ; Parikh, S. ; Kfuri-Rubens, R. ; Gander, M. ; Klein, D. ; Curion, F. ; He, Z. ; Fleck, J.S. ; Oost, K. ; Kahnwald, M. ; Barbiero, S. ; Mitrofanova, O. ; Maciag, G.J. ; Jensen, K.B. ; Lutolf, M. ; Liberali, P. ; Spence, J.R. ; Gjorevski, N. ; Beumer, J. ; Treutlein, B. ; Theis, F.J. ; Camp, J.G.
An integrated transcriptomic cell atlas of human endoderm-derived organoids.
2025 Scientific Article in Phenomics Phenomics, DOI: 10.1007/s43657-024-00205-6 (2025)
Gao, Z. ; Yan, X. ; Wang-Sattler, R. ; Covic, M. ; Yu, G. ; Ge, F. ; Lin, J. ; Chen, Q. ; Liu, J. ; Sharma, S. ; Molnos, S. ; Kühnel, B. ; Wilson, R. ; Adam, J. ; Brandmaier, S. ; Yu, S. ; Liang, F. ; Gieger, C.
Metabolomics reveals reasons for the efficacy of acupuncture in migraine patients: The role of anaerobic glycolysis and mitochondrial citrate in migraine relief.
2025 Scientific Article in Clinical Epigenetics Clin. Epigenet. 17:68 (2025)
Rajić, S. ; Delerue, T. ; Ronkainen, J. ; Zhang, R. ; Ciantar, J. ; Kostiniuk, D. ; Mishra, P.P. ; Lyytikäinen, L.P. ; Mononen, N. ; Kananen, L. ; Peters, A. ; Winkelmann, J. ; Kleber, M.E. ; Lorkowski, S. ; Kähönen, M. ; Lehtimäki, T. ; Raitakari, O. ; Waldenberger, M. ; Gieger, C. ; März, W. ; Harville, E.W. ; Sebert, S. ; Marttila, S. ; Raitoharju, E.
Regulation of nc886 (vtRNA2-1) RNAs is associated with cardiometabolic risk factors and diseases.
2025 Scientific Article in Scientific Reports Sci. Rep. 15:15791 (2025)
Ruß, A.K. ; Schreiber, S. ; Lieb, W. ; Vehreschild, J.J. ; Heuschmann, P.U. ; Illig, T. ; Appel, K.S. ; Vehreschild, M.J.G.T. ; Krefting, D. ; Reinke, L. ; Viebke, A. ; Poick, S. ; Störk, S. ; Reese, J.P. ; Zöller, T. ; Krist, L. ; Ellinghaus, D. ; Fösel, B. ; Gieger, C. ; Lorenz-Depiereux, B. ; Witzenrath, M. ; Anton, G. ; Krawczak, M. ; Heyckendorf, J. ; Bahmer, T.
Genome-wide association study of post COVID-19 syndrome in a population-based cohort in Germany.
2025 Scientific Article in Nature metabolism Nat. Metab., DOI: 10.1038/s42255-025-01294-x (2025)
Gutgesell, R.M. ; Khalil, A. ; Liskiewicz, A. ; Maity-Kumar, G. ; Novikoff, A. ; Grandl, G. ; Liskiewicz, D. ; Coupland, C. ; Karaoglu, Ö.E. ; Akindehin, S.E. ; Castelino, R.L. ; Curion, F. ; Liu, X. ; García-Cáceres, C. ; Cebrian Serrano, A. ; Douros, J.D. ; Knerr, P.J. ; Finan, B. ; DiMarchi, R.D. ; Sloop, K.W. ; Samms, R.J. ; Theis, F.J. ; Tschöp, M.H. ; Müller, T.D.
GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice.
2025 Scientific Article in Neuro-Oncology Neuro. Oncol., DOI: 10.1093/neuonc/noaf113 (2025)
Ruiz-Moreno, C. ; Salas, S.M. ; Samuelsson, E. ; Minaeva, M. ; Ibarra Del Rio, I.A. ; Grillo, M. ; Brandner, S. ; Roy, A. ; Forsberg-Nilsson, K. ; Kranendonk, M.E.G. ; Theis, F.J. ; Nilsson, M. ; Stunnenberg, H.G.
Charting the single-cell and spatial landscape of IDH-wildtype glioblastoma with GBmap.
2025 Scientific Article in Genome Biology Genome Biol. 26:100 (2025)
Maddhesiya, P. ; Lepko, T. ; Steiner‑Mezzardi, A. ; Schneider, J. ; Schwarz, V. ; Merl-Pham, J. ; Berger, F. ; Hauck, S.M. ; Ronfani, L. ; Bianchi, M.E. ; Simon, T. ; Krontira, A. ; Masserdotti, G. ; Götz, M. ; Ninkovic, J.
Hmgb2 improves astrocyte to neuron conversion by increasing the chromatin accessibility of genes associated with neuronal maturation in a proneuronal factor-dependent manner.
2025 Scientific Article in Translational Psychiatry Transl. Psychiatry 15:153 (2025)
Worf, K. ; Matosin, N. ; Gerstner, N. ; Fröhlich, A.S. ; Koller, A.C. ; Degenhardt, F. ; Thiele, H. ; Rietschel, M. ; Udawela, M. ; Scarr, E. ; Dean, B. ; Theis, F.J. ; Müller, N.S. ; Knauer-Arloth, J.
Exon-variant interplay and multi-modal evidence identify endocrine dysregulation in severe psychiatric disorders impacting excitatory neurons.
2025 Review in Nature Nature 640, 623-633 (2025)
Cui, H. ; Tejada Lapuerta, A. ; Brbic, M. ; Saez-Rodriguez, J. ; Cristea, S. ; Goodarzi, H. ; Lotfollahi, M. ; Theis, F.J. ; Wang, B.