acEX study
Background and objectives
Reduced insulin action plays a central role in type 2 diabetes and obesity. The latest research indicates that endurance exercise can not only improve metabolic processes in the body, but also the effect of insulin in the brain. This is associated with an improved metabolism, a reduction in the feeling of hunger and a reduction in unhealthy abdominal fat.
The extent to which a single training session influences the insulin effect in the brain is still largely unknown. This study attempts to answer this question.
Study design and program
The study comprises six measurement days. A screening followed by two preliminary examinations and three training sessions. .
Screening: Physical examination with blood sampling and cognitive tests (duration approx. 3 hours).
Preliminary examinations: Glucose tolerance test with blood sampling, examination of fat distribution using whole-body magnetic resonance imaging (MRI), measurement of resting energy expenditure, fitness test (2 appointments, duration approx. 2-4 hours each).
Training sessions: One training session on the cycle ergometer (endurance training and interval training) and control condition at rest, including blood sampling. Subsequent examination of brain activity using magnetic resonance imaging (MRI) after administration of insulin
nasal spray, as well as reaction tasks and questionnaires on a computer or tablet (3 appointments; duration approx. 1 hour).
Inclusion criteria
- Healthy women and men aged 20 to 65 years
and
- No more than 75 minutes of physical activity per week
Exclusion criteria
- Type 2 diabetes, cardiovascular diseases such as chronic heart failure, myocardial infarction, post-stroke condition
- Balance and coordination disorders, orthopaedic problems, ...
- Pregnancy / breastfeeding
- Psychiatric / neurological disease
- Taking psychotropic drugs
- Taking medication that affects the glucose metabolism
- Taking anticoagulants
- Contraindications to magnetic resonance imaging (e.g. metal in the body)
- Participation in other studies
Background and objectives
Reduced insulin action plays a central role in type 2 diabetes and obesity. The latest research indicates that endurance exercise can not only improve metabolic processes in the body, but also the effect of insulin in the brain. This is associated with an improved metabolism, a reduction in the feeling of hunger and a reduction in unhealthy abdominal fat.
The extent to which a single training session influences the insulin effect in the brain is still largely unknown. This study attempts to answer this question.
Study design and program
The study comprises seven measurement days. A screening followed by two preliminary examinations and three training sessions. .
Screening: Physical examination with blood sampling and cognitive tests (duration approx. 3 hours).
Preliminary examinations: Glucose tolerance test with blood sampling, examination of fat distribution using whole-body magnetic resonance imaging (MRI), measurement of resting energy expenditure, fitness test (2 appointments, duration approx. 2-4 hours each).
Training sessions: One training session on the cycle ergometer (endurance training and interval training) and control condition at rest, including blood sampling. Subsequent examination of brain activity using magnetic resonance imaging (MRI) after administration of insulin
nasal spray, as well as reaction tasks and questionnaires on a computer or tablet (3 appointments; duration approx. 1 hour).
Inclusion criteria
- Healthy women and men aged 20 to 65 years
and
- No more than 75 minutes of physical activity per week
Exclusion criteria
- Type 2 diabetes, cardiovascular diseases such as chronic heart failure, myocardial infarction, post-stroke condition
- Balance and coordination disorders, orthopaedic problems, ...
- Pregnancy / breastfeeding
- Psychiatric / neurological disease
- Taking psychotropic drugs
- Taking medication that affects the glucose metabolism
- Taking anticoagulants
- Contraindications to magnetic resonance imaging (e.g. metal in the body)
- Participation in other studies
If you have any questions about the study or would like to make an appointment, please contact us by e-mail:
