All IEG Publications
2024 Scientific Article in International Journal of Molecular Sciences Int. J. Mol. Sci. 25:11073 (2024)
Plasma lipidomics reveals lipid signatures of early pregnancy in mares.
2024 Scientific Article in Scientific Data Sci. Data 11:1159 (2024)
The Journey to a FAIR CORE DATA SET for Diabetes Research in Germany.
2024 Scientific Article in Metabolomics Metabolomics 20:109 (2024)
Infants with biliary atresia exhibit an altered amino acid profile in their newborn screening.
2024 Scientific Article in Advanced science Adv. Sci.:e2404661 (2024)
The eATP/P2×7R axis drives quantum dot-nanoparticle induced neutrophil recruitment in the pulmonary microcirculation.
2024 Scientific Article in Molecular Metabolism Mol. Metab. 90:102033 (2024)
HDAC5 controls a hypothalamic STAT5b-TH axis, the sympathetic activation of ATP-consuming futile cycles and adult-onset obesity in male mice.
2024 Scientific Article in Science Advances Sci. Adv. 10:eadl4374 (2024)
Loss of atrial natriuretic peptide signaling causes insulin resistance, mitochondrial dysfunction, and low endurance capacity.
2024 Scientific Article in Diabetologia Diabetologia, DOI: 10.1007/s00125-024-06282-6 (2024)
Role of human plasma metabolites in prediabetes and type 2 diabetes from the IMI-DIRECT study.
2024 Letter to the Editor in Mammalian Genome Mamm. Genome, DOI: 10.1007/s00335-024-10072-1 (2024)
Digital tools of analysis and data integration facilitate synergy between mouse and human brain research and enable translation.
2024 Scientific Article in Metabolomics Metabolomics 20:105 (2024)
Stool and blood metabolomics in the metabolic syndrome: A cross-sectional study.
2024 Scientific Article in Science Advances Sci. Adv. 10:eadp0443 (2024)
Opa1 processing is dispensable in mouse development but is protective in mitochondrial cardiomyopathy.
2024 Acta Diabetologica Acta Diabetol. 61, 1015-1015 (2024)
Correction: GALNT2 expression is associated with glucose control and serum metabolites in patients with type 2 diabetes.
2024 Scientific Article in Journal of Clinical Endocrinology & Metabolism, The J. Clin. Endocrinol. Metab.:dgae551 (2024)
GFR decline predicts total mortality and mediates the effect of tryptophan metabolism on death risk in type 2 diabetes.
2024 Scientific Article in Nature Communications Nat. Commun. 15:7111 (2024)
A roadmap to the molecular human linking multiomics with population traits and diabetes subtypes.
2024 Scientific Article in Life Science Alliance Life Sci. All. 7:15 (2024)
Examining the liver-pancreas crosstalk reveals a role for the molybdenum cofactor in β-cell regeneration.
2024 Scientific Article in Journal of Clinical Endocrinology & Metabolism, The J. Clin. Endocrinol. Metab.:dgae593 (2024)
Inflammation and prediction of death in type 2 diabetes. Evidence of an intertwined link with tryptophan metabolism.
2024 Scientific Article in Acta Diabetologica Acta Diabetol. 61, 1007-1013 (2024)
GALNT2 expression is associated with glucose control and serum metabolites in patients with type 2 diabetes.
Lecture Notes in Computer Science In: (Medical Image Understanding and Analysis). Gewerbestrasse 11, Cham, Ch-6330, Switzerland: Springer International Publishing Ag, 2024. 366-381 (Lect. Notes Comput. Sc. ; 14860 LNCS)
EchoVisuAL: Efficient Segmentation of Echocardiograms Using Deep Active Learning.
2024 Scientific Article in Reproduction, Fertility and Development Reprod. Fertil. Dev. 36:RD24079 (2024)
ShinySperm: Navigating the sperm proteome landscape.
2024 Scientific Article in Molecular and Cellular Proteomics Mol. Cell. Proteomics 23:100811 (2024)
Enhanced in situ spatial proteomics by effective combination of MALDI imaging and LC-MS/MS.
2024 Scientific Article in Endocrinology Endocrinology 165:bqae067 (2024)
Comparative phenotyping of mice reveals canonical and noncanonical physiological functions of TRα and TRβ.
2024 Review in Nature Communications Nat. Commun. 15:5574 (2024)
Improving laboratory animal genetic reporting: LAG-R guidelines.
2024 Scientific Article in Pituitary Pituitary, DOI: 10.1007/s11102-024-01424-w (2024)
Decreased β-cell volume and insulin secretion but preserved glucose tolerance in a growth hormone insensitive pig model.
2024 Scientific Article in European Journal of Epidemiology Eur. J. Epidemiol., DOI: 10.1007/s10654-024-01136-2 (2024)
Sex hormone-binding globulin may explain sex differences for glucose homeostasis and incidence of type 2 diabetes: The KORA study.
2024 Scientific Article in Cardiovascular Diabetology Cardiovasc. Diabetol. 23:199 (2024)
Bidirectional modulation of TCA cycle metabolites and anaplerosis by metformin and its combination with SGLT2i.
2024 Scientific Article in Nature Nature, 27 (2024)
Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs.
2024 Scientific Article in Thyroid Thyroid, DOI: 10.1089/thy.2023.0683 (2024)
Canonical and noncanonical contribution of thyroid hormone receptor isoforms alpha and beta to cardiac hypertrophy and heart rate in male mice.
2024 Scientific Article in Science Advances Sci. Adv. 10:eadj8769 (2024)
A brain-enriched circular RNA controls excitatory neurotransmission and restricts sensitivity to aversive stimuli.
2024 Scientific Article in American Journal of Physiology - Renal Physiology Am. J. Physiol.-Renal Physiol. 326, F792-F801 (2024)
The Calcium-sensing receptor (CaSR) has only a PTH-dependent role in the acute response of renal phosphatetransporters to phosphate intake.
2024 Scientific Article in Nature metabolism Nat. Metab., 29 (2024)
Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity.
2024 Scientific Article in Breast Cancer Research Breast Cancer Res. 26:74 (2024)
TRPS1 maintains luminal progenitors in the mammary gland by repressing SRF/MRTF activity.
2024 Scientific Article in Journal of Clinical Endocrinology & Metabolism, The J. Clin. Endocrinol. Metab. 109, e1697-e1707 (2024)
The association of cardiometabolic, diet and lifestyle parameters with plasma glucagon-like peptide-1: An IMI DIRECT study.
2024 Scientific Article in Nutrition, Metabolism and Cardiovascular Diseases Nutr. Metab. Cardiovasc. Dis. 34, 1807-1816 (2024)
Circulatory levels of lysophosphatidylcholine species in obese adolescents: Findings from cross-sectional and prospective lipidomics analyses.
2024 Scientific Article in EBioMedicine EBioMedicine 101:105024 (2024)
Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk: A nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC).
2024 Review in Journal of Physiology - London J. Physiol.-London 602, 1655-1658 (2024)
Turning fat into muscle: can this be an alternative to anti-obesity drugs such as semaglutide?
2024 Scientific Article in Pflügers Archiv Pflugers Arch. 476, 833-845 (2024)
A novel mouse model for familial hypocalciuric hypercalcemia (FHH1) reveals PTH-dependent and independent CaSR defects.
2024 Scientific Reports Sci. Rep. 14:3841 (2024)
Author Correction: Blood and adipose tissue steroid metabolomics and mRNA expression of steroidogenic enzymes in periparturient dairy cows differing in body condition.
2024 Scientific Article in Cell Research Cell Res. 34, 245-257 (2024)
MFSD7c functions as a transporter of choline at the blood-brain barrier.
2024 Scientific Article in Sleep Sleep 47:zsae015 (2024)
A patient-enriched MEIS1 coding variant causes a restless legs syndrome-like phenotype in mice.
2024 Scientific Article in International Journal of Biological Macromolecules Int. J. Biol. Macromol. 265:130962 (2024)
Metabolic effects of SGLT2i and metformin on 3-hydroxybutyric acid and lactate in db/db mice.
2024 Scientific Article in BMJ Open Diabetes Research & Care BMJ Open Diab. Res. Care 12:e003865 (2024)
Omentin associates with serum metabolite profiles indicating lower diabetes risk: KORA F4 Study.
2024 Scientific Article in Biomarker Research Biomark. Res. 12:31 (2024)
Serum metabolite signatures of cardiac function and morphology in individuals from a population-based cohort.
2024 Scientific Article in Thorax Thorax 79, 524-537 (2024)
COPD basal cells are primed towards secretory to multiciliated cell imbalance driving increased resilience to environmental stressors.
2024 Scientific Article in Respiratory Research Respir. Res. 25:49 (2024)
Assessment of wood smoke induced pulmonary toxicity in normal- and chronic bronchitis-like bronchial and alveolar lung mucosa models at air-liquid interface.
2024 Scientific Article in European Respiratory Journal Eur. Respir. J. 63:2301326 (2024)
Sfrp1 inhibits lung fibroblast invasion during transition to injury induced myofibroblasts.
2024 Scientific Article in Physiological reports Physiol. Rep. 12:e15901 (2024)
LncRNA U90926 is dispensable for the development of obesity-associated phenotypes in vivo.
2024 Scientific Article in Cell and Tissue Research Cell Tissue Res. 395, 271–283 (2024)
Yap/Taz activity is associated with increased expression of phosphoglycerate dehydrogenase that supports myoblast proliferation.
2024 Scientific Article in Obesity Obesity 32, 363-375 (2024)
Novel markers and networks related to restored skeletal muscle transcriptome after bariatric surgery.
2023 Alzheimer's & Dementia Poster: Basic Science and Pathogenesis – Part 1 (2023)
Individual bioenergetic capacity as a potential source of resilience to Alzheimer's disease.
2023 Scientific Article in Neuroscience Applied Neurosci. App. 2:101126 (2023)
GPR101 loss promotes insulin resistance and diet-induced obesity risk.
2023 Scientific Article in The Lancet Public Health Lancet Public Health 8, e453-e462 (2023)
Multiple morbidity across the lifespan in people with Down syndrome or intellectual disabilities: A population-based cohort study using electronic health records.
2023 Scientific Article in Kidney International Kidney Int. 105, 844-864 (2023)
Implication of transcription factor FOXD2 dysfunction in syndromic congenital anomalies of the kidney and urinary tract (CAKUT).
2023 Scientific Article in Journal of Clinical Endocrinology & Metabolism, The J. Clin. Endocrinol. Metab. 109, 1318-1327 (2023)
Skeletal muscle gene expression signatures of obese high- and low- responders to endurance exercise training.
2023 Scientific Article in Nature Communications Nat. Commun. 14:7674 (2023)
A reversible state of hypometabolism in a human cellular model of sporadic Parkinson's disease.
2023 Editorial in Diabetologie, Die Diabetologie 19, 103-105 (2023)
Mit präzisen Ansätzen die "patient journey" optimieren. Neue Wege der gezielteren Diabetesprävention und -therapie.
2023 Scientific Article in Nature Nature 623, 772-781 (2023)
Single-cell, whole-embryo phenotyping of mammalian developmental disorders.
2023 Scientific Article in Frontiers in Endocrinology Front. Endocrin. 14:1223162 (2023)
Association of sex hormones and sex hormone-binding globulin with liver fat in men and women: An observational and Mendelian randomization study.
2023 Scientific Article in Lancet Diabetes and Endocrinology Lancet Diabet. Endocrinol. 11, 798-810 (2023)
Mechanisms of weight loss-induced remission in people with prediabetes: A post-hoc analysis of the randomised, controlled, multicentre Prediabetes Lifestyle Intervention Study (PLIS).
2023 Scientific Article in American Journal of Physiology - Cell Physiology Am. J. Physiol.-Cell Physiol. 325, C1131-C1143 (2023)
Redox state and altered pyruvate metabolism contribute to a dose-dependent metformin-induced lactate production of human myotubes.
2023 Scientific Article in ACS Nano ACS Nano 17, 21056-21072 (2023)
Nanoparticle-exposure-triggered virus reactivation induces lung emphysema in mice.
2023 Scientific Article in Microbiology resource announcements : MRA Microbio. Res. Ann. 12:e0022023 (2023)
Genome sequences of bla NDM-1 producing Acinetobacter lactucae isolated from immunocompromised patients in India.
2023 Scientific Article in BMJ Open Diabetes Research & Care BMJ Open Diab. Res. Care 11:e003422 (2023)
Circulating metabolites improve the prediction of renal impairment in patients with type 2 diabetes.
2023 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 32, 2717-2734 (2023)
Insights into energy balance dysregulation from a mouse model of methylmalonic aciduria.
2023 Scientific Article in Methods in Enzymology Methods Enzymol. 689, 201-234 (2023)
17β-Hydroxysteroid dehydrogenases types 1 and 2: Enzymatic assays based on radiometric and mass-spectrometric detection.
2023 Letter to the Editor in European Journal of Epidemiology Eur. J. Epidemiol. 38, 713-715 (2023)
Lessons from the Singapore cohorts showcase symposium—open call for collaborations.
2023 Review in Mammalian Genome Mamm. Genome 34, 107-122 (2023)
A review of standardized high-throughput cardiovascular phenotyping with a link to metabolism in mice.
2023 Scientific Article in Cardiovascular Diabetology Cardiovasc. Diabetol. 22:141 (2023)
Identification of candidate metabolite biomarkers for metabolic syndrome and its five components in population-based human cohorts.
2023 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 110, 1068-1085 (2023)
Null and missense mutations of ERI1 cause a recessive phenotypic dichotomy in humans.
2023 Scientific Article in Molecular Metabolism Mol. Metab. 75:101768 (2023)
Maternal hyperglycemia induces alterations in hepatic amino acid, glucose and lipid metabolism of neonatal offspring: Multi-omics insights from a diabetic pig model.
2023 Science of the Total Environment, The Sci. Total Environ. 905:167050 (2023)
Corrigendum to “Longitudinal associations between metabolites and immediate, short- and medium-term exposure to ambient air pollution: Results from the KORA cohort study” [Sci. Total Environ. 900 (2023) 165780] (Science of the Total Environment (2023) 900, (S0048969723044030), (10.1016/j.scitotenv.2023.165780)).
2023 Review in Frontiers in Oncology Front. Oncol. 13:1120178 (2023)
Endometrial cancer diagnostic and prognostic algorithms based on proteomics, metabolomics, and clinical data: A systematic review.
2023 Nature Biotechnology Nat. Biotechnol. 41:1026 (2023)
Author Correction: Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models.
2023 Scientific Article in Life Science Alliance Life Sci. All. 6:e202201730 (2023)
Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain.
2023 Scientific Article in Biochimica et Biophysica Acta - Molecular Basis of Disease Biochim. Biophys. Acta-Mol. Basis Dis. 1869:166760 (2023)
AOX delays the onset of the lethal phenotype in a mouse model of Uqcrh (complex III) disease.
2023 Scientific Article in Nature Communications Nat. Commun. 14:5062 (2023)
Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits.
2023 Scientific Article in eLife eLife 12:e88350 (2023)
The negative adipogenesis regulator Dlk1 is transcriptionally regulated by Ifrd1 (TIS7) and translationally by its orthologue Ifrd2 (SKMc15).
2023 Scientific Article in PLoS ONE PLoS ONE 18:e0288542 (2023)
Standardized tissue sampling guidelines for histopathological and molecular analyses of rainbow trout (Oncorhynchus mykiss) in ecotoxicological studies.
2023 Scientific Article in Cell Metabolism Cell Metab. 35, 438-455.e7 (2023)
Estradiol regulates leptin sensitivity to control feeding via hypothalamic Cited1.
2023 Scientific Article in Mammalian Genome Mamm. Genome 34, 244-261 (2023)
Knockout mouse models as a resource for the study of rare diseases.
2023 Scientific Article in Mammalian Genome Mamm. Genome 34, 180-199 (2023)
Comprehensive ECG reference intervals in C57BL/6N substrains provide a generalizable guide for cardiac electrophysiology studies in mice.
2023 Scientific Article in Mammalian Genome Mamm. Genome 34, 200-215 (2023)
Echo2Pheno: A deep-learning application to uncover echocardiographic phenotypes in conscious mice.
2023 Scientific Article in Aging Cell Aging Cell 22:e13957 (2023)
The impact of the cardiovascular component and somatic mutations on ageing.
2023 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 110, 1394-1413 (2023)
Monoallelic variation in DHX9, the gene encoding the DExH-box helicase DHX9, underlies neurodevelopment disorders and Charcot-Marie-Tooth disease.
2023 Scientific Article in Molecular Metabolism Mol. Metab. 75:101774 (2023)
Differences in DNA methylation of HAMP in blood cells predicts the development of type 2 diabetes.
2023 Review in Mammalian Genome Mamm. Genome 34, 408-417 (2023)
INFRAFRONTIER: Mouse model resources for modelling human diseases.
2023 Editorial in Mammalian Genome Mamm. Genome 34, 105-106 (2023)
Introduction to Mammalian Genome special issue: Cardiovascular disease in the Mammalian Genome.
2023 Scientific Article in Nature Biotechnology Nat. Biotechnol. 41, 399-408 (2023)
Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models.
2023 Scientific Article in BMC Medicine BMC Med. 21:80 (2023)
Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts.
2023 Scientific Article in Disease Models and Mechanisms Dis. Model. Mech. 16:dmm049770 (2023)
Knockout mice represent an important tool for the multisystemic study of human monogenic heart disease.
2023 Scientific Article in Metabolites Metabolites 13:227 (2023)
Metabolic signatures elucidate the effect of body mass index on type 2 diabetes.
2023 Scientific Article in Molecular and Cellular Endocrinology Mol. Cell. Endocrinol. 565:111885 (2023)
TXNIP overexpression in mice enhances streptozotocin-induced diabetes severity.
2023 Scientific Article in International Journal of Obesity Int. J. Obes. 47, 313-324 (2023)
Acute and long-term exercise adaptation of adipose tissue and skeletal muscle in humans: A matched transcriptomics approach after 8-week training-intervention.
2023 Scientific Article in BMC Biology BMC Biol. 21:22 (2023)
Genome-wide screening reveals the genetic basis of mammalian embryonic eye development.
2023 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 120:e2200057120 (2023)
Intranasal delivery of full-length anti-Nogo-A antibody: A potential alternative route for therapeutic antibodies to central nervous system targets.
2023 Scientific Article in Methods in Molecular Biology Methods Mol. Biol. 2589, 145-155 (2023)
Development of pyrazine-anilinobenzamides as histone deacetylase HDAC1-3 selective inhibitors and biological testing against pancreas cancer cell lines.
2022 Nature Cardiovascular Research Nat. Cardio. Res. 1, 529-531 (2022)
Publisher Correction: Extensive identification of genes involved in congenital and structural heart disorders and cardiomyopathy (Nature Cardiovascular Research, (2022), 1, 2, (157-173), 10.1038/s44161-022-00018-8).
2022 Editorial in DDG-Informationen : Mitteilungen der Deutschen Diabetes-Gesellschaft DDG Informationen, 241-247 (2022)
Das Deutsche Zentrum für Diabetesforschung – Aktuelles aus der Wissenschaft.
2022 Scientific Article in Mammalian Genome Mamm. Genome 34, 229-243 (2022)
Knockout of the Complex III subunit Uqcrh causes bioenergetic impairment and cardiac contractile dysfunction.
2022 Scientific Article in BMC Neuroscience BMC Neurosci. 23:81 (2022)
Objective hearing threshold identification from auditory brainstem response measurements using supervised and self-supervised approaches.
2022 Scientific Article in Frontiers in Endocrinology Front. Endocrin. 13:1000650 (2022)
Associations of endogenous androgens and sex hormone-binding globulin with kidney function and chronic kidney disease.
2022 Review in Mammalian Genome Mamm. Genome 34, 331-350 (2022)
A rationale for considering heart/brain axis control in neuropsychiatric disease.
2022 Scientific Article in Scientific Reports Sci. Rep. 12:20791 (2022)
Analysis of genome-wide knockout mouse database identifies candidate ciliopathy genes.
2022 Scientific Article in American Journal of Physiology - Regulatory, Integrative and Comparative Physiology Am. J. Physiol.-Regul. Integr. Comp. Physiol. 324, R109-R119 (2022)
Aqp5--/-- mice exhibit reduced maximal O2 consumption under cold exposure, normal pulmonary gas exchange, and impaired formation of brown adipose tissue.
2022 Scientific Article in Allergy Allergy 78, 1218-1233 (2022)
Dietary digestible carbohydrates are associated with higher prevalence of asthma in humans and with aggravated lung allergic inflammation in mice.
2022 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 51, D539-D545 (2022)
CORUM: The comprehensive resource of mammalian protein complexes-2022.
2022 Scientific Article in Scientific Reports Sci. Rep. 12:19793 (2022)
New C3H KitN824K/WT cancer mouse model develops late-onset malignant mammary tumors with high penetrance.
2022 Scientific Article in Nature Communications Nat. Commun. 13:6830 (2022)
Deep phenotyping and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/6J mice.
2022 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 32, 1266-1275 (2022)
Identifying causal serum protein-cardiometabolic trait relationships using whole genome sequencing.
2022 Scientific Article in Diabetes Care Diabetes Care 45, 2892–2899 (2022)
Diabetes and obesity in down syndrome across the lifespan: A retrospective cohort study using U.K. electronic health records.
2022 Scientific Article in Scientific Reports Sci. Rep. 12:16396 (2022)
Insight into the pulmonary molecular toxicity of heated tobacco products using human bronchial and alveolar mucosa models at air-liquid interface.
2022 Review in Biomedicines Biomedicines 10:2461 (2022)
The legacy of parental obesity: Mechanisms of non-genetic transmission and reversibility.
2022 Scientific Article in Cells Cells 11:3289 (2022)
Dendritic cells or macrophages? The microenvironment of human clear cell renal cell carcinoma imprints a mosaic myeloid subtype associated with patient survival.
2022 Scientific Article in Molecular Metabolism Mol. Metab. 66:101616 (2022)
Validation of Mct8/Oatp1c1 dKO mice as a model organism for the Allan-Herndon-Dudley Syndrome.
2022 Scientific Article in BMC Medicine BMC Med. 20:351 (2022)
Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition.
2022 Scientific Article in Redox Biology Redox Biol. 57:102490 (2022)
Seizures, ataxia and parvalbumin-expressing interneurons respond to selenium supply in Selenop-deficient mice.
2022 Scientific Article in Metabolites Metabolites 12:846 (2022)
Fecal bile acids and neutral sterols are associated with latent microbial subgroups in the human gut.
2022 Scientific Article in Frontiers in Nutrition Front. Nutr. 9:933526 (2022)
Dynamic patterns of postprandial metabolic responses to three dietary challenges.
2022 Scientific Article in Cell Death Discovery Cell Death Discov. 8:387 (2022)
Mutations within the cGMP-binding domain of CNGA1 causing autosomal recessive retinitis pigmentosa in human and animal model.
2022 Scientific Article in EBioMedicine EBioMedicine 84:104276 (2022)
Machine learning for classification of hypertension subtypes using multi-omics: A multi-centre, retrospective, data-driven study.
2022 Scientific Article in Genetics in Medicine Genet. Med. 24, 2399-2407 (2022)
Biallelic loss-of-function variants in RABGAP1 cause a novel neurodevelopmental syndrome.
2022 Scientific Article in Scientific Reports Sci. Rep. 12:14608 (2022)
Monitoring longitudinal disease progression in a novel murine Kit tumor model using high-field MRI.
2022 Scientific Article in Metabolites Metabolites 12:755 (2022)
Predicting hypertension subtypes with machine learning using targeted metabolites and their ratios.
2022 Scientific Article in Metabolites Metabolites 12:679 (2022)
Preanalytical pitfalls in untargeted plasma nuclear magnetic resonance metabolomics of endocrine hypertension.
2022 Scientific Article in Pharmaceutics Pharmaceutics 14:1527 (2022)
Thermosensitive PLGA-PEG-PLGA hydrogel as depot matrix for allergen-specific immunotherapy.
2022 Scientific Article in Brain: A Journal of Neurology Brain 145, 4264-4274 (2022)
Gene therapy targeting the blood-brain barrier improves neurological symptoms in a model of genetic MCT8 deficiency.
2022 Scientific Article in European Journal of Nuclear Medicine and Molecular Imaging Eur. J. Nucl. Med. Mol. Imaging 49, 4338-4357 (2022)
X-ray multiscale 3D neuroimaging to quantify cellular aging and neurodegeneration postmortem in a model of Alzheimer’s disease.
2022 Scientific Article in EMBO Reports EMBO Rep.:e54078 (2022)
A novel stem cell type at the basal side of the subventricular zone maintains adult neurogenesis.
2022 Scientific Article in Journal of Feline Medicine and Surgery Open Reports JFMS Open Rep. 8, 20551169221081398 (2022)
Recovery after inadvertent intramedullary microchip implantation at C1–C2 in a kitten.
2022 Scientific Article in Nature Methods Nat. Methods 19, 803-811 (2022)
Mass spectrometry-based draft of the mouse proteome.
2022 Scientific Article in Nature Cardiovascular Research Nat. Cardio. Res. 1, 157-173 (2022)
Extensive identification of genes involved in congenital and structural heart disorders and cardiomyopathy.
2022 Scientific Article in Metabolites Metabolites 12:445 (2022)
Effects of acute and chronic resistance exercise on the skeletal muscle metabolome.
2022 Scientific Article in Frontiers in Medicine Front. Med. 9:875430 (2022)
Obesity and impaired metabolic health increase risk of COVID-19-related mortality in young and middle-aged adults to the level observed in older people: The LEOSS Registry.
2022 Scientific Article in Cell Reports Medicine Cell Rep. Med. 3:100477 (2022)
Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study.
2022 Scientific Article in Communications Biology Comm. Biol. 5:408 (2022)
Dietary intervention improves health metrics and life expectancy of the genetically obese Titan mouse.
2022 Scientific Article in PLoS Genetics PLoS Genet. 18:e1010190 (2022)
Mice lacking the mitochondrial exonuclease MGME1 develop inflammatory kidney disease with glomerular dysfunction.
2022 Review in Sports Medicine Sports Med. 52, 2569–2578 (2022)
Does a hypertrophying muscle fibre reprogramme its metabolism similar to a cancer cell?
2022 Scientific Article in BMJ Open BMJ Open 12:e058268 (2022)
The German Gestational Diabetes Study (PREG), a prospective multicentre cohort study: Rationale, methodology and design.
2022 Scientific Article in Scientific Reports Sci. Rep. 12:2297 (2022)
Blood and adipose tissue steroid metabolomics and mRNA expression of steroidogenic enzymes in periparturient dairy cows differing in body condition.
2022 Scientific Article in Transgenic Research Transgenic Res. 31, 227-237 (2022)
Skeletal muscle phenotyping of Hippo gene-mutated mice reveals that Lats1 deletion increases the percentage of type I muscle fibers.
2022 Scientific Article in Cells Cells 11:520 (2022)
Innate immune pathways promote oligodendrocyte progenitor cell recruitment to the injury site in adult Zebrafish brain.
2022 Scientific Reports Sci. Rep. 12:6793 (2022)
Author Correction: Maternal whole blood cell miRNA-340 is elevated in gestational diabetes and inversely regulated by glucose and insulin (Scientific Reports, (2018), 8, 1, (1366), 10.1038/s41598-018-19200-9).
2022 Scientific Article in Research in veterinary science Res. Vet. Sci. 146, 60-69 (2022)
Epaxial muscle atrophy is more evident in large dogs with intervertebral disc disease than in dogs with ischaemic myelopathy.
2022 Scientific Article in Biomedicines Biomedicines 10:616 (2022)
Bezafibrate reduces elevated hepatic fumarate in insulin-deficient mice.
2022 Scientific Article in Diabetes Diabetes 71, 1363-1370 (2022)
Circulating metabolites associate with and improve the prediction of all-cause mortality in type 2 diabetes.
2022 Scientific Article in EMBO Molecular Medicine EMBO Mol. Med.:e14817 (2022)
Early disruption of photoreceptor cell architecture and loss of vision in a humanized pig model of usher syndromes.
2022 Scientific Article in EMBO Molecular Medicine EMBO Mol. Med.:e14797 (2022)
Parkinson's disease motor symptoms rescue by CRISPRa-reprogramming astrocytes into GABAergic neurons.
2022 Scientific Article in Basic Research in Cardiology Basic Res. Cardiol. 117:11 (2022)
Uncovering the molecular identity of cardiosphere-derived cells (CDCs) by single-cell RNA sequencing.
2022 Nature Genetics Nat. Genet. 54, 358-360 (2022)
EMPReSS: Standardized phenotype screens for functional annotation of the mouse genome (vol 37, pg 1155, 2005).
2022 Scientific Article in Cell Reports Cell Rep. 38:110270 (2022)
Gut HIF2α signaling is increased after VSG, and gut activation of HIF2α decreases weight, improves glucose, and increases GLP-1 secretion.
2022 Scientific Article in Disease Models and Mechanisms Dis. Model. Mech. 15:dmm049205 (2022)
Post-synaptic scaffold protein TANC2 in psychiatric and somatic disease risk.
2022 Scientific Article in American Journal of Physiology - Endocrinology and Metabolism Am. J. Physiol. Endocrinol. Metab. 322, E85-E100 (2022)
Susceptibility to diet-induced obesity at thermoneutral conditions is independent of UCP1.
2022 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 31, 3367-3376 (2022)
First mitochondrial genome wide association study with metabolomics.
2022 Scientific Article in Life Science Alliance Life Sci. All. 5:e202101164 (2022)
Bis-choline tetrathiomolybdate prevents copper-induced blood-brain barrier damage.
2022 Scientific Article in Radiation Research Radiat. Res. 197, 67-77 (2022)
Complex long-term effects of radiation on adult mouse behaviour.
2022 Scientific Article in Neuropathology and Applied Neurobiology Neuropathol. Appl. Neurobiol. 48:e12750 (2022)
N471D WASH complex subunit strumpellin knock-in mice display mild motor and cardiac abnormalities and BPTF and KLHL11 dysregulation in brain tissue.
2022 Scientific Article in Radiation Research Radiat. Res. 197, 7-21 (2022)
On the nature of murine radiation-induced subcapsular cataracts: Optical coherence tomography-based fine classification, in vivo dynamics and impact on visual acuity.
In: Practical Handbook on the 3Rs in the Context of the Directive 2010/63/EU. 2021. 81-111
Animal welfare.
München, Technische Universität, TUM School of Life Sciences, Diss., 2021, 156 S.
Development of epigenomic signatures during intergenerational inheritance of diet-induced obesity and type 2 diabetes.
2021 Review in Diabetologie und Stoffwechsel Diabetol. Stoffwechs. 16, 473-475 (2021)
Veranlagung und Lebensstil – die Komplexität des Diabetes mellitus – Langerhans-Medaille 2021 – eine Kurzübersicht über den Preisträger Martin Hrabě de Angelis.
2021 Review in Cancer and Metastasis Reviews Cancer Metastasis Rev., DOI: 10.1007/s10555-021-10007-1 (2021)
Extracellular citrate and metabolic adaptations of cancer cells.
2021 Scientific Article in Science Advances Sci. Adv. 7:eabb3673 (2021)
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2019 Meeting abstract in Trials Trials 20 (2019)
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2019 Editorial in Diabetes Aktuell Diabetes akt. 17, 96 (2019)
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The saliva metabolome in association to oral health status.
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2019 Scientific Article in Experimental Eye Research Exp. Eye Res. 188:107632 (2019)
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2019 Conservation genetics Conservation genetics 20, 135-136 (2019)
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Paramount importance of sample quality in pre-clinical and clinical research-Need for standard operating procedures (SOPs).
2019 Scientific Article in Journal of Dairy Science J. Dairy Sci. 102, 754-767 (2019)
Acylcarnitine profiles in serum and muscle of dairy cows receiving conjugated linoleic acids or a control fat supplement during early lactation.
2019 Scientific Article in Molecular Neurobiology Mol. Neurobiol. 56, 4215-4230 (2019)
Crybb2 mutations consistently affect Schizophrenia endophenotypes in mice.
2019 Scientific Article in Gastroenterology Gastroenterology 156, 203-217.e20 (2019)
Levels of the autophagy-related 5 protein affect progression and metastasis of pancreatic tumors in mice.
2019 Scientific Article in Journal of Steroid Biochemistry and Molecular Biology, The J. Steroid Biochem. Mol. Biol. 185, 80-89 (2019)
Initial characterization of human DHRS1 (SDR19C1), a member of the short chain dehydrogenase/reductase superfamily.
2018 Scientific Article in Experimental Cell Research Exp. Cell Res. 372, 25-34 (2018)
Matrix mineralization controls gene expression in osteoblastic cells.
2018 Meeting abstract in Acta Ophthalmologica Acta Ophthalmol. 96, 4-4 (2018)
Animal case.
2018 Scientific Article in Communications Biology Comm. Biol. 1:236 (2018)
Identification of genes required for eye development by high-throughput screening of mouse knockouts.
2018 Scientific Article in Biochimica et Biophysica Acta - Molecular Basis of Disease Biochim. Biophys. Acta-Mol. Basis Dis. 1865, 2083-2093 (2018)
A mouse model for intellectual disability caused by mutations in the X-linked 2 '-O-methyltransferase Ftsj1 gene.
2018 Scientific Article in Cell Reports Cell Rep. 25, 3241-3251.e5 (2018)
The aryl hydrocarbon receptor pathway defines the time frame for restorative neurogenesis.
2018 Scientific Article in EMBO Molecular Medicine EMBO Mol. Med. 10:e9456 (2018)
Alternative oxidase-mediated respiration prevents lethal mitochondrial cardiomyopathy.
2018 Scientific Article in GigaScience GigaScience 7, DOI: 10.1093/gigascience/giy137 (2018)
A network-based conditional genetic association analysis of the human metabolome.
2018 Scientific Article in Nutrients Nutrients 10:1800 (2018)
Molecular fingerprints of iron parameters among a population-based sample.
2018 Scientific Article in Nutrition & metabolism Nutr. Metab. 15:78 (2018)
Circulating glutamate concentration as a biomarker of visceral obesity and associated metabolic alterations.
2018 Meeting abstract in Wiener medizinische Wochenschrift Wien. Med. Wochenschr. 130, 353-354 (2018)
Paternal circadian arrhythmia affects offspring health and feeding behaviour.
2018 Scientific Article in Experimental and Clinical Endocrinology & Diabetes Exp. Clin. Endocrinol. Diabet. 126, 20-29 (2018)
Impact of brain fatty acid signaling on peripheral insulin action in mice.
2018 Scientific Article in Molecular Metabolism Mol. Metab. 18, 42-50 (2018)
Glucose tolerance and insulin sensitivity define adipocyte transcriptional programs in human obesity.
2018 Scientific Article in Metabolomics Metabolomics 14:128 (2018)
Characterization of missing values in untargeted MS-based metabolomics data and evaluation of missing data handling strategies.
2018 Scientific Article in Stem Cell Reports Stem Cell Rep. 11, 897-911 (2018)
Reproducibility of molecular phenotypes after long-term differentiation to human iPSC-derived neurons: A multi-site omics study.
2018 Meeting abstract in Diabetologia Diabetologia 61, S259-S259 (2018)
Interindividual susceptibility to type 2 diabetes in mice: Hepatic transcriptome and DNA methylome profiling.
2018 Scientific Article in Journal of Visualized Experiments J. Vis. Exp. 143:e58601 (2018)
Measuring and interpreting oxygen consumption rates in whole fly head segments.
2018 Meeting abstract in Allergy Allergy 73, 232-232 (2018)
Sustained inhibition of the IL4/IL13 receptor complex during allergen specific immunotherapy.
2018 Meeting abstract in Allergy Allergy 73, 233-233 (2018)
A thermosensitive hydrogel as delivery system for immunomodulatory substances and allergens during allergen-specific immunotherapy.
2018 Scientific Article in Nature microbiology Nat. Microbiol. 3, 1161–1174 (2018)
Male offspring born to mildly ZIKV-infected mice are at risk of developing neurocognitive disorders in adulthood.
2018 Review in Diabetologie, Die Diabetologie 14, 486-492 (2018)
Mit Big Data zur personalisierten Diabetesprävention.
2018 Scientific Article in Atherosclerosis Atherosclerosis 276, 140-147 (2018)
Ldlr-/- and ApoE-/- mice better mimic the human metabolite signature of increased carotid intima media thickness compared to other animal models of cardiovascular disease.
2018 Scientific Article in Cell Cell 174, 1571-1585.e11 (2018)
Atlas of circadian metabolism reveals system-wide coordination and communication between clocks.
2018 Scientific Article in PLoS Biology PLoS Biol. 16:e2005651 (2018)
The mitochondrial transporter SLC25A25 links ciliary TRPP2 signaling and cellular metabolism.
2018 Scientific Article in EMBO Journal, The EMBO J.:e94813 (2018)
RNA editing of Filamin A pre-mRNA regulates vascular contraction and diastolic blood pressure.
2018 Scientific Article in Life Science Alliance Life Sci. All. 1:e201800106 (2018)
Neuron-specific inactivation of Wt1 alters locomotion in mice and changes interneuron composition in the spinal cord.
2018 Scientific computing world Sci. Comp. World August/September, 24-25 (2018)
How connecting data may lead to discoveries in medical research?
2018 Scientific Article in Cardiovascular Diabetology Cardiovasc. Diabetol. 17:120 (2018)
Metabolomic profiling implicates adiponectin as mediator of a favorable lipoprotein profile associated with NT-proBNP.
2018 Scientific Article in Metabolites Metabolites 8:45 (2018)
Night shift work affects urine metabolite profiles of nurses with early chronotype.
2018 Scientific Article in Scientific Reports Sci. Rep. 8:12262 (2018)
The human metabolic profile reflects macro- and micronutrient intake distinctly according to fasting time.
2018 Scientific Article in Biochemical and Biophysical Research Communications Biochem. Biophys. Res. Commun. 503, 2770-2777 (2018)
The heterozygous R155C VCP mutation: Toxic in humans! Harmless in mice?
2018 Scientific Article in Ageing research reviews Ageing Res. Rev. 47, 214-277 (2018)
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases.
2018 Scientific Article in Journal of Clinical Endocrinology & Metabolism, The J. Clin. Endocrinol. Metab. 103, 3856-3868 (2018)
Hepatic steatosis is associates with adverse molecular signatures in subjects without diabetes.
2018 Scientific Article in Analytica Chimica Acta Anal. Chim. Acta 1032, 18-31 (2018)
Dilution correction for dynamically influenced urinary analyte data.
2018 Scientific Article in Scientific Reports Sci. Rep. 8:11335 (2018)
Streptozotocin-induced beta-cell damage, high fat diet, and metformin administration regulate Hes3 expression in the adult mouse brain.
2018 Scientific Article in EMBO Molecular Medicine EMBO Mol. Med. 10:e8613 (2018)
Cited4 is a sex-biased mediator of the antidiabetic glitazone response in adipocyte progenitors.
2018 Scientific Article in International Journal of Epidemiology Int. J. Epidemiol. 47, 2070-2081 (2018)
Comparison of metabolite networks from four German population-based studies.
2018 Scientific Article in Molecular Metabolism Mol. Metab., DOI: 10.1016/j.molmet.2018.06.015 (2018)
Metabolic syndrome and extensive adipose tissue inflammation in morbidly obese Göttingen minipigs.
2018 Scientific Article in Scientific Reports Sci. Rep. 8:9810 (2018)
Instability of personal human metabotype is linked to all-cause mortality.
2018 Scientific Article in Hormone molecular biology and clinical investigation Horm. Mol. Biol. Clin. Investig. 34:20170082 (2018)
Circulating steroid levels as correlates of adipose tissue phenotype in premenopausal women.
2018 Scientific Article in Conservation genetics Conservation genetics 19, 995-1005 (2018)
The International Mouse Phenotyping Consortium (IMPC): A functional catalogue of the mammalian genome that informs conservation.
2018 Scientific Article in Kidney International Kidney Int. 94, 49-59 (2018)
The elevation of circulating fibroblast growth factor 23 without kidney disease does not increase cardiovascular disease risk.
2018 Scientific Article in PLoS Genetics PLoS Genet. 14:e1007329 (2018)
Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population.
2018 Scientific Article in European Journal of Medicinal Chemistry Eur. J. Med. Chem. 155, 61-76 (2018)
Structure-based design and profiling of novel 17 beta-HSD14 inhibitors.
2018 Review in Frontiers in Physiology Front. Physiol. 9:553 (2018)
Genes whose gain or loss-of-function increases skeletal muscle mass in mice: A systematic literature review.
2018 Scientific Article in Cell Metabolism Cell Metab. 27, 1294-1308.e7 (2018)
The polycomb-dependent epigenome controls beta cell dysfunction, dedifferentiation, and diabetes.
2018 Scientific Article in Nutrients Nutrients 10:547 (2018)
A vitamin E-enriched antioxidant diet interferes with the acute adaptation of the liver to physical exercise in mice.
2018 Scientific Article in Chemical Communications Chem. Commun. 54, 5426-5429 (2018)
hIAPP forms toxic oligomers in plasma.
2018 Scientific Article in Nature Communications Nat. Commun. 9:1990 (2018)
Bacterial encapsulins as orthogonal compartments for mammalian cell engineering.
2018 Scientific Article in Pigment Cell & Melanoma Research Pigment Cell Melanoma Res. 31, 693-707 (2018)
Melanocyte development in the mouse tail epidermis requires the Adamts9 metalloproteinase.
2018 Scientific Article in Scientific Reports Sci. Rep. 8:7547 (2018)
Intrauterine smoke exposure deregulates lung function, pulmonary transcriptomes, and in particular insulin-like growth factor (IGF)-1 in a sex-specific manner.
2018 Scientific Article in International Journal of Radiation Oncology, Biology, Physics Int. J. Radiat. Oncol. Biol. Phys. 101, 965-984 (2018)
Micro-imaging of brain cancer radiotherapy using phase-contrast computed tomography.
2018 Scientific Article in EMBO Molecular Medicine EMBO Mol. Med. 10:e8349 (2018)
Cholesterol metabolism promotes B-cell positioning during immune pathogenesis of chronic obstructive pulmonary disease.
2018 Scientific Article in PLoS Biology PLoS Biol. 16:e2005019 (2018)
Laboratory mouse housing conditions can be improved using common environmental enrichment without compromising data.
2018 Scientific Article in Molecular Metabolism Mol. Metab. 9, 57-68 (2018)
Genome-wide analysis of PDX1 target genes in human pancreatic progenitors.
2018 Review in Pharmacogenomics Pharmacogenomics 19, 577-587 (2018)
Pharmacogenetics of oral antidiabetic therapy.
2018 Scientific Article in Frontiers in Immunology Front. Immunol. 9:587 (2018)
RNase H2 loss in murine astrocytes results in cellular defects reminiscent of nucleic acid-mediated autoinflammation.
2018 Scientific Article in Scientific Reports Sci. Rep. 8:5975 (2018)
Defective immuno- and thymoproteasome assembly causes severe immunodeficiency.
2018 Scientific Article in JCI insight JCI insight 3:98864 (2018)
Mesenchymal TNFR2 promotes the development of polyarthritis and comorbid heart valve stenosis.
2018Poster: Federation of European Neuroscience Societies Forum, 7-11 July 2018, Berlin. (2018)
Identifying underlying mechanisms of voluntary activity by mining large data sets of genetically modified mouse lines.
2018 Scientific Article in Cellular Physiology and Biochemistry Cell. Physiol. Biochem. 45, 625-638 (2018)
Fetal serum metabolites are independently associated with gestational diabetes mellitus.
2018 Scientific Article in Molecular Metabolism Mol. Metab. 11, 113-128 (2018)
Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver.
2018 Scientific Article in European Heart Journal Eur. Heart J. 39, 2301-2310 (2018)
Altered metabolism distinguishes high-risk from stable carotid atherosclerotic plaques.
2018 Scientific Article in Frontiers in Endocrinology Front. Endocrin. 9:82 (2018)
Prediction of glucose tolerance without an oral glucose tolerance test.
2018 Scientific Article in Advanced functional materials Adv. Func. Mat. 28:1706793 (2018)
Genetically controlled lysosomal entrapment of superparamagnetic ferritin for multimodal and multiscale imaging and actuation with low tissue attenuation.
2018 Scientific Article in Journal of Clinical Endocrinology & Metabolism, The J. Clin. Endocrinol. Metab. 103, 2050-2060 (2018)
Comprehensive metabolic profiling reveals a lipid-rich fingerprint of free thyroxine far beyond classic parameters.
2018 Meeting abstract in Clinical Cancer Research Clin. Cancer Res. 24, 56-56 (2018)
Combined targeting of the Ewing sarcoma transcriptional program by blocking epigenetic readers and transcription initiation via EWS-FLI1.
2018 Meeting abstract in Clinical Cancer Research Clin. Cancer Res. 24, 57-57 (2018)
The endochondral bone protein CHM1 sustains an undifferentiated, invasive phenotype promoting lung metastasis in Ewing sarcoma.
2018 Scientific Article in Scientific Reports Sci. Rep. 8:4199 (2018)
Rapid and transient oxygen consumption increase following acute HDAC/KDAC inhibition in Drosophila tissue.
2018 Scientific Article in Diabetes, Obesity and Metabolism Diabetes Obes. Metab. 20, 1593-1601 (2018)
Pharmacokinetics of metformin in patients with gastrointestinal intolerance.
2018 Scientific Article in Journal of Neurochemistry J. Neurochem. 145, 258-270 (2018)
Faim2 contributes to neuroprotection by erythropoietin in transient brain ischemia.
2018 Scientific Article in Journal of Bone and Mineral Research J. Bone Min. Res. 33, 875-887 (2018)
Genetic and molecular insights into genotype-phenotype relationships in osteopathia striata with cranial sclerosis (OSCS) through the analysis of novel mouse Wtx mutant alleles.
2018 Scientific Article in Journal of Steroid Biochemistry and Molecular Biology, The J. Steroid Biochem. Mol. Biol. 178, 312-321 (2018)
Models including plasma levels of sphingomyelins and phosphatidylcholines as diagnostic and prognostic biomarkers of endometrial cancer.
2018 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 27, 1106-1121 (2018)
Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation.
2018 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 115, E2348-E2357 (2018)
Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice.
2018 Scientific Article in Cancer Research Cancer Res. 78, 2513-2523 (2018)
Extracellular citrate affects critical elements of cancer cell metabolism and supports cancer development in vivo.
2018 Review in Environment International Environ. Int. 114, 77-86 (2018)
Epigenetics as a mechanism linking developmental exposures to long-term toxicity.
2018 Scientific Article in Scientific Reports Sci. Rep. 8:737 (2018)
The effect of differentiation and TGFβ on mitochondrial respiration and mitochondrial enzyme abundance in cultured primary human skeletal muscle cells.
2018 Scientific Article in Nature Communications Nat. Commun. 9:288 (2018)
Identification of genetic elements in metabolism by high-throughput mouse phenotyping.
2018 Scientific Article in Cellular Physiology and Biochemistry Cell. Physiol. Biochem. 45, 614-624 (2018)
Cord blood lysophosphatidylcholine 16:1 is positively associated with birth weight.
2018 Scientific Article in Scientific Reports Sci. Rep. 8:1116 (2018)
Epigallocatechin gallate (EGCG) reduces the intensity of pancreatic amyloid fibrils in human islet amyloid polypeptide (hIAPP) transgenic mice.
2018 Scientific Article in Scientific Reports Sci. Rep. 8:1366 (2018)
Maternal whole blood cell miRNA-340 is elevated in gestational diabetes and inversely regulated by glucose and insulin.
2018 Review in Nature Reviews - Endocrinology Nat. Rev. Endocrinol. 14, 140-162 (2018)
Animal models of obesity and diabetes mellitus.
2018 Scientific Data Sci. Data 5:180002 (2018)
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.
2018 Scientific Article in Radiation and Environmental Biophysics Radiat. Environ. Biophys. 57, 99-113 (2018)
Lifetime study in mice after acute low-dose ionizing radiation: A multifactorial study with special focus on cataract risk.
2018 Scientific Article in Metabolomics Metabolomics 14:18 (2018)
High-throughput extraction and quantification method for targeted metabolomics in murine tissues.
2018 Scientific Article in Endocrine-Related Cancer Endocr. Relat. Cancer 25, 145-162 (2018)
Characterization of neuroendocrine tumors in heterozygous mutant MENX rats: A novel model of invasive medullary thyroid carcinoma.
2018 Scientific Article in Journal of Investigative Dermatology, The J. Invest. Dermatol. 138, 141-149 (2018)
MSX1-induced neural crest-like reprogramming promotes melanoma progression.
2018 Scientific Article in International Journal of Obesity Int. J. Obes. 42, 507-517 (2018)
A history of obesity leaves an inflammatory fingerprint in liver and adipose tissue.
2018 Scientific Article in Journal of Investigative Dermatology, The J. Invest. Dermatol. 138, 179-188 (2018)
The role of Fibroblast growth factor binding protein 1 in skin carcinogenesis and inflammation.
2018 Scientific Article in Journal of Breath Research J. Breath Res. 12:017102 (2018)
A systemic view on the distribution of diet-derived methanol and hepatic acetone in mice.
2017 Meeting abstract in Sleep Medicine Sleep Med. 40, E290-E291 (2017)
Circadian locomotor activity in meis1 knock-out mice.
2017 Nature Nature 551, 398 (2017)
Corrigendum: High-throughput discovery of novel developmental phenotypes.
2017 Scientific Article in Immunity Immunity 47, 1067-1082.e12 (2017)
Roquin suppresses the PI3K-mTOR signaling pathway to inhibit T helper cell differentiation and conversion of treg to Tfr cells.
2017 Scientific Article in Scientific Data Sci. Data 4:170179 (2017)
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.
2017 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 114, E11323-E11332 (2017)
Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo.
2017 Scientific Article in Molecular Metabolism Mol. Metab. 8, 158-166:doi:10.1016/j.molmet.2017.11.013 (2017)
Androgen receptor overexpression in prostate cancer in type 2 diabetes.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:15486 (2017)
Excessive fuel availability amplifies the FTO-mediated obesity risk: Results from the TUEF and Whitehall II studies.
2017 Scientific Article in Data in Brief Data Brief 14, 653-658 (2017)
Data on the effects of eIF6 downmodulation on the proportions of innate and adaptive immune system cell subpopulations and on thymocyte maturation.
2017 Meeting abstract in Annals of the Rheumatic Diseases : ARD online Ann. Rheum. Dis. 76, 500-500 (2017)
Cardiac, pulmonary and periodontal disease as comorbidities in TNF-driven models of chronic polyarthritis.
2017 Scientific Article in Cell Reports Cell Rep. 21, 1507-1520 (2017)
The role of Eif6 in skeletal muscle homeostasis revealed by endurance training co-expression networks.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:15453 (2017)
Female mice lacking Pald1 exhibit endothelial cell apoptosis and emphysema.
2017 Meeting abstract in Annals of the Rheumatic Diseases : ARD online Ann. Rheum. Dis. 76, A49-A49 (2017)
TNF delta ARE/+: A multimorbidity model of spondyorthropathies.
2017 Scientific Article in Cell Death and Differentiation Cell Death Differ. 24, 1948-1962 (2017)
High mobility group A1 protein modulates autophagy in cancer cells.
2017 Scientific Article in Nature Communications Nat. Commun. 8:886 (2017)
A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction.
2017 Scientific Article in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 24, 902-910 (2017)
MacroH2A1.1 regulates mitochondrial respiration by limiting nucleas NAD+ consumption.
2017 Scientific Article in Behavioural Brain Research Behav. Brain Res. 352, 187-196 (2017)
Understanding gene functions and disease mechanisms: Phenotyping pipelines in the German Mouse Clinic.
2017 Scientific Article in Drug discovery today Drug Discov. Today, DOI: 10.1016/j.ddmod.2017.08.002 (2017)
Genome wide conditional mouse knockout resources.
2017 Scientific Article in Cell Metabolism Cell Metab. 26, 620-632.e6 (2017)
Molecular integration of incretin and glucocorticoid action reverses immunometabolic dysfunction and obesity.
2017 Meeting abstract in Allergy Allergy 72, 40-40 (2017)
Interference into JAK/stat signalling-a concept for improved allergen-specific immunotherapy?
2017 Scientific Article in EMBO Reports EMBO Rep. 18, 2015-2029 (2017)
The BEACH protein LRBA is required for hair bundle maintenance in cochlear hair cells and for hearing.
2017 Scientific Article in Journal of Biomedical Science J. Biomed. Sci. 24:57 (2017)
Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1I27N mutant mice.
2017 Scientific Article in Respiratory Research Respir. Res. 18:152 (2017)
Transcriptomic analysis comparing mouse strains with extreme total lung capacities identifies novel candidate genes for pulmonary function.
2017 Scientific Article in Thorax Thorax 72, 1007-1020 (2017)
Pulmonary CCR2+CD4+ T cells are immune regulatory and attenuate lung fibrosis development.
2017 Other: Opinion in Molecular Metabolism Mol. Metab. 6, 1079-1080 (2017)
Anti-hypertensive treatment in pregnancy impacts offspring growth and metabolism: Q&A.
2017 Review in Endocrine Reviews Endocr. Rev. 38, 468-488 (2017)
Fibroblast growth factor 21 – metabolic role in mice and men.
2017 Scientific Article in Current Opinion in Systems Biology Curr. Opin. Syst. Biol. 4, 97-104 (2017)
Big data in large-scale systemic mouse phenotyping.
2017 Scientific Article in Diabetes Aktuell Diabetes akt. 15, 104-107 (2017)
Ernährungsgewohnheiten schlagen sich im Erbgut nieder.
2017 Scientific Article in Nature Communications Nat. Commun. 8:155 (2017)
Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice.
2017 Scientific Article in Molecular Metabolism Mol. Metab. 6, 1304-1312 (2017)
Point mutation of Ffar1 abrogates fatty acid-dependent insulin secretion, but protects against HFD-induced glucose intolerance.
2017 Scientific Article in Molecular Metabolism Mol. Metab. 6, 1226-1239 (2017)
Activated macrophages control human adipocyte mitochondrial bioenergetics via secreted factors.
2017 Scientific Article in PLoS Biology PLoS Biol. 15:e2001414 (2017)
Identifiers for the 21st century: How to design, provision, and reuse persistent identifiers to maximize utility and impact of life science data.
2017 Scientific Article in Developmental and comparative immunology Dev. Comp. Immunol. 77, 69-76 (2017)
High levels of eukaryotic Initiation Factor 6 (eIF6) are required for immune system homeostasis and for steering the glycolytic flux of TCR-stimulated CD4+ T cells in both mice and humans.
2017 Scientific Article in Nature Genetics Nat. Genet. 49, 1231-1238 (2017)
Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium.
2017 Scientific Article in Nature Communications Nat. Commun. 8:15475 (2017)
Prevalence of sexual dimorphism in mammalian phenotypic traits.
2017 Scientific Article in Molecular Metabolism Mol. Metab. 6, 1286-1295 (2017)
Angiopoietin-like protein 4 is an exercise-induced hepatokine in humans, regulated by glucagon and cAMP.
2017 Scientific Article in Molecular Metabolism Mol. Metab. 6, 931-940 (2017)
The Munich MIDY Pig Biobank - A unique resource for studying organ crosstalk in diabetes.
2017 Scientific Article in Water Research Water Res. 122, 290-298 (2017)
Iopromide exposure in Typha latifolia L.: Evaluation of uptake, translocation and different transformation mechanisms in planta.
2017 Scientific Article in Current Protocols of Mouse Biology Curr. Protoc. Mouse Biol. 7, 88-99 (2017)
A Fast, Easy, and Customizable Eight-Color Flow Cytometric Method for Analysis of the Cellular Content of Bronchoalveolar Lavage Fluid in the Mouse.
2017 Scientific Article in Disease Models and Mechanisms Dis. Model. Mech. 10, 981-991 (2017)
Meis1 effects on motor phenotypes and the sensorimotor system in mice.
2017 Scientific Article in Journal of Theoretical Biology J. Theor. Biol. 430, 32-44 (2017)
Modeling coexistence of oscillation and Delta/Notch-mediated lateral inhibition in pancreas development and neurogenesis.
2017 Scientific Article in Immunology Immunology 152, 402-413 (2017)
microRNA cluster 106a~363 is involved in T-Helper 17 (Th17) cell differentiation.
2017 Scientific Article in Particle and Fibre Toxicology Part. Fibre Toxicol. 14:19 (2017)
Early pulmonary response is critical for extra-pulmonary carbon nanoparticle mediated effects: Comparison of inhalation versus intra-arterial infusion exposures in mice.
2017 Meeting abstract in Haematologica - The Hematology Journal Haematologica 102, 333-333 (2017)
Lack of the ferroptosis inhibitor GPX4 in erythroid cells causes a block in reticulocyte maturation and a hypoxic signature with impaired hepcidin regulation.
2017 Meeting abstract in Glia Glia 65, E401-E401 (2017)
Proliferation and neural stem cell potential of diencephalic astrocytes revealed by genome-wide expression analysis is Smad4-dependent.
2017 Acta Diabetologica Acta Diabetol. 54, 713-714 (2017)
Erratum to: A novel insulin sensitivity index particularly suitable to measure insulin sensitivity during gestation.
2017 Scientific Article in Molecular Neurobiology Mol. Neurobiol. 55, 4580–4595 (2017)
Fgf9Y162C mutation alters information processing and social memory in mice.
2017 Meeting abstract in American Journal of Respiratory and Critical Care Medicine Am. J. Respir. Crit. Care Med. 195 (2017)
2d cross-omics integrated enrichment analysis of human and mice COPD lungs reveal novel pathological mechanisms of disease progression.
2017 Scientific Article in Theriogenology Theriogenology 96, 49-57 (2017)
Dry ice is a reliable substrate for the distribution of frozen mouse spermatozoa: A multi-centric study.
2017 Scientific Article in PLoS ONE PLoS ONE 12:e177148 (2017)
Common variation in the sodium/glucose cotransporter 2 gene SLC5A2 does neither affect fasting nor glucose-suppressed plasma glucagon concentrations.
2017 Meeting abstract in American Journal of Respiratory and Critical Care Medicine Am. J. Respir. Crit. Care Med. 195 (2017)
Epigenetic histone-1 modulator Hmgn5 regulates cellular apoptosis In COPD pathogenesis.
2017 Meeting abstract in American Journal of Respiratory and Critical Care Medicine Am. J. Respir. Crit. Care Med. 195 (2017)
Deficiency of immunoproteasome subunits increases alternative polarization of alveolar macrophages.
2017 Meeting abstract in Molecular and Cellular Pediatrics Mol. Cell. Pediatr. 4, 1:5 (2017)
Abstracts of the 52nd Workshop for Pediatric Research : Frankfurt, Germany. 27-28 October 2016.
2017 Scientific Article in Cell Metabolism Cell Metab. 25, 1334-1347.e4 (2017)
N-acyl taurines and acylcarnitines cause an imbalance in insulin synthesis and secretion provoking β cell dysfunction in type 2 diabetes.
2017 Scientific Article in Acta Neuropathologica Acta Neuropathol. 134, 241–254 (2017)
Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss.
2017 Scientific Article in Diabetes Diabetes 66, 2019-2032 (2017)
A low-frequency inactivating Akt2 variant enriched in the Finnish population is associated with fasting insulin levels and type 2 diabetes risk.
2017 Scientific Article in PLoS ONE PLoS ONE 12:e0178563 (2017)
Improved efficacy of allergen-specific immunotherapy by JAK inhibition in a murine model of allergic asthma.
2017 Scientific Article in Molecular Metabolism Mol. Metab. 6, 737-747 (2017)
Metformin causes a futile intestinal-hepatic cycle which increase energy expenditure and slows down development of a type 2 diabetes-like state.
2017 Scientific Article in Journal of Neuroscience Methods J. Neurosci. Methods, DOI: 10.1016/j.jneumeth.2017.05.005 (2017)
Analysis of locomotor behavior in the German Mouse Clinic.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:2397 (2017)
Extensive phenotypic characterization of a new transgenic mouse reveals pleiotropic perturbations in physiology due to mesenchymal hGH minigene expression.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:2235 (2017)
Sex-specific metabolic profiles of androgens and its main binding protein SHBG in a middle aged population without diabetes.
2017 Scientific Article in Molecular Psychiatry Mol. Psychiatry 23, 1345-1355 (2017)
A paternal methyl donor-rich diet altered cognitive and neural functions in offspring mice.
2017 Scientific Article in Molecular Metabolism Mol. Metab. 6, 440-446 (2017)
Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice.
2017 Meeting abstract in Reproduction in domestic animals Reprod. Dom. Anim. 52, 24-24 (2017)
Impaired weight gain and disproportionate organ growth, but preserved fertility in growth hormone receptor deficient pigs (Laron syndrome).
2017 Scientific Article in Metabolomics Metabolomics 13:48 (2017)
LysoPC-acyl C16:0 is associated with brown adipose tissue activity in men.
2017 Scientific Article in Chemico-Biological Interactions Chem. Biol. Interact. 276, 182-193 (2017)
Characterization of AKR1B16, a novel mouse aldo-keto reductase.
2017 Scientific Article in Scientific Reports Sci. Rep. 7, 42056 (2017)
The Rb1 tumour suppressor gene modifies telomeric chromatin architecture by regulating TERRA expression.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:44041 (2017)
The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes.
2017 Scientific Article in Molecular and Cellular Endocrinology Mol. Cell. Endocrinol. 443, 106-113 (2017)
Teneurin-2 (TENM2) deficiency induces UCP1 expression in differentiating human fat cells.
2017 Scientific Article in Journal of Clinical Investigation J. Clin. Invest. 127, 695-708 (2017)
Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance.
2017 Scientific Article in Particle and Fibre Toxicology Part. Fibre Toxicol. 14:2 (2017)
Nanoparticle exposure reactivates latent herpesvirus and restores a signature of acute infection.
2017 Scientific Article in PLoS ONE PLoS ONE 12:e0169223 (2017)
Maternal pre-pregnancy obesity is associated with altered placental transcriptome.
2017 Scientific Article in Metabolomics Metabolomics 13:28 (2017)
Cinnamon: Does it hold its promises in cows? Using non-targeted blood serum metabolomics profiling to test the effects of feeding cinnamon to dairy cows undergoing lactation-induced insulin resistance.
2017 Scientific Article in Biochimica et Biophysica Acta - Molecular Basis of Disease Biochim. Biophys. Acta-Mol. Basis Dis. 1863, 1605-1614 (2017)
Modification of the fatty acid composition of an obesogenic diet improves the maternal and placental metabolic environment in obese pregnant mice.
2017 Scientific Article in Disease Models and Mechanisms Dis. Model. Mech. 10, 163-171 (2017)
Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology.
2017 Scientific Article in Journal of Molecular Endocrinology J. Mol. Endocrinol. 58, 67-68 (2017)
Genetic characterization of a mouse line with primary aldosteronism.
2017 Scientific Article in Molecular Metabolism Mol. Metab. 6, 256-266 (2017)
Bezafibrate ameliorates diabetes via reduced steatosis and improved hepatic insulin sensitivity in diabetic TallyHo mice.
2017 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 45, 3031-3045 (2017)
Interplay between H1 and HMGN epigenetically regulates OLIG1&2 expression and oligodendrocyte differentiation.
2017 Scientific Article in Endocrine-Related Cancer Endocr. Relat. Cancer 24, 1-15 (2017)
Targeting PI3K/mTOR signaling exerts potent antitumor activity in pheochromocytoma in vivo.
2017 Scientific Article in Nature Chemical Biology Nat. Chem. Biol. 13, 91-98 (2017)
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition.
2016 Scientific Article in Journal of applied laboratory medicine J. Appl. Lab. Med. 1, 129-142 (2016)
Inter-Laboratory Robustness of Next-Generation Bile Acid Study in Mice and Humans: International Ring Trial Involving 12 Laboratories.
2016 Meeting abstract in Diabetologia Diabetologia 59, S259-S259 (2016)
Systemic metabolic effects exerted by a point mutation in the RED subdomain of PAX6.
2016 Meeting abstract in Diabetologia Diabetologia 59, S274-S274 (2016)
Mitogenic activity of the metabolically relevant hepatokine FGF21 in human carcinoma cells.
2016 Meeting abstract in Diabetologia Diabetologia 59, S127-S127 (2016)
Targeted metabolomics to predict the primary success of metformin monotherapy in type 2 diabetes.
2016 Meeting abstract in Diabetologia Diabetologia 59, S47-S47 (2016)
miRNA signatures in maternal whole blood cells of women with gestational diabetes.
2016 Meeting abstract in Diabetologia Diabetologia 59, S188-S188 (2016)
Dll1-and Dll4-mediated Notch signalling in adult pancreatic beta cells is essential for the structural integrity of islets and maintenance of glucose homeostasis.
2016 Meeting abstract in Diabetologia Diabetologia 59, S307-S307 (2016)
Polycomb controls metabolic homeostasis through a novel liver-to-adipose axis.
2016 Meeting abstract in Allergy Allergy 71, 507-507 (2016)
Experimental allergen-specific immunotherapy under the umbrella of JAK1/3 pathway inhibition substantial improved local parameters of allergic airway inflammation.
2016 Meeting abstract in Allergy Allergy 71, 47-47 (2016)
Alum-free thermosensitive hydrogel as matrix for immunomodulatory substances and allergens during allergen-specific immunotherapy.
2016 Meeting abstract in American Journal of Respiratory and Critical Care Medicine Am. J. Respir. Crit. Care Med. 193 (2016)
Reduced expression of the epigenetic regulator Hmgn5 enhances susceptibility to emphysema.
2016 Letter to the Editor in Obstetrical & gynecological survey Obstet. Gynecol. Surv. 71, 719-720 (2016)
Epigenetic germline inheritance of diet-induced obesity and insulin resistance.
2016 Meeting abstract in American Journal of Respiratory and Critical Care Medicine Am. J. Respir. Crit. Care Med. 193 (2016)
Mouse lung developmental gene expression profiling study identifies novel candidate genes for pulmonary function.
2016 Scientific Article in Molecular Neurobiology Mol. Neurobiol. 54, 8242–8262 (2016)
Serum response factor (SRF) ablation interferes with acute stress-associated immediate and long-term coping mechanisms.
2016 Scientific Article in Nature medicine Nat. Med. 22, 1428-1438 (2016)
Cardioprotection and lifespan extension by the natural polyamine spermidine.
2016 Scientific Article in Scientific Reports Sci. Rep. 6:37005 (2016)
12-months metabolic changes among gender dysphoric individuals under cross-sex hormone treatment: A targeted metabolomics study.
2016 Scientific Article in Genes Genomes Genetics G3 Genes Genomes Genetics G3 6, 4035-4046 (2016)
The first Scube3 mutant mouse line with pleiotropic phenotypic alterations.
2016 Scientific Article in Circulation: Cardiovascular Genetics Circ. Cardiovasc. Genet. 9, 487-494 (2016)
Cardiovascular risk factors associated with blood metabolite concentrations and their alterations over a 4-year period in a population-based cohort.
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0164298 (2016)
Sphingomyelin synthase 1 is essential for male fertility in mice.
2016 Meeting abstract in Journal of Investigative Dermatology, The J. Invest. Dermatol. 136, 2, S231-S231 (2016)
Alum-free thermosensitive hydrogel as subcutaneous matrix for immunomodulators and allergens during specific immunotherapy.
2016 Scientific Article in Cell Cell 167, 843-857.e14 (2016)
Chemical hybridization of glucagon and thyroid hormone optimizes therapeutic Impact for metabolic disease.
2016 Scientific Article in Journal of Clinical Endocrinology & Metabolism, The J. Clin. Endocrinol. Metab. 101, 4730-4742:jc20162588 (2016)
Metabolic fingerprints of circulating IGF-I and the IGF-I/IGFBP-3 ration: A multi-fluid metabolomics study.
2016 Review in Diabetologia Diabetologia 59, 2497-2502 (2016)
Key elements of metabolomics in the study of biomarkers of diabetes.
2016 Scientific Article in Mammalian Genome Mamm. Genome 27, 587-598 (2016)
Viable EdnraY129F mice feature human mandibulofacial dysostosis with alopecia (MFDA) syndrome due to the homologue mutation.
2016 Scientific Article in Nature Nature 537, 508-514 (2016)
High-throughput discovery of novel developmental phenotypes.
2016 Scientific Article in Diabetes Diabetes 65, 3776-3785 (2016)
Metformin effect on non-targeted metabolite profiles in patients with type 2 diabetes and multiple murine tissues.
2016 Scientific Article in Gut (eGut) Gut 67, 146-156 (2016)
Dynamic landscape of pancreatic carcinogenesis reveals early molecular networks of malignancy.
2016 Scientific Article in Journal of the American Society of Nephrology J. Am. Soc. Nephrol. 28, 761-768 (2016)
Hyperoxaluria requires TNF receptors to initiate crystal adhesion and kidney stone disease.
2016 Scientific Article in Glycoconjugate Journal Glycoconj. J. 34, 393–404 (2016)
A novel biological function of soluble biglycan: Induction of erythropoietin production and polycythemia.
2016 Scientific Article in Archives of Physiology and Biochemistry Arch. Physiol. Biochem. 122, 281-288 (2016)
Impact of fibroblast growth factor 21 on the secretome of human perivascular preadipocytes and adipocytes: A targeted proteomics approach.
2016 Scientific Article in Cell Cell 164, 353-364 (2016)
Trim28 haploinsufficiency triggers bi-stable epigenetic obesity.
2016 Scientific Article in Nature Nature 536, 41-47 (2016)
The genetic architecture of type 2 diabetes.
2016 Scientific Article in Nature Nature 535, 430-434 (2016)
Identification of proliferative and mature β-cells in the islets of Langerhans.
2016 Scientific Article in Diabetes Diabetes 65, 2849-2861 (2016)
TGFβ contributes to impaired exercise response by suppression of mitochondrial key regulators in skeletal muscle.
2016 Scientific Article in Journal of the American Association for Laboratory Animal Science J. Amer. Assoc. Lab. Anim. Sci. 55, 375-386 (2016)
Clinical chemistry reference intervals for C57BL/6J, C57BL/6N, and C3HeB/FeJ mice (Mus musculus).
2016 Meeting abstract in Cancer Research Cancer Res. 76:P1-06-02 (2016)
A force-sensitive organoid assay to quantify regenerative potential of single primary human mammary cells.
2016 Scientific Article in Diabetes Diabetes 65, 2540-2552 (2016)
Bezafibrate improves insulin sensitivity and metabolic flexibility in STZ-treated diabetic mice.
2016 Nature Communications Nat. Commun. 7:11835 (2016)
Erratum: Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression.
2016 Scientific Article in Mammalian Genome Mamm. Genome 27, 445-450 (2016)
INFRAFRONTIER: A European resource for studying the functional basis of human disease.
2016 Scientific Article in Gut (eGut) Gut 66, 1369-1381 (2016)
Lymphotoxin β receptor signalling executes Helicobacter pylori-driven gastric inflammation in a T4SS-dependent manner.
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0152996 (2016)
CIP2A promotes T-cell activation and immune response to Listeria monocytogenes infection.
2016 Scientific Article in Nature Communications Nat. Commun. 7:11317 (2016)
Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression.
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0153990 (2016)
Effects of genetic loci associated with central obesity on adipocyte lipolysis.
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0150472 (2016)
Generation and standardized, systemic phenotypic analysis of Pou3f3L423P mutant mice.
2016 Meeting abstract in Transgenic Research Transgenic Res. 25, 228 (2016)
EMMA: The European Mouse Mutant Archive.
2016 Scientific Article in Cell Death and Differentiation Cell Death Differ. 23, 1026-1037 (2016)
Immunoproteasome dysfunction augments alternative polarization of alveolar macrophages.
2016 Scientific Article in Nature Genetics Nat. Genet. 48, 497-499 (2016)
Epigenetic germline inheritance of diet-induced obesity and insulin resistance.
2016 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 25, 2082-2092 (2016)
Testing the role of predicted gene knockouts in human anthropometric trait variation.
2016 Scientific Article in Journal of Steroid Biochemistry and Molecular Biology, The J. Steroid Biochem. Mol. Biol. 159, 60-69 (2016)
Altered levels of acylcarnitines, phosphatidylcholines, and sphingomyelins in peritoneal fluid from ovarian endometriosis patients.
2016 Scientific Article in Journal of Breath Research J. Breath Res. 10:016009 (2016)
Diet-induced and mono-genetic obesity alter volatile organic compound signature in mice.
2016 Scientific Article in American Journal of Physiology - Renal Physiology Am. J. Physiol.-Renal Physiol. 310, F785-F795 (2016)
Oxalate-induced chronic kidney disease with its uremic and cardiovascular complications in C57BL/6 mice.
2016 Scientific Article in Molecular Metabolism Mol. Metab. 5, 283-295 (2016)
Mitochondrial gene polymorphisms alter hepatic cellular energy metabolism and aggravate diet-induced non-alcoholic steatohepatitis.
2016 Scientific Article in Haematologica - The Hematology Journal Haematologica 101, e48-e51 (2016)
Iron deficiency anemia in cyclic GMP kinase knockout mice.
2016 Scientific Article in Journal of Inherited Metabolic Disease J. Inherit. Metab. Dis. 39, 309-319 (2016)
Mildly compromised tetrahydrobiopterin cofactor biosynthesis due to Pts variants leads to unusual body fat distribution and abdominal obesity in mice.
2016 Scientific Article in EMBO Reports EMBO Rep. 17, 455-469 (2016)
Life span extension by targeting a link between metabolism and histone acetylation in Drosophila.
2016 Scientific Article in Mammalian Genome Mamm. Genome 27, 111-121 (2016)
Exome sequencing identifies a nonsense mutation in Fam46a associated with bone abnormalities in a new mouse model for skeletal dysplasia.
2016 Scientific Article in Journal of Diabetes Research J. Diabetes Res. 2016:4208156 (2016)
Longitudinal frequencies of blood leukocyte sub-populations differ between NOD and NOR mice, but do not predict diabetes in NOD mice.
2016 Scientific Article in Journal of Proteomics J. Proteomics 133, 66-75 (2016)
Liver lipid metabolism is altered by increased circulating estrogen to androgen ratio in male mouse.
2016 Scientific Article in Basic Research in Cardiology Basic Res. Cardiol. 111:6 (2016)
Knock-out of nexilin in mice leads to dilated cardiomyopathy and endomyocardial fibroelastosis.
2016 Scientific Article in Cell Stem Cell Cell Stem Cell 18, 396-409 (2016)
Identification and successful negotiation of a metabolic checkpoint in direct neuronal repogramming.
2016 Scientific Article in Journal of Proteome Research J. Proteome Res. 15, 554-562 (2016)
Diagnostic and prognostic metabolites identified for joint symptoms in the KORA population.
2016 Scientific Article in Mechanisms of Development Mech. Dev. 139, 51-64 (2016)
The global gene expression profile of the secondary transition during pancreatic development.
2016 Scientific Article in Clinical Science Clin. Sci. 130, 273-287 (2016)
Metabolomics screening identifies reduced L-carnitine to be associated with progressive emphysema.
2016 Scientific Article in Journal of the American Society of Nephrology J. Am. Soc. Nephrol. 27, 1175-1188 (2016)
A metabolome-wide association study of kidney function and disease in the general population.
2016 Scientific Article in Gut (eGut) Gut 65, 647-657 (2016)
A subset of metastatic pancreatic ductal adenocarcinomas depends quantitatively on oncogenic Kras/Mek/Erk-induced hyperactive mTOR signalling.
München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2015, 140 S.
Regulation of myokines in exercising human skeletal muscle cells obtained from phenotyped donors.
2015 Meeting abstract in Allergy Allergy 70, 459-460 (2015)
Local inhibition of IL-4-and IL-13-mediated signaling as adjuvant for tolerance induction during allergen-specific immunotherapy.
2015 Scientific Article in Genes and Nutrition Genes Nutr. 10:57 (2015)
Skeletal muscle mitochondrial uncoupling prevents diabetes but not obesity in NZO mice, a model for polygenic diabesity.
2015 Scientific Article in Archives of Physiology and Biochemistry Arch. Physiol. Biochem. 121, 194-205 (2015)
Identification of novel putative adipomyokines by a cross-species annotation of secretomes and expression profiles.
2015 Scientific Article in Archives of Biochemistry and Biophysics Arch. Biochem. Biophys. 589, 145-151 (2015)
A single night of sleep curtailment increases plasma acylcarnitines: Novel insights in the relationship between sleep and insulin resistance.
2015 Scientific Article in Mammalian Genome Mamm. Genome 27, 17-28 (2015)
Dexamethasone treatment alters insulin, leptin, and adiponectin levels in male mice as observed in DIO but does not lead to alterations of metabolic phenotypes in the offspring.
2015 Scientific Article in Frontiers in Behavioral Neuroscience Front. Behav. Neurosci. 9:302 (2015)
Conditional reduction of adult born doublecortin-positive neurons reversibly impairs selective behaviors.
2015 Scientific Article in Current Protocols of Mouse Biology Curr. Protoc. Mouse Biol. 5, 291-301:doi: 10.1002/9780470942390.mo160 (2015)
Tests for anxiety-related behavior in mice.
2015 Scientific Article in Current Protocols of Mouse Biology Curr. Protoc. Mouse Biol. 5, 331-358:doi: 10.1002/9780470942390.mo160 (2015)
Assessing cognition in mice.
2015 Meeting abstract in European Journal of Neurology Eur. J. Neurol. 22, 30 (2015)
Familial dyskinesia with facial myokymia due to ADCY5 mutation: Treatment with propranolol.
2015 Scientific Article in Arteriosclerosis, Thrombosis, and Vascular Biology Arterioscler. Thromb. Vasc. Biol. 36, 122-133 (2015)
MFAP4 promotes vascular smooth muscle migration, proliferation and accelerates neointima formation.
2015 Scientific Article in Genetic Epidemiology Genet. Epidemiol. 39, 499-508 (2015)
Evaluating the calibration and power of three gene-based association tests of rare variants for the X chromosome.
2015 Scientific Article in Frontiers in Behavioral Neuroscience Front. Behav. Neurosci. 9:302 (2015)
Conditional reduction of adult born doublecortin-positive neurons reversibly impairs selective behaviors.
In: Han, D.* ; Kaplowitz, N.* [Eds.]: Mitochondria in Liver Disease. Boca Raton, FL: CRC Press, 2015. 383-412
Mitochondrial function, dysfunction, and adaption in the liver during the development of diabetes.
2015 Scientific Article in Cellular Physiology and Biochemistry Cell. Physiol. Biochem. 37, 1474-1490 (2015)
Endothelin-1 overexpression improves renal function in eNOS knockout mice.
2015 Editorial in Archives of Biochemistry and Biophysics Arch. Biochem. Biophys. 589, 1-3 (2015)
Guest editorial: Special issue on metabolomics.
2015 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 24, 7286-7294 (2015)
Overexpression of the mitochondrial methyltransferase TFB1M in the mouse does not impact mitoribosomal methylation status of hearing.
2015 Meeting abstract in Nephrology Dialysis Transplantation Nephrol. Dial. Transplant. 30:SP045 (2015)
Detailed morphological analyses of a novel mouse model of site-specific glomerular thrombotic microangiopathy.
2015 Scientific Article in Nature Communications Nat. Commun. 6:8261 (2015)
eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription.
Berlin: epubli GmbH, 2015, 156 S. (Zugl. München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2015)
Network-based analysis of genetic and nutritional effects on human metabolism.
2015 Scientific Article in Journal of Neuroscience J. Neurosci. 35, 13385-13401 (2015)
Dickkopf3 promotes the differentiation of a rostrolateral midbrain dopaminergic neuronal subset in vivo and from pluripotent stem cells in vitro in the mouse.
2015 Scientific Article in Cell Metabolism Cell Metab. 22, 838-850 (2015)
Calcineurin links mitochondrial elongation with energy metabolism.
2015 Scientific Article in Archives of Biochemistry and Biophysics Arch. Biochem. Biophys. 589, 93-107 (2015)
Metabolic switch during adipogenesis: From branched chain amino acid catabolism to lipid synthesis.
2015 Scientific Article in Archives of Biochemistry and Biophysics Arch. Biochem. Biophys. 589, 152-157 (2015)
Physiological changes due to mild cooling in healthy lean males of white Caucasian and South Asian descent: A metabolomics study.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1005506 (2015)
Identification of four mouse diabetes candidate genes altering β-cell proliferation.
2015 Scientific Article in American Journal of Physiology - Endocrinology and Metabolism Am. J. Physiol. Endocrinol. Metab. 309, E736-E746 (2015)
Alterations of plasma metabolite profiles related to adipose tissue distribution and cardiometabolic risk.
2015 Scientific Article in Archives of Biochemistry and Biophysics Arch. Biochem. Biophys. 589, 138-144 (2015)
Type 2 diabetes is associated with postprandial amino acid measures.
2015 Scientific Article in PLoS ONE PLoS ONE 10:e0134503 (2015)
Cox4i2, Ifit2, and Prdm11 mutant mice: Effective selection of genes predisposing to an altered airway inflammatory response from a large compendium of mutant mouse lines.
2015 Scientific Article in Metabolomics Metabolomics 11, 1815-1833 (2015)
Gender-specific pathway differences in the human serum metabolome.
2015 Scientific Article in Development / Company of Biologists Development 142, 3009-3020 (2015)
Meis1 coordinates a network of genes implicated in eye development and microphthalmia.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1005423 (2015)
SLIRP regulates the rate of mitochondrial protein synthesis and protects LRPPRC from degradation.
2015 Scientific Article in Glia Glia 63, 2340-2361 (2015)
Astrocyte reactivity after brain injury - the role of galectins 1 and 3.
2015 Scientific Article in Scientific Reports Sci. Rep. 5:12673 (2015)
Validated prediction of pro-invasive growth factors using a transcriptome-wide invasion signature derived from a complex 3D invasion assay.
2015 Scientific Article in Experimental and Clinical Endocrinology & Diabetes Exp. Clin. Endocrinol. Diabet. 123, 433-438 (2015)
Metabolic profiles during an oral glucose tolerance test in pregnant women with and without gestational diabetes.
2015 Scientific Article in Diabetes Care Diabetes Care 38, 1858-1867 (2015)
Effects of metformin on metabolite profiles and LDL cholesterol in patients with type 2 diabetes.
2015 Scientific Article in Nature Genetics Nat. Genet. 47, 969-978 (2015)
Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.
2015 Scientific Article in Mammalian Genome Mamm. Genome 26, 467-481 (2015)
Principles and application of LIMS in mouse clinics.
2015 Scientific Article in Journal of the American Heart Association J. Am. Heart Assoc. 4:e002153 (2015)
Heart-specific knockout of the mitochondrial Thioredoxin reductase (Txnrd2) induces metabolic and contractile dysfunction in the aging myocardium.
2015 Scientific Article in Transgenic Research Transgenic Res. 24, 921-927 (2015)
Blastocyst genotyping for quality control of mouse mutant archives: An ethical and economical approach.
2015 Scientific Article in Methods in Molecular Biology Methods Mol. Biol. 1322, 187-198 (2015)
Determination and analysis of cellular metabolic changes by noncanonical Hedgehog signaling.
2015 Meeting abstract in Glia Glia 63, E64 (2015)
Identification and successful negotiation of a metabolic checkpoint in direct neuronal reprogramming.
2015 Scientific Article in Genome Research Genome Res. 25, 1295-1308 (2015)
Functional compensation among HMGN variants modulates the DNase I hypersensitive sites at enhancers.
2015 Scientific Article in Cell Stem Cell Cell Stem Cell 17, 74-88 (2015)
Transcriptional mechanisms of proneural factors and REST in regulating neuronal reprogramming of astrocytes.
2015 Scientific Article in Steroids Steroids 103, 123-144 (2015)
Steroids in teleost fishes: A functional point of view.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1005274 (2015)
The human blood metabolome-transcriptome interface.
2015 Scientific Article in Diabetologia Diabetologia 58, 1845-1854 (2015)
Type 2 diabetes alters metabolic and transcriptional signatures of glucose and amino acid metabolism during exercise and recovery.
2015 Scientific Article in Development / Company of Biologists Development 142, 3239-3251 (2015)
Quantification of regenerative potential in primary human mammary epithelial cells.
2015 Scientific Article in Molecular and Cellular Proteomics Mol. Cell. Proteomics 14, 2764-2774 (2015)
The epoxyeicosatrienoic acid pathway enhances hepatic insulin signaling and is repressed in insulin-resistant mouse liver.
2015 Scientific Article in Nature Communications Nat. Commun. 6:7208 (2015)
Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels.
2015 Scientific Article in Developmental Cell Dev. Cell 33, 644-659 (2015)
MIM-induced membrane bending promotes dendritic spine initiation.
2015 Scientific Article in Thorax Thorax 70, 862-872 (2015)
Microfibrillar-associated protein 4 modulates airway smooth muscle cell phenotype in experimental asthma.
2015 Meeting abstract in Journal of Crohn's and Colitis J. Crohns Colitis 9, S104 (2015)
Mitochondrial dysfunction impairs epithelial proliferative control and stemness in the intestinal crypts.
2015 Scientific Article in PLoS Biology PLoS Biol. 13:e1002151 (2015)
Applying the ARRIVE guidelines to an in vivo database.
2015 Scientific Article in Genetics Genetics 200, 707-718 (2015)
Non-additive effects of genes in human metabolomics.
2015 Scientific Article in Diabetes Aktuell Diabetes akt. 13, 72-74 (2015)
Epigenetische Vererbung - ist die Zukunft diabetisch?
2015 Scientific Article in Diabetes Aktuell Diabetes akt. 13, 58-62 (2015)
5 Jahre erfolgreiche translationale Forschung - Deutsches Zentrum für Diabetesforschung.
2015 Review in Glia Glia 63, 1452-1468 (2015)
Reactive astrocytes as neural stem or progenitor cells: In vivo lineage, In vitro potential, and genome-wide expression analysis.
2015 Scientific Article in BMC Genomics BMC Genomics 16:351 (2015)
Genomic characterization of mutant laboratory mouse strains by exome sequencing and annotation lift-over.
2015 Scientific Article in PLoS ONE PLoS ONE 10:e0125304 (2015)
New mutation in the mouse Xpd/Ercc2 gene leads to recessive cataracts.
2015 Scientific Article in American Journal of Clinical Nutrition Am. J. Clin. Nutr. 101, 1241-1250 (2015)
Amino acids, lipid metabolites, and ferritin as potential mediators linking red meat consumption to type 2 diabetes.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1005165 (2015)
The power of gene-based rare variant methods to detect disease-associated variation and test hypotheses about complex disease.
2015 Meeting abstract in Journal of Investigative Dermatology, The J. Invest. Dermatol. 135, S111 (2015)
MSX1-induced neural crest-like reprograming promotes melanoma progression.
2015 Scientific Article in Cellular Physiology and Biochemistry Cell. Physiol. Biochem. 35, 2272-2284 (2015)
Mice lacking Free Fatty Acid Receptor 1 (GPR40/FFAR1) are protected against conjugated linoleic acid-induced fatty liver but develop inflammation and insulin resistance in the brain.
2015 Scientific Article in Molecular Metabolism Mol. Metab. 4, 519-527 (2015)
Fibroblast growth factor 21 is elevated in metabolically unhealthy obesity and affects lipid deposition, adipogenesis, and adipokine secretion of human abdominal subcutaneous adipocytes.
2015 Letter to the Editor in International Journal of Cardiovascular Imaging Int. J. Cardiovasc. Imaging 31, 1137 (2015)
Erratum to: High throughput phenotyping of left and right ventricular cardiomyopathy in calcineurin transgene mice.
2015 Meeting abstract in Experimental and Clinical Endocrinology & Diabetes Exp. Clin. Endocrinol. Diabet. 123:P09_16 (2015)
Pilot study on the effects of cross-sex hormone treatment in transsexual persons on metabolism by means of metabolomics profiling.
2015 Scientific Article in American Journal of Physiology - Lung Cellular and Molecular Physiology Am. J. Physiol. Lung Cell Mol. Physiol. 308, L1114-L1124 (2015)
Characterization of spontaneous air space enlargement in mice lacking microfibrillar-associated protein 4.
2015 Scientific Article in Methods in Molecular Biology Methods Mol. Biol. 1295, 55-64 (2015)
Methods for proteomics-based analysis of the human muscle secretome using an in vitro exercise model.
2015 Scientific Article in Journal of Biological Chemistry, The J. Biol. Chem. 290, 6531-6545 (2015)
Aldo-Keto Reductase 1B15 (AKR1B15): A mitochondrial human aldo-keto reductase with activity toward steroids and 3-keto-acyl-CoA conjugates.
2015 Scientific Article in Current Protocols of Mouse Biology Curr. Protoc. Mouse Biol. 5, 65-84 (2015)
Glucose tolerance tests for systematic screening of glucose homeostasis in mice.
2015 Scientific Article in Circulation Circulation 131, 1191-1201 (2015)
ADAMTS-7 inhibits re-endothelialization of injured arteries and promotes vascular remodeling via cleavage of thrombospondin-1.
2015 Editorial in BioSpektrum BioSpektrum 21, 20-21 (2015)
Vererbung von Merkmalen außerhalb der primären Sequenz der DNA.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1004876 (2015)
Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus.
2015 Scientific Article in BioMetals Biometals 28, 293-306 (2015)
Screen for alterations of iron related parameters in N-ethyl-N-nitrosurea-treated mice identified mutant lines with increased plasma ferritin levels.
2015 Scientific Article in International Journal of Cardiovascular Imaging Int. J. Cardiovasc. Imaging 31, 669-679 (2015)
High throughput phenotyping of left and right ventricular cardiomyopathy in calcineurin transgene mice.
2015 Scientific Article in Cell Reports Cell Rep. 10, 131-139 (2015)
Stem-cell-like properties and epithelial plasticity arise as stable traits after transient Twist1 activation.
2015 Scientific Article in Circulation Circulation 131, 774-785 (2015)
Metabolite profiling and cardiovascular event risk: A prospective study of three population-based cohorts.
2015 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 24, 2247-2266 (2015)
MTO1 mediates tissue-specificity of OXPHOS defects via tRNA modification and translation optimization, which can be bypassed by dietary intervention.
2015 Scientific Article in Developmental Biology Dev. Biol. 399, 2-14 (2015)
Loss of Npn1 from motor neurons causes postnatal deficits independent from Sema3A signaling.
2015 Scientific Article in Gastroenterology Gastroenterology 148, 626-638 (2015)
Impaired autophagy induces chronic atrophic pancreatitis in mice via sex- and nutrition-dependent processes.
2015 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 53, D1171-D1175 (2015)
INFRAFRONTIER - providing mutant mouse resources as research tools for the international scientific community.
2015 Scientific Article in Journal of Nutritional Biochemistry, The J. Nutr. Biochem. 26, 75-81 (2015)
The development of diet-induced obesity and associated metabolic impairments in Dj-1 deficient mice.
2015 Scientific Article in Analytical and Bioanalytical Chemistry Anal. Bioanal. Chem. 407, 343-354 (2015)
Combining metabolomic non-targeted GC×GC-ToF-MS analysis and chemometric ASCA-based study of variances to assess dietary influence on type 2 diabetes development in a mouse model.
2015 Scientific Article in Molecular Metabolism Mol. Metab. 4, 39-50 (2015)
High fat diet-induced modifications in membrane lipid and mitochondrial-membrane protein signatures precede the development of hepatic insulin resistance in mice.
2015 Scientific Article in Diabetologia Diabetologia 58, 374-383 (2015)
Nutritional strategy to prevent fatty liver and insulin resistance independent from obesity by reducing glucose-dependent insulinotropic polypeptide responses in mice.
2015 Scientific Article in Mammalian Genome Mamm. Genome 26, 33-42 (2015)
Generation of mice lacking DUF1220 protein domains: Effects on fecundity and hyperactivity.
2015 Scientific Article in Diabetes Diabetes 64, 284-290 (2015)
Metformin supports the antidiabetic effect of a sodium glucose cotransporter 2 inhibitor by suppressing endogenous glucose production in diabetic mice.
2015 Scientific Article in Neuropsychopharmacology Neuropsychopharmacology 40, 338-349 (2015)
Differential and converging molecular mechanisms of antidepressants' action in the hippocampal dentate gyrus.
München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2014, 151 S.
Diet induced obesity differentially affects mitochondrial function in skeletal muscle and liver of C57BL/6J mice.
2014 Scientific Article in Current Protocols of Mouse Biology Curr. Protoc. Mouse Biol. 4, 67-83 (2014)
In vitro fertilization in mice using the MBCD-GSH protocol.
2014 Scientific Article in Current Protocols of Mouse Biology Curr. Protoc. Mouse Biol. 4, 85-104 (2014)
Contemporary techniques for freezing mouse spermatozoa.
2014 Scientific Article in Current Protocols of Mouse Biology Curr. Protoc. Mouse Biol. 4, 47-65 (2014)
Transporting mouse embryos and germplasm as frozen or unfrozen materials.
2014 Scientific Article in Current Protocols of Mouse Biology Curr. Protoc. Mouse Biol. 4, 205-227 (2014)
Conservation of mouse models through embryo freezing.
2014 Meeting abstract in European Journal of Cancer Eur. J. Cancer 50, S57 (2014)
p27 is a haploinsufficient tumor suppressor in MENX rats and this associates with the development of invasive medullary thyroid carcinoma.
2014 Meeting abstract in Experimental and Clinical Endocrinology & Diabetes Exp. Clin. Endocrinol. Diabet. 122:OP4_11 (2014)
FGF21 inhibits adiponectin secretion in human adipocytes.
2014 Meeting abstract in Diabetologia Diabetologia 57, S172 (2014)
Defective compensatory insulin secretion causes HFD-induced glucose intolerance in mice with point mutation in free fatty acid receptor 1.
2014 Scientific Article in PLoS ONE PLoS ONE 9:e114918 (2014)
MTO1-deficient mouse model mirrors the human phenotype showing complex I defect and cardiomyopathy.
2014 Scientific Article in Diabetes Diabetes 63, 4230-4238 (2014)
Differential transcriptome analysis of diabetes-resistant and -sensitive mouse islets reveals significant overlap with human diabetes susceptibility genes.
2014 Scientific Article in Beitrage zur Entomologie Beitr. Entomol. 64, 221-229 (2014)
Haplotypes, median networks, and diagnostic characters as tools to elucidate the intraspecific genetic and taxonomic structure of bumblebees, with a description of Bombus cryptarum pallidocinctus new subspecies (Hymenoptera: Apida: Bombus).
2014 Scientific Article in Chemico-Biological Interactions Chem. Biol. Interact. 234, 297-308 (2014)
Important roles of the AKR1C2 and SRD5A1 enzymes in progesterone metabolism in endometrial cancer model cell lines.
2014 Scientific Article in PLoS ONE PLoS ONE 9:e113125 (2014)
Uromodulin retention in thick ascending limb of Henle's loop affects SCD1 in neighboring proximal tubule: Renal transcriptome studies in mouse models of uromodulin-associated kidney disease.
2014 Scientific Article in Cell Reports Cell Rep. 9, 1292-1305 (2014)
Uncoupling Malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation.
2014 Scientific Article in International Journal of Cancer Int. J. Cancer 136, 2293-2303 (2014)
MiR-34a deficiency accelerates medulloblastoma formation in vivo.
2014 Scientific Article in PLoS ONE PLoS ONE 9:e111239 (2014)
Impact of temporal variation on design and analysis of mouse knockout phenotyping studies.
2014 Scientific Article in Nature Communications Nat. Commun. 5:5215 (2014)
Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts.
2014 Meeting abstract in Transgenic Research Transgenic Res. 23, 851-852 (2014)
Efficient shipment of refrigerated mouse embryos across Europe.
2014 Meeting abstract in Transgenic Research Transgenic Res. 23, 851 (2014)
The INFRAFRONTIER research infrastructure and EMMA: The European mouse mutant archive.
2014 Meeting abstract in Transgenic Research Transgenic Res. 23, 899 (2014)
Infrafrontier research infrastructure.
2014 Scientific Article in PLoS Computational Biology PLoS Comput. Biol. 10:e1003843 (2014)
Fast synchronization of ultradian oscillators controlled by Delta-Notch signaling with Cis-inhibition.
2014 Meeting abstract in Allergy Allergy 69, 365 (2014)
In utero cigarette smoke exposure affects foetal pulmonary signalling networks in a murine model.
2014 Scientific Article in Mammalian Genome Mamm. Genome 25, 497-507 (2014)
A review of standardized metabolic phenotyping of animal models.
2014 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 111, 13127-13132 (2014)
Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes.
2014 Scientific Article in European Journal of Immunology Eur. J. Immunol. 44, 3232-3239 (2014)
Endothelial amine oxidase AOC3 transiently controbutes to adaptive immune responses in the airways.
2014 Scientific Article in American Journal of Physiology - Lung Cellular and Molecular Physiology Am. J. Physiol. Lung Cell Mol. Physiol. 307, L692-L706 (2014)
Cigarette smoke-induced iBALT mediates macrophage activation in a B cell-dependent manner in COPD.
2014 Scientific Article in Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids Biochim. Biophys. Acta-Mol. Cell Biol. Lipids 1841, 1563-1570 (2014)
The lipid profile of brown adipose tissue is sex-specific in mice.
2014 Scientific Article in PLoS ONE PLoS ONE 9:e104568 (2014)
Pleiotropic functions for transcription factor Zscan10.
2014 Scientific Article in Molecular Cancer Mol. Cancer 13:182 (2014)
A Rb1 promoter variant with reduced activity contributes to osteosarcoma susceptibility in irradiated mice.
2014 Scientific Article in Journal of Biomedical Science J. Biomed. Sci. 21:68 (2014)
Standardized, systemic phenotypic analysis of Slc12a1 I299F mutant mice.
2014 Scientific Article in EMBO Journal, The EMBO J. 33, 2020-2039 (2014)
Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders.
2014 Review in Cellular and Molecular Life Sciences - CMLS Cell. Mol. Life Sci. 71, 4325-4346 (2014)
Longevity, aging and rapamycin.
2014 Scientific Article in Journal of Proteome Research J. Proteome Res. 13, 4220-4231 (2014)
The importance of sulfur-containing metabolites in discriminating fecal extracts between normal and type 2 diabetic mice.
2014 Scientific Article in International Journal of Nanomedicine Int. J. Nanomed. 9, 2815-2832 (2014)
Surface modifications of silica nanoparticles are crucial for their inert versus proinflammatory and immunomodulatory properties.
2014 Scientific Article in International Journal of Sport Nutrition and Exercise Metabolism Int. J. Sport Nutr. Exerc. Metab. 24, 215-226 (2014)
Serum metabolites related to cardiorespiratory fitness, physical activity energy expenditure, sedentary time and vigorous activity.
2014 Scientific Article in Journal of Translational Medicine J. Transl. Med. 12:161 (2014)
Metabolomics of Ramadan fasting: An opportunity for the controlled study of physiological responses to food intake.
2014 Scientific Article in ISME Journal ISME J. 8, 2380-2396 (2014)
Distinct signatures of host-microbial meta-metabolome and gut microbiome in two C57BL/6 strains under high-fat diet.
2014 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 23, 5597-5614 (2014)
Peroxidasin is essential for eye development in the mouse.
2014 Scientific Article in PLoS ONE PLoS ONE 9:e98072 (2014)
Abnormal brain iron metabolism in Irp2 deficient mice is associated with mild neurological and behavioral impairments.
2014 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 94, 710-720 (2014)
Simulation of finnish population history, guided by empirical genetic data, to assess power of rare-variant tests in Finland.
2014 Scientific Article in Journal of Immunology J. Immunol. 192, 3507-3517 (2014)
Differential kinetics of antigen dependency of CD4+ and CD8+ T cells.
2014 Meeting abstract in Experimental Dermatology Exp. Dermatol. 23, E42 (2014)
The role of SOX10 in melanoma cell invasion.
2014 Scientific Article in Journal of Chromatography J. Chromatogr. B 966, 77-82 (2014)
Integrated enrichment analysis and pathway-centered visualization of metabolomics, proteomics, transcriptomics, and genomics data by using the InCroMAP software.
2014 Scientific Article in Frontiers in Behavioral Neuroscience Front. Behav. Neurosci. 8:125 (2014)
A robust and reliable non-invasive test for stress responsivity in mice.
2014 Scientific Article in Journal of Comparative Physiology B J. Comp. Physiol. B 184, 763-775 (2014)
High-throughput phenotypic assessment of cardiac physiology in four commonly used inbred mouse strains.
2014 Scientific Article in PLoS ONE PLoS ONE 9:e94882 (2014)
Mitochondrial DNA variants in obesity.
2014 Scientific Article in Obesity Obesity 22, 925-931 (2014)
Polymorphism rs3123554 in CNR2 reveals gender-specific effects on body weight and affects loss of body weight and cerebral insulin action.
2014 Scientific Article in PLoS ONE PLoS ONE 9:e93148 (2014)
Metabolic signatures of cultured human adipocytes from metabolically healthy versus unhealthy obese individuals.
2014 Scientific Article in Genome Medicine Genome Med. 6:25 (2014)
Interrogating causal pathways linking genetic variants, small molecule metabolites and circulating lipids.
2014 Scientific Article in Journal of Endocrinological Investigation J. Endocrinol. Invest. 37, 369-374 (2014)
Increased amino acids levels and the risk of developing hypertriglyceridemia in a 7-year follow-up.
2014 Scientific Article in Molecular Biotechnology : MB Online Mol. Biotechnol. 56, 697-713 (2014)
Simple derivation of transgene-free iPS cells by a dual recombinase approach.
2014 Scientific Article in Allergy Allergy 69, 632-642 (2014)
A common atopy-associated variant in the TH2 cytokine locus control region impacts transcriptional regulation and alters SMAD3 and SP1 binding.
2014 Scientific Article in Journal of Neuroscience J. Neurosci. 34, 4187-4199 (2014)
Genetic evidence for the adhesion protein IgSF9/Dasm1 to regulate inhibitory synapse development independent of its intracellular domain.
2014 Scientific Article in Journal of Proteome Research J. Proteome Res. 13, 2339-2351 (2014)
High fat diet induced isoform changes of the Parkinson’s disease protein DJ-1.
2014 Scientific Article in Genome Research Genome Res. 24, 592-603 (2014)
Restless Legs Syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon.
2014 Scientific Article in International Journal of Obesity Int. J. Obes. 38, 1388-1396 (2014)
Linking diet, physical activity, cardiorespiratory fitness and obesity to serum metabolite networks: Findings from a population-based study.
2014 Scientific Article in PLoS ONE PLoS ONE 9:e89728 (2014)
Targeted metabolomics identifies reliable and stable metabolites in human serum and plasma samples.
2014 Scientific Article in Journal of Biological Chemistry, The J. Biol. Chem. 289, 10715-10726 (2014)
No amelioration of uromodulin maturation and trafficking defect by sodium-4-phenylbutyrate in vivo: Studies in mouse models of uromodulin-associated kidney disease.
2014 Scientific Article in Journal of Breath Research J. Breath Res. 8:016004 (2014)
Effects of diet-matrix on volatile organic compounds in breath in diet-induced obese mice.
2014 Scientific Article in Journal of Biological Chemistry, The J. Biol. Chem. 289, 10769-10784 (2014)
Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.
München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2014, 202 S.
In vivo and in vitro analysis of Dll1 and Pax6 function in the adult mouse pancreas.
2014 Review in Cell Cell 156, 343-358 (2014)
Leveraging cross-species transcription factor binding site patterns: From diabetes risk loci to disease mechanisms.
2014 Scientific Article in Journal of Hepatology J. Hepatol. 60, 816-823 (2014)