Helmholtz Diabetes Center Institute of Experimental Genetics
The aim of the Institute of Experimental Genetics (IEG) is to further the understanding of mechanisms that underlie the etiology of human diseases. Metabolic diseases with focus on diabetes are key areas of research. Experimental set-ups are centered on the mouse as pre-clinical model organism with direct translation of results to humans. Besides studying the effects of genotypes, the institute identifies and characterizes environmental and epigenetic factors and the mechanisms by which these act on the etiology of diseases.
The aim of the Institute of Experimental Genetics (IEG) is to further the understanding of mechanisms that underlie the etiology of human diseases. Metabolic diseases with focus on diabetes are key areas of research. Experimental set-ups are centered on the mouse as pre-clinical model organism with direct translation of results to humans. Besides studying the effects of genotypes, the institute identifies and characterizes environmental and epigenetic factors and the mechanisms by which these act on the etiology of diseases.
Aim of our Research
The aim of the Institute of Experimental Genetics (IEG) is to further the understanding of mechanisms that underlie the etiology of human diseases. Metabolic diseases with focus on diabetes are key areas of research. Experimental set-ups are centered on the mouse as pre-clinical model organism with direct translation of results to humans. Besides studying the effects of genotypes, the institute identifies and characterizes environmental and epigenetic factors and the mechanisms by which these act on the etiology of diseases.
Selected Publications of the IEG
Read more2024 Scientific Article in Endocrinology
Comparative phenotyping of mice reveals canonical and noncanonical physiological functions of TRα and TRβ.
2024 Review in Nature Communications
Improving laboratory animal genetic reporting: LAG-R guidelines.
2024 Scientific Article in Pituitary
Decreased β-cell volume and insulin secretion but preserved glucose tolerance in a growth hormone insensitive pig model.
2024 Scientific Article in European Journal of Epidemiology
Sex hormone-binding globulin may explain sex differences for glucose homeostasis and incidence of type 2 diabetes: The KORA study.
2024 Scientific Article in Cardiovascular Diabetology
Bidirectional modulation of TCA cycle metabolites and anaplerosis by metformin and its combination with SGLT2i.
2024 Scientific Article in Nature