Helmholtz Diabetes Center
Institute of Experimental Genetics
The Institute of Experimental Genetics (IEG) aims to further the understanding of mechanisms underlying human diseases' etiology. Metabolic diseases with a focus on diabetes are key areas of research. Experimental set-ups are centered on the mouse as a pre-clinical model organism with direct translation of results to humans. Besides studying the effects of genotypes, the institute identifies and characterizes environmental and epigenetic factors and the mechanisms by which these act on the etiology of diseases.
The Institute of Experimental Genetics (IEG) aims to further the understanding of mechanisms underlying human diseases' etiology. Metabolic diseases with a focus on diabetes are key areas of research. Experimental set-ups are centered on the mouse as a pre-clinical model organism with direct translation of results to humans. Besides studying the effects of genotypes, the institute identifies and characterizes environmental and epigenetic factors and the mechanisms by which these act on the etiology of diseases.
Selected Publications of the IEG
Saad, C. ; Jung-Klawitter, S. ; Dimitrov, B. ; Aguilar-Pimentel, J.A. ; Becker, L. ; da Silva Buttkus, P. ; Dragano, N.R.V. ; Garrett, L. ; Hölter, S.M. ; Rathkolb, B. ; Sanz-Moreno, A. ; Spielmann, N. ; Fuchs, H. ; Gailus-Durner, V. ; Schaaf, C.P. ; la Marca, G. ; Damiano, R. ; Lefeber, D.J. ; Engelke, U. ; Hrabě de Angelis, M. ; Houten, S.M. ; Kölker, S.
Aminoadipate-semialdehyde synthase, a potential target for substrate reduction therapy in glutaric aciduria type 1.Laurent, K. ; Teperino, R. ; Hrabě de Angelis, M. ; Skerrett-Byrne, D.A. ; Beckers, J.
Epigenetic legacy: The role of sperm miRNAs in the paternal inheritance of diabetes and obesity development.Oestereicher, M.A. ; da Silva Buttkus, P. ; Gailus-Durner, V. ; Marschall, S. ; Fuchs, H. ; Hrabě de Angelis, M. ; Schneltzer, E. ; Spielmann, N.
Rethinking ratio-based normalization: A guide towards model-based approaches in heart weight analysis.Teperino, R. ; Adamová, M. ; Aljabali, S. M. ; Pai, S. ; Gerlini, R. ; Paez-Perez, I. ; Matz-Soja, M. ; Heyne, S. ; Lempradl, A. ; Basilicata, M.F. ; Hrabě de Angelis, M. ; Gebhardt, R. ; Schleicher, E. ; Häring, H.U. ; Pospisilik, J.A.
Liver-derived Indian Hedgehog (Ihh) couples fast-feed transition to thermogenic and metabolic homeostasis.Hass, D, ; Madsen, A.N. ; da Silva Buttkus, P. ; Kjølbye, A.L. ; Støy, S. ; Nøhr-Meldgaard, J. ; Sandahl, T.D. ; Hrabě de Angelis, M. ; Jorgensen, R. ; Rohm, M. ; van de Bunt, M.
Lipidated Interleukin-22 reduces body weight and spares lean mass in mice by a novel gut acting mechanism additive to GLP-1 agonism.Inau, E.T. ; Dedié, A. ; Anastasova, I. ; Schick, R. ; Fröhlich, B. ; Roden, M. ; Birkenfeld, A.L. ; Hrabě de Angelis, M. ; Preusse, M. ; Waltemath, D. ; Zeleke, A.A.
Lessons learned from implementing FAIRification workflows in diabetes research in Germany.Atabaki, N.N. ; Coral, D.E. ; Pomares-Millan, H. ; Smith, K. ; Behjat, H.H. ; Koivula, R.W. ; Tura, A. ; Miller, H. ; Pinnick, K. ; Agudelo, L. ; Allin, K.H. ; Brown, A.A. ; Chabanova, E. ; Chmura, P.J. ; Jacobsen, U.P. ; Dawed, A.Y. ; Elders, P.J.M. ; Fernandez-Tajes, J.J. ; Forgie, I.M. ; Haid, M. ; Hansen, T.H. ; Hansen, E.L. ; Jones, A.G. ; Kokkola, T. ; Kalamajski, S. ; Mahajan, A. ; McDonald, T.J. ; McEvoy, D. ; Muilwijk, M. ; Tsirigos, K.D. ; Vangipurapu, J. ; van Oort, S. ; Vestergaard, H. ; Adamski, J. ; Beulens, J.W. ; Brunak, S. ; Dermitzakis, E.T. ; Giordano, G.N. ; Gupta, R. ; Hansen, T. ; Hart, L.T. ; Hattersley, A.T. ; Hodson, L. ; Laakso, M. ; Loos, R.J.F. ; Merino, J. ; Ohlsson, M. ; Pedersen, O. ; Ridderstråle, M. ; Ruetten, H. ; Rutters, F. ; Schwenk, J.M. ; Tomlinson, J. ; Walker, M. ; Yaghootkar, H. ; Karpe, F. ; McCarthy, M.I. ; Thomas, E.L. ; Bell, J.D. ; Mari, A. ; Pavo, I. ; Pearson, E.R. ; Viñuela, A. ; Franks, P.W.
A biological-systems-based analysis using proteomic and metabolic network inference reveals mechanistic insights into hepatic steatosis.Harada, M. ; Adam, J. ; Han, S. ; Shi, M. ; Ge, J. ; Lintelmann, J. ; Cecil, A. ; Zukunft, S. ; Prehn, C. ; Witting, M. ; Scheerer, M.F. ; Neschen, S. ; Irmler, M. ; Beckers, J. ; Adamski, J. ; Teupser, D. ; Linkohr, B. ; Gieger, C. ; Hrabě de Angelis, M. ; Peters, A. ; Wang-Sattler, R.
Urea cycle modulation by combined SGLT2 inhibitors and metformin.
Head of Metabolism Research - German Mouse Clinic - Institute of Experimental Genetics
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Group Leader
Member and Spokesperson of the Executive Board (acting), Research Director Helmholtz Munich, Full Professor and Chair of Experimental Genetics Technical University Munich, Director of the Institute of Experimental Genetics Helmholtz Munich
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