Helmholtz Diabetes Center
Institute of Experimental Genetics
The Institute of Experimental Genetics (IEG) aims to further the understanding of mechanisms underlying human diseases' etiology. Metabolic diseases with a focus on diabetes are key areas of research. Experimental set-ups are centered on the mouse as a pre-clinical model organism with direct translation of results to humans. Besides studying the effects of genotypes, the institute identifies and characterizes environmental and epigenetic factors and the mechanisms by which these act on the etiology of diseases.
The Institute of Experimental Genetics (IEG) aims to further the understanding of mechanisms underlying human diseases' etiology. Metabolic diseases with a focus on diabetes are key areas of research. Experimental set-ups are centered on the mouse as a pre-clinical model organism with direct translation of results to humans. Besides studying the effects of genotypes, the institute identifies and characterizes environmental and epigenetic factors and the mechanisms by which these act on the etiology of diseases.
Selected Publications of the IEG
Teperino, R. ; Adamová, M. ; Aljabali, S. M. ; Pai, S. ; Gerlini, R. ; Paez-Perez, I. ; Matz-Soja, M. ; Heyne, S. ; Lempradl, A. ; Basilicata, M.F. ; Hrabě de Angelis, M. ; Gebhardt, R. ; Schleicher, E. ; Häring, H.U. ; Pospisilik, J.A.
Liver-derived Indian Hedgehog (Ihh) couples fast-feed transition to thermogenic and metabolic homeostasis.Hass, D, ; Madsen, A.N. ; da Silva Buttkus, P. ; Kjølbye, A.L. ; Støy, S. ; Nøhr-Meldgaard, J. ; Sandahl, T.D. ; Hrabě de Angelis, M. ; Jorgensen, R. ; Rohm, M. ; van de Bunt, M.
Lipidated Interleukin-22 reduces body weight and spares lean mass in mice by a novel gut acting mechanism additive to GLP-1 agonism.Inau, E.T. ; Dedié, A. ; Anastasova, I. ; Schick, R. ; Fröhlich, B. ; Roden, M. ; Birkenfeld, A.L. ; Hrabě de Angelis, M. ; Preusse, M. ; Waltemath, D. ; Zeleke, A.A.
Lessons learned from implementing FAIRification workflows in diabetes research in Germany.Atabaki, N.N. ; Coral, D.E. ; Pomares-Millan, H. ; Smith, K. ; Behjat, H.H. ; Koivula, R.W. ; Tura, A. ; Miller, H. ; Pinnick, K. ; Agudelo, L. ; Allin, K.H. ; Brown, A.A. ; Chabanova, E. ; Chmura, P.J. ; Jacobsen, U.P. ; Dawed, A.Y. ; Elders, P.J.M. ; Fernandez-Tajes, J.J. ; Forgie, I.M. ; Haid, M. ; Hansen, T.H. ; Hansen, E.L. ; Jones, A.G. ; Kokkola, T. ; Kalamajski, S. ; Mahajan, A. ; McDonald, T.J. ; McEvoy, D. ; Muilwijk, M. ; Tsirigos, K.D. ; Vangipurapu, J. ; van Oort, S. ; Vestergaard, H. ; Adamski, J. ; Beulens, J.W. ; Brunak, S. ; Dermitzakis, E.T. ; Giordano, G.N. ; Gupta, R. ; Hansen, T. ; Hart, L.T. ; Hattersley, A.T. ; Hodson, L. ; Laakso, M. ; Loos, R.J.F. ; Merino, J. ; Ohlsson, M. ; Pedersen, O. ; Ridderstråle, M. ; Ruetten, H. ; Rutters, F. ; Schwenk, J.M. ; Tomlinson, J. ; Walker, M. ; Yaghootkar, H. ; Karpe, F. ; McCarthy, M.I. ; Thomas, E.L. ; Bell, J.D. ; Mari, A. ; Pavo, I. ; Pearson, E.R. ; Viñuela, A. ; Franks, P.W.
A biological-systems-based analysis using proteomic and metabolic network inference reveals mechanistic insights into hepatic steatosis.Harada, M. ; Adam, J. ; Han, S. ; Shi, M. ; Ge, J. ; Lintelmann, J. ; Cecil, A. ; Zukunft, S. ; Prehn, C. ; Witting, M. ; Scheerer, M.F. ; Neschen, S. ; Irmler, M. ; Beckers, J. ; Adamski, J. ; Teupser, D. ; Linkohr, B. ; Gieger, C. ; Hrabě de Angelis, M. ; Peters, A. ; Wang-Sattler, R.
Urea cycle modulation by combined SGLT2 inhibitors and metformin.Trigg, N.A. ; Mulhall, J.E. ; Nixon, B. ; Laurent, K. ; Pai, S. ; Smyth, S.P. ; Burke, N.D. ; Beckers, J. ; Bromfield, E.G. ; Karr, T.L. ; Lord, T. ; Pleuger, C. ; Schjenken, J.E. ; Hrabě de Angelis, M. ; Teperino, R. ; Skerrett-Byrne, D.A.
Curating fertility—proteomic remodelling of sperm during epididymal transit.Lorenz, S. ; Wahida, A. ; Bostock, M.J. ; Seibt, T. ; Santos Dias Mourão, A. ; Levkina, A. ; Trümbach, D. ; Soudy, M. ; Emler, D. ; Rothammer, N. ; Woo, M.S. ; Sonner, J.K. ; Novikova, M. ; Henkelmann, B. ; Aldrovandi, M. ; Kaemena, D.F. ; Mishima, E. ; Vermonden, P. ; Zong, Z. ; Cheng, D. ; Nakamura, T. ; Ito, J. ; Doll, S. ; Proneth, B. ; Bürkle, E. ; Rizzollo, F. ; Escamilla Ayala, A. ; Napolitano, V. ; Kolonko, M. ; Gaussmann, S. ; Merl-Pham, J. ; Hauck, S.M. ; Pertek, A. ; Orschmann, T. ; Van San, E. ; Vanden Berghe, T. ; Hass, D, ; Maida, A. ; Frenz, J.M. ; Pedrera, L. ; Dolga, A.M. ; Kraiger, M. ; Hrabě de Angelis, M. ; Fuchs, H. ; Ebert, G. ; Lenberg, J. ; Friedman, J. ; Scale, C. ; Agostinis, P. ; Zimprich, A. ; Vogt Weisenhorn, D.M. ; Garrett, L. ; Hölter, S.M. ; Wurst, W. ; Glaab, E. ; Lewerenz, J. ; Popper, B. ; Sieben, C. ; Steinacker, P. ; Zischka, H. ; García-Sáez, A.J. ; Tietze, A. ; Ramesh, S.K. ; Ayton, S. ; Vincendeau, M. ; Friese, M.A. ; Wigby, K. ; Sattler, M. ; Mann, M. ; Ingold, I. ; Jayavelu, A.K. ; Popowicz, G.M. ; Conrad, M.
A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis.Oestereicher, M.A. ; Ward, C.S. ; Schneltzer, E. ; Marschall, S. ; Fuchs, H. ; Gailus-Durner, V. ; Bou About, G. ; Selloum, M. ; Meziane, H. ; Stewart, M. ; Teboul, L. ; Norris, C.M. ; Pimm, D. ; Kan, M. ; Lopez Gomez, F. ; Wilson, R. ; Monroy, M. ; Pasha, S. ; Zabrodska, E. ; Prochazka, J. ; Pajuelo Reguera, D. ; Nichtová, Z. ; Herault, Y. ; Wells, S. ; Parkinson, H. ; Heaney, J.D. ; Sedlacek, R. ; Gao, X. ; Hrabě de Angelis, M. ; Spielmann, N.
Establishing standardized transthoracic echocardiography reference ranges for mouse models: Insights into the impact of anesthesia, sex, and age.
Head of Metabolism Research - German Mouse Clinic - Institute of Experimental Genetics
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Member and Spokesperson of the Executive Board (acting), Research Director Helmholtz Munich, Full Professor and Chair of Experimental Genetics Technical University Munich, Director of the Institute of Experimental Genetics Helmholtz Munich
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