Publications of Martin Hrabě de Angelis
2024 Scientific Article in Science Advances Sci. Adv. 10:eadp0443 (2024)
Opa1 processing is dispensable in mouse development but is protective in mitochondrial cardiomyopathy.
2024 Scientific Article in Life Science Alliance Life Sci. All. 7:15 (2024)
Examining the liver-pancreas crosstalk reveals a role for the molybdenum cofactor in β-cell regeneration.
Lecture Notes in Computer Science In: (Medical Image Understanding and Analysis). 2024. 366-381 (Lect. Notes Comput. Sc. ; 14860 LNCS)
EchoVisuAL: Efficient Segmentation of Echocardiograms Using Deep Active Learning.
2024 Scientific Article in Endocrinology Endocrinology 165:bqae067 (2024)
Comparative phenotyping of mice reveals canonical and noncanonical physiological functions of TRα and TRβ.
2024 Review in Nature Communications Nat. Commun. 15:5574 (2024)
Improving laboratory animal genetic reporting: LAG-R guidelines.
2024 Scientific Article in Pituitary Pituitary, DOI: 10.1007/s11102-024-01424-w (2024)
Decreased β-cell volume and insulin secretion but preserved glucose tolerance in a growth hormone insensitive pig model.
2024 Scientific Article in Cardiovascular Diabetology Cardiovasc. Diabetol. 23:199 (2024)
Bidirectional modulation of TCA cycle metabolites and anaplerosis by metformin and its combination with SGLT2i.
2024 Scientific Article in Nature Nature, 27 (2024)
Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs.
2024 Scientific Article in Thyroid Thyroid, DOI: 10.1089/thy.2023.0683 (2024)
Canonical and noncanonical contribution of thyroid hormone receptor isoforms alpha and beta to cardiac hypertrophy and heart rate in male mice.
2024 Scientific Article in Science Advances Sci. Adv. 10:eadj8769 (2024)
A brain-enriched circular RNA controls excitatory neurotransmission and restricts sensitivity to aversive stimuli.
2024 Scientific Article in American Journal of Physiology - Renal Physiology Am. J. Physiol.-Renal Physiol. 326, F792-F801 (2024)
The Calcium-sensing receptor (CaSR) has only a PTH-dependent role in the acute response of renal phosphatetransporters to phosphate intake.
2024 Scientific Article in Nature metabolism Nat. Metab., 29 (2024)
Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity.
2024 Scientific Article in Breast Cancer Research Breast Cancer Res. 26:74 (2024)
TRPS1 maintains luminal progenitors in the mammary gland by repressing SRF/MRTF activity.
2024 Review in Journal of Physiology - London J. Physiol.-London 602, 1655-1658 (2024)
Turning fat into muscle: can this be an alternative to anti-obesity drugs such as semaglutide?
2024 Scientific Article in Pflügers Archiv Pflugers Arch. 476, 833-845 (2024)
A novel mouse model for familial hypocalciuric hypercalcemia (FHH1) reveals PTH-dependent and independent CaSR defects.
2024 Scientific Article in Sleep Sleep 47:zsae015 (2024)
A patient-enriched MEIS1 coding variant causes a restless legs syndrome-like phenotype in mice.
2024 Scientific Article in International Journal of Biological Macromolecules Int. J. Biol. Macromol. 265:130962 (2024)
Metabolic effects of SGLT2i and metformin on 3-hydroxybutyric acid and lactate in db/db mice.
2024 Scientific Article in Physiological reports Physiol. Rep. 12:e15901 (2024)
LncRNA U90926 is dispensable for the development of obesity-associated phenotypes in vivo.
2024 Scientific Article in Obesity Obesity 32, 363-375 (2024)
Novel markers and networks related to restored skeletal muscle transcriptome after bariatric surgery.
2023 Scientific Article in Neuroscience Applied Neurosci. App. 2:101126 (2023)
GPR101 loss promotes insulin resistance and diet-induced obesity risk.
2023 Scientific Article in Kidney International Kidney Int. 105, 844-864 (2023)
Implication of transcription factor FOXD2 dysfunction in syndromic congenital anomalies of the kidney and urinary tract (CAKUT).
2023 Scientific Article in Journal of Clinical Endocrinology & Metabolism, The J. Clin. Endocrinol. Metab. 109, 1318-1327 (2023)
Skeletal muscle gene expression signatures of obese high- and low- responders to endurance exercise training.
2023 Editorial in Diabetologie, Die Diabetologie 19, 103-105 (2023)
Mit präzisen Ansätzen die "patient journey" optimieren. Neue Wege der gezielteren Diabetesprävention und -therapie.
2023 Scientific Article in American Journal of Physiology - Cell Physiology Am. J. Physiol.-Cell Physiol. 325, C1131-C1143 (2023)
Redox state and altered pyruvate metabolism contribute to a dose-dependent metformin-induced lactate production of human myotubes.
2023 Scientific Article in Lancet Diabetes and Endocrinology Lancet Diabet. Endocrinol. 11, 798-810 (2023)
Mechanisms of weight loss-induced remission in people with prediabetes: A post-hoc analysis of the randomised, controlled, multicentre Prediabetes Lifestyle Intervention Study (PLIS).
2023 Scientific Article in Nature Nature 623, 772-781 (2023)
Single-cell, whole-embryo phenotyping of mammalian developmental disorders.
2023 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 32, 2717-2734 (2023)
Insights into energy balance dysregulation from a mouse model of methylmalonic aciduria.
2023 Scientific Article in Molecular Metabolism Mol. Metab. 75:101768 (2023)
Maternal hyperglycemia induces alterations in hepatic amino acid, glucose and lipid metabolism of neonatal offspring: Multi-omics insights from a diabetic pig model.
2023 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 110, 1068-1085 (2023)
Null and missense mutations of ERI1 cause a recessive phenotypic dichotomy in humans.
2023 Review in Mammalian Genome Mamm. Genome 34, 107-122 (2023)
A review of standardized high-throughput cardiovascular phenotyping with a link to metabolism in mice.
2023 Scientific Article in Life Science Alliance Life Sci. All. 6:e202201730 (2023)
Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain.
2023 Scientific Article in Mammalian Genome Mamm. Genome 34, 244-261 (2023)
Knockout mouse models as a resource for the study of rare diseases.
2023 Scientific Article in Mammalian Genome Mamm. Genome 34, 180-199 (2023)
Comprehensive ECG reference intervals in C57BL/6N substrains provide a generalizable guide for cardiac electrophysiology studies in mice.
2023 Scientific Article in Biochimica et Biophysica Acta - Molecular Basis of Disease Biochim. Biophys. Acta-Mol. Basis Dis. 1869:166760 (2023)
AOX delays the onset of the lethal phenotype in a mouse model of Uqcrh (complex III) disease.
2023 Scientific Article in Mammalian Genome Mamm. Genome 34, 200-215 (2023)
Echo2Pheno: A deep-learning application to uncover echocardiographic phenotypes in conscious mice.
2023 Scientific Article in Aging Cell Aging Cell 22:e13957 (2023)
The impact of the cardiovascular component and somatic mutations on ageing.
2023 Scientific Article in eLife eLife 12:e88350 (2023)
The negative adipogenesis regulator Dlk1 is transcriptionally regulated by Ifrd1 (TIS7) and translationally by its orthologue Ifrd2 (SKMc15).
2023 Review in Mammalian Genome Mamm. Genome 34, 408-417 (2023)
INFRAFRONTIER: Mouse model resources for modelling human diseases.
2023 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 110, 1394-1413 (2023)
Monoallelic variation in DHX9, the gene encoding the DExH-box helicase DHX9, underlies neurodevelopment disorders and Charcot-Marie-Tooth disease.
2023 Scientific Article in Molecular Metabolism Mol. Metab. 75:101774 (2023)
Differences in DNA methylation of HAMP in blood cells predicts the development of type 2 diabetes.
2023 Scientific Article in Disease Models and Mechanisms Dis. Model. Mech. 16:dmm049770 (2023)
Knockout mice represent an important tool for the multisystemic study of human monogenic heart disease.
2023 Scientific Article in International Journal of Obesity Int. J. Obes. 47, 313-324 (2023)
Acute and long-term exercise adaptation of adipose tissue and skeletal muscle in humans: A matched transcriptomics approach after 8-week training-intervention.
2023 Scientific Article in BMC Biology BMC Biol. 21:22 (2023)
Genome-wide screening reveals the genetic basis of mammalian embryonic eye development.
2022 Editorial in DDG-Informationen : Mitteilungen der Deutschen Diabetes-Gesellschaft DDG Informationen, 241-247 (2022)
Das Deutsche Zentrum für Diabetesforschung – Aktuelles aus der Wissenschaft.
2022 Scientific Article in Mammalian Genome Mamm. Genome 34, 229-243 (2022)
Knockout of the Complex III subunit Uqcrh causes bioenergetic impairment and cardiac contractile dysfunction.
2022 Scientific Article in BMC Neuroscience BMC Neurosci. 23:81 (2022)
Objective hearing threshold identification from auditory brainstem response measurements using supervised and self-supervised approaches.
2022 Review in Mammalian Genome Mamm. Genome 34, 331-350 (2022)
A rationale for considering heart/brain axis control in neuropsychiatric disease.
2022 Scientific Article in Scientific Reports Sci. Rep. 12:20791 (2022)
Analysis of genome-wide knockout mouse database identifies candidate ciliopathy genes.
2022 Scientific Article in Allergy Allergy 78, 1218-1233 (2022)
Dietary digestible carbohydrates are associated with higher prevalence of asthma in humans and with aggravated lung allergic inflammation in mice.
2022 Scientific Article in American Journal of Physiology - Regulatory, Integrative and Comparative Physiology Am. J. Physiol.-Regul. Integr. Comp. Physiol. 324, R109-R119 (2022)
Aqp5--/-- mice exhibit reduced maximal O2 consumption under cold exposure, normal pulmonary gas exchange, and impaired formation of brown adipose tissue.
2022 Scientific Article in Scientific Reports Sci. Rep. 12:19793 (2022)
New C3H KitN824K/WT cancer mouse model develops late-onset malignant mammary tumors with high penetrance.
2022 Scientific Article in Nature Communications Nat. Commun. 13:6830 (2022)
Deep phenotyping and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/6J mice.
2022 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 32, 1266-1275 (2022)
Identifying causal serum protein-cardiometabolic trait relationships using whole genome sequencing.
2022 Scientific Article in Molecular Metabolism Mol. Metab. 66:101616 (2022)
Validation of Mct8/Oatp1c1 dKO mice as a model organism for the Allan-Herndon-Dudley Syndrome.
2022 Scientific Article in Cell Death Discovery Cell Death Discov. 8:387 (2022)
Mutations within the cGMP-binding domain of CNGA1 causing autosomal recessive retinitis pigmentosa in human and animal model.
2022 Scientific Article in Redox Biology Redox Biol. 57:102490 (2022)
Seizures, ataxia and parvalbumin-expressing interneurons respond to selenium supply in Selenop-deficient mice.
2022 Scientific Article in Genetics in Medicine Genet. Med. 24, 2399-2407 (2022)
Biallelic loss-of-function variants in RABGAP1 cause a novel neurodevelopmental syndrome.
2022 Scientific Article in Scientific Reports Sci. Rep. 12:14608 (2022)
Monitoring longitudinal disease progression in a novel murine Kit tumor model using high-field MRI.
2022 Scientific Article in Pharmaceutics Pharmaceutics 14:1527 (2022)
Thermosensitive PLGA-PEG-PLGA hydrogel as depot matrix for allergen-specific immunotherapy.
2022 Scientific Article in European Journal of Nuclear Medicine and Molecular Imaging Eur. J. Nucl. Med. Mol. Imaging 49, 4338-4357 (2022)
X-ray multiscale 3D neuroimaging to quantify cellular aging and neurodegeneration postmortem in a model of Alzheimer’s disease.
2022 Scientific Article in Nature Methods Nat. Methods 19, 803-811 (2022)
Mass spectrometry-based draft of the mouse proteome.
2022 Scientific Article in Nature Cardiovascular Research Nat. Cardio. Res. 1, 157-173 (2022)
Extensive identification of genes involved in congenital and structural heart disorders and cardiomyopathy.
2022 Scientific Article in Frontiers in Medicine Front. Med. 9:875430 (2022)
Obesity and impaired metabolic health increase risk of COVID-19-related mortality in young and middle-aged adults to the level observed in older people: The LEOSS Registry.
2022 Scientific Article in Communications Biology Comm. Biol. 5:408 (2022)
Dietary intervention improves health metrics and life expectancy of the genetically obese Titan mouse.
2022 Scientific Article in PLoS Genetics PLoS Genet. 18:e1010190 (2022)
Mice lacking the mitochondrial exonuclease MGME1 develop inflammatory kidney disease with glomerular dysfunction.
2022 Scientific Article in Transgenic Research Transgenic Res. 31, 227-237 (2022)
Skeletal muscle phenotyping of Hippo gene-mutated mice reveals that Lats1 deletion increases the percentage of type I muscle fibers.
2022 Scientific Article in BMJ Open BMJ Open 12:e058268 (2022)
The German Gestational Diabetes Study (PREG), a prospective multicentre cohort study: Rationale, methodology and design.
2022 Review in Sports Medicine Sports Med. 52, 2569–2578 (2022)
Does a hypertrophying muscle fibre reprogramme its metabolism similar to a cancer cell?
2022 Scientific Reports Sci. Rep. 12:6793 (2022)
Author Correction: Maternal whole blood cell miRNA-340 is elevated in gestational diabetes and inversely regulated by glucose and insulin (Scientific Reports, (2018), 8, 1, (1366), 10.1038/s41598-018-19200-9).
2022 Scientific Article in Biomedicines Biomedicines 10:616 (2022)
Bezafibrate reduces elevated hepatic fumarate in insulin-deficient mice.
2022 Nature Genetics Nat. Genet. 54, 358-360 (2022)
EMPReSS: Standardized phenotype screens for functional annotation of the mouse genome (vol 37, pg 1155, 2005).
2022 Scientific Article in Disease Models and Mechanisms Dis. Model. Mech. 15:dmm049205 (2022)
Post-synaptic scaffold protein TANC2 in psychiatric and somatic disease risk.
2022 Scientific Article in American Journal of Physiology - Endocrinology and Metabolism Am. J. Physiol. Endocrinol. Metab. 322, E85-E100 (2022)
Susceptibility to diet-induced obesity at thermoneutral conditions is independent of UCP1.
2022 Scientific Article in Neuropathology and Applied Neurobiology Neuropathol. Appl. Neurobiol. 48:e12750 (2022)
N471D WASH complex subunit strumpellin knock-in mice display mild motor and cardiac abnormalities and BPTF and KLHL11 dysregulation in brain tissue.
2022 Scientific Article in Radiation Research Radiat. Res. 197, 7-21 (2022)
On the nature of murine radiation-induced subcapsular cataracts: Optical coherence tomography-based fine classification, in vivo dynamics and impact on visual acuity.
In: Practical Handbook on the 3Rs in the Context of the Directive 2010/63/EU. 2021. 81-111
Animal welfare.
2021 Review in Diabetologie und Stoffwechsel Diabetol. Stoffwechs. 16, 473-475 (2021)
Veranlagung und Lebensstil – die Komplexität des Diabetes mellitus – Langerhans-Medaille 2021 – eine Kurzübersicht über den Preisträger Martin Hrabě de Angelis.
2021 Scientific Article in Cells Cells 10:3443 (2021)
Tgf-β induction of mir-143/145 is associated to exercise response by influencing differentiation and insulin signaling molecules in human skeletal muscle.
2021 Editorial in Diabetologie, Die Diabetologie 17, 777-779 (2021)
Mit Big Data zu einer gezielteren Diabetes-Prävention und -Therapie.
2021 Scientific Article in Frontiers in Medicine Front. Med. 8:751277 (2021)
Differential effects of insulin-deficient diabetes mellitus on visceral vs. subcutaneous adipose tissue-multi-omics insights from the Munich MIDY pig model.
2021 Scientific Article in Faculty of 1000 Research F1000 Res. 10:456 (2021)
Moving forward with forward genetics: A summary of the INFRAFRONTIER Forward Genetics Panel Discussion.
2021 Scientific Article in Molecular Metabolism Mol. Metab. 54:101359 (2021)
Exercise prevents fatty liver by modifying the compensatory response of mitochondrial metabolism to excess substrate availability.
2021 Scientific Article in Disease Models and Mechanisms Dis. Model. Mech. 14:dmm049285 (2021)
A scalable, clinically severe pig model for Duchenne muscular dystrophy.
2021 Scientific Article in EMBO Molecular Medicine EMBO Mol. Med.:e14397 (2021)
Characterising a homozygous two-exon deletion in UQCRH: Comparing human and mouse phenotypes.
2021 Scientific Article in Genes Genes 12:1732 (2021)
Distinct morphological and behavioural alterations in ENU-induced heterozygous Trpc7K810stop mutant mice.
2021 Review in Lancet Diabetes and Endocrinology Lancet Diabet. Endocrinol. 9, 786-798 (2021)
COVID-19 and metabolic disease: Mechanisms and clinical management.
2021 Review in Diabetologie, Die Diabetologie 17, 780–787 (2021)
DZDconnect: Using connected data to fight diabetes.
2021 Scientific Article in Journal of Clinical Investigation J. Clin. Invest. 131:e142202 (2021)
Hyperexcitable interneurons trigger cortical spreading depression in an Scn1a migraine model.
2021 Scientific Article in Diabetes Diabetes 70, 2785-2795:2785-2795 (2021)
Different effects of lifestyle intervention in high- and low-risk prediabetes.
2021 Scientific Article in Nature Communications Nat. Commun. 12:4957 (2021)
Offspring born to influenza A virus infected pregnant mice have increased susceptibility to viral and bacterial infections in early life.
2021 Review in Mammalian Genome Mamm. Genome, DOI: 10.1007/s00335-021-09892-2 (2021)
INFRAFRONTIER quality principles in systemic phenotyping.
2021 Scientific Article in Molecular Metabolism Mol. Metab. 54:101334 (2021)
A point mutation in the Pdia6 gene results in loss of pancreatic β-cell identity causing overt diabetes.
2021 Scientific Article in Antioxidants Antioxidants 10:1103 (2021)
Nox4 maintains blood pressure during low sodium diet.
2021 Scientific Article in Diabetes Aktuell Diabetes akt. 19, 62-65 (2021)
Einfluss von Genetik und Epigenetik auf die Entstehung von Diabetes.
2021 Scientific Article in Science Advances Sci. Adv. 7:eabg6424 (2021)
Disruption of paternal circadian rhythm affects metabolic health in male offspring via nongerm cell factors.
2021 Scientific Article in Mammalian Genome Mamm. Genome 32, 332-349 (2021)
A comprehensive phenotypic characterization of a whole-body Wdr45 knock-out mouse.
2021 Scientific Article in Journal of Molecular and Cellular Cardiology J. Mol. Cell. Cardiol. 156, 45-56 (2021)
Creld1 regulates myocardial development and function.
2021 Nature Nature 589, E6 (2021)
Publisher Correction: Inhibition of LTβR signalling activates WNT-induced regeneration in lung (Nature, (2020), 588, 7836, (151-156), 10.1038/s41586-020-2882-8).
2021 Nature Communications Nat. Commun. 12:1804 (2021)
Author Correction: Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice (Nature Communications, (2020), 11, 1, (624), 10.1038/s41467-019-14069-2).
2021 Scientific Article in PLoS ONE PLoS ONE 16:e0248594 (2021)
Unbiased analysis of obesity related, fat depot specific changes of adipocyte volumes and numbers using light sheet fluorescence microscopy.
2021 Scientific Article in Physiological research Physiol. Res. 70, 227-236 (2021)
Analysis of the sex-specific variability of blood parameters in C3H inbred mice by using data from a long-term, high-throughput project.
2021 Review in Nature Genetics Nat. Genet. 53, 416-419 (2021)
A resource of targeted mutant mouse lines for 5,061 genes.
2021 Scientific Article in FASEB Journal FASEB J. 35:e21302 (2021)
Systemic Jak1 activation provokes hepatic inflammation and imbalanced FGF23 production and cleavage.
2021 Scientific Article in Experimental Eye Research Exp. Eye Res. 204:108432 (2021)
Ionising radiation causes vision impairment in neonatal B6C3F1 mice.
2021 Scientific Article in Metabolites Metabolites 11:89 (2021)
Validation of candidate phospholipid biomarkers of chronic kidney disease in hyperglycemic individuals and their organ-specific exploration in leptin receptor-deficient db/db mouse.
2021 Scientific Article in Nature medicine Nat. Med. 27, 49-57 (2021)
Pathophysiology-based subphenotyping of individuals at elevated risk for type 2 diabetes.
2021 Scientific Article in PLoS Genetics PLoS Genet. 16:e1009190 (2021)
Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density.
2021 Scientific Article in International Journal of Radiation Biology Int. J. Radiat. Biol. 97, 156-169 (2021)
Dose-dependent long-term effects of a single radiation event on behaviour and glial cells.
2021 Scientific Article in Brain and behavior Brain Behav. 11:e01928 (2021)
Diabetes type 2 risk gene Dusp8 is associated with altered sucrose reward behavior in mice and humans.
2020 Editorial in Diabetologie, Die Diabetologie 16, 627-629 (2020)
Neues aus der Diabetesforschung.
2020 Scientific Article in Metabolites Metabolites 10:472 (2020)
Mouse age matters: How age affects the murine plasma metabolome.
2020 Scientific Article in Xenotransplantation Xenotransplantation, DOI: 10.1111/xen.12664 (2020)
Growth hormone receptor knockout to reduce the size of donor pigs for preclinical xenotransplantation studies.
2020 Scientific Article in Biomedicines Biomedicines 8:507 (2020)
Increased expressions of matrix metalloproteinases (MMPs) in prostate cancer tissues of men with type 2 diabetes.
2020 Scientific Article in Nature Nature 588, 151–156 (2020)
Inhibition of LTβR signalling activates WNT-induced regeneration in lung.
2020 Scientific Article in Scientific Reports Sci. Rep. 10:18334 (2020)
Increased estrogen to androgen ratio enhances immunoglobulin levels and impairs B cell function in male mice.
2020 Scientific Article in Communications Biology Comm. Biol. 3:628 (2020)
PAX6 mutation alters circadian rhythm and beta cell function in mice without affecting glucose tolerance.
2020 Scientific Article in Cancer Research Cancer Res. 80, 5231-5244 (2020)
Phosphorylation control of p53 DNA binding cooperativity balances tumorigensis and aging.
2020 Scientific Article in Science Advances Sci. Adv. 6:eaaz4551 (2020)
METTL6 is a tRNA m3C methyltransferase that regulates pluripotency and tumor cell growth.
2020 Scientific Article in Diabetes Diabetes 69, 2756-2765 (2020)
Machine learning approaches reveal metabolic signatures of incident chronic kidney disease in individuals with prediabetes and type 2 diabetes.
2020 Scientific Article in Royal Society Open Science R. Soc. Open Sci. 7:200701 (2020)
Ectopic fat accumulation in human astrocytes impairs insulin action.
2020 Scientific Article in Genes Genes 11:1174 (2020)
Characterization of hormone-dependent pathways in six human prostate-cancer cell lines: A gene-expression study.
2020 Scientific Article in Journal of Personalized Medicine J. Pers. Med. 10:E124 (2020)
Transcript levels of aldo-keto reductase family 1 subfamily C (AKR1C) are increased in prostate tissue of patients with type 2 diabetes.
2020 Scientific Article in Journal of Clinical Investigation J. Clin. Invest. 130, 6093-6108 (2020)
Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity.
2020 Scientific Article in Scientific Reports Sci. Rep. 10:12407 (2020)
Increased mitochondrial respiration of adipocytes from metabolically unhealthy obese compared to healthy obese individuals.
2020 Scientific Article in Neuroscience Letters Neurosci. Lett. 735:135206 (2020)
Physiological relevance of the neuronal isoform of inositol-1,4,5-trisphosphate 3-kinases in mice.
2020 Editorial in Mammalian Genome Mamm. Genome, DOI: 10.1007/s00335-020-09843-3 (2020)
Introduction to mammalian genome special issue: Epigenetics.
2020 Scientific Article in Acta Neuropathologica Acta Neuropathol. 140, 121–142 (2020)
Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS.
2020 Scientific Article in PLoS ONE PLoS ONE 15:e0230162 (2020)
The occurrence of tarsal injuries in male mice of C57BL/6N substrains in multiple international mouse facilities.
2020 Review in Cell Cell 181, 1189-1193 (2020)
Biomedical research goes viral: Dangers and opportunities.
2020 Scientific Article in Journal of Neuroscience Methods J. Neurosci. Methods 339:108744 (2020)
Establishing sample-preparation protocols for X-ray phase-contrast CT of rodent spinal cords: Aldehyde fixations and osmium impregnation.
2020 Review in Mammalian Genome Mamm. Genome 31, 119–133 (2020)
Nutrition and its role in epigenetic inheritance of obesity and diabetes across generations.
2020 Scientific Article in Mammalian Genome Mamm. Genome 31, 30-48 (2020)
A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes.
2020 Scientific Article in Genes and Development Genes Dev. 34, 715-729 (2020)
The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs.
2020 Other: Opinion in Mammalian Genome Mamm. Genome 31, 49-53 (2020)
PATHBIO: An international training program for precision mouse phenotyping.
2020 Scientific Article in Nature Communications Nat. Commun. 11:655 (2020)
Human and mouse essentiality screens as a resource for disease gene discovery.
2020 Scientific Article in Diabetes Diabetes 69, 915-926 (2020)
DLL1- and DLL4-mediated Notch signaling is essential for adult pancreatic islet homeostasis.
2020 Scientific Article in Translational Psychiatry Transl. Psychiatry 10:66 (2020)
A truncating Aspm allele leads to a complex cognitive phenotype and region-specific reductions in parvalbuminergic neurons.
2020 Scientific Article in Molecular Metabolism Mol. Metab. 36:100978 (2020)
Functional changes of the liver in the absence of growth hormone (GH) action - Proteomic and metabolomic insights from a GH receptor deficient pig model.
2020 Review in Genome Biology Genome Biol. 21:18 (2020)
The deep genome project.
In: Beyond Our Genes. 2020. 175-208
The (not so) controversial role of DNA methylation in epigenetic inheritance across generations.
2020 Scientific Article in PLoS Genetics PLoS Genet. 16:e1008577 (2020)
High-throughput discovery of genetic determinants of circadian misalignment.
2020 Scientific Article in Investigative Ophthalmology & Visual Science, IOVS Invest. Ophthalmol. Vis. Sci. 61:44 (2020)
Mutation in Bmpr1b leads to optic disc coloboma and ventral retinal gliosis in mice.
2020 Scientific Article in Cell Reports Cell Rep. 30, 3183-3194.e4 (2020)
iTAG-RNA isolates cell-specific transcriptional responses to environmental stimuli and identifies an RNA-based endocrine axis.
2020 Scientific Article in Nature Communications Nat. Commun. 11:624 (2020)
Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice.
2020 Scientific Article in Nature Communications Nat. Commun. 11:296 (2020)
Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification.
2020 Scientific Article in Biochimica et Biophysica Acta - Molecular Basis of Disease Biochim. Biophys. Acta-Mol. Basis Dis. 1866:165622 (2020)
In-depth phenotyping reveals common and novel disease symptoms in a hemizygous knock-in mouse model (Mut-ko/ki) of mut-type methylmalonic aciduria.
2020 Scientific Article in Experimental Eye Research Exp. Eye Res. 190:107871 (2020)
Spectral domain - Optical coherence tomography (SD-OCT) as a monitoring tool for alterations in mouse lenses.
2020 Scientific Article in Bioinformatics Bioinformatics 36, 1492-1500 (2020)
Soft windowing application to improve analysis of high-throughput phenotyping data.
2020 Scientific Article in Journal of Clinical Endocrinology & Metabolism, The J. Clin. Endocrinol. Metab. 105, 14-25:dgz020 (2020)
AMPK subunits harbor largely non-overlapping genetic determinants for body fat mass, glucose- and cholesterol metabolism.
2020 Scientific Article in Haematologica - The Hematology Journal Haematologica 105, 937-950 (2020)
Glutathione peroxidase 4 and vitamin E control reticulocyte maturation, stress erythropoiesis and iron homeostasis.
2019 Scientific Article in Scientific Reports Sci. Rep. 9:19483 (2019)
Dusp8 affects hippocampal size and behavior in mice and humans.
2019 Meeting abstract in Acta Physiologica Acta Physiol. 227 (2019)
Constitutive activation of Jak1 leads to increased fibroblast growth factor 23 levels in mice.
2019 Meeting abstract in European Journal of Human Genetics Eur. J. Hum. Genet. 27, 818-819 (2019)
A homozygous two exon deletion in UQCRH: Matching mouse and human phenotype.
2019 Scientific Article in Nature metabolism Nat. Metab. 1, 1009-1026 (2019)
Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity.
2019 Scientific Article in European Journal of Cell Biology Eur. J. Cell Biol. 98:151046 (2019)
CRN2 binds to TIMP4 and MMP14 and promotes perivascular invasion of glioblastoma cells.
2019 Scientific Article in Haematologica - The Hematology Journal Haematologica 105, 2484-2495 (2019)
Murine tissue actor disulfide mutation causes a bleeding phenotype with sex specific organ pathology and lethality.
2019 Meeting abstract in Allergy Allergy 74, 197-198 (2019)
Effects of IL-4 receptor a blockade during allergen-specific immunotherapy in a murine model of allergic asthma.
2019 Scientific Article in Fluids and barriers of the CNS Fluids barriers CNS 16:30 (2019)
Claudin-12 is not required for blood-brain barrier tight junction function.
2019 Scientific Article in Scientific Reports Sci. Rep. 9:11211 (2019)
Genome-wide screening of mouse knockouts reveals novel genes required for normal integumentary and oculocutaneous structure and function.
2019 Scientific Article in Disease Models and Mechanisms Dis. Model. Mech. 12:dmm039156 (2019)
Mild maternal hyperglycemia in INSC93S transgenic pigs causes impaired glucose tolerance and metabolic alterations in neonatal offspring.
2019 Scientific Article in Molecular Metabolism Mol. Metab. 26, 30-44 (2019)
Multi-omics insights into functional alterations of the liver in insulin-deficient diabetes mellitus.
2019 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 116, 11872-11877 (2019)
Gain-of-function mutations in a member of the Src family kinases cause autoinflammatory bone disease in mice and humans.
2019 Editorial in Diabetes Aktuell Diabetes akt. 17, 96 (2019)
Vom Labor zum Patienten - Translationale Diabetesforschung.
2019 Scientific Article in Journal of Inherited Metabolic Disease J. Inherit. Metab. Dis. 42, 839-849 (2019)
Low catalytic activity is insufficient to induce disease pathology in triosephosphate isomerase deficiency.
2019 Scientific Article in Experimental Eye Research Exp. Eye Res. 188:107632 (2019)
Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia.
2019 Scientific Article in Allergy Allergy 74, 1549-1560 (2019)
IL-4 receptor a blockade prevents sensitization and alters acute and long-lasting effects of allergen-specific immunotherapy of murine allergic asthma.
2019 Scientific Article in Journal of Clinical Investigation J. Clin. Invest. 129, 1772-1778 (2019)
Calcium-dependent blood-brain barrier breakdown by NOX5 limits postreperfusion benefit in stroke.
2019 Scientific Article in Frontiers in Physiology Front. Physiol. 10:262 (2019)
Genes whose gain or loss-of-function increases endurance performance in mice: a systematic literature review.
2019 Communications Biology Comm. Biol. 2:97 (2019)
Author Correction: Identification of genes required for eye development by high-throughput screening of mouse knockouts (Communications Biology, (2018), 1, 1, (236), 10.1038/s42003-018-0226-0).
2019 Scientific Article in Translational Psychiatry Transl. Psychiatry 9:7 (2019)
Cognitive impairment and autistic-like behaviour in SAPAP4-deficient mice.
2019 Scientific Article in Journal of Clinical Endocrinology & Metabolism, The J. Clin. Endocrinol. Metab. 104, 1090-1098 (2019)
A polygenic risk score of lipolysis-increasing alleles determines visceral fat mass and proinsulin conversion.
2019 Conservation genetics Conservation genetics 20, 135-136 (2019)
The International Mouse Phenotyping Consortium (IMPC): A functional catalogue of the mammalian genome that informs conservation (vol 19, pg 995, 2018).
2019 Scientific Article in Molecular Metabolism Mol. Metab. 20, 28-37 (2019)
Preadipocytes of obese humans display gender-specific bioenergetic responses to glucose and insulin.
2019 Scientific Article in Molecular Neurobiology Mol. Neurobiol. 56, 4215-4230 (2019)
Crybb2 mutations consistently affect Schizophrenia endophenotypes in mice.
2018 Meeting abstract in Acta Ophthalmologica Acta Ophthalmol. 96, 4-4 (2018)
Animal case.
2018 Scientific Article in Communications Biology Comm. Biol. 1:236 (2018)
Identification of genes required for eye development by high-throughput screening of mouse knockouts.
2018 Scientific Article in Biochimica et Biophysica Acta - Molecular Basis of Disease Biochim. Biophys. Acta-Mol. Basis Dis. 1865, 2083-2093 (2018)
A mouse model for intellectual disability caused by mutations in the X-linked 2 '-O-methyltransferase Ftsj1 gene.
2018 Scientific Article in EMBO Molecular Medicine EMBO Mol. Med. 10:e9456 (2018)
Alternative oxidase-mediated respiration prevents lethal mitochondrial cardiomyopathy.
2018 Scientific Article in Experimental and Clinical Endocrinology & Diabetes Exp. Clin. Endocrinol. Diabet. 126, 20-29 (2018)
Impact of brain fatty acid signaling on peripheral insulin action in mice.
2018 Scientific Article in Molecular Metabolism Mol. Metab. 18, 42-50 (2018)
Glucose tolerance and insulin sensitivity define adipocyte transcriptional programs in human obesity.
2018 Scientific Article in Journal of Visualized Experiments J. Vis. Exp. 143:e58601 (2018)
Measuring and interpreting oxygen consumption rates in whole fly head segments.
2018 Meeting abstract in Allergy Allergy 73, 233-233 (2018)
A thermosensitive hydrogel as delivery system for immunomodulatory substances and allergens during allergen-specific immunotherapy.
2018 Meeting abstract in Allergy Allergy 73, 232-232 (2018)
Sustained inhibition of the IL4/IL13 receptor complex during allergen specific immunotherapy.
2018 Scientific Article in Nature microbiology Nat. Microbiol. 3, 1161–1174 (2018)
Male offspring born to mildly ZIKV-infected mice are at risk of developing neurocognitive disorders in adulthood.
2018 Review in Diabetologie, Die Diabetologie 14, 486-492 (2018)
Mit Big Data zur personalisierten Diabetesprävention.
2018 Scientific Article in EMBO Journal, The EMBO J.:e94813 (2018)
RNA editing of Filamin A pre-mRNA regulates vascular contraction and diastolic blood pressure.
2018 Scientific Article in Biochemical and Biophysical Research Communications Biochem. Biophys. Res. Commun. 503, 2770-2777 (2018)
The heterozygous R155C VCP mutation: Toxic in humans! Harmless in mice?
2018 Scientific Article in Life Science Alliance Life Sci. All. 1:e201800106 (2018)
Neuron-specific inactivation of Wt1 alters locomotion in mice and changes interneuron composition in the spinal cord.
2018 Scientific Article in Metabolites Metabolites 8:45 (2018)
Night shift work affects urine metabolite profiles of nurses with early chronotype.
2018 Scientific computing world Sci. Comp. World August/September, 24-25 (2018)
How connecting data may lead to discoveries in medical research?
2018 Scientific Article in Ageing research reviews Ageing Res. Rev. 47, 214-277 (2018)
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases.
2018 Scientific Article in Scientific Reports Sci. Rep. 8:11335 (2018)
Streptozotocin-induced beta-cell damage, high fat diet, and metformin administration regulate Hes3 expression in the adult mouse brain.
2018 Scientific Article in Analytica Chimica Acta Anal. Chim. Acta 1032, 18-31 (2018)
Dilution correction for dynamically influenced urinary analyte data.
2018 Scientific Article in EMBO Molecular Medicine EMBO Mol. Med. 10:e8613 (2018)
Cited4 is a sex-biased mediator of the antidiabetic glitazone response in adipocyte progenitors.
2018 Scientific Article in Molecular Metabolism Mol. Metab., DOI: 10.1016/j.molmet.2018.06.015 (2018)
Metabolic syndrome and extensive adipose tissue inflammation in morbidly obese Göttingen minipigs.
2018 Scientific Article in Kidney International Kidney Int. 94, 49-59 (2018)
The elevation of circulating fibroblast growth factor 23 without kidney disease does not increase cardiovascular disease risk.
2018 Scientific Article in Conservation genetics Conservation genetics 19, 995-1005 (2018)
The International Mouse Phenotyping Consortium (IMPC): A functional catalogue of the mammalian genome that informs conservation.
2018 Scientific Article in PLoS Genetics PLoS Genet. 14:e1007329 (2018)
Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population.
2018 Review in Frontiers in Physiology Front. Physiol. 9:553 (2018)
Genes whose gain or loss-of-function increases skeletal muscle mass in mice: A systematic literature review.
2018 Scientific Article in Nutrients Nutrients 10:547 (2018)
A vitamin E-enriched antioxidant diet interferes with the acute adaptation of the liver to physical exercise in mice.
2018 Scientific Article in Chemical Communications Chem. Commun. 54, 5426-5429 (2018)
hIAPP forms toxic oligomers in plasma.
2018 Scientific Article in Nature Communications Nat. Commun. 9:1990 (2018)
Bacterial encapsulins as orthogonal compartments for mammalian cell engineering.
2018 Scientific Article in Pigment Cell & Melanoma Research Pigment Cell Melanoma Res. 31, 693-707 (2018)
Melanocyte development in the mouse tail epidermis requires the Adamts9 metalloproteinase.
2018 Scientific Article in Molecular Metabolism Mol. Metab. 9, 57-68 (2018)
Genome-wide analysis of PDX1 target genes in human pancreatic progenitors.
2018 Scientific Article in International Journal of Radiation Oncology, Biology, Physics Int. J. Radiat. Oncol. Biol. Phys. 101, 965-984 (2018)
Micro-imaging of brain cancer radiotherapy using phase-contrast computed tomography.
2018 Scientific Article in PLoS Biology PLoS Biol. 16:e2005019 (2018)
Laboratory mouse housing conditions can be improved using common environmental enrichment without compromising data.
2018 Scientific Article in EMBO Molecular Medicine EMBO Mol. Med. 10:e8349 (2018)
Cholesterol metabolism promotes B-cell positioning during immune pathogenesis of chronic obstructive pulmonary disease.
2018 Review in Pharmacogenomics Pharmacogenomics 19, 577-587 (2018)
Pharmacogenetics of oral antidiabetic therapy.
2018 Scientific Article in JCI insight JCI insight 3:98864 (2018)
Mesenchymal TNFR2 promotes the development of polyarthritis and comorbid heart valve stenosis.
2018 Scientific Article in Frontiers in Immunology Front. Immunol. 9:587 (2018)
RNase H2 loss in murine astrocytes results in cellular defects reminiscent of nucleic acid-mediated autoinflammation.
2018 Scientific Article in Scientific Reports Sci. Rep. 8:5975 (2018)
Defective immuno- and thymoproteasome assembly causes severe immunodeficiency.
2018Poster: Federation of European Neuroscience Societies Forum, 7-11 July 2018, Berlin. (2018)
Identifying underlying mechanisms of voluntary activity by mining large data sets of genetically modified mouse lines.
2018 Scientific Article in Molecular Metabolism Mol. Metab. 11, 113-128 (2018)
Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver.
2018 Scientific Article in Frontiers in Endocrinology Front. Endocrin. 9:82 (2018)
Prediction of glucose tolerance without an oral glucose tolerance test.
2018 Scientific Article in Advanced functional materials Adv. Func. Mat. 28:1706793 (2018)
Genetically controlled lysosomal entrapment of superparamagnetic ferritin for multimodal and multiscale imaging and actuation with low tissue attenuation.
2018 Scientific Article in Scientific Reports Sci. Rep. 8:4199 (2018)
Rapid and transient oxygen consumption increase following acute HDAC/KDAC inhibition in Drosophila tissue.
2018 Scientific Article in Journal of Neurochemistry J. Neurochem. 145, 258-270 (2018)
Faim2 contributes to neuroprotection by erythropoietin in transient brain ischemia.
2018 Scientific Article in Journal of Bone and Mineral Research J. Bone Min. Res. 33, 875-887 (2018)
Genetic and molecular insights into genotype-phenotype relationships in osteopathia striata with cranial sclerosis (OSCS) through the analysis of novel mouse Wtx mutant alleles.
2018 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 115, E2348-E2357 (2018)
Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice.
2018 Scientific Article in Nature Communications Nat. Commun. 9:288 (2018)
Identification of genetic elements in metabolism by high-throughput mouse phenotyping.
2018 Scientific Article in Scientific Reports Sci. Rep. 8:737 (2018)
The effect of differentiation and TGFβ on mitochondrial respiration and mitochondrial enzyme abundance in cultured primary human skeletal muscle cells.
2018 Scientific Article in Scientific Reports Sci. Rep. 8:1116 (2018)
Epigallocatechin gallate (EGCG) reduces the intensity of pancreatic amyloid fibrils in human islet amyloid polypeptide (hIAPP) transgenic mice.
2018 Scientific Article in Scientific Reports Sci. Rep. 8:1366 (2018)
Maternal whole blood cell miRNA-340 is elevated in gestational diabetes and inversely regulated by glucose and insulin.
2018 Review in Nature Reviews - Endocrinology Nat. Rev. Endocrinol. 14, 140-162 (2018)
Animal models of obesity and diabetes mellitus.
2018 Scientific Data Sci. Data 5:180002 (2018)
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.
2018 Scientific Article in Metabolomics Metabolomics 14:18 (2018)
High-throughput extraction and quantification method for targeted metabolomics in murine tissues.
2018 Scientific Article in International Journal of Obesity Int. J. Obes. 42, 507-517 (2018)
A history of obesity leaves an inflammatory fingerprint in liver and adipose tissue.
2018 Scientific Article in Journal of Investigative Dermatology, The J. Invest. Dermatol. 138, 179-188 (2018)
The role of Fibroblast growth factor binding protein 1 in skin carcinogenesis and inflammation.
2018 Scientific Article in Journal of Breath Research J. Breath Res. 12:017102 (2018)
A systemic view on the distribution of diet-derived methanol and hepatic acetone in mice.
2017 Meeting abstract in Sleep Medicine Sleep Med. 40, E290-E291 (2017)
Circadian locomotor activity in meis1 knock-out mice.
2017 Nature Nature 551, 398 (2017)
Corrigendum: High-throughput discovery of novel developmental phenotypes.
2017 Scientific Article in Immunity Immunity 47, 1067-1082.e12 (2017)
Roquin suppresses the PI3K-mTOR signaling pathway to inhibit T helper cell differentiation and conversion of treg to Tfr cells.
2017 Scientific Article in Scientific Data Sci. Data 4:170179 (2017)
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.
2017 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 114, E11323-E11332 (2017)
Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo.
2017 Scientific Article in Data in Brief Data Brief 14, 653-658 (2017)
Data on the effects of eIF6 downmodulation on the proportions of innate and adaptive immune system cell subpopulations and on thymocyte maturation.
2017 Meeting abstract in Annals of the Rheumatic Diseases : ARD online Ann. Rheum. Dis. 76, 500-500 (2017)
Cardiac, pulmonary and periodontal disease as comorbidities in TNF-driven models of chronic polyarthritis.
2017 Scientific Article in Cell Reports Cell Rep. 21, 1507-1520 (2017)
The role of Eif6 in skeletal muscle homeostasis revealed by endurance training co-expression networks.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:15453 (2017)
Female mice lacking Pald1 exhibit endothelial cell apoptosis and emphysema.
2017 Meeting abstract in Annals of the Rheumatic Diseases : ARD online Ann. Rheum. Dis. 76, A49-A49 (2017)
TNF delta ARE/+: A multimorbidity model of spondyorthropathies.
2017 Scientific Article in Nature Communications Nat. Commun. 8:886 (2017)
A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction.
2017 Scientific Article in Behavioural Brain Research Behav. Brain Res. 352, 187-196 (2017)
Understanding gene functions and disease mechanisms: Phenotyping pipelines in the German Mouse Clinic.
2017 Scientific Article in Drug discovery today Drug Discov. Today, DOI: 10.1016/j.ddmod.2017.08.002 (2017)
Genome wide conditional mouse knockout resources.
2017 Scientific Article in Cell Metabolism Cell Metab. 26, 620-632.e6 (2017)
Molecular integration of incretin and glucocorticoid action reverses immunometabolic dysfunction and obesity.
2017 Meeting abstract in Allergy Allergy 72, 40-40 (2017)
Interference into JAK/stat signalling-a concept for improved allergen-specific immunotherapy?
2017 Scientific Article in EMBO Reports EMBO Rep. 18, 2015-2029 (2017)
The BEACH protein LRBA is required for hair bundle maintenance in cochlear hair cells and for hearing.
2017 Scientific Article in Journal of Biomedical Science J. Biomed. Sci. 24:57 (2017)
Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1I27N mutant mice.
2017 Review in Endocrine Reviews Endocr. Rev. 38, 468-488 (2017)
Fibroblast growth factor 21 – metabolic role in mice and men.
2017 Scientific Article in Current Opinion in Systems Biology Curr. Opin. Syst. Biol. 4, 97-104 (2017)
Big data in large-scale systemic mouse phenotyping.
2017 Scientific Article in Diabetes Aktuell Diabetes akt. 15, 104-107 (2017)
Ernährungsgewohnheiten schlagen sich im Erbgut nieder.
2017 Scientific Article in Nature Communications Nat. Commun. 8:155 (2017)
Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice.
2017 Scientific Article in Molecular Metabolism Mol. Metab. 6, 1304-1312 (2017)
Point mutation of Ffar1 abrogates fatty acid-dependent insulin secretion, but protects against HFD-induced glucose intolerance.
2017 Scientific Article in Molecular Metabolism Mol. Metab. 6, 1226-1239 (2017)
Activated macrophages control human adipocyte mitochondrial bioenergetics via secreted factors.
2017 Scientific Article in Developmental and comparative immunology Dev. Comp. Immunol. 77, 69-76 (2017)
High levels of eukaryotic Initiation Factor 6 (eIF6) are required for immune system homeostasis and for steering the glycolytic flux of TCR-stimulated CD4+ T cells in both mice and humans.
2017 Scientific Article in Nature Communications Nat. Commun. 8:15475 (2017)
Prevalence of sexual dimorphism in mammalian phenotypic traits.
2017 Scientific Article in Nature Genetics Nat. Genet. 49, 1231-1238 (2017)
Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium.
2017 Scientific Article in Water Research Water Res. 122, 290-298 (2017)
Iopromide exposure in Typha latifolia L.: Evaluation of uptake, translocation and different transformation mechanisms in planta.
2017 Scientific Article in Current Protocols of Mouse Biology Curr. Protoc. Mouse Biol. 7, 88-99 (2017)
A Fast, Easy, and Customizable Eight-Color Flow Cytometric Method for Analysis of the Cellular Content of Bronchoalveolar Lavage Fluid in the Mouse.
2017 Scientific Article in Disease Models and Mechanisms Dis. Model. Mech. 10, 981-991 (2017)
Meis1 effects on motor phenotypes and the sensorimotor system in mice.
2017 Scientific Article in Journal of Theoretical Biology J. Theor. Biol. 430, 32-44 (2017)
Modeling coexistence of oscillation and Delta/Notch-mediated lateral inhibition in pancreas development and neurogenesis.
2017 Scientific Article in Molecular Metabolism Mol. Metab. 6, 931-940 (2017)
The Munich MIDY Pig Biobank - A unique resource for studying organ crosstalk in diabetes.
2017 Scientific Article in Molecular Metabolism Mol. Metab. 6, 1286-1295 (2017)
Angiopoietin-like protein 4 is an exercise-induced hepatokine in humans, regulated by glucagon and cAMP.
2017 Scientific Article in Molecular Neurobiology Mol. Neurobiol. 55, 4580–4595 (2017)
Fgf9Y162C mutation alters information processing and social memory in mice.
2017 Meeting abstract in American Journal of Respiratory and Critical Care Medicine Am. J. Respir. Crit. Care Med. 195 (2017)
Epigenetic histone-1 modulator Hmgn5 regulates cellular apoptosis In COPD pathogenesis.
2017 Meeting abstract in Molecular and Cellular Pediatrics Mol. Cell. Pediatr. 4, 1:5 (2017)
Abstracts of the 52nd Workshop for Pediatric Research : Frankfurt, Germany. 27-28 October 2016.
2017 Scientific Article in Cell Metabolism Cell Metab. 25, 1334-1347.e4 (2017)
N-acyl taurines and acylcarnitines cause an imbalance in insulin synthesis and secretion provoking β cell dysfunction in type 2 diabetes.
2017 Scientific Article in Diabetes Diabetes 66, 2019-2032 (2017)
A low-frequency inactivating Akt2 variant enriched in the Finnish population is associated with fasting insulin levels and type 2 diabetes risk.
2017 Scientific Article in Acta Neuropathologica Acta Neuropathol. 134, 241–254 (2017)
Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss.
2017 Scientific Article in PLoS ONE PLoS ONE 12:e0178563 (2017)
Improved efficacy of allergen-specific immunotherapy by JAK inhibition in a murine model of allergic asthma.
2017 Scientific Article in Molecular Metabolism Mol. Metab. 6, 737-747 (2017)
Metformin causes a futile intestinal-hepatic cycle which increase energy expenditure and slows down development of a type 2 diabetes-like state.
2017 Scientific Article in Journal of Neuroscience Methods J. Neurosci. Methods, DOI: 10.1016/j.jneumeth.2017.05.005 (2017)
Analysis of locomotor behavior in the German Mouse Clinic.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:2397 (2017)
Extensive phenotypic characterization of a new transgenic mouse reveals pleiotropic perturbations in physiology due to mesenchymal hGH minigene expression.
2017 Scientific Article in Molecular Psychiatry Mol. Psychiatry 23, 1345-1355 (2017)
A paternal methyl donor-rich diet altered cognitive and neural functions in offspring mice.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:44041 (2017)
The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes.
2017 Scientific Article in Journal of Clinical Investigation J. Clin. Invest. 127, 695-708 (2017)
Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance.
2017 Scientific Article in Biochimica et Biophysica Acta - Molecular Basis of Disease Biochim. Biophys. Acta-Mol. Basis Dis. 1863, 1605-1614 (2017)
Modification of the fatty acid composition of an obesogenic diet improves the maternal and placental metabolic environment in obese pregnant mice.
2017 Scientific Article in Journal of Molecular Endocrinology J. Mol. Endocrinol. 58, 67-68 (2017)
Genetic characterization of a mouse line with primary aldosteronism.
2017 Scientific Article in Molecular Metabolism Mol. Metab. 6, 256-266 (2017)
Bezafibrate ameliorates diabetes via reduced steatosis and improved hepatic insulin sensitivity in diabetic TallyHo mice.
2017 Scientific Article in Disease Models and Mechanisms Dis. Model. Mech. 10, 163-171 (2017)
Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology.
2017 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 45, 3031-3045 (2017)
Interplay between H1 and HMGN epigenetically regulates OLIG1&2 expression and oligodendrocyte differentiation.
2016 Meeting abstract in Diabetologia Diabetologia 59, S259-S259 (2016)
Systemic metabolic effects exerted by a point mutation in the RED subdomain of PAX6.
2016 Meeting abstract in Diabetologia Diabetologia 59, S274-S274 (2016)
Mitogenic activity of the metabolically relevant hepatokine FGF21 in human carcinoma cells.
2016 Meeting abstract in Diabetologia Diabetologia 59, S188-S188 (2016)
Dll1-and Dll4-mediated Notch signalling in adult pancreatic beta cells is essential for the structural integrity of islets and maintenance of glucose homeostasis.
2016 Meeting abstract in Diabetologia Diabetologia 59, S127-S127 (2016)
Targeted metabolomics to predict the primary success of metformin monotherapy in type 2 diabetes.
2016 Meeting abstract in Diabetologia Diabetologia 59, S47-S47 (2016)
miRNA signatures in maternal whole blood cells of women with gestational diabetes.
2016 Meeting abstract in Allergy Allergy 71, 507-507 (2016)
Experimental allergen-specific immunotherapy under the umbrella of JAK1/3 pathway inhibition substantial improved local parameters of allergic airway inflammation.
2016 Meeting abstract in Allergy Allergy 71, 47-47 (2016)
Alum-free thermosensitive hydrogel as matrix for immunomodulatory substances and allergens during allergen-specific immunotherapy.
2016 Letter to the Editor in Obstetrical & gynecological survey Obstet. Gynecol. Surv. 71, 719-720 (2016)
Epigenetic germline inheritance of diet-induced obesity and insulin resistance.
2016 Meeting abstract in American Journal of Respiratory and Critical Care Medicine Am. J. Respir. Crit. Care Med. 193 (2016)
Reduced expression of the epigenetic regulator Hmgn5 enhances susceptibility to emphysema.
2016 Scientific Article in Molecular Neurobiology Mol. Neurobiol. 54, 8242–8262 (2016)
Serum response factor (SRF) ablation interferes with acute stress-associated immediate and long-term coping mechanisms.
2016 Scientific Article in Nature medicine Nat. Med. 22, 1428-1438 (2016)
Cardioprotection and lifespan extension by the natural polyamine spermidine.
2016 Scientific Article in Genes Genomes Genetics G3 Genes Genomes Genetics G3 6, 4035-4046 (2016)
The first Scube3 mutant mouse line with pleiotropic phenotypic alterations.
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0164298 (2016)
Sphingomyelin synthase 1 is essential for male fertility in mice.
2016 Meeting abstract in Journal of Investigative Dermatology, The J. Invest. Dermatol. 136, 2, S231-S231 (2016)
Alum-free thermosensitive hydrogel as subcutaneous matrix for immunomodulators and allergens during specific immunotherapy.
2016 Scientific Article in Cell Cell 167, 843-857.e14 (2016)
Chemical hybridization of glucagon and thyroid hormone optimizes therapeutic Impact for metabolic disease.
2016 Scientific Article in Nature Nature 537, 508-514 (2016)
High-throughput discovery of novel developmental phenotypes.
2016 Scientific Article in Mammalian Genome Mamm. Genome 27, 587-598 (2016)
Viable EdnraY129F mice feature human mandibulofacial dysostosis with alopecia (MFDA) syndrome due to the homologue mutation.
2016 Scientific Article in Diabetes Diabetes 65, 3776-3785 (2016)
Metformin effect on non-targeted metabolite profiles in patients with type 2 diabetes and multiple murine tissues.
2016 Scientific Article in Metabolomics Metabolomics 12:151 (2016)
Removing the bottlenecks of cell culture metabolomics: Fast normalization procedure, correlation of metabolites to cell number, and impact of the cell harvesting method.
2016 Scientific Article in Journal of the American Society of Nephrology J. Am. Soc. Nephrol. 28, 761-768 (2016)
Hyperoxaluria requires TNF receptors to initiate crystal adhesion and kidney stone disease.
2016 Scientific Article in Glycoconjugate Journal Glycoconj. J. 34, 393–404 (2016)
A novel biological function of soluble biglycan: Induction of erythropoietin production and polycythemia.
2016 Scientific Article in Archives of Physiology and Biochemistry Arch. Physiol. Biochem. 122, 281-288 (2016)
Impact of fibroblast growth factor 21 on the secretome of human perivascular preadipocytes and adipocytes: A targeted proteomics approach.
2016 Scientific Article in Nature Nature 536, 41-47 (2016)
The genetic architecture of type 2 diabetes.
2016 Scientific Article in Diabetes Diabetes 65, 2849-2861 (2016)
TGFβ contributes to impaired exercise response by suppression of mitochondrial key regulators in skeletal muscle.
2016 Scientific Article in Journal of the American Association for Laboratory Animal Science J. Amer. Assoc. Lab. Anim. Sci. 55, 375-386 (2016)
Clinical chemistry reference intervals for C57BL/6J, C57BL/6N, and C3HeB/FeJ mice (Mus musculus).
2016 Scientific Article in Diabetes Diabetes 65, 2540-2552 (2016)
Bezafibrate improves insulin sensitivity and metabolic flexibility in STZ-treated diabetic mice.
2016 Nature Communications Nat. Commun. 7:11835 (2016)
Erratum: Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression.
2016 Scientific Article in Mammalian Genome Mamm. Genome 27, 445-450 (2016)
INFRAFRONTIER: A European resource for studying the functional basis of human disease.
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0152996 (2016)
CIP2A promotes T-cell activation and immune response to Listeria monocytogenes infection.
2016 Scientific Article in Nature Communications Nat. Commun. 7:11317 (2016)
Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression.
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0150472 (2016)
Generation and standardized, systemic phenotypic analysis of Pou3f3L423P mutant mice.
2016 Meeting abstract in Transgenic Research Transgenic Res. 25, 228 (2016)
EMMA: The European Mouse Mutant Archive.
2016 Scientific Article in Nature Genetics Nat. Genet. 48, 497-499 (2016)
Epigenetic germline inheritance of diet-induced obesity and insulin resistance.
2016 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 25, 2082-2092 (2016)
Testing the role of predicted gene knockouts in human anthropometric trait variation.
2016 Scientific Article in Journal of Breath Research J. Breath Res. 10:016009 (2016)
Diet-induced and mono-genetic obesity alter volatile organic compound signature in mice.
2016 Scientific Article in American Journal of Physiology - Renal Physiology Am. J. Physiol.-Renal Physiol. 310, F785-F795 (2016)
Oxalate-induced chronic kidney disease with its uremic and cardiovascular complications in C57BL/6 mice.
2016 Scientific Article in Journal of Inherited Metabolic Disease J. Inherit. Metab. Dis. 39, 309-319 (2016)
Mildly compromised tetrahydrobiopterin cofactor biosynthesis due to Pts variants leads to unusual body fat distribution and abdominal obesity in mice.
2016 Scientific Article in Haematologica - The Hematology Journal Haematologica 101, e48-e51 (2016)
Iron deficiency anemia in cyclic GMP kinase knockout mice.
2016 Scientific Article in Mammalian Genome Mamm. Genome 27, 111-121 (2016)
Exome sequencing identifies a nonsense mutation in Fam46a associated with bone abnormalities in a new mouse model for skeletal dysplasia.
2016 Scientific Article in Journal of Diabetes Research J. Diabetes Res. 2016:4208156 (2016)
Longitudinal frequencies of blood leukocyte sub-populations differ between NOD and NOR mice, but do not predict diabetes in NOD mice.
2016 Scientific Article in Journal of Proteomics J. Proteomics 133, 66-75 (2016)
Liver lipid metabolism is altered by increased circulating estrogen to androgen ratio in male mouse.
2016 Scientific Article in Basic Research in Cardiology Basic Res. Cardiol. 111:6 (2016)
Knock-out of nexilin in mice leads to dilated cardiomyopathy and endomyocardial fibroelastosis.
2015 Meeting abstract in Allergy Allergy 70, 459-460 (2015)
Local inhibition of IL-4-and IL-13-mediated signaling as adjuvant for tolerance induction during allergen-specific immunotherapy.
2015 Scientific Article in Mammalian Genome Mamm. Genome 27, 17-28 (2015)
Dexamethasone treatment alters insulin, leptin, and adiponectin levels in male mice as observed in DIO but does not lead to alterations of metabolic phenotypes in the offspring.
2015 Scientific Article in Frontiers in Behavioral Neuroscience Front. Behav. Neurosci. 9:302 (2015)
Conditional reduction of adult born doublecortin-positive neurons reversibly impairs selective behaviors.
2015 Scientific Article in Current Protocols of Mouse Biology Curr. Protoc. Mouse Biol. 5, 291-301:doi: 10.1002/9780470942390.mo160 (2015)
Tests for anxiety-related behavior in mice.
2015 Scientific Article in Current Protocols of Mouse Biology Curr. Protoc. Mouse Biol. 5, 331-358:doi: 10.1002/9780470942390.mo160 (2015)
Assessing cognition in mice.
2015 Scientific Article in Arteriosclerosis, Thrombosis, and Vascular Biology Arterioscler. Thromb. Vasc. Biol. 36, 122-133 (2015)
MFAP4 promotes vascular smooth muscle migration, proliferation and accelerates neointima formation.
2015 Scientific Article in Genetic Epidemiology Genet. Epidemiol. 39, 499-508 (2015)
Evaluating the calibration and power of three gene-based association tests of rare variants for the X chromosome.
2015 Scientific Article in Frontiers in Behavioral Neuroscience Front. Behav. Neurosci. 9:302 (2015)
Conditional reduction of adult born doublecortin-positive neurons reversibly impairs selective behaviors.
In: Han, D.* ; Kaplowitz, N.* [Eds.]: Mitochondria in Liver Disease. Boca Raton, FL: CRC Press, 2015. 383-412
Mitochondrial function, dysfunction, and adaption in the liver during the development of diabetes.
2015 Meeting abstract in Nephrology Dialysis Transplantation Nephrol. Dial. Transplant. 30:SP045 (2015)
Detailed morphological analyses of a novel mouse model of site-specific glomerular thrombotic microangiopathy.
2015 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 24, 7286-7294 (2015)
Overexpression of the mitochondrial methyltransferase TFB1M in the mouse does not impact mitoribosomal methylation status of hearing.
2015 Scientific Article in Nature Communications Nat. Commun. 6:8261 (2015)
eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription.
2015 Scientific Article in Cell Metabolism Cell Metab. 22, 838-850 (2015)
Calcineurin links mitochondrial elongation with energy metabolism.
2015 Scientific Article in Archives of Biochemistry and Biophysics Arch. Biochem. Biophys. 589, 93-107 (2015)
Metabolic switch during adipogenesis: From branched chain amino acid catabolism to lipid synthesis.
2015 Scientific Article in PLoS ONE PLoS ONE 10:e0134503 (2015)
Cox4i2, Ifit2, and Prdm11 mutant mice: Effective selection of genes predisposing to an altered airway inflammatory response from a large compendium of mutant mouse lines.
2015 Scientific Article in Development / Company of Biologists Development 142, 3009-3020 (2015)
Meis1 coordinates a network of genes implicated in eye development and microphthalmia.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1005423 (2015)
SLIRP regulates the rate of mitochondrial protein synthesis and protects LRPPRC from degradation.
2015 Scientific Article in Diabetes Care Diabetes Care 38, 1858-1867 (2015)
Effects of metformin on metabolite profiles and LDL cholesterol in patients with type 2 diabetes.
2015 Scientific Article in Nature Genetics Nat. Genet. 47, 969-978 (2015)
Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.
2015 Scientific Article in Mammalian Genome Mamm. Genome 26, 467-481 (2015)
Principles and application of LIMS in mouse clinics.
2015 Scientific Article in Journal of the American Heart Association J. Am. Heart Assoc. 4:e002153 (2015)
Heart-specific knockout of the mitochondrial Thioredoxin reductase (Txnrd2) induces metabolic and contractile dysfunction in the aging myocardium.
2015 Scientific Article in Transgenic Research Transgenic Res. 24, 921-927 (2015)
Blastocyst genotyping for quality control of mouse mutant archives: An ethical and economical approach.
2015 Scientific Article in Genome Research Genome Res. 25, 1295-1308 (2015)
Functional compensation among HMGN variants modulates the DNase I hypersensitive sites at enhancers.
2015 Scientific Article in Steroids Steroids 103, 123-144 (2015)
Steroids in teleost fishes: A functional point of view.
2015 Scientific Article in Diabetologia Diabetologia 58, 1845-1854 (2015)
Type 2 diabetes alters metabolic and transcriptional signatures of glucose and amino acid metabolism during exercise and recovery.
2015 Scientific Article in Developmental Cell Dev. Cell 33, 644-659 (2015)
MIM-induced membrane bending promotes dendritic spine initiation.
2015 Scientific Article in Thorax Thorax 70, 862-872 (2015)
Microfibrillar-associated protein 4 modulates airway smooth muscle cell phenotype in experimental asthma.
2015 Scientific Article in PLoS Biology PLoS Biol. 13:e1002151 (2015)
Applying the ARRIVE guidelines to an in vivo database.
2015 Scientific Article in Diabetes Aktuell Diabetes akt. 13, 72-74 (2015)
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2015 Scientific Article in Diabetes Aktuell Diabetes akt. 13, 58-62 (2015)
5 Jahre erfolgreiche translationale Forschung - Deutsches Zentrum für Diabetesforschung.
2015 Scientific Article in BMC Genomics BMC Genomics 16:351 (2015)
Genomic characterization of mutant laboratory mouse strains by exome sequencing and annotation lift-over.
2015 Scientific Article in PLoS ONE PLoS ONE 10:e0125304 (2015)
New mutation in the mouse Xpd/Ercc2 gene leads to recessive cataracts.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1005165 (2015)
The power of gene-based rare variant methods to detect disease-associated variation and test hypotheses about complex disease.
2015 Scientific Article in Molecular Metabolism Mol. Metab. 4, 519-527 (2015)
Fibroblast growth factor 21 is elevated in metabolically unhealthy obesity and affects lipid deposition, adipogenesis, and adipokine secretion of human abdominal subcutaneous adipocytes.
2015 Letter to the Editor in International Journal of Cardiovascular Imaging Int. J. Cardiovasc. Imaging 31, 1137 (2015)
Erratum to: High throughput phenotyping of left and right ventricular cardiomyopathy in calcineurin transgene mice.
2015 Scientific Article in American Journal of Physiology - Lung Cellular and Molecular Physiology Am. J. Physiol. Lung Cell Mol. Physiol. 308, L1114-L1124 (2015)
Characterization of spontaneous air space enlargement in mice lacking microfibrillar-associated protein 4.
2015 Scientific Article in Methods in Molecular Biology Methods Mol. Biol. 1295, 55-64 (2015)
Methods for proteomics-based analysis of the human muscle secretome using an in vitro exercise model.
2015 Scientific Article in Current Protocols of Mouse Biology Curr. Protoc. Mouse Biol. 5, 65-84 (2015)
Glucose tolerance tests for systematic screening of glucose homeostasis in mice.
2015 Scientific Article in Circulation Circulation 131, 1191-1201 (2015)
ADAMTS-7 inhibits re-endothelialization of injured arteries and promotes vascular remodeling via cleavage of thrombospondin-1.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1004876 (2015)
Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus.
2015 Scientific Article in BioMetals Biometals 28, 293-306 (2015)
Screen for alterations of iron related parameters in N-ethyl-N-nitrosurea-treated mice identified mutant lines with increased plasma ferritin levels.
2015 Scientific Article in International Journal of Cardiovascular Imaging Int. J. Cardiovasc. Imaging 31, 669-679 (2015)
High throughput phenotyping of left and right ventricular cardiomyopathy in calcineurin transgene mice.
2015 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 24, 2247-2266 (2015)
MTO1 mediates tissue-specificity of OXPHOS defects via tRNA modification and translation optimization, which can be bypassed by dietary intervention.
2015 Scientific Article in Developmental Biology Dev. Biol. 399, 2-14 (2015)
Loss of Npn1 from motor neurons causes postnatal deficits independent from Sema3A signaling.
2015 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 53, D1171-D1175 (2015)
INFRAFRONTIER - providing mutant mouse resources as research tools for the international scientific community.
2015 Scientific Article in Analytical and Bioanalytical Chemistry Anal. Bioanal. Chem. 407, 343-354 (2015)
Combining metabolomic non-targeted GC×GC-ToF-MS analysis and chemometric ASCA-based study of variances to assess dietary influence on type 2 diabetes development in a mouse model.
2015 Scientific Article in Molecular Metabolism Mol. Metab. 4, 39-50 (2015)
High fat diet-induced modifications in membrane lipid and mitochondrial-membrane protein signatures precede the development of hepatic insulin resistance in mice.
2015 Scientific Article in Mammalian Genome Mamm. Genome 26, 33-42 (2015)
Generation of mice lacking DUF1220 protein domains: Effects on fecundity and hyperactivity.
2015 Scientific Article in Diabetes Diabetes 64, 284-290 (2015)
Metformin supports the antidiabetic effect of a sodium glucose cotransporter 2 inhibitor by suppressing endogenous glucose production in diabetic mice.
2014 Meeting abstract in Experimental and Clinical Endocrinology & Diabetes Exp. Clin. Endocrinol. Diabet. 122:OP4_11 (2014)
FGF21 inhibits adiponectin secretion in human adipocytes.
2014 Meeting abstract in Diabetologia Diabetologia 57, S172 (2014)
Defective compensatory insulin secretion causes HFD-induced glucose intolerance in mice with point mutation in free fatty acid receptor 1.
2014 Scientific Article in PLoS ONE PLoS ONE 9:e114918 (2014)
MTO1-deficient mouse model mirrors the human phenotype showing complex I defect and cardiomyopathy.
2014 Scientific Article in Beitrage zur Entomologie Beitr. Entomol. 64, 221-229 (2014)
Haplotypes, median networks, and diagnostic characters as tools to elucidate the intraspecific genetic and taxonomic structure of bumblebees, with a description of Bombus cryptarum pallidocinctus new subspecies (Hymenoptera: Apida: Bombus).
2014 Scientific Article in PLoS ONE PLoS ONE 9:e113125 (2014)
Uromodulin retention in thick ascending limb of Henle's loop affects SCD1 in neighboring proximal tubule: Renal transcriptome studies in mouse models of uromodulin-associated kidney disease.
2014 Scientific Article in International Journal of Cancer Int. J. Cancer 136, 2293-2303 (2014)
MiR-34a deficiency accelerates medulloblastoma formation in vivo.
2014 Scientific Article in PLoS ONE PLoS ONE 9:e111239 (2014)
Impact of temporal variation on design and analysis of mouse knockout phenotyping studies.
2014 Scientific Article in Nature Communications Nat. Commun. 5:5215 (2014)
Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts.
2014 Meeting abstract in Transgenic Research Transgenic Res. 23, 851 (2014)
The INFRAFRONTIER research infrastructure and EMMA: The European mouse mutant archive.
2014 Scientific Article in PLoS Computational Biology PLoS Comput. Biol. 10:e1003843 (2014)
Fast synchronization of ultradian oscillators controlled by Delta-Notch signaling with Cis-inhibition.
2014 Scientific Article in Mammalian Genome Mamm. Genome 25, 497-507 (2014)
A review of standardized metabolic phenotyping of animal models.
2014 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 111, 13127-13132 (2014)
Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes.
2014 Scientific Article in European Journal of Immunology Eur. J. Immunol. 44, 3232-3239 (2014)
Endothelial amine oxidase AOC3 transiently controbutes to adaptive immune responses in the airways.
2014 Scientific Article in PLoS ONE PLoS ONE 9:e104568 (2014)
Pleiotropic functions for transcription factor Zscan10.
2014 Scientific Article in Journal of Biomedical Science J. Biomed. Sci. 21:68 (2014)
Standardized, systemic phenotypic analysis of Slc12a1 I299F mutant mice.
2014 Scientific Article in EMBO Journal, The EMBO J. 33, 2020-2039 (2014)
Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders.
2014 Scientific Article in Journal of Proteome Research J. Proteome Res. 13, 4220-4231 (2014)
The importance of sulfur-containing metabolites in discriminating fecal extracts between normal and type 2 diabetic mice.
2014 Scientific Article in ISME Journal ISME J. 8, 2380-2396 (2014)
Distinct signatures of host-microbial meta-metabolome and gut microbiome in two C57BL/6 strains under high-fat diet.
2014 Scientific Article in PLoS ONE PLoS ONE 9:e98072 (2014)
Abnormal brain iron metabolism in Irp2 deficient mice is associated with mild neurological and behavioral impairments.
2014 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 23, 5597-5614 (2014)
Peroxidasin is essential for eye development in the mouse.
2014 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 94, 710-720 (2014)
Simulation of finnish population history, guided by empirical genetic data, to assess power of rare-variant tests in Finland.
2014 Scientific Article in Frontiers in Behavioral Neuroscience Front. Behav. Neurosci. 8:125 (2014)
A robust and reliable non-invasive test for stress responsivity in mice.
2014 Scientific Article in Journal of Comparative Physiology B J. Comp. Physiol. B 184, 763-775 (2014)
High-throughput phenotypic assessment of cardiac physiology in four commonly used inbred mouse strains.
2014 Scientific Article in PLoS ONE PLoS ONE 9:e93148 (2014)
Metabolic signatures of cultured human adipocytes from metabolically healthy versus unhealthy obese individuals.
2014 Scientific Article in Genome Medicine Genome Med. 6:25 (2014)
Interrogating causal pathways linking genetic variants, small molecule metabolites and circulating lipids.
2014 Scientific Article in Genome Research Genome Res. 24, 592-603 (2014)
Restless Legs Syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon.
2014 Scientific Article in Journal of Breath Research J. Breath Res. 8:016004 (2014)
Effects of diet-matrix on volatile organic compounds in breath in diet-induced obese mice.
2014 Scientific Article in Journal of Biological Chemistry, The J. Biol. Chem. 289, 10715-10726 (2014)
No amelioration of uromodulin maturation and trafficking defect by sodium-4-phenylbutyrate in vivo: Studies in mouse models of uromodulin-associated kidney disease.
2014 Scientific Article in Journal of Biological Chemistry, The J. Biol. Chem. 289, 10769-10784 (2014)
Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.
2014 Scientific Article in Journal of Hepatology J. Hepatol. 60, 816-823 (2014)
Liver adapts mitochondrial function to insulin resistant and diabetic states in mice.
2014 Scientific Article in Biochimica et Biophysica Acta - Molecular Basis of Disease Biochim. Biophys. Acta-Mol. Basis Dis. 1842, 304–317 (2014)
Peri-conceptional obesogenic exposure induces sex-specific programming of disease susceptibilities in adult mouse offspring.
2014 Scientific Article in Mammalian Genome Mamm. Genome 25, 129-140 (2014)
Online breath gas analysis in unrestrained mice by hs-PTR-MS.
2014 Scientific Article in Biomedical Chromatography Biomed. Chromatogr. 28, 231-240 (2014)
The impact of blood on liver metabolite profiling - a combined metabolomic and proteomic approach.
2014 Scientific Article in European Journal of Pain Eur. J. Pain 18, 249-257 (2014)
Smad-interacting protein 1 affects acute and tonic, but not chronic pain.
Zeitschrift für Gastroenterologie In:. 2013. K283 (Z. Gastroenterol. ; 51)
Cholestatic ABCB4-deficient mice reveal depression/anxiety-like behavior.
2013 Scientific Article in Nature Genetics Nat. Genet. 45, 1418-1427 (2013)
Evaluating empirical bounds on complex disease genetic architecture.
2013 Scientific Article in Bioinformatics Bioinformatics 29, 2419-2426 (2013)
Assessing association between protein truncating variants and quantitative traits.
2013 Scientific Article in Genetic Epidemiology Genet. Epidemiol. 37, 539-550 (2013)
Recommended joint and meta-analysis strategies for case-control association testing of single low-count variants.
2013 Meeting abstract in Acta Ophthalmologica Acta Ophthalmol. 91 (2013)
The eye screen of the German Mouse Clinic (GMC) - new genetic insights into eye development and ocular disorders.
2013 Meeting abstract in Diabetologia Diabetologia 56, S331 (2013)
Metabolic profiling of cultured human adipocytes from metabolically malign versus benign obese individuals.
2013 Meeting abstract in European Heart Journal Eur. Heart J. 34, 1058 (2013)
Single housing reduces lung hemorrhages in male mice with tissue factor disulfide mutation and protects them from lethality.
2013 Scientific Article in PLoS ONE PLoS ONE 8:e82392 (2013)
Efficient isolation of pure and functional mitochondria from mouse tissues using automated tissue disruption and enrichment with anti-TOM22 magnetic beads.
2013 Scientific Article in Histology and Histopathology Histol. Histopathol. 28, 79-88 (2013)
Inbred wild type mouse strains have distinct spontaneous morphological phenotypes.
2013 Scientific Article in PLoS ONE PLoS ONE 8:e80923 (2013)
A broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington’s diesease CAG knock-in mice.
2013 Scientific Article in PLoS ONE PLoS ONE 8:e81833 (2013)
Prdm6 is essential for cardiovascular development in vivo.
2013 Scientific Article in PLoS ONE PLoS ONE 8:e78337 (2013)
Standardized, systemic phenotypic analysis of UmodC93F and UmodA227T mutant mice.
2013 Scientific Article in American Journal of Physiology - Cell Physiology Am. J. Physiol.-Cell Physiol. 305, C877-C886 (2013)
Cytokine response of primary human myotubes in an in vitro exercise model.
2013 Review in Journal of Internal Medicine J. Intern. Med. 274, 425-439 (2013)
Identification of biomarkers for apoptosis in cancer cell lines using metabolomics: Tolls for individualized medicine.
2013 Scientific Article in Experimental Dermatology Exp. Dermatol. 22, 667-669 (2013)
Ligand-independent epidermal growth factor receptor hyperactivation increases sebaceous gland size and sebum secretion in mice.
2013 Scientific Article in Mammalian Genome Mamm. Genome 24, 333-348 (2013)
Crybb2 coding for βB2-crystallin affects sensorimotor gating and hippocampal function.
2013 Scientific Article in Journal of Immunology J. Immunol. 191, 3913-3921 (2013)
IFIT2 is an effector protein of type 1 IFN-mediated amplification of lipopolysaccharide (LPS)-induced TNF-α secretion and LPS-induced endotoxin shock.
2013 Scientific Article in Mammalian Genome Mamm. Genome 24, 376-388 (2013)
Long-term experiment to study the development, interaction and influencing factors of DEXA parameters.
2013 Scientific Article in Diabetologia Diabetologia 57, 192-203 (2013)
Retinal proteome alterations in a mouse model of type 2 diabetes.
2013 Scientific Article in Pediatric Research Pediatr. Res. 74, 384-392 (2013)
Abca3 haploinsufficiency is a risk factor for lung injury induced by hyperoxia or mechanical ventilation in a murine model.
2013 Scientific Article in Biochimica et Biophysica Acta - Proteins and Proteomics Biochim. Biophys. Acta-Proteins Proteom. 1844, 1011-1017 (2013)
Secretome profiling of primary human skeletal muscle cells.
2013 Scientific Article in Genome Biology Genome Biol. 14:R82 (2013)
A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains.
2013 Scientific Article in Mammalian Genome Mamm. Genome 24, 295-302 (2013)
Lens density tracking in mice by Scheimpflug imaging.
2013 Scientific Article in Molecular Metabolism Mol. Metab. 2, 435-446 (2013)
Phenotypic comparison of common mouse strains developing high-fat diet-induced hepatosteatosis.
2013 Scientific Article in Journal of Clinical Investigation J. Clin. Invest. 123, 3272-3291 (2013)
Rapamycin extends murine lifespan but has limited effects on aging.
2013 Scientific Article in American Journal of Pathology, The Am. J. Pathol. 183, 352-368 (2013)
An ENU mutagenesis-derived mouse model with a dominant Jak1 mutation resembling phenotypes of systemic autoimmune disease.
2013 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 22, 4871-4887 (2013)
Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA, and inflammatory factors.
2013 Scientific Article in Human Mutation Hum. Mutat. 34, 1102-1110 (2013)
Cytoplasmic mislocalization of POU3F4 due to novel mutations leads to deafness in humans and mice.
2013 Scientific Article in Current Protocols of Mouse Biology Curr. Protoc. Mouse Biol. 3, 69-100 (2013)
Clinical chemistry and other laboratory tests on mouse plasma and serum.
2013 Scientific Article in Current Protocols of Mouse Biology Curr. Protoc. Mouse Biol. 3, 101-119 (2013)
Blood collection from mice and hematological analyses on mouse blood.
2013 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 22, 4148-4163 (2013)
Type of uromodulin mutation and allelic status influence onset and severity of uromodulin-associated kidney disease in mice.
2013 Scientific Article in Bone: Official Journal of the International Bone and Mineral Society Bone 55, 501-511 (2013)
Modeling hepatic osteodystrophy in Abcb4 deficient mice.
2013 Scientific Article in Mammalian Genome Mamm. Genome 24, 198-205 (2013)
Longitudinal fundus and retinal studies with SD-OCT: A comparison of five mouse inbred strains.
2013 Review in Journal of Steroid Biochemistry and Molecular Biology, The J. Steroid Biochem. Mol. Biol. 137, 165-173 (2013)
Zebrafish and steroids: What do we know and what do we need to know?
2013 Scientific Article in PLoS ONE PLoS ONE 8:e61903 (2013)
Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived 'browning’ factor Irisin, determines insulin sensitivity.
2013 Scientific Article in Journal of Clinical Endocrinology & Metabolism, The J. Clin. Endocrinol. Metab. 98, E1137-E1142 (2013)
Production and release of acylcarnitines by primary myotubes reflect the differences in fasting fat oxidation of the donors.
2013 Scientific Article in Journal of Biological Chemistry, The J. Biol. Chem. 288, 16690-16703 (2013)
High mobility group N proteins modulate the fidelity of the cellular transcriptional profile in a tissue- and variant-specific manner.
2013 Scientific Article in Molecular Vision Mol. Vis. 19, 877-884 (2013)
Novel small-eye allele in paired box gene 6 (Pax6) is caused by a point mutation in intron 7 and creates a new exon.
2013 Scientific Article in PLoS ONE PLoS ONE 8:e61406 (2013)
Mouse nuclear myosin 1 knock-out shows interchangeability and redundancy of myosin isoforms in the cell nucleus.
2013 Scientific Article in Systembiologie.de Systembiologie.de 6, 16-19 (2013)
Wer hat an der Uhr gedreht? Regulationsmechanismen der Segmentierung im Wirbeltierembryo.
2013 Scientific Article in PLoS Biology PLoS Biol. 11:e1001506 (2013)
Neuronal expression of glucosylceramide synthase in central nervous system regulates body weight and energy homeostasis.
2013 Scientific Article in DNA Repair DNA Repair 12, 356-366 (2013)
SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities.
2013 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 110, 3782-3787 (2013)
Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides.
2013 Scientific Article in Diabetes Care Diabetes Care 36, 2331-2338 (2013)
Circulating lysophosphatidylcholines are markers of a metabolically benign nonalcoholic fatty liver.
2013 Scientific Article in Biochemical and Biophysical Research Communications Biochem. Biophys. Res. Commun. 432, 389-393 (2013)
Ex-vivo assessment and non-invasive in vivo imaging of internal hemorrhages in Aga2/+ mutant mice.
2013 Scientific Article in Journal of Bone and Mineral Metabolism J. Bone Miner. Metab. 31, 293-303 (2013)
In vitro analysis of bone phenotypes in Col1a1 and Jagged1 mutant mice using a standardized osteoblast cell culture system.
2013 Scientific Article in PLoS ONE PLoS ONE 8:e54851 (2013)
Zebrafish 20β-hydroxysteroid dehydrogenase type 2 is important for glucocorticoid catabolism in stress response.
2013 Scientific Article in Journal of Proteome Research J. Proteome Res. 12, 1331-1343 (2013)
Apoe, Mbl2 and Psp plasma protein levels correlate with diabetic phenotype in NZO mice - an optimized rapid workflow for SRM-based quantification.
2013 Review in Antioxidants & Redox Signaling Antioxid. Redox Signal. 18, 1418-1427 (2013)
Neuroprotection after stroke by targeting NOX4 as a source of oxidative stress.
2013 Scientific Article in Journal of Investigative Dermatology, The J. Invest. Dermatol. 133, 49-58 (2013)
Differential effects of neurofibromin gene dosage on melanocyte development.
2013 Scientific Article in Diabetes Diabetes 62, 639-648 (2013)
Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach.
2013 Scientific Article in Oncogene Oncogene 32, 2586–2591 (2013)
Overexpression of the anti-apoptotic protein AVEN contributes to increased malignancy in hematopoietic neoplasms.
2012 Scientific Article in Diabetes Aktuell Diabetes akt. 10, 106-110 (2012)
Forschen für eine Zukunft ohne Diabetes - Deutsches Zentrum für Diabetesforschung.
2012 Meeting abstract in Tierärztliche Praxis / K, Kleintiere Tierarztl. Prax. Ausg. K Kleintiere Heimtiere 3:A29 (2012)
Spontane ZNS-Veränderungen in den Screens der German Mouse Clinic.
2012 Scientific Article in PLoS ONE PLoS ONE 7:e50818 (2012)
The endocytic adaptor Eps15 controls marginal zone B cell numbers.
2012 Scientific Article in Journal of Endocrinology J. Endocrinol. 215, 375-381 (2012)
Gender-, strain- and inheritance-dependent variation in aldosterone secretion in mice.
2012 Scientific Article in Journal of natural medicines J. Nat. Med. 18, 1847-1856 (2012)
Targeted estrogen delivery reverses the metabolic syndrome.
2012 Scientific Article in Mammalian Genome Mamm. Genome 23, 559-571 (2012)
Centralized mouse repositories.
2012 Scientific Article in FASEB Journal FASEB J. 26, 5081-5091 (2012)
The hepatic phosphatidylcholine transporter ABCB4 as modulator of glucose homeostasis.
2012 Scientific Article in Mammalian Genome Mamm. Genome 23, 600-610 (2012)
Mouse large-scale phenotyping initiatives: Overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute mouse genetics project.
2012 Scientific Article in Mammalian Genome Mamm. Genome 23, 611-622 (2012)
Innovations in phenotyping of mouse models in the German Mouse Clinic.
2012 Scientific Article in PLoS ONE PLoS ONE 7:e44609 (2012)
In vivo functional requirement of the mouse Ifitm1 gene for germ cell development, interferon mediated immune response and somitogenesis.
2012 Scientific Article in Mammalian Genome Mamm. Genome 23, 580-586 (2012)
The mammalian gene function resource: The International Knockout Mouse Consortium.
2012 Scientific Article in Molecular Systems Biology Mol. Syst. Biol. 8:615 (2012)
Novel biomarkers for pre-diabetes identified by metabolomics.
2012 Scientific Article in European Journal of Immunology Eur. J. Immunol. 42, 2395-2408 (2012)
A hypomorphic mutation in the Gfi1 transcriptional repressor results in a novel form of neutropenia.
2012 Scientific Article in Molecular and Cellular Endocrinology Mol. Cell. Endocrinol. 362, 139-148 (2012)
Enhanced oxidative stress and endocrine pancreas alterations are linked to a novel glucokinase missense mutation in ENU-derived Munich GckD217V mutants.
2012 Scientific Article in Journal of Comparative Neurology, The J. Comp. Neurol. 520, 3150-3180 (2012)
Visualizing corticotropin-releasing hormone receptor type 1 expression and neuronal connectivities in the mouse using a novel multifunctional allele.
2012 Scientific Article in Journal of Dermatological Science J. Dermatol. Sci. 67, 190-192 (2012)
Gsdma3I359N is a novel ENU-induced mutant mouse line for studying the function of Gasdermin A3 in the hair follicle and epidermis.
2012 Scientific Article in Journal of the American Association for Laboratory Animal Science J. Amer. Assoc. Lab. Anim. Sci. 51, 418-435 (2012)
Structural and functional concepts in current mouse phenotyping and archiving facilities.
2012 Scientific Article in PLoS ONE PLoS ONE 7:e41537 (2012)
Functional inactivation of the genome-wide association study obesity gene neuronal growth regulator 1 in mice causes a body mass phenotype.
2012 Scientific Article in Mammalian Genome Mamm. Genome 23, 416-430 (2012)
New mouse models for metabolic bone diseases generated by genome-wide ENU mutagenesis.
2012 Scientific Article in FASEB Journal FASEB J. 26, 2916-2930 (2012)
Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology.
2012 Scientific Article in European Journal of Oral Sciences Eur. J. Oral Sci. 120, 269-277 (2012)
Does enamelin have pleiotropic effects on organs other than the teeth? Lessons from a phenotyping screen of two enamelin-mutant mouse lines.
2012 Scientific Article in FASEB Journal FASEB J. 26, 4418-4428 (2012)
Srgap3-/- mice present a neurodevelopmental disorder with schizophrenia-related intermediate phenotypes.
In: Suhre, K.* [Eds.]: Genetics Meets Metabolomics: from Experiment to Systems Biology. Springer, 2012. 85-106
Mouse genetics and metabolic mouse phenotyping.
2012 Scientific Article in BMC Neuroscience BMC Neurosci. 13:61 (2012)
Voluntary wheel running in mice increases the rate of neurogenesis without affecting anxiety-related behaviour in single tests.
2012 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 21, 3535-3545 (2012)
Cardiopulmonary dysfunction in the osteogenesis imperfecta mouse model Aga2 and human patients are caused by bone-independent mechanisms.
2012 Scientific Article in Acta Neuropathologica Acta Neuropathol. 124, 187-197 (2012)
Long-term proteasomal inhibition in transgenic mice by UBB+1 expression results in dysfunction of central respiration control reminiscent of brainstem neuropathology in Alzheimer patients.
2012 Scientific Article in PLoS Computational Biology PLoS Comput. Biol. 8:e1002586 (2012)
From dynamic expression patterns to boundary formation in the presomitic mesoderm.
In: Ruf, T.* ; Bieber, C.* ; Arnold, W.* ; Millesi, E.* [Eds.]: Living in a Seasonal World. Berlin, Heidelberg: Springer, 2012. 459-469
Systematic screening for mutant mouse lines with defects in body temperature regulation.
2012 Scientific Article in PLoS ONE PLoS ONE 7:e38310 (2012)
Large-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous system.
2012 Scientific Article in Nature Methods Nat. Methods 9, 615-620 (2012)
FMT-XCT: In vivo animal studies with hybrid fluorescence molecular tomography-X-ray computed tomography.
2012 Scientific Article in PLoS ONE PLoS ONE 7:e35035 (2012)
MAPK signaling determines anxiety in the juvenile mouse brain but depression-like behavior in adults.
2012 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 109, 9354-9359 (2012)
Modeling disease mutations by gene targeting in one-cell mouse embryos.
2012 Scientific Article in PLoS Genetics PLoS Genet. 8:e1002711 (2012)
Prdm5 regulates collagen gene transcription by association with RNA polymerase II in developing bone.
2012 Scientific Article in American Journal of Pathology, The Am. J. Pathol. 180, 1378-1385 (2012)
Negative feedback mechanisms surpass the effect of intrinsic EGFR activation during skin chemical carcinogenesis.
2012 Scientific Article in Molecular and Cellular Endocrinology Mol. Cell. Endocrinol. 349, 202-213 (2012)
Discovery of a novel enzyme mediating glucocorticoid catabolism in fish: 20beta-hydroxysteroid dehydrogenase type 2.
2012 Scientific Article in Mammalian Genome Mamm. Genome 23, 259-269 (2012)
Clinical chemistry of human FcRn transgenic mice.
2012 Scientific Article in Experimental Neurology Exp. Neurol. 235, 214-227 (2012)
Pink1-deficiency in mice impairs gait, olfaction and serotonergic innervation of the olfactory bulb.
2012 Scientific Article in PLoS Genetics PLoS Genet. 8:e1002568 (2012)
Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans.
2012 Scientific Article in PLoS ONE PLoS ONE 7:e32354 (2012)
Expression of Tas1 taste receptors in mammalian spermatozoa: Functional role of Tas1r1 in regulating basal Ca2+ and cAMP concentrations in spermatozoa.
2011Vortrag: EUMODIC-Abschluss-Meeting, 21-22 November 2011, Genf. (2011)
Optic nerve phenotypes.
2011 Scientific Article in Particle and Fibre Toxicology Part. Fibre Toxicol. 8:28 (2011)
Carbon-nanoparticle-triggered acute lung inflammation and its resolution are not altered in PPARγ-defective (P465L) mice.
2011 Scientific Article in Particle and Fibre Toxicology Part. Fibre Toxicol. 8:30 (2011)
Comparison of particle-exposure triggered pulmonary and systemic inflammation in mice fed with three different diets.
2011 Scientific Article in Biochemical and Biophysical Research Communications Biochem. Biophys. Res. Commun. 413, 537-540 (2011)
Systematic selection of housekeeping genes for gene expression normalization in chicken embryo fibroblasts infected with Newcastle disease virus.
2011 Scientific Article in Mammalian Genome Mamm. Genome 22, 495-505 (2011)
Generation of N-ethyl-N-nitrosourea-induced mouse mutants with deviations in hematological parameters.
2011 Scientific Article in European Journal of Endocrinology Eur. J. Endocrinol. 165, 555-561 (2011)
Monocarboxylate transporter 8 deficiency: Altered thyroid morphology and persistent high triiodothyronine/thyroxine ratio after thyroidectomy.
2011 Scientific Article in Pain Pain 152, 2384-2398 (2011)
The transcription factor Smad-interacting protein 1 controls pain sensitivity via modulation of DRG neuron excitability.
2011 Scientific Article in Nature Nature 477, 54-60 (2011)
Human metabolic individuality in biomedical and pharmaceutical research.
2011 Scientific Article in Respiratory Research Respir. Res. 12, 94 (2011)
Impaired resolution of inflammatory response in the lungs of JF1/Msf mice following carbon nanoparticle instillation.
2011 Scientific Article in Nature Communications Nat. Commun. 2:395 (2011)
Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells.
2011 Scientific Article in PLoS ONE PLoS ONE 6:e23678 (2011)
The pathologic effect of a novel neomorphic Fgf9Y162C allele is restricted to decreased vision and retarded lens growth.
2011 Scientific Article in Diabetologia Diabetologia 54, 2132-2142 (2011)
Osteopontin deficiency protects against obesity-induced hepatic steatosis and attenuates glucose production in mice.
2011 Scientific Article in Journal of Biomolecular Screening J. Biomol. Screen. 16, 467-475 (2011)
Identification of a potential biomarker for FABP4 inhibition: The power of lipidomics in preclinical drug testing.
2011 Scientific Article in Arthritis & Rheumatology Arthritis Rheum. 63, 1301-1311 (2011)
A novel N-ethyl-N-nitrosourea-induced mutation in phospholipase Cγ2 causes inflammatory arthritis, metabolic defects, and male infertility in vitro in a murine model.
2011 Scientific Article in Journal of Biological Chemistry, The J. Biol. Chem. 286, 18614-18622 (2011)
Requirement of the RNA-editing enzyme ADAR2 for normal physiology in mice.
2011 Scientific Article in Molecular Vision Mol. Vis. 17, 1164-1171 (2011)
Microphakia and congenital cataract formation in a novel Lim2C51R mutant mouse.
2011 Scientific Article in Investigative Ophthalmology & Visual Science, IOVS Invest. Ophthalmol. Vis. Sci. 52, 2571-2576 (2011)
First mutation in the βA2-crystallin encoding gene is associated with small lenses and age-related cataracts.
2011 Scientific Article in OMICS OMICS 15, 141-154 (2011)
Huge splicing frequency in human Y chromosomal UTY gene.
2011 Scientific Article in Journal of Cell Science J. Cell Sci. 124, 1245-1255 (2011)
Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia.
2011 Scientific Article in Endocrinology Endocrinology 152, 326-331 (2011)
Utilization of a mutagenesis screen to generate mouse models of hyperaldosteronism.
2011 Scientific Article in Blood Blood 117, 519-529 (2011)
Immune modulation by Fas ligand reverse signaling: Lymphocyte proliferation is attenuated by the intracellular Fas ligand domain.
2011 Review in Methods Methods 53, 120-135 (2011)
Mouse phenotyping.
2010 Scientific Article in Proceedings of SPIE Proc. SPIE 7622:762230 (2010)
Development and quality characterization of a novel CT system.
2010 Editorial in Science Science 330, 592-593 (2010)
Research funding: Sustaining the data and bioresource commons.
2010Vortrag: 5.International PTR-MS Conference, 26-31 January 2011, Obergurgl, A. (2010)
An innovative approach to the analysis of VOCs exhaled by mice under regular housing conditions at the German Mouse Clinic using hs-PTR-MS.
2010Vortrag: International Symposium on Genetic Disease, 14-16 February 2011, Manipal / Indien. (2010)
Mouse Models for Human Eye Diseases: First mutation in the beta-A2-crystallin encoding gene is associated with small lenses and age-related cataracts.
2010Vortrag: EVER-Jahrestagung 2010, 07 Oktober 2010, Kreta. (2010)
First genetically characterized mouse model for age-related cataracts is a mutation in the ßA2-crystallin encoding gene.
2010Vortrag: EVER-Meeting (Eurpean Vision and Eye Researchers), 6.-9. Oktober 2010, Kreta. (2010)
Mutation in the Bmpr1b gene affects optic nerve development.
2010Vortrag: 94. Jahrestagung der Deutschen Gesellschaft für Pathologie, 27.-30.05.2010, Berlin. (2010)
Morphological and molecular characterization of a novel mouse mutant for the peripheral myelin protein 22 (Pmp22 gene)- Associated with Peripheral Neuropathy. .
2010Vortrag: 6. Pro-Retina Research Colloquium Potsdam: Retinal Degeneration, 9-10 April 2010, Potsdam, Germany. (2010)
Mouse models to identify novel disease genes.
2010Vortrag: XIX Biennal Meeting of the International Society for Eye Research (ISER), 18-23 July 2010, Montreal, Canada. (2010)
New lessons from mouse mutants for eye and lens development: The role of BMPR1B, FGF9, FGF10 and GJF1.
2010Vortrag: 14th Human Genome Meeting, 18-21 May 2010, Montpellier, France. (2010)
First genetically characterized mouse model for age-related cataracts is a mutation in the beta-A2-crystallin encoding gene.
2010Vortrag: German-Austria Workshop on Breath Gas Analysis, 7-9 June 2010, Greifswald, Germany. (2010)
Search for true VOCs of breath gas by head space analysis in mice under regular housing conditions at the German Mouse Clinic using hs-PTR-MS.
2010 Scientific Article in PLoS ONE PLoS ONE 5:e13953 (2010)
Metabolic footprint of diabetes: A multiplatform metabolomics study in an epidemiological setting.
2010 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 107, 15022-15026 (2010)
Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases.
2010 Scientific Article in Beitrage zur Entomologie Beitr. Entomol. 60, 229-242 (2010)
A phylogenetic framework for the North American bumblebee species of the subgenus Bombus sensu stricto (Bombus affinis, B. franklini, B. moderatus, B. occidentalis & B. terricola) based on mitochondrial DNA markers.
2010 Scientific Article in Beitrage zur Entomologie Beitr. Entomol. 60, 13-32 (2010)
Phylogenetic relationships of the bumblebees Bombus moderatus, B. albocinctus, B. burjaeticus, B. florilegus and B. cryptarum based on mitochondrial DNA markers: A complex of closely related taxa with circumpolar distribution.
2010 Scientific Article in Biochemical and Biophysical Research Communications Biochem. Biophys. Res. Commun. 399, 531-536 (2010)
Selection and evaluation of stable housekeeping genes for gene expression normalization in carbon nanoparticle-induced acute pulmonary inflammation in mice.
2010 Scientific Article in PLoS Biology PLoS Biol. 8:e1000479 (2010)
Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration.
2010 Scientific Article in Pathologe, Der Pathologe 31, 2, 147-152 (2010)
Charakterisierung von ENU-Mausmutanten. Tiermodelle für menschliche Erkrankungen mittels morphologischer und molekularer Methoden.
2010 Scientific Article in Gene Expression Patterns Gene Expr. Patterns 10, 265-273 (2010)
Combination of in silico and in situ hybridisation approaches to identify potential Dll1 associated miRNAs during mouse embryogenesis.
2010 Scientific Article in EMBO Journal, The EMBO J. 29, 2421-2432 (2010)
CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice.
2010 Scientific Article in Science Science 328, 1158-1161 (2010)
Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes.
2010 Scientific Article in American Journal of Physiology - Renal Physiology Am. J. Physiol.-Renal Physiol. 298, F1405-F1415 (2010)
Mutation of the Na⁺-K⁺-2Cl‾ cotransporter NKCC2 in mice is associated with severe polyuria and a urea-selective concentrating defect without hyperreninemia.
2010 Scientific Article in Nature Biotechnology Nat. Biotechnol. 28, 684-685 (2010)
Systematic phenotyping of mouse mutants.
2010 Scientific Article in Journal of Neuroscience J. Neurosci. 30, 9103-9116 (2010)
Urocortin 3 modulates social discrimination abilities via corticotropin-releasing hormone receptor type 2.
2010 Scientific Article in Journal of Biological Chemistry, The J. Biol. Chem. 285, 21724-21735 (2010)
Calcium oxalate stone formation in the inner ear as a result of an Slc26a4 mutation.
2010 Scientific Article in PLoS ONE PLoS ONE 5:e9468 (2010)
Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice.
2010 Scientific Article in Development / Company of Biologists Development 137, 437-445 (2010)
Domain-specific control of neurogenesis achieved through patterned regulation of Notch ligand expression.
2010 Scientific Article in American Journal of Physiology - Endocrinology and Metabolism Am. J. Physiol. Endocrinol. Metab. 298, E512-E523 (2010)
Phenotypic and pathomorphological characteristics of a novel mutant mouse model for maturity-onset diabetes of the young type 2 (MODY 2).
2010 Scientific Article in Experimental and Molecular Pathology Exp. Mol. Pathol. 88, 216-218 (2010)
EGFR ligands exert diverging effects on male reproductive organs.
2010 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 38, D570-D576 (2010)
EMMA - mouse mutant resources for the international scientific community.
2010 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 38, 1, D577-D585 (2010)
EuroPhenome: A repository for high-throughput mouse phenotyping data.
2010 Scientific Article in American Journal of Respiratory and Critical Care Medicine Am. J. Respir. Crit. Care Med. 181, 7-16 (2010)
Specific CD8 T cells in IgE-mediated allergy correlate with allergen dose and allergic phenotype.
2010 Scientific Article in Nature Genetics Nat. Genet. 42, 137-141 (2010)
A genome-wide perspective of genetic variation in human metabolism.
2010 Scientific Article in Mammalian Genome Mamm. Genome 21, 13-27 (2010)
Microphthalmia, parkinsonism, and enhanced nociception in Pitx3(416insG ) mice.
2010 Scientific Article in Genes, Brain and Behavior Genes Brain Behav. 9, 305-317 (2010)
DJ-1-deficient mice show less TH-positive neurons in the ventral tegmental area and exhibit non-motoric behavioural impairments.
2009 Scientific Article in Investigative Ophthalmology & Visual Science, IOVS Invest. Ophthalmol. Vis. Sci. 50, 5653-5661 (2009)
Reduced corneal thickness and enlarged anterior chamber in a novel ColVIIIa2(G257D) mutant mouse.
2009Vortrag: 11th European Congress of Endocrinology, 25-29 April 2009, Istanbul, Turkey. (2009)
Characterisation of a mouse model with mutagenesis induced hyperaldosteronism.
2009Vortrag: 52. Symposion der Deutschen Gesellschaft für Endokrinologie, 04-07 May 2009, Gießen, Germany. (2009)
Characterisation of a mouse model with mutagenesis induced hyperaldosteronism.
2009 Scientific Article in Methods in Molecular Biology Methods Mol. Biol. 530, 407-420 (2009)
Sperm cryopreservation and in vitro fertilization.
2009 Scientific Article in Methods in Molecular Biology Methods Mol. Biol. 530, 463-509 (2009)
Systemic first-line phenotyping.
2009 Other: Opinion in Nature Nature 461, 171-173 (2009)
Post-publication sharing of data and tools.
2009 Scientific Article in Mammalian Genome Mamm. Genome 20, 664-673 (2009)
Effect of IVF and laser zona dissection on DNA methylation pattern of mouse zygotes.
2009 Scientific Article in American Journal of Physiology - Renal Physiology Am. J. Physiol.-Renal Physiol. 297, F1391-F1398 (2009)
Novel missense mutation of uromodulin in mice causes renal dysfunction with alterations in urea handling, energy, and bone metabolism.
2009 Scientific Article in Investigative Ophthalmology & Visual Science, IOVS Invest. Ophthalmol. Vis. Sci. 50, 4311-4318 (2009)
A new Fgf10 mutation in the mouse leads to atrophy of the harderian gland and slit-eye phenotype in heterozygotes: A novel model for dry-eye disease?
2009 Scientific Article in Cytogenetic and Genome Research Cytogenet. Genome Res. 125, 186-200 (2009)
Targeted disruption of the mouse Npal3 gene leads to deficits in behavior, increased IgE levels, and impaired lung function.
2009 Scientific Article in Infection and Immunity Infect. Immun. 77, 3948-3957 (2009)
Clinical chemistry of congenic mice with quantitative trait loci for predicted responses to Trypanosoma congolense infection.
2009 Scientific Article in Methods in Molecular Biology Methods Mol. Biol. 530, 407-420 (2009)
Sperm cryopreservation and in vitro fertilization.
2009 Scientific Article in Methods in Molecular Biology Methods Mol. Biol. 530, 463-509 (2009)
Systemic first-line phenotyping.
2009 Scientific Article in PLoS ONE PLoS ONE 4:e5170 (2009)
Mechanisms controlling anaemia in Trypanosoma congolense infected mice.
2009 Scientific Article in PLoS ONE PLoS ONE 4:e6054 (2009)
Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes.
2009 Scientific Article in FASEB Journal FASEB J. 23, 3233-3242 (2009)
Mitochondrial glutathione peroxidase 4 disruption causes male infertility.
2009 Scientific Article in Journal of Biological Chemistry, The J. Biol. Chem. 284, 23083-23093 (2009)
Characterization of phospholipase Cγ enzymes with gain-of-function mutations.
2009 Scientific Article in Journal of Neuroscience J. Neurosci. 29, 9439-9449 (2009)
Neuronal 3',3,5-triiodothyronine (T₃) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T₃ transporter mutated in Allan-Herndon-Dudley syndrome.
2009 Scientific Article in Journal of Biomedical Science J. Biomed. Sci. 16:53 (2009)
N-ethyl-N-nitrosourea mutagenesis produced a small number of mice with altered plasma electrolyte levels.
2009 Scientific Article in International Journal of Cancer Int. J. Cancer 124, 140-149 (2009)
Cancer-retina antigens as potential paraneoplastic antigens in melanoma-associated retinopathy.
2009 Scientific Article in Nature Genetics Nat. Genet. 41, 614-618 (2009)
An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice.
2009 Scientific Article in British Journal of Cancer BJC Br. J. Cancer 100, 656-662 (2009)
Overexpressed vs mutated Kras in murine fibroblasts: A molecular phenotyping study.
2009 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 106, 3354-3359 (2009)
Inflammation and mitochondrial fatty acid beta-oxidation link obesity to early tumor promotion.
2009 Scientific Article in Developmental Biology Dev. Biol. 328, 285-296 (2009)
Catweasel mice: A novel role for Six1 in sensory patch development and a model for branchio-oto-renal syndrome.
2009 Scientific Article in Cell Cell 137, 961-971 (2009)
A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice.
2009 Review in Nature Reviews - Genetics Nat. Rev. Genet. 10, 371-380 (2009)
Towards better mouse models: Enhanced genotypes, systemic phenotyping and envirotype modelling.
2009 Review in Current Pharmaceutical Biotechnology Curr. Pharm. Biotechnol. 10, 236-243 (2009)
The German Mouse Clinic: A platform for systemic phenotype analysis of mouse models.
2009 Scientific Article in Experimental Physiology Exp. Physiol. 94, 412-421 (2009)
Generation of N-ethyl-N-nitrosourea-induced mouse mutants with deviations in plasma enzyme activities as novel organ-specific disease models.
2009 Scientific Article in FEBS Letters FEBS Lett. 583, 1349-1357 (2009)
The C-terminal cytoplasmic domain of human proEGF is a negative modulator of body and organ weights in transgenic mice.
2009 Scientific Article in Endocrinology Endocrinology 150, 1722-1730 (2009)
Expression pattern of G protein-coupled receptor 30 in LacZ reporter mice.
2009 Scientific Article in Mammalian Genome Mamm. Genome 20, 152-161 (2009)
Genome-wide search for genes that modulate inflammatory arthritis caused by Ali18 mutation in mice.
2009Schutzrecht WO 2009/146937 A1 (2009)
Scanner device and method for computed tomography imaging.
2009 Scientific Article in Biochimica et Biophysica Acta - Bioenergetics Biochim. Biophys. Acta-Bioenerg. 1787, 371-376 (2009)
Neurological phenotype and reduced lifespan in heterozygous Tim23 knockout mice, the first mouse model of defective mitochondrial import.
2008 Scientific Article in BMC Developmental Biology BMC Dev. Biol. 8:118 (2008)
Pleiotropic effects in Eya3 knockout mice.
2008 Scientific Article in Mammalian Genome Mamm. Genome 19, 77-84 (2008)
A phenotype-driven ENU mutagenesis screen for the identification of dominant mutations involved in alcohol consumption.
2008Vortrag: ENDO, The Endocrine Society's 90th Annual Meeting, 15-18 June .2008, San Francisco, USA. (2008)
Establishment of a mutagenesis screen to identify mice with high aldosterone levels.
2008 Scientific Article in PLoS Genetics PLoS Genet. 4:e1000282 (2008)
Genetics meets metabolomics: A genome-wide association study of metabolite profiles in human serum.
2008 Scientific Article in Molecular Oncology Mol. Oncol. 2, 356-367 (2008)
The CALM and CALM/AF10 interactor CATS is a marker for proliferation.
2008 Scientific Article in PLoS Genetics PLoS Genet. 4:e1000238 (2008)
The novel mouse mutation Oblivion inactivates the PMCA2 pump and causes progressive hearing loss.
2008 Scientific Article in PLoS Genetics PLoS Genet. 4:e1000207 (2008)
A Myo6 mutation destroys coordination between the myosin heads, revealing new functions of myosin VI in the stereocilia of mammalian inner ear hair cells.
2008 Scientific Article in Genesis : The Journal of Genetics and Development Genesis 46, 463-477 (2008)
Sall4 isoforms act during proximal-distal and anterior-posterior axis formation in the mouse embryo.
2008 Scientific Article in Nature Genetics Nat. Genet. 40, 963-970 (2008)
Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects.
2008 Scientific Article in Neurobiology of Aging Neurobiol. Aging 29, 1404-1411 (2008)
Creatine improves health and survival of mice.
2008 Scientific Article in Behavior Genetics Behav. Genet. 38, 396-406 (2008)
Deletion of glucose transporter GLUT8 in mice increases locomotor activity.
2008 Scientific Article in Frontiers in Bioscience Front. Biosci. 13, 5810-5823 (2008)
'Sighted C3H' mice - a tool for analysing the influence of vision on mouse behaviour?
2008 Scientific Article in Frontiers in Bioscience Front. Biosci. 13, 6269-6275 (2008)
Variation of the response to the optokinetic drum among various strains of mice.
2008 Scientific Article in Investigative Ophthalmology & Visual Science, IOVS Invest. Ophthalmol. Vis. Sci. 49, 1525-1532 (2008)
Mutation in a novel connexin-like gene (Gjf1) in the mouse affects early lens development and causes a variable small-eye phenotype.
2008 Scientific Article in BMC Bioinformatics BMC Bioinformatics 9:169 (2008)
MausDB: An open source application for phenotype data and mouse colony management in large-scale mouse phenotyping projects.
2008 Scientific Article in Journal of Musculoskeletal and Neuronal Interactions J. Musculoskelet. Neuronal. Interact. 8, 13-14 (2008)
Phenotypic characterization of mouse models for bone-related diseases in the German Mouse Clinic.
2008 Scientific Article in Proteomics Proteomics 8, 1248-1256 (2008)
Systematic gene expression profiling of mouse model series reveals coexpressed genes.
2008 Scientific Article in Proteomics Proteomics 8, 1257-1265 (2008)
Transcriptome and proteome analysis of early embryonic mouse brain development.
2008 Scientific Article in Proteomics Proteomics 8, 1165-1169 (2008)
An approach to handling and interpretation of ambiguous data in transcriptome and proteome comparisons.
2008 Scientific Article in Mutation Research / Fundamental and Molecular Mechanisms of Mutagenesis Mutat. Res. -Fund. Mol. Mech. Mutag. 651, 105-113 (2008)
The chemotherapeutic agents nocodazole and amsacrine cause meiotic delay and non-disjunction in spermatocytes of mice.
2008 Scientific Article in Rheumatology Rheumatology 47, 292-300 (2008)
Novel lymphocyte-independent mechanisms to initiate inflammatory arthritis via bone marrow-derived cells of Ali18 mutant mice.
2008 Scientific Article in American Journal of Physiology - Endocrinology and Metabolism Am. J. Physiol. Endocrinol. Metab. 294, 232-240 (2008)
Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects.
2008 Scientific Article in PLoS Genetics PLoS Genet. 4:e7 (2008)
ER stress-mediated apoptosis in a new mouse model of Osteogenesis imperfecta.
In: Weiner, H.* ; Lindahl, R.* ; Maser, E.* ; Plapp, B.* [Eds.]:. West Lafayette, Indiana, USA: Purdue Univ. Press, 2007. 281-287 ( ; 13)
A comparison of methods for assays of steroidogenic enzymes: New GC/MS versus HPLC and TLC.
2007Vortrag: NGFN-Projektleiter-Treffen, 10-11 November 2007, Heidelberg, Germany. (2007)
Systemic analysis of mouse mutants at the German Mouse Clinic.
2007Vortrag: 6th NGFN Meeting 2007, 10-11 November 2007, Heidelberg, Germany. (2007)
German Mouse Clinic: Systematic gene expression profiling of mouse models reveals co-expressed genes.
2007Vortrag: 21st International Mammalian Genome Conference (IMGC) 2007, 28th October - 1st November 2007, Kyoto, Japan. (2007)
MausDB: The German Mouse Clinic open source phenotype- and mouse management system.
2007Vortrag: 19th Mouse Molecular Genetics Meeting, 5-9 September 2007, Hinxton/Cambridge, UK. (2007)
A genetic screen for modifiers of the delta1-dependent notch signalling function in the mouse.
2007Vortrag: Neuroscience Conference, 3-07 November 2007, San Diego, USA. (2007)
A mouse model for human-specific changes in FOXP2, a gene important for speech and language.
2007Vortrag: HUPO Brain Proteome Project, 8th March 2007, Hinxton, England. (2007)
Deciphering genotype-phenotype correlation : The German Mouse Clinic and more.
2007Vortrag: ECTS 34th European Symposium on Calcified Tissues, 7th May 2007, Copenhagen, Denmark. (2007)
New models for bone and cartilage related disorders and new ways of mouse models characterization.
2007Vortrag: EUMODIC Kick-Off Meeting, 22.02.2006, Barcelona. (2007)
High throughput phenotyping supported by a workflow management system – experiences of the German Mouse Clinic.
2007Vortrag: Human Brain Proteome Meeting, 9-11 January 2007, Schloss Rauischholzhausen, Germany. (2007)
Systematic phenotyping of mouse mutants in the German Mouse Clinic.
2007Vortrag: Graduiertenkollegs 1034 „Die Bedeutung genetischer Polymorphismen in der Onkologie:, 12th February 2007, Göttingen, Germany. (2007)
The German Mouse Clinic.
2007 Scientific Article in Reproduction, Fertility and Development Reprod. Fertil. Dev. 19, 984-994 (2007)
Emergency prevention of extinction of a transgenic allele in a less-fertile transgenic mouse line by crossing with an inbred or outbred mouse strain coupled with assisted reproductive technologies.
2007 Scientific Article in BioSpektrum BioSpektrum 13, 504-506 (2007)
Von der funktionellen Genomforschung zur systemischen Krankheitsanalyse.
2007 Scientific Article in Lipids Lipids 42, 731-737 (2007)
Generation of ENU-induced mouse mutants with hypocholesterolemia: Novel tools for dissecting plasma lipoprotein homeostasis.
2007 Scientific Article in American Journal of Physiology - Renal Physiology Am. J. Physiol.-Renal Physiol. 292, 1560-1567 (2007)
Screening for increased plasma urea levels in a large-scale ENU mouse mutagenesis project reveals kidney disease models.
2007 Scientific Article in Proteomics Proteomics 7, 2490-2496 (2007)
High Performance Proteomics: 7th HUPO Brain Proteome Project Workshop.
2007 Scientific Article in Journal of Theoretical Biology J. Theor. Biol. 248, 120-129 (2007)
Cell-based simulation of dynamic expression patterns in the presomitic mesoderm.
2007 Scientific Article in BMC Developmental Biology BMC Dev. Biol. 7:81 (2007)
KIT is required for hepatic function during mouse post-natal development.
2007 Scientific Article in BMC Developmental Biology BMC Dev. Biol. 7:68 (2007)
Compartmentalised expression of Delta-like 1 in epithelial somites is required for the formation of intervertebral joints.
2007 Scientific Article in Journal of Dental Research - JDR Online J. Dent. Res. 86, 764-768 (2007)
A mutation in the enamelin gene in a mouse model.
Enzymology and molecular biology of carbonyl metabolism In: Weiner, H.* [Eds.]: Enzymology and Molecular Biology of Carbonyl Metabolism. West Lafayette, Ind.: Purdue Univ. Press, 2007. 281-287 (Enzymol. Mol. Biol. Carbonyl Metab. ; 13)
A comparison of methods for assays of steroidogenic enzymes : New GC/MS versus HPLC and TLC.
2007 Scientific Article in Briefings in Functional Genomics Brief. Funct. Genomic. Proteomic. 6, 186-192 (2007)
EMMA - The European mouse mutant archive.
2007 Scientific Article in Diabetes Diabetes 56, 1268-1276 (2007)
Dominant-Negative Effects of a Novel Mutated Ins2 Allele Causes Early-Onset Diabetes and Severe ß-Cell Loss in Munich Ins2C95S Mutant Mice.
2007 Scientific Article in Mammalian Genome Mamm. Genome 18, 173-186 (2007)
Impact of IVC housing on emotionality and fear learning in male C3HeB/FeJ and C57BL/6J mice.
2007 Scientific Article in Biochemical and Biophysical Research Communications Biochem. Biophys. Res. Commun. 359, 947-951 (2007)
Targeted inactivation of the murine Abca3 gene leads to respiratory failure in newborns with defective lamellar bodies.
In: Fox, J.* [Eds.]: The Mouse in Biomedical Research. Amsterdam: Elsevier, 2007. 225-260
Chemical mutagenesis in mice.
2007 Scientific Article in Naturwissenschaften, Die Naturwissenschaften 94, 401-406 (2007)
Power matters in closing the phenotyping gap.
2007 Scientific Article in Physiological Genomics Physiol. Genomics 28, 301-310 (2007)
Profiling at mRNA, protein, and metabolite levels reveals alterations in renal amino acid handling and glutathione metabolism in kidney tissue of Pept2–/– mice.
2007 Scientific Article in Mammalian Genome Mamm. Genome 18, 157-163 (2007)
Integration of mouse phenome data resources.
2007 Scientific Article in Genetics Genetics 175, 1451-1463 (2007)
A genetic screen for modifiers of the delta1-dependent notch signaling function in the mouse.
2007 Scientific Article in Gene Gene 389, 174-185 (2007)
The mouse Trm1-like gene is expressed in neural tissues and plays a role in motor coordination and exploratory behaviour.
2007 Scientific Article in Journal of Steroid Biochemistry and Molecular Biology, The J. Steroid Biochem. Mol. Biol. 103, 35-43 (2007)
Functional genome analysis indicates loss of 17beta-hydroxysteroid dehydrogenase type 2 enzyme in the zebrafish.
2006 Scientific Article in Methods in Molecular Biology Methods Mol. Biol. 329, 397-407 (2006)
Use of chemical mutagenesis in mouse embryonic stem cells.
2006 Scientific Article in Mammalian Genome Mamm. Genome 17, 1172-1182 (2006)
Morphologic and molecular characterization of two novel Krt71 (Krt2-6g) mutations : Krt71(rco12) and Krt71(rco13).
In: Fox, J.G.* ; Barthold, S.W.* ; Davisson, M.T.* ; Newcomer, C.E.* ; Quimby, F.W.* ; Smith, A.L.* [Eds.]: The Mouse in Biomedical Research, 2nd Edition. Amsterdam: Elsevier Press, 2006. 225-260 ( ; 1)
Chemical mutagenesis in mice.
In: Hrabě de Angelis, M.* ; Chambon, P.* ; Brown, S.* [Eds.]: Standards of Mouse Model Phenotyping. Weinheim: Wiley-VCH, 2006. 35-86
Screening for bone and cartilage phenotypes in mice.
2006Vortrag: GRID, 25th January 2007, Giessen, Germany. (2006)
The German Mouse Clinic: Systematic, comprehensive and standardized phenotyping of mouse mutant lines.
2006Vortrag: International Mouse Genome Congress (IMGC), 12-16 November 2006, Charleston, USA. (2006)
Open access mouse phenotyping platform: The German Mouse Clinic.
2006Vortrag: Entwicklungsbiologischer Sino-German Workshop über Mesodermbildung und -differenzierung, 0.-03 September 2006, Beijing, China. (2006)
The Notch gene regulatory network during somitogenesis.
2006Vortrag: ICMSB, 2nd August 2006, München, Germany. (2006)
The Notch gene regulatory network during somitogenesis.
2006Vortrag: Mouse Molecular Genetics Meeting, 28th. August - 3rd September 2006, Cold Spring Harbor, USA. (2006)
A new standard: Phenotyping in the German Mouse Clinic.
2006Vortrag: Mouse Molecular Genetics, 30th August 2006 - 3rd September 2006, Cold Spring Harbor, USA. (2006)
Towards the function of the PDZ-binding domain of Delta1.
2006 Scientific Article in Journal of Molecular Endocrinology J. Mol. Endocrinol. 37, 185-197 (2006)
Transcriptional regulation of human and murine 17β-hydroxysteroid dehydrogenase type-7 confers its participation in cholesterol biosynthesis.
2006 Scientific Article in Journal of Neuroscience Methods J. Neurosci. Methods 157, 82-90 (2006)
Systematic, standardized and comprehensive neurological phenotyping of inbred mice strains in the Germany Mouse Clinic.
2006 Scientific Article in Mammalian Genome Mamm. Genome 17, 851-857 (2006)
Variations of eye size parameters among different strains of mice.
2006 Scientific Article in Genetics Genetics 173, 2111-2119 (2006)
Multiple quantitative trait loci modify cochlear hair cell degeneration in the Beethoven (tmc1Bth) mouse model of progressive hearing loss DFNA36.
2006 Scientific Article in Mammalian Genome Mamm. Genome 17, 915-926 (2006)
New ENU-induced semidominant mutation, Ali18, causes inflammatory arthritis, dermatitis and osteoporosis in the mouse.
2006 Scientific Article in Journal of Investigative Dermatology, The J. Invest. Dermatol. 126, 1013-1016 (2006)
A mouse Keratin 1 mutation causes dark skin and epidermolytic hyperkeratosis.
2006 Scientific Article in Journal of Investigative Dermatology, The J. Invest. Dermatol. 127, 60-64 (2006)
Identification of a Keratin 4 mutation in a chemically induced mouse mutant that models white sponge nevus.
2006 Scientific Article in Applied Physics Letters Appl. Phys. Lett. 88:102102 (2006)
Conductivity of single-stranded and double-stranded deoxyribose nucleic acid under ambient conditions: The dominance of water.
2006 Scientific Article in Theoretical Biology and Medical Modelling Theor. Biol. Med. Model. 3, 11:11 (2006)
Number of active transcription factor binding sites is essential for the Hes7 oscillator.
2006 Scientific Article in Molecular and Cellular Biology Mol. Cell. Biol. 26, 2317-2326 (2006)
Generation and characterization of dickkopf3 mutant mice.
2006 Scientific Article in Mammalian Genome Mamm. Genome 17, 93-102 (2006)
Genotype-specific environmental impact on the variance of blood values in inbred and F1 hybrid mice.
2006 Scientific Article in Biology of Reproduction Biol. Reprod. 74, 246-252 (2006)
Risk assessment of mouse hepatitis virus infection via in vitro fertilization and embryo transfer by the use of zona-intact and laser-microdissected oocytes.
2005 Scientific Article in Gene Expression Patterns Gene Expr. Patterns 6, 94-101 (2005)
Identification of Dll1 (Delta1) target genes during mouse embryogenesis using differential expression profiling.
2005 Scientific Article in GenomXPress GenomXPress 2, 7-10 (2005)
Mäuse als Modelle für menschliche Erkrankungen.
2005 Scientific Article in Investigative Ophthalmology & Visual Science, IOVS Invest. Ophthalmol. Vis. Sci. 46, 4671-4683 (2005)
Three novel Pax6 alleles in the mouse leading to the same small-eye phenotype caused by different consequences at target promoters.
2005 Scientific Article in International Journal of Audiology Int. J. Audiol. 44, 171-177 (2005)
Two new mouse mutants with vestibular defects that map to the highly mutable locus on chromosome 4.
2005 Scientific Article in Nature Genetics Nat. Genet. 37, 1155 (2005)
EMPReSS: Standardized phenotype screens for functional annotation of the mouse genome.
2005 Scientific Article in Nature Methods Nat. Methods 2, 403-404 (2005)
Introducing the German Mouse Clinic: Open access platform for standardized phenotyping.
2005 Scientific Article in Nephron : Experimental Nephrology Nephron Exp. Nephrol 100, 143-149 (2005)
Large-scale albuminuria screen for nephropathy models in chemically induced mouse mutants.
2005 Scientific Article in Journal of Molecular Endocrinology J. Mol. Endocrinol. 35, 305-316 (2005)
Androgen metabolism via 17β-hydroxysteroid dehydrogenase type 3 in mammalian and non-mammalian vertebrates: Comparison of the human and the zebrafish enzyme.
2005 Scientific Article in Infection and Immunity Infect. Immun. 73, 5952-5960 (2005)
Sex-dependent susceptibility to Listeria monocytogenes infection is mediated by differential interleukin-10 production.
2005 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 102, 8621-8626 (2005)
Identification of coexpressed gene clusters in a comparative analysis of transcriptome and proteome in mouse tissues.
2005 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 33, 2, W779-W782 (2005)
LitMiner and WikiGene: Identifying problem-related key players of gene regulation using publication abstracts.
2005 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 33, 2, W496-W500 (2005)
ARTS: A web-based tool for the set-up of high-throughput genome-wide mapping panels for the SNP genotyping of mouse mutants.
2005 Scientific Article in Mutation Research / Fundamental and Molecular Mechanisms of Mutagenesis Mutat. Res. -Fund. Mol. Mech. Mutag. 583, 158-167 (2005)
Orthovanadate increased the frequency of aneuploid mouse sperm without micronucleus induction in mouse bone marrow erythrocytes at the same dose level.
2005 Scientific Article in Laryngoscope, The Laryngoscope 115, 116-124 (2005)
Hush puppy: A new mouse mutant with pinna, ossicle and inner ear defects.
2005 Scientific Article in Immunity Immunity 22, 451-465 (2005)
Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase Cgamma2 that specifically increases external Ca2+ entry.
2005 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 33, 864-872 (2005)
Linking disease-associated genes to regulatory networks via promoter organization.
2005 Scientific Article in Molecular and Cellular Biology Mol. Cell. Biol. 25, 1980-1988 (2005)
Cytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac development.
2005 Scientific Article in Mammalian Genome Mamm. Genome 16, 1-10 (2005)
Assessment of a systematic expression profiling approach in ENU-induced mouse mutant lines.
2005 Scientific Article in American Journal of Respiratory and Critical Care Medicine Am. J. Respir. Crit. Care Med. 171, 880-888 (2005)
Genomewide linkage analysis identifies novel genetic loci for lung function in mice.
2005 Scientific Article in International Journal of Cancer Int. J. Cancer 114, 590-597 (2005)
Identification and validation of novel ERBB2 (HER2, NEU) targets including genes involved in angiogenesis.
In: Heinrich, U.* [Eds.]: Effects of air contaminants on the respiratory tract - Interpretations from molecular to meta analysis. 9. International Inhalat. Stuttgart: Fraunhofer-IRB-Verl., 2004. 435-444 (INIS Monographs)
Differences in lung function among mouse inbred strains are genetically determined.
In: Hedrich, H.J.* ; Bullock, G.* [Eds.]: The Laboratory Mouse. Amsterdam: Elsevier, 2004. 47-84
Mouse genomics.
2004 Scientific Article in Nature Genetics Nat. Genet. 36, 925-927 (2004)
The European dimension for the mouse genome mutagenesis program.
2004 Scientific Article in Otology & Neurotology Otol. Neurotol. 25, 707-713 (2004)
Characterization of a new mouse mutant, flouncer, with a balance defect and inner ear malformation.
2004 Scientific Article in Journal of Lipid Research J. Lipid Res. 45, 2132-2137 (2004)
Hypercholesterolemia in ENU-induced mouse mutants.
2004 Scientific Article in Journal of Dental Research - JDR Online J. Dent. Res. 83, 608-812 (2004)
Amelogenesis imperfecta in a new animal model - a mutation in chromosome 5 (human 4q21).
2004 Scientific Article in Endocrinology Endocrinology 145, 2531-2541 (2004)
A novel missense mutation in the mouse growth hormone gene causes semidominant dwarfism, hyperghrelinemia and obesity.
2004 Scientific Article in Mammalian Genome Mamm. Genome 15, 686-697 (2004)
A Myo7a mutation cosegregates with stereocilia defects and low-frequency hearing impairment.
2004 Scientific Article in Genomics Genomics 84, 824-835 (2004)
The dominant alopecia phenotypes Bareskin, Rex-denuded and recuced coat 2 are caused by mutations in gasdermin 3.
2004 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 101, 14126-14131 (2004)
Targeted disruption of the Walker-Warburg syndrome gene Pomt1 in mouse results in embryonic lethality.
2004 Scientific Article in Nature Genetics Nat. Genet. 36, 961-968 (2004)
Effects of G-protein mutations on skin color.
2004 Scientific Article in Mammalian Genome Mamm. Genome 15, 424-432 (2004)
An ENU-induced mutation in AP-2alpha leads to middle ear and ocular defects in Doarad mice.
2004 Scientific Article in Genomics Genomics 83, 932-935 (2004)
The novel mouse microphthalmia mutations Mitfmi-enu5 and Mitfmi-bcc2 produce dominant negative Mitf proteins.
2004 Scientific Article in Cytogenetic and Genome Research Cytogenet. Genome Res. 104, 271-276 (2004)
Heritable translocations by dermal exposure of male mice to acrylamide.
2004 Scientific Article in Investigative Ophthalmology & Visual Science, IOVS Invest. Ophthalmol. Vis. Sci. 45, 601-609 (2004)
Electroretinography as a screening method for mutations causing retinal dysfunction in mice.
2004 Scientific Article in Reproduction, Fertility and Development Reprod. Fertil. Dev. 16, 211-212 (2004)
Importance of embryo transfers in transgenic mouse facilities.
2003 Scientific Article in Journal of Investigative Dermatology, The J. Invest. Dermatol. 121, 674-680 (2003)
Alopecia in a Novel Mouse Model RCO3 Is Caused by mK6irs1 Deficiency.
2003 Scientific Article in Current Genomics Curr. Genomics 4, 615-621 (2003)
Artefacts and Reliability of DNA Microarray Expression Profiling Data.
2003 Scientific Article in Atemwegs- und Lungenkrankheiten Atemwegs- Lungenkr. 29, 331-333 (2003)
Variabilität der Lungenfunktion bei Maus-Inzuchtstämmen.
2003 Scientific Article in Journal of Molecular Biology J. Mol. Biol. 333, 229-235 (2003)
Interaction of the MAGUK family member Acvrinp1 and the cytoplasmic domain of the notch ligand Delta1.
2003 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 31, 2-10 (2003)
Specificity assessment from fractionation experiments (SAFE) : a novel method to evaluate microarray probe specificity based on hybridisation strinencies.
2003 Scientific Article in Genes and Development Genes Dev. 17, 214-228 (2003)
Genetics of dark skin in mice.
2003 Scientific Article in Development / Company of Biologists Development 130, 1391-1402 (2003)
Delta-Notch signaling controls the generation of neurons/glia from neural stem cells in a stepwise process.
2003 Scientific Article in Methods in Molecular Biology Methods Mol. Biol. 209, 249-266 (2003)
Random ENU Mutagenesis.
2003 Scientific Article in Methods in Molecular Biology Methods Mol. Biol. 209, 35-50 (2003)
In Vitro Fertilization / Cryopreservation.
2003 Scientific Article in Development / Company of Biologists Development 130, 3-13 (2003)
Node and midline defects are associated with left-right development in Delta1 mutant embryos.
2003 Scientific Article in Science Science 300, 808-812 (2003)
Mutations in Dynein Link Motor Neuron Degeneration to Defects in Retrograde Transport.
2002 Scientific Article in Nature Genetics Nat. Genet. 30, 257-258 (2002)
Beethoven, a mouse model for dominant, progressive hearing loss DFNA36.
2002 Scientific Article in Development / Company of Biologists Development 129, 5029-5040 (2002)
Modulation of the notch signaling by Mash1 and DIx1/2 regulates sequential specification and differentiation of progenitor cell types in the subcortical telencephalon.
2002 Scientific Article in Mammalian Genome Mamm. Genome 13, 452-455 (2002)
V76D mutation in a conserved gammaD-crystallin region leads to dominant cataracts in mice.
2002 Scientific Article in Current Genomics Curr. Genomics 3, 121-129 (2002)
Molecular Phenotyping of Mouse Mutant Resources by RNA Expression Profiling.
2001 Scientific Article in Genomics Genomics 74, 320-332 (2001)
Isolation and Characterization of a Novel Gene from the DiGeorge Chromosomal Region That Encodes for a Mediator Subunit.
2001 Scientific Article in Briefings in Bioinformatics Brief. Bioinform. 2, 170-180 (2001)
Large-scale production of mouse phenotypes : the search for animal models for inherited diseases in humans.
2001 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 98, 3873-3878 (2001)
The Notch ligand Jagged1 is required for inner ear sensory development.
2001 Scientific Article in Current Opinion in Chemical Biology Curr. Opin. Chem. Biol. 6, 17-23 (2001)
Large-scale mutational analysis for the annotation of the mouse genome.
2001 Scientific Article in Experimental Eye Research Exp. Eye Res. 73, 867-876 (2001)
Characterization of a Mutation in the Lens-specific MP70 Encoding Gene of the Mouse Leading to a Dominant Cataract.
2001 Scientific Article in Investigative Ophthalmology & Visual Science, IOVS Invest. Ophthalmol. Vis. Sci. 42, 1574-1580 (2001)
Aey2, a New Mutation in the ßB2-Crystallin-Encoding Gene of the Mouse.
2001 Scientific Article in Genetics Genetics 157, 1313-1320 (2001)
Ethylnitrosourea-induced mutation in mice leads to the expression of a novel protein in the eye and to dominant cataracts.
2001 Scientific Article in International Archives of Allergy and Immunology Int. Arch. Allergy Immunol. 124, 25-28 (2001)
ENU Mouse Mutagenesis : Generation of Mouse Mutants with Aberrant Plasma IgE Levels.
2001 Scientific Article in Investigative Ophthalmology & Visual Science, IOVS Invest. Ophthalmol. Vis. Sci. 42, 2909-2915 (2001)
Characterization of a New, Dominant V124E Mutation in the Mouse alphaA-Crystallin-Encoding Gene.
2001 Scientific Article in Science Science 291, 1251-1255 (2001)
Sequence interpretation. Functional annotation of mouse genome sequences.
2000 Scientific Article in Mechanisms of Development Mech. Dev. 95, 23-34 (2000)
Distinct regulatory elements direct Delta1 expression in the nervous system and paraxial mesoderm of transgenic mice.
2000 Scientific Article in Annals of the New York Academy of Sciences Ann. NY Acad. Sci. 919, 239-245 (2000)
From developmental biology to developmental toxicology.
2000 Scientific Article in Mammalian Genome Mamm. Genome 11, 528-530 (2000)
Screening for dysmorphological abnormalities-a powerful tool to isolate new mouse mutants.
2000 Scientific Article in Developmental Biology Dev. Biol. 227, 91-103 (2000)
Oscillating Expression of c-Hey2 in the Presomitic Mesoderm Suggests That the Segmentation Clock May Use Combinatorial Signaling through Multiple Interacting bHLH Factors.
2000 Scientific Article in Mammalian Genome Mamm. Genome 11, 543-546 (2000)
The clinical-chemical screen in the Munich ENU Mouse Mutagenesis Project : Screening for clinically relevant phenotypes.
2000 Scientific Article in Mammalian Genome Mamm. Genome 11, 547-551 (2000)
The biochemical metabolite screen in the Munich ENU Mouse Mutagenesis Project : Determination of amino acids and acylcarnitines by tandem mass spectrometry.
2000 Scientific Article in Mammalian Genome Mamm. Genome 11, 552-554 (2000)
Comet assay as a tool to screen for mouse models with inherited radiation sensitivity.
2000 Scientific Article in Mammalian Genome Mamm. Genome 11, 507-510 (2000)
The large-scale Munich ENU-mouse-mutagenesis screen.
2000 Scientific Article in Mammalian Genome Mamm. Genome 11, 590-593 (2000)
MouseNet databases : Digital management of a large-scale mutagenesis project.
2000 Scientific Article in Developmental Dynamics Dev. Dyn. 219, 192-200 (2000)
Mouse mutant "Rib-vertebrae" (rv) : a defect in somite polarity.
2000 Editorial in Mammalian Genome Mamm. Genome 11, 471-471 (2000)
Great times for mouse genetics: Getting ready for large-scale ENU-mutagenesis.
2000 Scientific Article in Mammalian Genome Mamm. Genome 11, 526-527 (2000)
Identification of immunological relevant phenotypes in ENU mutagenized mice.
2000 Scientific Article in Nature Genetics Nat. Genet. 25, 444-447 (2000)
Genome-wide, large-scale production of mutant mice by ENU mutagenesis.
2000 Scientific Article in Mammalian Genome Mamm. Genome 11, 484-488 (2000)
Effects of ENU dosage on mouse strains.
2000 Scientific Article in British Journal of Audiology Br. J. Audiol 34, 85-86 (2000)
Several new mouse mutations affect semicircular canal morphogenesis of the inner ear.
2000 Scientific Article in Experimental Physiology Exp. Physiol. 85, 635-644 (2000)
Special review series - Gene manipulation and integrative physiology.
1999 Scientific Article in Genomics Genomics 62, 67-73 (1999)
Mutation in the ßA3/A1-Crystallin Encoding Gene Cryba1 Causes a Dominant Cataract in the Mouse.
1999 Scientific Article in Mechanisms of Development Mech. Dev. 84, 165-168 (1999)
Expression of the mouse Delta1 gene during organogenesis and fetal development.
1999 Scientific Article in Trends in Genetics Trends Genet. 15, 128-131 (1999)
Cryopreservation of mouse spermatozoa : double your mouse space.
1999 Scientific Article in Mechanisms of Development Mech. Dev. 84, 169-172 (1999)