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Martin Hrabě de Angelis, Prof. Dr., Dr. h.c. mult.

Research Director Helmholtz Munich, Full Professor and Chair of Experimental Genetics Technical University Munich Germany, Director of the Institute of Experimental Genetics Helmholtz Munich
+49 89 3187 3502Email meBuilding/Room: 35.14 / 317

Prof. Hrabě de Angelis’ areas of research include genetics, diabetes, phenotyping and data mining.

Martin Hrabě de Angelis studied biology at Philipps University in Marburg and completed his PhD on the influence of growth factors on early embryonic development in 1994. During his time as a postdoctoral researcher (1994 – 1997) at the internationally recognized Jackson Laboratory in Bar Harbor (USA), he examined the Delta/Notch signaling pathway and somitogenesis in mouse models. Deciphering the genetic underpinning for pattern formation of the body axis has been a major focus. Already at that time modelling human health and disease has been of major interest.

In 1997 he returned to Germany and headed the working group “Functional Genetics” at the Institute for Mammalian Genetics GSF, Munich. Together with Prof. Rudi Balling and colleagues he successfully performed the first comprehensive ENU-mutagenesis screen for disease models, resulting in great many new models, which have been used in the own laboratory and world-wide. 

In 2001, Martin founded the world first Mouse Clinic (German Mouse Clinic) for the systemic analysis of mouse models for human disease including a special focus on metabolism. This was possible in his new position as director of the Institute of Experimental Genetics at Helmholtz Munich (German Research Center for Environmental Health). In 2003, he was appointed to the Chair of Experimental Genetics at Technical University Munich. He is also the director of the European research consortium "INFRAFRONTIER".

Hrabě de Angelis and colleagues have shown that dietary obesity and diabetes mellitus can be epigenetically inherited from the offspring via egg cells as well as sperm. By studying knockout mice, each of which lacked a precisely selected gene, he succeeded in identifying 51 unknown genes that could play an important role in the development of metabolic diseases and diabetes. His published research articles, have been cited over 42 000 times. Martin Hrabě de Angelis directs national and international research projects. He is co-founder and board member of the German Center for Diabetes Research (DZD, 2009). He is also elected member of the National Academy of Science (Leopoldina)

 

 

Fields of Work and Expertise

Metabolism & DiabetesLarge Scale Functional Genomics/GeneticsEpigeneticsData Mining

Professional Background

Since 2020

Research Director Helmholtz Zentrum München GmbH

2003

Full Professor (W3) and Chair of Experimental Genetics Technical University München Germany

2000

Director Institute of Experimental Genetics, Helmholtz Zentrum München GmbH

1997-2000

1997-2000: Independent group leader within the German Human Genome Project (DHGP) and coordinator of the ENU mutagenesis project at the Institute of Mammalian Genetics, GSF, Munich

1994-1997

Postdoctoral fellow at Jackson Laboratory, Bar Harbor, ME, USA (DFG and NIH stipend)

1994

PhD in Biology at Philipps University Marburg (summa cum laude)

1990

Study Biology, Sports, Pedagogy at Philipps University Marburg, (State examination passed with distinction)

Honors and Awards

  • Paul Langerhans Medal – Highest recognition of the DDG (German Diabetes Society)
    2021

  • IMPC award of excellence
    2019

  • Member of the National Academy of Sciences LEOPOLDINA
    2018

  • Dr. med. honoris causa Technical University Dresden Germany
    2018

  • Dr. vet. med. honoris causa. Ludwig Maximilian University Munich Germany
    2017

  • Dr. med. honoris causa Eberhard-Karls University Tübingen Germany
    2016

  • Paula und Richard von Hertwig award for interdisciplinary research
    2003 & 2010

  • JAX/NIH stipend postdoctoral fellow
    1996-97

  • DFG Stipend as postdoctoral fellow
    1994-96

  • Summa cum laude for overall performance PhD
    1994

Highlight Publications

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