Publications
2022 Letter to the Editor in Development / Company of Biologists Development 149:dev201404 (2022)
In preprints: Improving and interrogating embryo models.
2022 Scientific Article in Cell Reports Cell Rep. 41:111656 (2022)
Quantitative RNA imaging in single live cells reveals age-dependent asymmetric inheritance.
2022 Scientific Article in PLoS Computational Biology PLoS Comput. Biol. 18:e1010640 (2022)
Altered expression response upon repeated gene repression in single yeast cells.
2022 Scientific Article in Biophysical Journal Biophys. J. 121, 4702-4713 (2022)
Single-molecule experiments reveal the elbow as an essential folding guide in SMC coiled coil arms.
2022 Scientific Article in BMC Biology BMC Biol. 20:174 (2022)
Segmentation, tracking and cell cycle analysis of live-cell imaging data with Cell-ACDC.
2022 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 119:e2200512119 (2022)
EBNA2-EBF1 complexes promote MYC expression and metabolic processes driving S-phase progression of Epstein-Barr virus-infected B cells.
2022 Scientific Article in Life Science Alliance Life Sci. All. 5:e202201572 (2022)
The MLL3/4 complexes and MiDAC co-regulate H4K20ac to control a specific gene expression program.
Methods in Molecular Biology In: Histone Methyltransferases. 2022. 327-403 (Methods Mol. Biol. ; 2529)
Identifying specific protein interactors of nucleosomes carrying methylated histones using quantitative mass spectrometry.
2022 Scientific Article in Molecular Biology of the Cell Mol. Biol. Cell 33:lt1 (2022)
Whi5 is diluted and protein synthesis does not dramatically increase in pre-Start G1.
2022 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 50, 8491-8511 (2022)
TET1 regulates gene expression and repression of endogenous retroviruses independent of DNA demethylation.
2022 Scientific Article in PLoS Computational Biology PLoS Comput. Biol. 18:e1009552 (2022)
The role of cell geometry and cell-cell communication in gradient sensing.
2022 Scientific Article in Cell Reports Cell Rep. 38:110547 (2022)
A 3D transcriptomics atlas of the mouse nose sheds light on the anatomical logic of smell.
2022 Scientific Article in Nature Communications Nat. Commun. 13:1303 (2022)
The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD.
2022 Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 29:282 (2022)
Author Correction: Retinoic acid signaling is critical during the totipotency window in early mammalian development.
2022 Scientific Article in Nature Genetics Nat. Genet. 54, 318–327 (2022)
DNA replication fork speed underlies cell fate changes and promotes reprogramming.
2022 Review in Nature Reviews - Genetics Nat. Rev. Genet. 23, 563-580 (2022)
Histone post-translational modifications - cause and consequence of genome function.
2021 Scientific Article in Nature Nature 600, 285-289 (2021)
Single-cell transcriptomic characterization of a gastrulating human embryo.
2021 Scientific Article in Molecular Cell Mol. Cell 81, 4861-4875.e7 (2021)
Transcriptional and chromatin-based partitioning mechanisms uncouple protein scaling from cell size.
2021 Scientific Article in Nature Communications Nat. Commun. 12:4202 (2021)
Transcription coordinates histone amounts and genome content.
2021 Scientific Article in Molecular Cell Mol. Cell 81, 2944-2959.e10 (2021)
Nascent RNA antagonizes the interaction of a set of regulatory proteins with chromatin.
2021 Scientific Article in Nature metabolism Nat. Metab. 3, 1091-1108 (2021)
Cell competition acts as a purifying selection to eliminate cells with mitochondrial defects during early mouse development.
2021 Review in EMBO Reports EMBO Rep. 22:e52774 (2021)
Histone acylations and chromatin dynamics: Concepts, challenges, and links to metabolism.
2021 Scientific Article in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 28, 521-532 (2021)
Retinoic acid signaling is critical during the totipotency window in early mammalian development.
2021 Scientific Article in Molecular Cell Mol. Cell 81, 2793-2807.e8 (2021)
Methylation of histone H3 at lysine 37 by Set1 and Set2 prevents spurious DNA replication.
2021Vortrag: Cell Bio Virtual 2020, 2-16 December 2020, Virtual. (2021)
Coordination of mitochondrial homeostasis with cell size.
2021 Scientific Article in Science Science 371:eabb2986 (2021)
Characterization of a common progenitor pool of the epicardium and myocardium.
2021 Scientific Article in EMBO Reports EMBO Rep. 22:e51009 (2021)
Succinylation of H3K122 destabilizes nucleosomes and enhances transcription.
2021 Review in Nucleic Acids Research Nucleic Acids Res. 49, 3020–3032 (2021)
Staying true to yourself: Mechanisms of DNA methylation maintenance in mammals
2020 Scientific Article in STAR Protocols STAR Protoc. 1:100228 (2020)
Microfluidics for single-cell lineage tracking over time to characterize transmission of phenotypes in Saccharomyces cerevisiae.
2020 Review in Annual Review of Genetics Annu. Rev. Genet. 54, 167-187 (2020)
Measuring and modeling single-cell heterogeneity and fate decision in mouse embryos.
2020 Scientific Article in Science Advances Sci. Adv. 6:eaaz4551 (2020)
METTL6 is a tRNA m3C methyltransferase that regulates pluripotency and tumor cell growth.
2020 Review in Current Genetics Curr. Genet. 66, 1029–1035 (2020)
The past determines the future: Sugar source history and transcriptional memory.
2020 Scientific Article in Nature Communications Nat. Commun. 11:3559 (2020)
Alveolar regeneration through a Krt8+transitional stem cell state that persists in human lung fibrosis.
2020 Scientific Article in Molecular Metabolism Mol. Metab. 40:101038 (2020)
Differential regulation of the immune system in a brain-liver-fats organ network during short-term fasting.
2020 Scientific Article in Nature Communications Nat. Commun. 11:2952 (2020)
Cell size sets the diameter of the budding yeast contractile ring.
2020 Scientific Article in Molecular Cell Mol. Cell 78, 915-925 (2020)
Single-cell tracing dissects regulation of maintenance and inheritance of transcriptional reinduction memory.
2020 Review in Molecular Metabolism Mol. Metab. 38:100951 (2020)
Interactions between metabolism and chromatin in plant models.
2020 Scientific Article in Bioinformatics Bioinformatics 36, 4296-4300 (2020)
COMUNET: A tool to explore and visualize intercellular communication.
2020 Review in Molecular Metabolism Mol. Metab. 38:100987 (2020)
You are what you eat-How nutrition and metabolism shape the genome through epigenetics.
2020 Meeting abstract in Wound repair and regeneration Wound Repair Regen. 28, A7-A7 (2020)
Fate trajectory modeling reveals convergence of airway derived progenitors and AT2 cells on transient KRT8+alveolar cell state during lung regeneration.
2020 Scientific Article in Bioinformatics Bioinformatics 36, 4291-4295 (2020)
Automatic identification of relevant genes from low-dimensional embeddings of single-cell RNA-seq data.
2020 Scientific Article in Genes and Development Genes Dev. 34, 715-729 (2020)
The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs.
2019 Nature Structural & Molecular Biology Nat. Struct. Mol. Biol., DOI: 10.1038/s41594-019-0341-8 (2019)
Author Correction: G-tract RNA removes Polycomb repressive complex 2 from genes (Nature Structural & Molecular Biology, (2019), 26, 10, (899-909), 10.1038/s41594-019-0293-z).
2019 Scientific Article in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 26, 899-909 (2019)
G-tract RNA removes Polycomb repressive complex 2 from genes.
2019 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 116, 16046-16055 (2019)
Epstein-Barr virus reprograms human B lymphocytes immediately in the prelatent phase of infection.
2019Poster: CSH meeting: mechanisms of metabolic signaling, 14 May 2019, Cold Spring Harbour, NY, USA. (2019)
Glucose starvation in Huh7 cells triggers a transcriptional memory.
2019 Scientific Article in Scientific Reports Sci. Rep. 9:6584 (2019)
The interactome of a family of potential methyltransferases in HeLa cells.
2019 Other: Opinion in Molecular & Cellular Oncology Mol. Cell. Oncol. 6:1605820 (2019)
A chromatin-based signalling mechanism directs the switch from mutagenic to error-free repair of DNA double strand breaks.
2019 Scientific Article in Nature Cell Biology Nat. Cell Biol. 21, 311-318 (2019)
H4K20meO recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.
2019 Editorial in Epigenomics Epigenomics 11, 363-366 (2019)
Histone H1, the forgotten histone.
2018 Scientific Article in Science Science 362, 1182-1186 (2018)
A DNA methylation reader complex that enhances gene transcription.
2018 Scientific Article in Chemical senses Chem. Senses 44, 7-9 (2018)
Interspecific variation of olfactory preferences in flies, mice, and humans.
2018 Scientific Article in Molecular Cell Mol. Cell 72, 739-752 (2018)
Critical role of the UBL domain in stimulating the E3 ubiquitin ligase activity of UHRF1 toward chromatin.
2018Poster: 40 years Myc, 50 years Polymerase II, and 65 years Dirk Eick!, 9 November 2018, Planegg-Martinsried. (2018)
Regulation of transcription: RNA Pol II and Myc.
2018 Scientific Article in Nature Communications Nat. Commun. 9:1653 (2018)
Global profiling of protein-DNA and protein-nucleosome binding affinities using quantitative mass spectrometry.
2018 Review in Molecular Systems Biology Mol. Syst. Biol. 14:e8046 (2018)
Using single-cell genomics to understand developmental processes and cell fate decisions.
2018 Review in Molecular Metabolism Mol. Metab., DOI: 10.1016/j.molmet.2018.01.007 (2018)
Metabolic intermediates - Cellular messengers talking to chromatin modifiers.
2018 Scientific Article in Scientific Reports Sci. Rep. 8:1801 (2018)
Spatiotemporal patterning of EpCAM is important for murine embryonic endo-And mesodermal differentiation.
2017 Review in Current Opinion in Cell Biology Curr. Opin. Cell Biol. 49, 53-58 (2017)
The phenomenology of cell size control.
2017 Scientific Article in Nature Nature 552, 239-243 (2017)
Pluripotent state transitions coordinate morphogenesis in mouse and human embryos.
2017 Scientific Article in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 24, 1048–1056 (2017)
Histone propionylation is a mark of active chromatin.
2017 Scientific Article in Journal of Cell Biology, The J. Cell Biol. 216, 3017-3028 (2017)
Dynamic changes in H1 subtype composition during epigenetic reprogramming.
2017 Scientific Article in PLoS Genetics PLoS Genet. 13:e1006959 (2017)
Loss of the chromatin modifier Kdm2aa causes BrafV-600E -independent spontaneous melanoma in zebrafish.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:5418 (2017)
Bromodomain factors of BET family are new essential actors of pericentric heterochromatin transcriptional activation in response to heat shock.
2017 Scientific Article in OncoTarget Oncotarget 8, 38239-38250 (2017)
Selective elimination of long INterspersed element-1 expressing tumour cells by targeted expression of the HSV-TK suicide gene.
2016 Scientific Article in Nature Genetics Nat. Genet. 48, 681-686 (2016)
Histone H3 globular domain acetylation identifies a new class of enhancers.
2016 Review in Trends in Genetics Trends Genet. 32, 42-56 (2016)
Lateral thinking: How histone modifications regulate gene expression.
2016 Scientific Article in Biochimica et Biophysica Acta - Gene Regulatory Mechanisms Biochim. Biophys. Acta-Gene Regul. Mech. 1859, 486-495 (2016)
The role of linker histone H1 modifications in the regulation of gene expression and chromatin dynamics.
2016 Scientific Article in Nature Communications Nat. Commun. 7:10782 (2016)
Hypothalamic leptin action is mediated by histone deacetylase 5.
2016 Scientific Article in Genome Biology Genome Biol. 17:8 (2016)
H1 gets the genome in shape.
2016 Editorial in Cell Cell 164, 341-342 (2016)