Molecular Targets and Therapeutics Center
Institute of Functional Epigenetics
At the Institute of Functional Epigenetics (IFE), we aim to uncover how epigenetic information is stored and how the environment controls our epigenome to identify novel therapeutic targets.
At the Institute of Functional Epigenetics (IFE), we aim to uncover how epigenetic information is stored and how the environment controls our epigenome to identify novel therapeutic targets.
IFE Members
Deputy Director of the Institute of Functional Epigenetics
Group Leader, Institute of Functional Epigenetics, Molecular Targets & Therapeutics Center
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Latest Publications
Chadha, Y. ; Kukhtevich, I. ; Stegmaier, T. ; Padovani, F. ; Schneider, R. ; Schmoller, K.M.
Single-cell imaging reveals a key role of Bck2 in yeast cell size adaptation to nutrient challenges.Munoz-Barrera, M. ; Mata-Cabana, A. ; Moreno-Rivero, A. ; Piubeli, F.A. ; Ren-Barroso, B. ; Al-Refaie, N. ; Gutierrez, G. ; Cabianca, D.S. ; Olmedo, M.
HLH-30/TFEB is necessary for chromatin reorganization and maintenance of cell quiescence during starvation in C. elegans.Hamad, S.G. ; Makhlouf, M. ; Agrebi, N. ; Kaddourah, A. ; Abu-Hasan, M. ; Al‐Adba, B. ; Sadoun, A. ; Hubrack, S.Z. ; Aamer, W. ; Ruiz Tejada Segura, M.L. ; Scialdone, A. ; Machaca, K. ; Saraiva, L.R. ; Bout-Tabaku, S. ; Lo, B.
Unraveling immune dysregulation in ZNFX1 deficiency: From interferonopathies to macrophage activation syndrome.Solovey, M. ; Celik, M.A. ; Salcher, F. ; Gülec, C. ; Abdalfattah, M. ; Ali, M.I.H ; Heinig, M. ; Scialdone, A. ; Ziemann, F. ; Colomé-Tatché, M.
Community: Component based differential cell communication analysis in large multi-sample case-control scRNAseq datasets.Finger, F. ; Frost, M. ; Watanabe, S. ; Ma, T. ; Kang, T. ; Biswas, D. ; Perez, R.Z. ; Anton, V. ; Dollet, L. ; Markussen, L.K. ; Senoo, N. ; Karavaeva, I.E. ; Basse, A.L. ; Dmytriyeva, O. ; TeSlaa, T.A. ; Havelund, J.F. ; Ehrlich, A.M. ; Moreno‐Torres, M. ; Yonamine, C.Y. ; Andersen, N.R. ; Blom, I. ; García‐Carrizo, F. ; Siripoksup, P. ; Asping, M. ; Nielsen, T.S. ; Nygård, M. ; Klein, A.B. ; Tvardovskiy, A. ; Nicolaisen, T.S. ; Nygård, M. ; Qvortrup, K. ; Prats, C. ; Rabinowitz, J.D. ; Clemmensen, C. ; Sylow, L. ; Zierath, J.R. ; Treebak, J.T. ; Schulz, T..J. ; Grevengoed, T.J. ; Claypool, S.M. ; Prudent, J. ; Wüst, R.C.I. ; Mandrup, S. ; Houtkooper, R.H. ; Sakamoto, K. ; Færgeman, N.J. ; Larsen, M.R. ; Funai, K. ; Larsen, S. ; Gerhart‐Hines, Z.
Mitochondrial membrane lipid cardiolipin controls fiber-type adaptations in aging muscle via estrogen-related receptor γ.Rizzo, F. ; Ben-Shem, A. ; Timmers, H.T.M. ; Bartke, T. ; Vincent, S.D. ; Tora, L.
Step-brothers in arms, SAGA and ATAC co-activator complexes, use different strategies.Padovani, F. ; Čavka, I. ; Neves, A.R.R. ; López, C.P. ; Al-Refaie, N. ; Bolcato, L. ; Chatzitheodoridou, D. ; Chadha, Y. ; Lagos, P. ; Stegmaier, T. ; Su, X.A. ; Lengefeld, J. ; Cabianca, D.S. ; Köhler, S. ; Schmoller, K.M.
SpotMAX: A generalist framework for multidimensional automatic spot detection and quantification.Pabst, F.R. ; Cabianca, D.S.
A lipid kinase joins the transcriptional machinery.Moukham, H. ; Caligaris, M. ; Six, P. ; Padovani, F. ; Schmoller, K.M. ; Virgilio, C.D. ; Nicastro, R. ; Tripodi, F. ; Coccetti, P.
SNF1/AMPK controls its own localization by phosphorylating its activating kinase Sak1.Wunder, T. ; Eulitz, L. ; Kramer, L. ; Ali, Z.M. ; Ostermeier, M. ; Leu, C. ; Szulc, B. ; Holzner, L.J. ; Fechter, J. ; Padovani, F. ; Brandt, B. ; Girr, P. ; Teh, J.T. ; Mühlbauer, S. ; Sotos, C. ; Angstenberger, M. ; Mackinder, L.C.M. ; Schmoller, K.M. ; Rädler, J.O. ; Nickelsen, J. ; de Vries, J. ; Kunz, H.H.
Conserved and lineage-specific roles of KEA-mediated Ion homeostasis in chlamydomonas.Dengler, L. ; Padovani, F. ; Lemke, B. ; Brugger, R. ; Benedikt, A. ; Westermann, B. ; Maček, B. ; Schmoller, K.M. ; Ewald, J.C.
In the absence of mitochondrial fusion unequal segregation of mitochondria drives mtDNA loss.Kim, J. ; Xie, S. ; Valenzuela, L.F. ; Xiao, J. ; Lanz, M.C. ; Gao, X. ; Swaffer, M. ; Mitchell, C.E. ; Rubin, S.M. ; Schmoller, K.M. ; Skotheim, J.M.
A Fkh1/2 binding site array in the WHI5 promoter drives sub-scaling transcription.Balan, T. ; Petitalot, A. ; Albert, J.R. ; Abbou, L. ; Chevreux, G. ; Al-Sady, B. ; Aygenli, B.Ö. ; Bartke, T. ; Margueron, R. ; Duharcourt, S.
A H3K27me3 reader complex couples H3K27me3 accumulation to nascent transcription of transposable elements in Paramecium.Langstein-Skora, I. ; Schmid, A. ; Huth, F. ; Shabani, D. ; Spechtenhauser, L. ; Likhodeeva, M. ; Kunert, F. ; Metzner, F.J. ; Emenecker, R.J. ; Richardson, M.O. ; Aftab, W. ; Götz, M.J. ; Payer, S. ; Pietrantoni, N. ; Valka, V. ; Ravichandran, S.K. ; Bartke, T. ; Karl-Peter, H. ; Gerland, U. ; Korber, P. ; Holehouse, A.S.
Sequence and chemical specificity define the functional landscape of intrinsically disordered regions.Papa, C. ; Rose, A. ; Martin, H.N.G. ; Useini, A. ; Geier, F. ; Liao, L. ; Rodriguez Aguilera, J.R. ; Valina-Allo, P. ; Hoffmann, A. ; Tvardovskiy, A. ; Zulfqar, F. ; Zimmerman, A. ; Schicht, G. ; Ott, F. ; Körner, C. ; Engelmann, B. ; Rolle-Kampczyk, U. ; von Bergen, M. ; Meier, M. ; Bartke, T. ; Seehofer, D. ; Klöting-Blüher, N. ; Matz-Soja, M. ; Damm, G. ; Boeckel, J.N. ; Buescher, J.M. ; Blüher, M. ; Laufs, U. ; Bondareva, O. ; Sträter, N. ; Künze, G. ; Heiker, J.T. ; Sheikh, B.N.
Bempedoic acid directly binds and activates PPARα.Our Institute in Numbers
Epigenetics@Helmholtz Munich
Research School EpiCrossBorders
International Training Network Cell2Cell
CRC Chromatin Dynamics
CRC Chemical Biology of Epigenetic Modifications
German Research Foundation
Ludwig-Maximilians-Universität München
Contact Institute Office
