Computational Health Center
Institute of Neurogenomics
At the Institute of Neurogenomics (ING), we study the genomic basis of neurological diseases to pave the way to a healthier life.
At the Institute of Neurogenomics (ING), we study the genomic basis of neurological diseases to pave the way to a healthier life.
Our Mission
Our overall goal is to identify the genomic basis of neurological diseases in order to improve the diagnosis of our patients and provide tailored personalized treatment. We seek to understand the genomic architecture of complex inherited diseases and to study the underlying molecular mechanisms that burden patients with an increased susceptibility. Understanding predisposition allows us to model how environmental factors coalesce to amplify disease manifestation. This knowledge helps us to formulate precise treatments for our patients, taking into consideration their genetic makeup as well as “multi-omic” information. Ultimately, we want to combat disease by predicting susceptibility at an early stage and then preventing the onset.
Our approach is to combine clinical insight gleaned from our patients with high-throughput “omics” analysis such as array-based genotyping, next generation sequencing, and analysis of the proteome, transcriptome and other omics layers. We then investigate the functional relevance of identified markers using cellular and animal models.
We partner with specialized outpatient clinics at the Klinikum rechts der Isar of the Technische Universität München and specialized hospitals in order to learn the needs of our patients. Moreover, with respect for patients and their family’s cooperative spirit, we can transfer the knowledge we gain directly back into the clinic for prevention, self-observation and treatment.
People at ING
Technical Assistant
Personal Assistant Prof. Winkelmann
PhD student
PhD Student
Post Doc
Senior Scientist
Silke Baselice-Denkmann
PostDoc
Assistant
Staff Scientist
Post Doc
Group Leader
PhD student
PhD student
PhD student
Group Leader
PhD student
Neurologist /RLS Ambulanz
Deputy Head
Senior Scientist
Technical Assistant
PhD student
Senior Scientist
Senior Scientist, FA für Humangenetik
Senior Scientist, FA für Humangenetik
Senior Scientist
Publications
Raimondo, F. ; Bi, H. ; Komeyer, V. ; Kasper, J. ; Primus, S.A. ; Hoffstaedter, F. ; Mandal, S. ; Waite, L.K. ; Winkelmann, J. ; Oexle, K. ; Eickhoff, S.B. ; Tahmasian, M. ; Patil, K.R.
Can we predict sleep health based on brain features? A large-scale machine learning study using UK Biobank.Lai, L. ; Jong, A. ; Delerue, T. ; Lin, J. ; Thorand, B. ; Heier, M. ; Prokisch, H. ; Farzeen, A. ; Winkelmann, J. ; Thiering, E. ; Gieger, C. ; Peters, A. ; Waldenberger, M.
Association of DNA methylation with hypertension and blood pressure: A 7-year longitudinal study from KORA F4/FF4.Romito, L.M. ; Telese, R. ; Kaymak, A. ; Colucci, F. ; Elia, A.E. ; Rinaldo, S. ; Devigili, G. ; Cilia, R. ; Zorzi, G. ; Mazzoni, A. ; Leta, V. ; Zech, M. ; Carecchio, M. ; Garavaglia, B. ; Levi, V. ; Andreasi, N.G. ; Eleopra, R.
Sex-related differences in the short and long-term outcome of internal pallidus stimulation for dystonia.Lopriore, P. ; Ünlütürk, Z. ; Klopstock, T. ; Karaa, A. ; Rouzier, C. ; Domínguez-González, C. ; Lamperti, C. ; Mancuso, M. ; Cecchi, G. ; Montano, V. ; Siciliano, G. ; Nicoletta, V. ; Maioli, M. ; Primiano, G. ; Servidei, S. ; La Morgia, C. ; Carelli, V. ; Valentino, M.L. ; Caporali, L. ; Arena, I.G. ; Musumeci, O. ; Lopergolo, D. ; Malandrini, A. ; Gallus, G.N. ; Filosto, M. ; Bello, L. ; Pegoraro, E. ; Comi, G.P. ; Magri, F. ; Ronchi, D. ; Di Fonzo, A. ; Percetti, M. ; Azzimonti, M. ; Büchner, B. ; Prokisch, H. ; Bermejo-Guerrero, L. ; Procaccio, V. ; Gaignard, P. ; Echaniz-Laguna, A. ; Schiff, M. ; Rötig, A. ; Toutain, A. ; Paquis-Flucklinger, V. ; Morel, G. ; Robin, S. ; Nadaj-Pakleza, A. ; Chanson, J.B. ; Chaussenot, A. ; Ait-El-Mkadem Saadi, S. ; Trimouille, A. ; Tranchant, C. ; Salort-Campana, E. ; Bieth, E. ; Sacconi, S. ; Duval, F. ; Restrepo Vera, J.L. ; Molnar, M.J. ; Vissing, J. ; Haas, R. ; Larson, A. ; Enns, G.M. ; Parikh, S. ; Goldstein, A. ; Hirano, M.
Clinical and genotypic spectrum of twinkle-related disorders: Insights from a multinational cohort study.Dzinovic, I. ; Zech, M.
Dystonia: Insights into mechanisms and Nnvel therapeutics.Ciantar, J. ; Rajić, S. ; Kostiniuk, D. ; Raulamo, E. ; Kartiosuo, N. ; Lai, L. ; Mishra, P.P. ; Lyytikäinen, L.P. ; Kleber, M.E. ; Rovio, S. ; Mykkänen, J. ; Pahkala, K. ; Peters, A. ; Winkelmann, J. ; März, W. ; Kähönen, M. ; Raitakari, O. ; Lehtimäki, T. ; Waldenberger, M. ; Marttila, S. ; Raitoharju, E.
Genome-wide DNA methylation patterns for indicators of liver steatosis: A longitudinal multiomic study.Nakamura, K. ; Kishita, Y. ; Sugiura, A. ; Ozaki, K. ; Yatsuka, Y. ; Matsumoto, N. ; Okazaki, A. ; Prokisch, H. ; Maruyama, K. ; Iwasa, H. ; Murayama, K. ; Matsumoto, H. ; Ohtake, A. ; Shiraishi, Y. ; Okazaki, Y.
Identification of intronic variants in NDUFA3 as a cause of leigh syndrome by whole genome sequencing and RNA sequencing.Yao,Y. ; Wolf, K. ; Breitner-Busch, S. ; Zhang, S. ; Waldenberger, M. ; Winkelmann, J. ; Schneider, A.E. ; Peters, A.
Long-term exposure to traffic-related air pollution is associated with epigenetic age acceleration.Gasparini, G. ; Kraus, C. ; Rusha, E. ; Orschmann, T. ; Wortmann, S.B. ; Mayr, J.H. ; Ardissone, A. ; Iuso, A.
Generation of two human iPSC lines from fibroblasts of BPAN patients carrying pathogenic variants in the WDR45 gene.Pauli, J. ; Garger, D. ; Peymani, F. ; Wettich, J. ; Sachs, N. ; Wirth, J. ; Steiger, K. ; Hillig, C. ; Zhang, H. ; Tabas, I. ; Tall, A.R. ; Li, M. ; Reilly, M.P. ; Branzan, D. ; Prokisch, H. ; Menden, M.P. ; Maegdefessel, L.
Single cell spatial transcriptomics integration deciphers the morphological heterogeneity of atherosclerotic carotid arteries.
Contact
Contact