Computational Health Center
Institute of Neurogenomics
At the Institute of Neurogenomics (ING), we study the genomic basis of neurological diseases to pave the way to a healthier life.
At the Institute of Neurogenomics (ING), we study the genomic basis of neurological diseases to pave the way to a healthier life.
Our Mission
Our overall goal is to identify the genomic basis of neurological diseases in order to improve the diagnosis of our patients and provide tailored personalized treatment. We seek to understand the genomic architecture of complex inherited diseases and to study the underlying molecular mechanisms that burden patients with an increased susceptibility. Understanding predisposition allows us to model how environmental factors coalesce to amplify disease manifestation. This knowledge helps us to formulate precise treatments for our patients, taking into consideration their genetic makeup as well as “multi-omic” information. Ultimately, we want to combat disease by predicting susceptibility at an early stage and then preventing the onset.
Our approach is to combine clinical insight gleaned from our patients with high-throughput “omics” analysis such as array-based genotyping, next generation sequencing, and analysis of the proteome, transcriptome and other omics layers. We then investigate the functional relevance of identified markers using cellular and animal models.
We partner with specialized outpatient clinics at the Klinikum rechts der Isar of the Technische Universität München and specialized hospitals in order to learn the needs of our patients. Moreover, with respect for patients and their family’s cooperative spirit, we can transfer the knowledge we gain directly back into the clinic for prevention, self-observation and treatment.
People at ING
Silke Baselice-Denkmann
Personal Assistant Prof. Winkelmann
PostDoc
wissenschaftlicher Mitarbeiter
Technical Assistant
PhD
PhD
Post Doc
PhD Student
Post Doc
Senior Scientist
PostDoc
Staff Scientist
Assistant
Post Doc
PhD student
PhD student
PhD student
PhD student
wissenschaftlicher Mitarbeiter
PhD candidate
Neurologist /RLS Ambulanz
Deputy Head
Senior Scientist
wissenschaftliche Mitarbeiterin
PhD student
Technical Assistant
Senior Scientist
Senior Scientist, FA für Humangenetik
Senior Scientist, FA für Humangenetik
Senior Scientist
Publications
Vill, K. ; Brunet, T. ; Brugger, M. ; Wagner, M. ; Baumann, M. ; Schatz, U. ; Pechmann, A. ; Hannibal, I. ; Tacke, M. ; Giunta, C. ; Wohlgemuth, W. ; Wildgruber, M. ; Muller-Felber, W. ; Blaschek, A. ; Rohrbach, M. ; Huf, V.
Between myopathy and mortality: Challenges in the diagnosis of PLOD1-related kyphoscoliotic Ehlers-Danlos syndrome.Harrer, P. ; Kranz, A. ; Becker, L. ; Garrett, L. ; Hölter, S.M. ; Sanz-Moreno, A. ; Amarie, O.V. ; Rathkolb, B. ; Leuchtenberger, S. ; Gailus-Durner, V. ; Fuchs, H. ; Hrabě de Angelis, M. ; Saparov, A. ; Sieber, C. ; Kittke, V. ; Mirza-Schreiber, N. ; Stewart, A.F. ; Winkelmann, J. ; Oexle, K. ; Pocratsky, A. ; Zech, M.
Motor coordination and behavioural deficits in a mouse model of KMT2B-related dystonia.Badmann, S. ; Saparov, A. ; Harrer, P. ; Beuschlein, J. ; Daumer-Haas, C. ; Graf, E. ; Ludwig, C. ; Mergner, J. ; Brunet, T. ; Jacob, M. ; Prokisch, H. ; Winkelmann, J. ; Meitinger, T. ; Zech, M. ; Wagner, M.
Splice effect of a synonymous variant in AP4B1: Multiomics approach establishes the diagnosis in two sisters with spastic paraplegia.Semmler, L. ; Büchner, B. ; Kornblum, C. ; Deschauer, M. ; Wortmann, S. ; Morgia, C.L. ; Servidei, S. ; Freisinger, P. ; Mensch, A. ; Schuelke, M. ; Prokisch, H. ; Mancuso, M. ; Lamperti, C. ; Klopstock, T. ; Bertini, E. ; Bischoff, A.T. ; Boy, N. ; Bruno, C. ; Carelli, V. ; Cecchi, G. ; Claeys, K. ; Distelmaier, F. ; Filosto, M. ; Garone, C. ; Hempel, M. ; Karall, D. ; Kmop, C. ; Kotzaeridou, R. ; Lopriore, P. ; Mongini, T. ; Montano, V. ; Musumeci, O. ; Nicoletta, V. ; Primiano, G. ; Procopio, E. ; Rinaldi, R. ; Ruggiero, L. ; Santer, R. ; Sasse, H. ; Schäfer, J. ; Schlein, C. ; Schöls, L. ; Strube, D. ; Thaele, A. ; Valentino, M.L. ; Kleist, J.v. ; Zeng, L.
Mitochondrial diabetes mellitus: Real world insights from the GENOMIT registry–a multinational, longitudinal cohort study.Miljanić, K. ; Žigman, T. ; Tomac, V. ; Pušeljić, S. ; Zrno, N. ; Fumić, K. ; Ozretić, D. ; Mayr, J.A. ; Prokisch, H. ; Barić, I. ; Petković Ramadža, D.
Clinical, neuroimaging, genetic, and outcome characteristics of Leigh syndrome: Experience from a single tertiary center.Scholz, J.J. ; Piel, S.Y.L. ; Evangelakos, I. ; Müller, C. ; Karall, D. ; Reinhart-Steininger, B. ; Steinbrücker, K. ; Stulnig, T. ; Rohde, J. ; Mayr, J. ; Wagner, M. ; Biabani, A. ; Mair, T. ; Müller, K. ; Schlüter, H. ; Weidemann, S. ; Chirico, V. ; Weiler-Normann, C. ; Hagel, C. ; Knisely, A.S. ; Heeren, J. ; Schoser, B. ; Kubisch, C. ; Hempel, M. ; Prokisch, H. ; Wortmann, S.B. ; Worthmann, A. ; Schlein, C.
Biallelic TXNIP deficiency is associated with a multisystemic metabolic disease.Boggan, R.M. ; Michalettou, T. ; Ng, Y.S. ; Franklin, I.G. ; Cortés, L.T. ; Alston, C.L. ; Blakely, E.L. ; Büchner, B. ; Bugiardini, E. ; Colclough, K. ; Feeney, C. ; Hanna, M.G. ; Hattersley, A.T. ; Klopstock, T. ; Kornblum, C. ; Mancuso, M. ; Patel, K.A. ; Pitceathly, R.D.S. ; Pizzamiglio, C. ; Prokisch, H. ; Schäfer, J. ; Schaefer, A.M. ; Shepherd, M. ; Thaele, A. ; Thomas, R.H. ; Turnbull, D.M. ; Woodward, C.E. ; McFarland, R. ; Taylor, R.W. ; Cordell, H.J. ; Pickett, S.J.
Identification of nuclear genetic loci linked to clinical features of the m.3243A>G mitochondrial DNA variant.Sorrentino, U. ; Brugger, M. ; Saparov, A. ; Dzinovic, I. ; Harrer, P. ; Lösecke, S. ; Derderian, K. ; Pavlov, M. ; Kopajtich, R. ; Prokisch, H. ; Iuso, A. ; Mazurkiewicz-Bełdzińska, M. ; Weiss, D. ; Ludwig, C. ; Abele, M. ; Mergner, J. ; Winkelmann, J. ; Brunet, T. ; Schinwelski, M. ; Graf, E. ; Kloth-Stachnau, K. ; Herget, T. ; Krygier, M. ; Zech, M.
Resolving complex structural variants in undiagnosed rare movement disorders via multimodal genomics and multi-omics.Winkelmann, J. ; Schormair, B.
Polygenic risk scores in neurological disorders: Restless legs syndrome as a translational model.Schmieder, R.S. ; Schlieben, L.D. ; Amosov, A. ; Krefting, J. ; Santer, R. ; von Scheidt, M. ; Semma, F. ; Sander, M. ; Holdenrieder, S. ; Pavlov, M. ; Li, L. ; Arens, S. ; Kordonouri, O. ; Koenig, W. ; Leipold, G. ; Meitinger, T. ; Schunkert, H. ; Prokisch, H. ; Sanin, V.
Genetic screening of children for familial hypercholesterolaemia: The VRONI study.
Contact
Contact