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Computational Health Center Institute of Neurogenomics

We study the genomic basis of neurological diseases in order to pave the way to a healthier life.

We study the genomic basis of neurological diseases in order to pave the way to a healthier life.

Our Mission

Our overall goal is to identify the genomic basis of neurological diseases in order to improve the diagnosis of our patients and provide tailored personalized treatment. We seek to understand the genomic architecture of complex inherited diseases and to study the underlying molecular mechanisms that burden patients with an increased susceptibility. Understanding predisposition allows us to model how environmental factors coalesce to amplify disease manifestation. This knowledge helps us to formulate precise treatments for our patients, taking into consideration their genetic makeup as well as “multi-omic” information. Ultimately, we want to combat disease by predicting susceptibility at an early stage and then preventing the onset.

Our approach is to combine clinical insight gleaned from our patients with high-throughput “omics” analysis such as array-based genotyping, next generation sequencing, and analysis of the proteome, transcriptome and other omics layers. We then investigate the functional relevance of identified markers using cellular and animal models.

We partner with specialized outpatient clinics at the Klinikum rechts der Isar of the Technische Universität München and specialized hospitals in order to learn the needs of our patients. Moreover, with respect for patients and their family’s cooperative spirit, we can transfer the knowledge we gain directly back into the clinic for prevention, self-observation and treatment. 

Research Groups

Helmholtz Munich | cco Barbara Schormair

Precision Neuromedicine / Winkelmann/Schormair Lab

We strive to achieve comprehensive genetic and multi-omic disease characterization to enable mechanistic understanding as well as improved health outcomes via enhanced prediction, prevention, diagnosis, and personalized treatment.

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Neurogenetic Systems Analysis / Oexle Lab

We address the principles of neural biosystems, their genetic foundations, and their pathological alterations. We use the results of our investigations for improving diagnostics and disease prediction.

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Prokisch Lab

We aim at providing computational solutions for patient diagnosis and treatment.

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Neuronal and Astrocytic Partnerships for Sleep physiology laboratory (NAPS Lab) / Williams Lab

We aim to study how the brain senses sleep and to identify which brain cells are responsible for translating sleep need into actual sleep time.

People at ING

Dr. Riccardo Berutti

Post Doc

Marieta Borzes

Technische Assistentin

Dr. Theresa Brunet

Post Doc

Celestine Dutta

Technische Assistentin

Ivana Džinović

Doktorandin

Michael Färberböck

Technischer Assistent

Aiman Farzeen

Doktorandin

Philip Harrer

Doktorand

Dr. Margarita Hessel

Wissenschaftliche Mitarbeiterin

Dr. Arcangela Iuso

Post Doc

Volker Kittke

Doktorand

Robert Kopajtich

Wissenschaftlicher Mitarbeiter

Martina Kuhnert

Assistentin der AG Leitung

Chia-Luen Leu

Doktorand

Vanessa Mandel

Doktorandin

Dr. Nazanin Mirza-Schreiber

Wissenschaftliche Mitarbeitern

Prof. Dr. Dr. h. c. Wolfgang H. Oertel

Wissenschaftler

Prof. Dr. Konrad Oexle

AG Leiter

ING Office

Fatemeh Peymani

Doktorandin

Sabrina Primus

Dr. Holger Prokisch

AG Leiter

Nathalie Schandra

Neurologin

Lea Dewi Schlieben

Doktorandin

Dr. Barbara Schormair

Stellvertretende Leiterin

Dr. Simone Schuffenhauer

Post Doc

Dr. Masaru Shimura

Post Doc

Dmitrii Smirnov

Doktorand

Elisabeth Stephan

Technische Assistentin

Dr. Erik Tilch

Post Doc

Dr. Cătălina Vasilescu

Post Doc

Dr. Matias Wagner

Post Doc

Dr. Rhiannan Williams

AG Leiterin

Prof. Dr. Juliane Winkelmann

Direktorin

Dr. Eva Winnebeck

Senior Scientist

Enrica Zanuttigh

Doktorandin

Priv.-Doz. Dr. Michael Zech

Senior Scientist

Dr. Chen Zhao

Wissenschaftlicher Mitarbeiter

Monika Zimmermann

Technische Assistentin

Publications

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2022 Scientific Article in Nucleic Acids Research

Nassar, L.R. ; Barber, G.P. ; Benet-Pages, A. ; Casper, J. ; Clawson, H. ; Diekhans, M. ; Fischer, C. ; Gonzalez, J.N. ; Hinrichs, A.S. ; Lee, B.T. ; Lee, C.M. ; Muthuraman, P. ; Nguy, B. ; Pereira, T. ; Nejad, P. ; Perez, G. ; Raney, B.J. ; Schmelter, D. ; Speir, M.L. ; Wick, B.D. ; Zweig, A.S. ; Haussler, D. ; Kuhn, R.M. ; Haeussler, M. ; Kent, W.J.

The UCSC genome browser database: 2023 update.

2022 Scientific Article in Genetics in Medicine

Vogel, G.F. ; Mozer-Glassberg, Y. ; Landau, Y.E. ; Schlieben, L.D. ; Prokisch, H. ; Feichtinger, R.G. ; Mayr, J.A. ; Brennenstuhl, H. ; Schröter, J. ; Pechlaner, A. ; Alkuraya, F.S. ; Baker, J.J. ; Barcia, G. ; Baric, I. ; Braverman, N. ; Burnyte, B. ; Christodoulou, J. ; Ciara, E. ; Coman, D. ; Das, A.M. ; Darin, N. ; Della Marina, A. ; Distelmaier, F. ; Eklund, E.A. ; Ersoy, M. ; Fang, W. ; Gaignard, P. ; Ganetzky, R.D. ; Gonzales, E. ; Howard, C.R. ; Hughes, J. ; Konstantopoulou, V. ; Kose, M. ; Kerr, M. ; Khan, A. ; Lenz, D. ; McFarland, R. ; Margolis, M.G. ; Morrison, K. ; Müller, T. ; Murayama, K. ; Nicastro, E. ; Pennisi, A. ; Peters, H. ; Piekutowska-Abramczuk, D. ; Rötig, A. ; Santer, R. ; Scaglia, F. ; Schiff, M. ; Shagrani, M. ; Sharrard, M. ; Soler-Alfonso, C. ; Staufner, C. ; Storey, I. ; Stormon, M. ; Taylor, R.W. ; Thorburn, D.R. ; Teles, E.L. ; Wang, J.S. ; Weghuber, D. ; Wortmann, S.

Genotypic and phenotypic spectrum of infantile liver failure due to pathogenic TRMU variants.

2022 Scientific Article in Journal of Neurology

Krenn, M. ; Sener, M. ; Rath, J. ; Zulehner, G. ; Keritam, O. ; Wagner, M. ; Laccone, F. ; Iglseder, S. ; Marte, S. ; Baumgartner, M. ; Eisenkölbl, A. ; Liechtenstein, C. ; Rudnik, S. ; Quasthoff, S. ; Grinzinger, S. ; Spenger, J. ; Wortmann, S.B. ; Löscher, W.N. ; Zimprich, F. ; Kellersmann, A. ; Rappold, M. ; Bernert, G. ; Freilinger, M. ; Cetin, H.

The clinical and molecular landscape of congenital myasthenic syndromes in Austria: A nationwide study.