Computational Health Center Institute of Neurogenomics
We study the genomic basis of neurological diseases in order to pave the way to a healthier life.
We study the genomic basis of neurological diseases in order to pave the way to a healthier life.
Our Mission
Our overall goal is to identify the genomic basis of neurological diseases in order to improve the diagnosis of our patients and provide tailored personalized treatment. We seek to understand the genomic architecture of complex inherited diseases and to study the underlying molecular mechanisms that burden patients with an increased susceptibility. Understanding predisposition allows us to model how environmental factors coalesce to amplify disease manifestation. This knowledge helps us to formulate precise treatments for our patients, taking into consideration their genetic makeup as well as “multi-omic” information. Ultimately, we want to combat disease by predicting susceptibility at an early stage and then preventing the onset.
Our approach is to combine clinical insight gleaned from our patients with high-throughput “omics” analysis such as array-based genotyping, next generation sequencing, and analysis of the proteome, transcriptome and other omics layers. We then investigate the functional relevance of identified markers using cellular and animal models.
We partner with specialized outpatient clinics at the Klinikum rechts der Isar of the Technische Universität München and specialized hospitals in order to learn the needs of our patients. Moreover, with respect for patients and their family’s cooperative spirit, we can transfer the knowledge we gain directly back into the clinic for prevention, self-observation and treatment.
People at ING
People at ING
Publications
Read more2025 Scientific Article in Kidney international reports
Trio exome sequencing in VACTERL association.
2024 Scientific Article in Cardiovascular Research
Meis transcription factors regulate cardiac conduction system development and adult function.
2024 Scientific Article in Communications Medicine
Interpretable multimodal machine learning (IMML) framework reveals pathological signatures of distal sensorimotor polyneuropathy.
2024 Letter to the Editor in Brain communications
Are there two disjunct episignatures for KMT2B-related disease?
2024 Scientific Article in Communications Biology
Novel loci and biomedical consequences of iron homoeostasis variation.
2024 Scientific Article in JAMA Pediatrics
Clinical actionability of genetic findings in cerebral palsy: A systematic review and meta-analysis.
2024 Scientific Article in Hepatology communications
Missense variants in the TRPMr7 α-kinase domain are associated with recurrent pediatric acute liver failure.
2024 Scientific Article in Scientific Reports
RLS-associated MEIS transcription factors control distinct processes in human neural stem cells.
2024 Letter to the Editor in Movement Disorders
Reply to: "Clinical and molecular profiling in GNAO1 permits phenotype-genotype correlation".
2024 Scientific Article in European Journal of Human Genetics
WDR45-related encephalopathy mimicking Leigh syndrome associated with complex I deficiency: A case report.
2024 Scientific Article in JIMD Reports
Expanding the genetic and clinical spectrum of SLC25A42-associated disorders and testing of pantothenic acid to improve CoA level in vitro.
2024 Scientific Article in Movement Disorders
Genome aggregation database version 4-allele frequency changes and impact on variant interpretation in dystonia.
2024 Scientific Article in Clinical Genetics