Computational Health Center Institute of Neurogenomics
We study the genomic basis of neurological diseases in order to pave the way to a healthier life.
We study the genomic basis of neurological diseases in order to pave the way to a healthier life.
Our Mission
Our overall goal is to identify the genomic basis of neurological diseases in order to improve the diagnosis of our patients and provide tailored personalized treatment. We seek to understand the genomic architecture of complex inherited diseases and to study the underlying molecular mechanisms that burden patients with an increased susceptibility. Understanding predisposition allows us to model how environmental factors coalesce to amplify disease manifestation. This knowledge helps us to formulate precise treatments for our patients, taking into consideration their genetic makeup as well as “multi-omic” information. Ultimately, we want to combat disease by predicting susceptibility at an early stage and then preventing the onset.
Our approach is to combine clinical insight gleaned from our patients with high-throughput “omics” analysis such as array-based genotyping, next generation sequencing, and analysis of the proteome, transcriptome and other omics layers. We then investigate the functional relevance of identified markers using cellular and animal models.
We partner with specialized outpatient clinics at the Klinikum rechts der Isar of the Technische Universität München and specialized hospitals in order to learn the needs of our patients. Moreover, with respect for patients and their family’s cooperative spirit, we can transfer the knowledge we gain directly back into the clinic for prevention, self-observation and treatment.
Publications
Read more2022 Scientific Article in European Journal of Nutrition
Pooled analysis of epigenome-wide association studies of food consumption in KORA, TwinsUK and LLS.
2022 Scientific Article in Journal of Molecular Neuroscience : JMN Online
Whole-exome sequencing study of consanguineous Parkinson's disease families and related phenotypes: Report of Twelve novel variants.
2022 Scientific Article in Translational Psychiatry
Hypothesis-driven genome-wide association studies provide novel insights into genetics of reading disabilities.
2022 Scientific Article in Frontiers in cell and developmental biology
Somatic mosaicism in STAG2-associated cohesinopathies: Expansion of the genotypic and phenotypic spectrum.
2022 Scientific Article in International Journal of Molecular Sciences
TREML2 gene expression and its missense variant rs3747742 associate with white matter hyperintensity volume and Alzheimer's disease-related brain atrophy in the general population.
2022 Editorial in Movement Disorders
Nuclear pore complex dysfunction in dystonia pathogenesis: Nucleoporins in the spotlight.
2022 Scientific Article in Movement Disorders
Confirmation of a causal role for SHQ1 variants in early infantile-onset recessive dystonia.
2022 Scientific Article in Brain Pathology
Leigh syndrome is the main clinical characteristic of PTCD3 deficiency.
2022 Letter to the Editor in Movement Disorders