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Dr. Sophie Dobiasch

Junior Group Leader Personalized Radiooncology, Institute of Radiation Medicine (IRM)

Dr. Sophie Dobiasch

Junior Group Leader Personalized Radiooncology, Institute of Radiation Medicine (IRM)

Career

In August 2015, she started a career as a clinician scientist at the Department of Radiation Oncology, Klinikum rechts der Isar. Through various research funding programs, she established the basis of her research focus “Personalized RadioOncology of pancreatic cancer”, and set up a junior research group.

Thematically and methodologically, she could build on her experimental thesis in the field of targeted nanoparticles for improved imaging and therapy in pancreatic cancer at the European Pancreatic Cancer Center Heidelberg.

As a clinician scientist, she aims to combine clinical activities and scientific projects, develop novel ideas and concepts, and work on translation from the lab to the clinic, as well as clinical questions from the clinic in the lab. With these translational approaches, she is closely involved in SFB 1321, the German Consortium for Translational Cancer Research (DKTK), and the working group young DEGRO of the society of radiation oncology.

In addition, her profile is completed by intercultural competencies from several stays abroad in Japan, Great Britain, India, and Nepal.

Her research focuses on mechanisms of radioresistance of pancreatic cancer. The treatment of pancreatic cancer, one of the most aggressive and lethal human tumors, is still an unsolved health problem. The poor survival can be attributed to a high genetic heterogeneity leading to therapeutic resistance. Therefore, individualized high-precision radiation concepts in combination with cytotoxic agents, targeted therapies, or herbal substances are new therapeutic approaches for pancreatic cancer.

The major goal of the research is to overcome the radioresistance of pancreatic cancer and thereby pave the way to novel effective treatments and improve the clinical outcome of patients with pancreatic cancer.

 

Skills and Expertise

Pancreatic Cancer  Tumor Mouse Models  Translational Research  Small Animal Imaging     Small Animal High-Precision Irradiation 

Professional Career

2018

Junior Group Leader

Institute of Radiation Medicine (IRM), Helmholtz Munich

Since 2015

Clinician Scientist

Department of Radiation Oncology, Klinikum rechts der Isar, Technical University Munich (TUM)

Since 2015

Medical doctor (MD)

European Pancreatic Cancer Center Heidelberg, Heidelberg University Hospital

2008-2015

Medical School

Ruprecht-Karls University Heidelberg

Honors and Awards

2018
Research grant, Helmholtz Munich
2018
Research grant, Hans und Klementia Langmatz Stiftung
2018
Award for 2nd best young investigator talk, 4th Conference on Small Animal Precision Image-Guided Radiotherapy
2016
Research grant, Medical Faculty of the Technical University of Munich, KKF

Most important publications

2022 Nature Methods

Giansanti P, Samaras P, Bian Y, Meng C, Coluccio A, Frejno M, Jakubowsky H, Dobiasch S, Hazarika R, Rechenberger J, Calzada-Wack J, Krumm J, Mueller S, Lee C, Wimberger N, Lautenbacher L, Hassan Z, Chang Y, Falcomatà C, Bayer F, Baerthel S, Schmidt T, Rad R, Combs S, The M, Johannes F, Saur D, Hrabe de Angelis M, Wilhelm M, Schneider G, Kuster B.

Mass spectrometry-based draft of the mouse proteome.

Private thoughts

My key vision is to improve the outcome of patients with pancreatic cancer. Within a framework of translational research, novel preclinical approaches target radioresistance by innovative irradiation concepts and combination treatments.

My key vision is to improve the outcome of patients with pancreatic cancer. Within a framework of translational research, novel preclinical approaches target radioresistance by innovative irradiation concepts and combination treatments.

Networks and Affiliations

Logo DKTK Deutsches Konsortium für Translationale Krebsforschung

DKTK German Cancer Consortium

Logo Technische Universität München

Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University Munich (TUM)

Logo Technische Universität München

Institute for Pathology, Technical University Munich (TUM)

Logo Technische Universität München

Proteomics and Bioanalytic, Technical University Munich (TUM)

European Pancreas Center, Heidelberg University Hospital

Translational Cancer Research, University Medical Center Göttingen