ISF Institute of Stem Cell Research
The ISF investigates the basic molecular and cellular mechanisms for stem cell maintenance and stem cell differentiation. On this basis, the ISF develops approaches for the replacement of degenerated cell types, either by activation of endogenous stem cells or by re-programming other endogenous cells for repair.
The ISF investigates the basic molecular and cellular mechanisms for stem cell maintenance and stem cell differentiation. On this basis, the ISF develops approaches for the replacement of degenerated cell types, either by activation of endogenous stem cells or by re-programming other endogenous cells for repair.
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Our Publications
2024 Nat Neurosci. 2024 Jul 2.
2024 Neuron 112:1117-1132.e9
2024 Nature Communication 15(1):2866
2024 Genes and Development 38: 98-114
Pancellular organelles and sub-organelles – from common functions to cellular diversity.
2024 Journal of Biological Chemistry, 300(2):105648
Ribosome inactivation regulates translation elongation in neurons.
2023 Nature Medicine 29, 3149-3161
Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain.
2022 Scientific Article in Molecular Systems Biology
Probing cell identity hierarchies by fate titration and collision during direct reprogramming.
2022 Scientific Article in Science
Spatial centrosome proteome of human neural cells uncovers disease-relevant heterogeneity.
2022 Scientific Article in Science Advances
Excessive local host-graft connectivity in aging and amyloid-loaded brain.
2022 Scientific Article in Science Advances
Brain injury environment critically influences the connectivity of transplanted neurons.
2022 Review in Trends in Cell Biology
Centrosome heterogeneity in stem cells regulates cell diversity.
2022 Scientific Article in Cells
Innate immune pathways promote oligodendrocyte progenitor cell recruitment to the injury site in adult Zebrafish brain.
2022 Scientific Article in EMBO Molecular Medicine
Parkinson's disease motor symptoms rescue by CRISPRa-reprogramming astrocytes into GABAergic neurons.
2022 Scientific Article in Advanced science
Molecular signature of astrocytes for gene delivery by the synthetic adeno-associated viral vector rAAV9P1.
2022 Scientific Article in Cellular and Molecular Life Sciences - CMLS
The extracellular matrix molecule tenascin-C modulates cell cycle progression and motility of adult neural stem/progenitor cells from the subependymal zone.
2022 Review in Neuron
Direct neuronal reprogramming: Fast forward from new concepts toward therapeutic approaches.
2021 Scientific Article in Frontiers in cell and developmental biology