Wang-Sattler Group

We aim to improve personalized healthcare by integrating OMICs data using statistical, bioinformatical and machine learning approaches.

Scientific Focus

The Wang-Sattler group is studying metabolic diseases (e.g. type 2 diabetes and cardiovascular diseases). We use statistical, bioinformatical and machine learning approaches to integrate metabolomics, transcriptomics, epigenomics, genomics data, and information from public databases to better understand the pathophysiological mechanisms. This helps us to identify candidate biomarkers and drug targets, with the final goal to translate our discoveries into clinical practice.

The Wang-Sattler Group

See all

2024 Int J Biol Macromol

Makoto Harada, Siyu Han, Mengya Shi, Jianhong Ge, Shixiang Yu, Jonathan Adam, Jerzy Adamski, Markus F Scheerer, Susanne Neschen, Martin Hrabe de Angelis, Rui Wang-Sattler

Metabolic effects of SGLT2i and metformin on 3-hydroxybutyric acid and lactate in db/db mice

2024 Cardiovasc Diabetol

Makoto Harada, Jonathan Adam, Marcela Covic, Jianhong Ge, Stefan Brandmaier, Caroline Muschet, Jialing Huang, Siyu Han, Martina Rommel, Markus Rotter, Margit Heier, Robert P Mohney, Jan Krumsiek, Gabi Kastenmüller, Wolfgang Rathmann, Zhongmei Zou, Sven Zukunft, Markus F Scheerer, Susanne Neschen, Jerzy Adamski, Christian Gieger, Annette Peters, Donna P Ankerst, Thomas Meitinger, Tanya L Alderete, Martin Hrabe de Angelis, Karsten Suhre, Rui Wang-Sattler

Bidirectional modulation of TCA cycle metabolites and anaplerosis by metformin and its combination with SGLT2i

2024 Metabolites

Shixiang Yu, Siyu Han, Mengya Shi, Makoto Harada, Jianhong Ge, Xuening Li, Xiang Cai, Margit Heier, Gabi Karstenmüller, Karsten Suhre, Christian Gieger, Wolfgang Koenig, Wolfgang Rathmann, Annette Peters, Rui Wang-Sattler

Prediction of Myocardial Infarction Using a Combined Generative Adversarial Network Model and Feature-Enhanced Loss Function

2023 Cardiovasc Diabetol

Mengya Shi, Siyu Han, Kristin Klier, Gisela Fobo, Corinna Montrone, Shixiang Yu, Makoto Harada, Ann-Kristin Henning, Nele Friedrich, Martin Bahls, Marcus Dörr, Matthias Nauck, Henry Völzke, Georg Homuth, Hans J Grabe, Cornelia Prehn, Jerzy Adamski, Karsten Suhre, Wolfgang Rathmann, Andreas Ruepp, Johannes Hertel, Annette Peters, Rui Wang-Sattler

Identification of candidate metabolite biomarkers for metabolic syndrome and its five components in population-based human cohorts

2022 Brief Bioinform

Siyu Han, Jialing Huang, Francesco Foppiano, Cornelia Prehn, Jerzy Adamski, Karsten Suhre, Ying Li, Giuseppe Matullo, Freimut Schliess, Christian Gieger, Annette Peters, Rui Wang-Sattler

TIGER: technical variation elimination for metabolomics data using ensemble learning architecture

2020 Diabetes

Jialing Huang, Cornelia Huth, Marcela Covic, Martina Troll, Jonathan Adam, Sven Zukunft, Cornelia Prehn, Li Wang, Jana Nano, Markus F Scheerer, Susanne Neschen, Gabi Kastenmüller, Karsten Suhre, Michael Laxy, Freimut Schliess, Christian Gieger, Jerzy Adamski, Martin Hrabe de Angelis, Annette Peters, Rui Wang-Sattler

Machine Learning Approaches Reveal Metabolic Signatures of Incident Chronic Kidney Disease in Individuals With Prediabetes and Type 2 Diabetes

2015 Diabetes Care

Tao Xu, Stefan Brandmaier, Ana C Messias, Christian Herder, Harmen H M Draisma, Ayse Demirkan, Zhonghao Yu, Janina S Ried , Toomas Haller, Margit Heier, Monica Campillos, Gisela Fobo, Renee Stark, Christina Holzapfel, Jonathan Adam, Shen Chi, Markus Rotter, Tommaso Panni, Anne S Quante, Ying He, Cornelia Prehn, Werner Roemisch-Margl, Gabi Kastenmüller, Gonneke Willemsen, René Pool, Katarina Kasa, Ko Willems van Dijk, Thomas Hankemeier, Christa Meisinger, Barbara Thorand, Andreas Ruepp, Martin Hrabé de Angelis, Yixue Li, H-Erich Wichmann, Bernd Stratmann, Konstantin Strauch, Andres Metspalu, Christian Gieger, Karsten Suhre, Jerzy Adamski, Thomas Illig, Wolfgang Rathmann, Michael Roden, Annette Peters, Cornelia M van Duijn, Dorret I Boomsma, Thomas Meitinger, Rui Wang-Sattler

Effects of metformin on metabolite profiles and LDL cholesterol in patients with type 2 diabetes

2012 Mol Syst Biol

Rui Wang-Sattler, Zhonghao Yu, Christian Herder, Ana C Messias, Anna Floegel, Ying He, Katharina Heim, Monica Campillos, Christina Holzapfel, Barbara Thorand, Harald Grallert, Tao Xu, Erik Bader, Cornelia Huth, Kirstin Mittelstrass, Angela Döring, Christa Meisinger, Christian Gieger, Cornelia Prehn, Werner Roemisch-Margl, Maren Carstensen, Lu Xie, Hisami Yamanaka-Okumura, Guihong Xing, Uta Ceglarek, Joachim Thiery, Guido Giani, Heiko Lickert, Xu Lin, Yixue Li, Heiner Boeing, Hans-Georg Joost, Martin Hrabé de Angelis, Wolfgang Rathmann, Karsten Suhre, Holger Prokisch, Annette Peters, Thomas Meitinger, Michael Roden, H-Erich Wichmann, Tobias Pischon, Jerzy Adamski, Thomas Illig

Novel biomarkers for pre-diabetes identified by metabolomics

2009 Science

Stephanie A Blandin, Rui Wang-Sattler, Marina Lamacchia, Julien Gagneur, Gareth Lycett, Ye Ning, Elena A Levashina, Lars M Steinmetz

Dissecting the genetic basis of resistance to malaria parasites in Anopheles gambiae

2005 Immunity

Luís F Moita, Rui Wang-Sattler, Kristin Michel, Timo Zimmermann, Stephanie Blandin, Elena A Levashina, Fotis C Kafatos

In vivo identification of novel regulators and conserved pathways of phagocytosis in A. gambiae

2001 Proc Natl Acad Sci U S A

R Wang, L Zheng, Y T Touré, T Dandekar, F C Kafatos

When genetic distance matters: measuring genetic differentiation at microsatellite loci in whole-genome scans of recent and incipient mosquito species