January 24, 2023 Group Signaling and Immunity publishes manuscript in Frontier in Immunology on the tight crosstalk of TRAF6 and MALT1 in T cells.www.frontiersin.org/articles/10.3389/fimmu.2023.1111398/fullread more
Molecular Targets and Therapeutics, January 18, 2023 New Research Unit Signaling & Translation (SAT) establishedOn January 1, 2023, the new independent research unit 'Signaling & Translation' (SAT) was established at Helmholtz Munich (Neuherberg campus) under the leadership of Prof. Dr. Daniel Krappmann. As part of the 'Molecular Targets and Therapeutics…read more
January 01, 2023 Research Unit Signaling & Translation (SAT) establishedwww.helmholtz-munich.de/en/sat read more
New Research Findings, VIRO, December 22, 2022 Unraveling key determinant of successful therapeutic vaccination against chronic hepatitis B Hepatitis B virus (HBV) infections remain a major global health problem – according to the World Health Organization (WHO) there are around 300 million HBV carriers worldwide. Current treatments rarely succeed in curing the infection. At present,…read more
IES, IFE, December 19, 2022 The use of embryo models to study development - a perspectiveIn the perspective article "In preprints: improving and interrogating embryo models", Antonio Scialdone from the Institute for Epigenetics and Stem Cells, the Institute of Functional Epigenetics, and the Institute of Computational Biology at…read more
Awards & Grants, MCD, December 09, 2022 Marcus Conrad as a new member of the Hinterzarten Circle of the DFG on Cancer ResearchThe Review Board for Medicine of the Deutsche Forschungsgemeinschaft (DFG) has appointed Helmholtz Munich scientist Dr. Marcus Conrad as a new member of the DFG’s Hinterzarten Circle on Cancer Research. Marcus Conrad succeeds Prof. Greten from…read more
MCD, November 28, 2022 "Highly Cited Researchers" 2022 Marcus Conrad is listed as one of the most influential scientists for the third year in a rowread more
IFE, November 16, 2022 Sharing = Caring? – Asymmetric RNA Segregation depends on the replicative age of cellsWhen a cell divides, the correct distribution of cellular content, such as RNAs, to daughter cells is essential. By tagging RNAs with the new diSpinach aptamer in combination with a self-made microfluidics device, researchers at the Institute of…read more
Featured Publication, VIRO, October 27, 2022 Development of a thermostable therapeutic vaccine to combat chronic hepatitis BMore than three percent of the world’s population (around 300 million people) are living with a chronic hepatitis B virus (HBV) infection. Having chronic hepatitis B increases the risk for patients to develop liver failure, liver cancer or cirrhosis…read more
IFE, October 13, 2022 Summer Intern Ecaterina Radzichevici contributes to publication about the structural maintenance of chromosomeSince 2016, the annual Summer Internship Program in Epigenetics, Stem Cells, and Artificial Intelligence gives international students the opportunity to work alongside world-leading scientists on original research. Under the supervision of Kurt…read more
Featured Publication, ZYTO, October 11, 2022 AI-based explainable classification of disease subtypes Helmholtz Munich researcher Kristian Unger, head of Translational Bioinformatics at the Department of Radiation Cytogenetics (ZYTO), together with scientists from the LMU Radiation Clinic and the LMU Medical Physics, has developed the AI method…read more
New Research Findings, INET, October 10, 2022 Landscape of molecular contacts: How the coronavirus SARS-CoV-2 communicates with human cellsWhat exactly are the molecular interactions between the virus causing COVID-19 and its human host? How might our genetic differences cause different disease courses? And how do still-emerging virus variants differ in their host-virus interactions? To…read more
Featured Publication, ZYTO, October 05, 2022 Five genes enable prediction of survival in head and neck tumorsSurface molecules EGFR and Integrin beta 4 play a key role in this process Frequently, cancer patients do not die because of their “initial tumor” in a specific organ. Only when individual cells of the primary tumor transform, migrate or colonize…read more
Molecular Targets and Therapeutics, AZS, TOXI, September 30, 2022 Institute News September 2022Relaunch of our new TOXI Webpageread more
VIRO, September 22, 2022 Helmholtz Munich presented preclinical data portending PH-762 to enhance persistence of T cells for tumor cell killing At the 9th Immunotherapy of Cancer Conference (ITOC), held September 22 to 24, 2022 in Munich, Helmholtz Munich presented preclinical data showing that PH-762, an INTASYL compound targeting PD-1, increases the frequency of a T cell population…read more
IFE, August 08, 2022 Cell-ACDC – For those about to analyze microscopy imagesEven though deep learning has led to improvements, the downstream analysis of live-cell microscopy images remains a bottleneck. Recently, researchers from the Institute of Functional Epigenetics published their open-source and user-friendly software…read more
New Research Findings, MCD, August 03, 2022 Vitamin K Prevents Cell Death: A New Function for a Long-Known MoleculeA team of researchers located at Helmholtz Munich reports on a novel function of vitamin K, which is generally known for its importance in blood clotting. The researchers discovered that the fully reduced form of vitamin K acts as an antioxidant…read more
IFE, July 28, 2022 A beginner’s guide to catching the readers – Till Bartke publishes protocols to identify modification-specific nucleosome interactorsAs part of the book series ‘Methods in Molecular Biology’, Springer Nature has released the methods and protocols collection ‘Histone Methyltransferases’. The chapter contributed by Till Bartke and colleagues from the Institute of Functional…read more
New Research Findings, Molecular Targets and Therapeutics, AMIR, July 25, 2022 How Tiny Changes Help T Cells to SurviveResearchers gain a fundamental insight for epitranscriptomics and immune response. The research group around Vigo Heissmeyer and Taku Ito-Kureha of Helmholtz Munich and Ludwig-Maximilians-Universität München has revealed the essential function of m6A…read more
Awards & Grants, Environmental Health, LHI, Molecular Targets and Therapeutics, MCD, July 22, 2022 FERROPath Consortium: Helmholtz Munich Researchers Receive BMBF Research FundingThe German Federal Ministry of Education and Research (BMBF) is funding research of new treatment strategies for preventing tissue ischemia-reperfusion injury (IRI) as part of the FERROPath consortium. Starting in July 2022, the consortium receives…read more
Awards & Grants, Molecular Targets and Therapeutics, VIRO, July 14, 2022 Preventing the Next Pandemic: EU Funds Research Infrastructure in the Munich AreaThe EU grant “PerForM-REACT” supports an infrastructure in the greater Munich area for pandemic management and prevention. Helmholtz Munich will receive new equipment for a biosafety level 3 laboratory where researchers can conduct important studies…read more
IFE, July 06, 2022 FASEB Biological Methylation Conference: bringing basic biochemical findings to therapy organized by R. SchneiderExperts from academia and the pharmaceutical industry came together at “The Biological Methylation Conference: Fundamental Mechanism in Human Health and Disease” in Catania to share new exciting results about protein and RNA methylations as well as…read more
Molecular Targets and Therapeutics, STB, June 27, 2022 Hope in the Fight Against ParasitesEvery year, millions of people fall ill with Chagas or sleeping sickness. Both diseases are caused by parasites that are spreading from tropical countries to Europe. Researchers have discovered a weak spot in those parasites, which may be a key to a…read more
Molecular Targets and Therapeutics, MCD, May 05, 2022 EMBO WorkshopFERROPTOSIS: When metabolism meets cell death23. - 27. April 2023 in Seeon, GermanyRegistration read more
Stem Cells, IES, IFE, April 09, 2022 What stands behind the message sent by histone PTMs?Over the last 60 years, research has shed light on histone PTMs and their role in all DNA-templated processes. In the last decade, novel methodologies, such as genome-wide sequencing approaches, have paved the way toward understanding how their…read more
Stem Cells, IES, IFE, April 08, 2022 Communication is the key, also between cells.Just as we use Google Maps, cells rely on gradient sensing of signal molecules to reach their destination. However, in their case, the destination is the source of the attractant and not the restaurant of choice. Using mathematical models,…read more
Stem Cells, IES, IFE, March 22, 2022 Always follow your nose – On the trail of the anatomical logic of smellThe sense of smell is essential for almost all animals. It helps find food, detect dangers, and distinguish between friends and enemies. As the saying goes: You really get up my nose. Research carried out at Helmholtz Munich has shown that…read more
IFE, March 14, 2022 Epigenetic regulator promotes immunopathogenesis in COPDArticle in Nature Communications: Reduction of PRMT7 protein could stop tissue damageread more
Stem Cells, IES, IFE, February 02, 2022 Summer School on Chromatin Biology: A hands-on expeditionWe are delighted to announce the launch of the "1st Helmholtz Summer School on Chromatin Biology: A hands-on expedition", which will take place at the Neuherberg Campus of Helmholtz Munich, from August 15-26, 2022.read more
New Research Findings, Molecular Targets and Therapeutics, VIRO, February 01, 2022 COVID-19: Breakthrough Infection Can Substitute for a Third Vaccine ShotAccording to a new study led by Ulrike Protzer, a breakthrough infection after two vaccinations achieves the same protective effect as an additional booster vaccination. According to the study by Helmholtz Munich, LMU and TUM, the decisive factor for…read more
ZYTO, January 19, 2022 Tumor Relapse in Head and Neck show molecular Dynamics and HeterogeneityTherapy-resistant head and neck tumors and their relapses exhibit molecular profiles that, as now discovered, indicate marked tumor heterogeneity and molecular dynamics within one patient. The composition of tumor subpopulations influenced by therapy…read more
New Research Findings, VIRO, December 17, 2021 A Medication Against SARS-CoV-2: New Strategy Also Promises Protection Against Future Virus VariantsVaccines against the SARS-CoV-2 virus have been made possible by an unprecedented worldwide partnership. However, medications against Covid-19 have yet seen only partial success. With the support of the Bavarian Research Foundation, a Munich research…read more
New Research Findings, IES, ICB, IFE, November 24, 2021 Scientists Open the Black Box of the Milestone Stage of Human Embryonic Development for the First TimeFor the first time, scientists based at Helmholtz Munich and the University of Oxford were able to shed light on one of the most critical stages of human embryonic development (gastrulation). The finding, published in the journal Nature, will…read more
Stem Cells, IES, IFE, November 18, 2021 A milestone for developmental biology - Scientists publish the first single-transcriptome of a human gastrulation embryo (Kopie 1)For the first time, scientists based at Helmholtz Zentrum München and the University of Oxford were able to shed light on one of the most critical stages of human embryonic development (gastrulation). Their findings will drive future studies to…read more
ZYTO, October 25, 2021 Method for determining clonogenic growth in vitro extendedHorst Zitzelsberger and Daniel Samaga from the Research Unit Radiation Cytogenetics, together with researchers from the LMU Hospital and the former Clinical Cooperation Group "Personalized Radiotherapy in Head and Neck Tumors", succeeded in renewing…read more
Transfer, New Research Findings, VIRO, September 27, 2021 Bioengineering Meets Hepatitis B: Researchers Design Promising Novel Therapeutic CandidatesResearchers have designed antibodies as novel therapeutic candidates for the treatment of chronic hepatitis B and hepatocellular carcinoma. Their study in human cell cultures and in living mice showed the elimination of antigen-positive cells and…read more
New Research Findings, VIRO, July 30, 2021 Mix-and-match Vaccine Against COVID-19 Tested: Immune Response Stronger Than After Two Doses of Astrazeneca VaccineFor safety reasons, the Standing Committee on Vaccination (STIKO) in Germany recommends that anyone under the age of 60 who initially received a vaccine from AstraZeneca should be given an mRNA vaccine at their second appointment. Up until now, there…read more
IFE, July 21, 2021 The prestigious Academia Europeae has elected our Institute Director as memberAfter a rigorous peer review process, the board of trustees of Academia Europeae, the pan-European academy of science, humanities and letters, has elected our Epigenetics expert Prof. Robert Schneider and the Stem Cell expert Prof. Maria-Elena…read more
Stem Cells, IES, IFE, July 21, 2021 Mitochondrial defects characterize 'loser' cells in cell competitionThe work of the Scialdone Lab at the Helmholtz Zentrum München and the Rodriguez at the Imperial College elucidates that differences in mitochondrial activity are key determinants for cellular fitness in various contexts, where endogenous cell…read more
New Research Findings, IES, ICB, IFE, July 20, 2021 Revealing the Secrets of Cell Competition Cellular competition is a crucial quality control process that ensures that the development of an organism relies on healthy cells. Researchers revealed the secrets underlying cell competition and what features can pre-determine whether a cell will…read more
Awards & Grants, Stem Cells, IES, IFE, July 20, 2021 The Prestigious Academia Europeae Has Elected Two Helmholtz Munich Researchers as MembersAfter a rigorous peer review process, the board of trustees of Academia Europeae, the pan-European academy of science, humanities and letters, has elected the Stem Cell expert Maria-Elena Torres-Padilla as well as the Epigenetics expert Robert…read more
New Research Findings, VIRO, May 21, 2021 The viruses in our genes: When activated, they damage brain developmentResearchers have been able to prove for the first time that activation of distinct human endogenous retroviruses, which are part of our genome, impair brain development dramatically. This finding could help to advance research into therapies for…read more
Transfer, New Research Findings, TOXI, April 27, 2021 First-in-class Cancer Immunotherapy Drug in Clinical TrialA small molecule has entered a novel clinical trial for cancer immunotherapy. The molecule inhibits an enzyme called MALT1 that plays a critical role in suppressing immune reactions against tumor cells. Preclinical studies showed that blocking MALT1…read more
Transfer, Awards & Grants, Molecular Targets and Therapeutics, STB, October 12, 2020 Helmholtz Zentrum München Is the Recipient of the 2020 Erwin Schrödinger PrizeResearchers at Helmholtz Zentrum München and the University of Bochum received this year's Erwin Schrödinger Prize in recognition of their efforts to develop a cure for parasitic diseases such as Chagas disease with a new compound. The prize is…read more
Awards & Grants, STB, August 24, 2020 Artificial Intelligence (AI) And Machine Learning Are Revolutionizing the Way New Drugs Are DesignedHelmholtz Zentrum München is coordinating a European network to train the next generation of researchers in drug development.read more
New Research Findings, INET, July 01, 2020 To listen is to survive: Unravelling how plants process informationResearchers at Helmholtz Zentrum München and Ludwig-Maximilians-University (LMU) mapped the signaling network in plants and discovered novel insights about how plants process information about their environment. This gives new potential to strategies…read more
Awards & Grants, Stem Cells, ISF, MCD, April 02, 2020 Spotlight for ERC Advanced Grant awardees Magdalena Götz and Marcus ConradWanted: Established, leading principal investigator with a track-record of significant research achievements in the last 10 years. Found: At Helmholtz Zentrum München. Magdalena Götz and Marcus Conrad both receive an ERC Advanced Grant for their…read more
New Research Findings, VIRO, March 05, 2020 Improving human health with phage-based therapeuticsGut bacteria are central to human health. They are a key player in contributing to immune regulation, pathogen protection, food and drug metabolism, and vitamin synthesis. Another supporting actor in the gut, however, are bacteriophages or short…read more
Transfer, New Research Findings, VIRO, February 03, 2020 Hepatitis B: New Therapeutic Approach May Help to Cure Chronic Hepatitis B InfectionResearchers at Helmholtz Zentrum München, Technical University of Munich (TUM) and the German Center for Infection Research (DZIF) have developed a novel therapeutic approach to cure chronic hepatitis B. The scientists found that the large amount of…read more