Dr. Michael Sterr
Group Leader Single-Cell Genomics UnitDr. Michael Sterr
Group leader Single-Cell Genomics, Institute of Diabetes and Regeneration Research (IDR)
“By using single-cell genomics, we can increase our understanding of the developmental programs that govern the formation of pancreatic and intestinal endocrine cells to improve diabetes therapy”
Dr. Michael Sterr
Group leader Single-Cell Genomics, Institute of Diabetes and Regeneration Research (IDR)
“By using single-cell genomics, we can increase our understanding of the developmental programs that govern the formation of pancreatic and intestinal endocrine cells to improve diabetes therapy”
Research focus and Academic Career
Michael studied Bioengineering and Biology in Munich.
In 2013 he joined the Lab of Heiko Lickert for his PhD, where he studied the epigenetics of the endocrine cell fate decision in both pancreas and intestine.
During his postdoc time, he focused on single-cell genomics techniques and data analysis to dissect the dynamics of endocrine differentiation.
Since 2021, he leads the Single-Cell Genomics Group at the Institute of Diabetes and Regeneration Research.
Single-cell based methods are key technologies to uncover the cellular complexity of biological systems, and allow the characterization different cell types and cellular states, as well as the reconstruction developmental trajectories. Leveraging single-cell transcriptomic and epigenomic analyses, Michael aims to provide insight into the molecular mechanisms guiding the endocrine lineage decision and the specification of different endocrine cell types.
Professional Career
Head of the group Single Cell Analysis
Helmholtz Zentrum München, Institute of Diabetes and Regeneration Research, Neuherberg, Germany
Postdoc
Helmholtz Zentrum München, Institute of Diabetes and Regeneration Research, Neuherberg, Germany
PhD Student
Helmholtz Zentrum München, Institute of Diabetes and Regeneration Research, Prof. Dr. Heiko Lickert. Project: “Transcriptional Regulation of Endocrine Cell Formation and Function in Pancreas and Intestine”
Most important publications
PubMed2022 Glia 70( 11), 2062– 2078
Diet triggers specific responses of hypothalamic astrocytes in time and region dependent manner
2022 Diabetes 71 (9): 1962–1978
Heterogeneous Development of β-Cell Populations in Diabetes-Resistant and -Susceptible Mice
2022 Clin Cancer Res 1;28(5):1038-1052
Therapy-Related Transcriptional Subtypes in Matched Primary and Recurrent Head and Neck Cancer
2021 Int J Mol Sci 20;22(22):12526
Synaptotagmin-13 Is a Neuroendocrine Marker in Brain, Intestine and Pancreas
2021 Nature Metabolism 3, 1202–1216
2021 Nat Biomed Eng 5, 897–913
2021 Molecular Metabolism Sep 6;54:101330
Vertical sleeve gastrectomy triggers fast β-cell recovery upon overt diabetes
2021 Nature Cell Biology 23, 692–703
Epithelial cell plasticity drives endoderm formation during gastrulation
2021 Nature 590, 326–331
Inceptor counteracts insulin signalling in β -cells to control glycaemia
2021 Nature Cell Biology 23, 23–31