Publications 2024
Read more2024 Scientific Article in Science Signaling
Reciprocal regulation of mTORC1 signaling and ribosomal biosynthesis determines cell cycle progression in activated T cells.
2024 Scientific Article in PLoS Computational Biology
Quantitative modeling of signaling in aggressive B cell lymphoma unveils conserved core network.
2024 Scientific Article in European Journal of Immunology
A20 intrinsically influences human effector T-cell survival and function by regulating both NF-κB and JNK signaling.
2024 Scientific Article in Nature Communications
Suppression of ferroptosis by vitamin A or radical-trapping antioxidants is essential for neuronal development.
2024 Scientific Article in JACS Au
Screening privileged alkyl Guanidinium motifs under host-mimicking conditions reveals a novel antibiotic with an unconventional mode of action.
2024 Scientific Article in Frontiers in Immunology
Activation of the aryl hydrocarbon receptor improves allergen-specific immunotherapy of murine allergic airway inflammation: A novel adjuvant option?
2024 Scientific Article in Cell Death & Disease
Fatty acid-binding protein 5 is a functional biomarker and indicator of ferroptosis in cerebral hypoxia.
2024 Scientific Article in Molecular Cell
Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism.
Publications 2023
Read more2023 Scientific Article in Cancers
Non-oncogene addiction of KRAS-mutant cancers to IL-1β via versican and mononuclear IKKβ.
2023 Scientific Article in Journal of Immunotherapy and Precision Oncology
Translational studies using the MALT1 inhibitor (S)-mepazine to induce Treg fragility and potentiate immune checkpoint therapy in cancer.
2023 Scientific Article in Blood
Oncogene-induced MALT1 protease activity drives post-transcriptional gene expression in malignant lymphomas.
2023 Scientific Article in Frontiers in Immunology
TRAF6 controls T cell homeostasis by maintaining the equilibrium of MALT1 scaffolding and protease functions.
Publications 2022
Read more2022 Scientific Article in European Journal of Medicinal Chemistry
Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma.
2022 Scientific Article in Computational and Structural Biotechnology Journal
Unleashing high content screening in hit detection - Benchmarking AI workflows including novelty detection.
2022 Scientific Article in Journal of Experimental Medicine
Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing.
2022 Scientific Article in Scientific Reports
Small molecule mediated inhibition of protein cargo recognition by peroxisomal transport receptor PEX5 is toxic to Trypanosoma.
2022 Review in Journal for ImmunoTherapy of Cancer
Combining precision oncology and immunotherapy by targeting the MALT1 protease.
2022 Scientific Article in Bio-Protocol
Optimized CRISPR-Cas9-based strategy for complex gene targeting in murine embryonic stem cells for germline transmission.
2022 Scientific Article in Science Advances
Modulation of pre-mRNA structure by hnRNP proteins regulates alternative splicing of MALT1.
2022 Scientific Article in Current Protocols
Methods to detect small molecule inhibition of RING E3 ligase activity.
2022 Scientific Article in Science Signaling
Phosphorylation of serine-893 in CARD11 suppresses the formation and activity of the CARD11-BCL10-MALT1 complex in T and B cells.
2022 Scientific Article in ACS Chemical Biology
Machine learning classifies ferroptosis and apoptosis cell death modalities with TfR1 immunostaining.
2022 Scientific Article in JCI insight
Prdm6 controls heart development by regulating neural crest cell differentiation and migration.
2022 Scientific Article in Journal of Clinical Immunology
Expanding the clinical and immunological phenotypes and natural history of MALT1 deficiency.
2022 Scientific Article in Cellular and Molecular Life Sciences - CMLS
A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells.
2022 Scientific Article in Cell Chemical Biology
Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses.
2022 Scientific Article in Journal of the European Academy of Dermatology and Venereology
Microbial dysbiosis in a mouse model of atopic dermatitis mimics shifts in human microbiome and correlates with the key pro-inflammatory cytokines IL-4, IL-33 and TSLP.
2022 Editorial in Signal transduction and targeted therapy
Vaccination versus SARS-CoV-2 Omicron: Three vaccine doses win the battle.
2022 Nature Structural & Molecular Biology
Author Correction: Retinoic acid signaling is critical during the totipotency window in early mammalian development.
2022 Scientific Article in Advanced science
Molecular signature of astrocytes for gene delivery by the synthetic adeno-associated viral vector rAAV9P1.
2022 Scientific Article in American Journal of Respiratory Cell and Molecular Biology
High-content screen identifies cyclosporin A as a novel ABCA3-specific molecular corrector.
Publications 2021
Read more2021 Meeting abstract in Journal for ImmunoTherapy of Cancer
Reprogramming regulatory T cells (TREG) using a MALT1 inhibitor for cancer therapy.
2021 Scientific Article in Science Advances
Phenotypic drug screening in a human fibrosis model identified a novel class of antifibrotic therapeutics.
2021 Scientific Article in EMBO Molecular Medicine
KRAS signaling in malignant pleural mesothelioma.
2021 Scientific Article in Journal of Alzheimer's Disease
Inhalational anesthetics do not deteriorate amyloid-β-derived pathophysiology in alzheimer's disease: Investigations on the molecular, neuronal, and behavioral level.
2021 Scientific Article in Science immunology
TRAF6 prevents fatal inflammation by homeostatic suppression of MALT1 protease.
2021 Scientific Article in Molecular Informatics
Highly accurate filters to flag frequent hitters in alphascreen assays by suggesting their mechanism.
2021 Scientific Article in Cell Reports
Cilium induction triggers differentiation of glioma stem cells.
2021 Review in Expert Opinion on Therapeutic Patents
A patent review of MALT1 inhibitors (2013-present).
2021 Scientific Article in Nature Structural & Molecular Biology
Retinoic acid signaling is critical during the totipotency window in early mammalian development.
2021 Scientific Article in British Journal of Pharmacology
A drug screen with approved compounds identifies amlexanox as a novel Wnt/β-catenin activator inducing lung epithelial organoid formation.
2021 Scientific Article in FASEB Journal
Evolutionary and functional analyses demonstrate conserved ferroptosis protection by Arabidopsis GPXs in mammalian cells.
2021 Scientific Article in Cell Stem Cell
Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3.
2021 Scientific Article in Neuro-Oncology
Cannabidiol converts NFκB into a tumor suppressor in glioblastoma with defined antioxidative properties.
2021 Review in International Journal of Molecular Sciences
Origin and expansion of the serine protease repertoire in the myelomonocyte lineage.
2021 Scientific Article in Plants
Genome-wide analysis of MDHAR gene family in four cotton species provides insights into fiber development via regulating AsA redox homeostasis.
2021 Scientific Article in EMBO Molecular Medicine
Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism.
Publications 2020
Read more2020 Scientific Article in Nature Communications
Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly.
2020 Scientific Article in Frontiers in Pharmacology
Increased tumoral microenvironmental pH improves cytotoxic effect of pharmacologic ascorbic acid in castration-resistant prostate cancer cells.
2020 Scientific Article in Radiation Oncology
Transcriptome network of the papillary thyroid carcinoma radiation marker CLIP2.
2020 Scientific Article in Molecular Oncology
Nonsense-mediated decay factor SMG7 sensitizes cells to TNF alpha-induced apoptosis via CYLD tumor suppressor and the noncoding oncogenePvt1.
2020 Scientific Article in Nature Communications
Post-surgical adhesions are triggered by calcium-dependent membrane bridges between mesothelial surfaces.
2020 Scientific Article in Journal of Medicinal Chemistry
Use of non-natural amino acids for the design and synthesis of a selective, cell-permeable MALT1 activity-based probe.
2020 Scientific Article in mBio
Viral DNA binding protein SUMOylation promotes PML nuclear body localization next to viral replication centers.
2020 Scientific Article in Nature Communications
A central role of IKK2 and TPL2 in JNK activation and viral B-cell transformation.
2020 Scientific Article in Nature Communications
Human and mouse essentiality screens as a resource for disease gene discovery.
2020 Other: Opinion in Biochemistry
Ferroptosis suppressor protein 1 (FSP1) and coenzyme Q(10) cooperatively suppress ferroptosis.
2020 Scientific Article in Scientific Reports
Sox2 controls Schwann cell self-organization through fibronectin fibrillogenesis.
Publications 2019
Read more2019 Meeting abstract in Neuro-Oncology
RelA-activity is essential for cannabidiol-mediated cytotoxicity in an identified subset of glioblastoma.
2019 Scientific Article in Cell Reports
MALT1 phosphorylation controls activation of T lymphocytes and survival of ABC-DLBCL tumor cells.
2019 Scientific Article in Nature Communications
Regulation of the endosomal SNX27-retromer by OTULIN.
2019 Scientific Article in Journal of Cell Science
Mitochondrial Alkbh1 localizes to mtRNA granules and its knockdown induces the mitochondrial UPR in humans and C. elegans.
2019 Leukemia
S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells (vol 32, pg 214, 2018).
2019 Scientific Article in Nature Communications
Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells.
2019 Scientific Article in Nature Communications