Zitzelsberger

Head Research Unit Translational Metabolic Oncology

+49 89 3187 3421 Zitzelsberger@helmholtz-munich.de

“My vision is a comprehensive understanding of molecular landscapes of human tumors to support precision cancer treatment and to improve clinical outcomes.”

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Horst Zitzelsberger received his diploma in human genetics and earned his doctorate in biology.

His scientific career started at the LMU at the Radiobiological Institute as scientific assistant in 1995. A major focus were molecular mechanisms and markers of radiation-induced carcinogenesis. 2001 he took over the leadership of the research group Cytogenetics at the Helmholtz Zentrum München. At the same time he habilitated at the Medical Faculty of the LMU Munich in radiobiology and was appointed as Associated Professor in 2008. In parallel, he became acting director of the Institute of Molecular Radiobiology and expanded his research focus to include translational radiation oncology mainly in the field of head and neck cancer. Until now he is head of the Research Unit Radiation Cytogenetics and implemented together with Kristian Unger multi-omics approaches and translational bioinformatics in the research field. A joint clinical cooperation group with the Department of Radiation Oncology at the LMU (director: Claus Belka) strengthened the focus on clinical cohorts and personalized cancer treatment strategies.

Molecular Cytogenetics Multi-Omics studies Translational Radiation Oncology Prognostic markers Therapeutic stratification and targets

Brix, N. ; Samaga, D. ; Gehr, K. ; Danko, B. ; Schumann, M. ; Drexler, G. ; Alnatsha, A. ; Beyer, G. ; Mahajan, U. ; Selmansberger, M. ; Mayerle, J. ; Belka, C. ; Zitzelsberger, H. ; Lauber, K.

LDAcoop: Integrating non-linear population dynamics into the analysis of clonogenic growth in vitro.

Köker, S.C. ; Tsokanos, F.-F. ; El-Merahbi, R. ; Jha, A.K. ; Cicatelli, K. ; Weber, P. ; Mhamane, A. ; Kaltenecker, D. ; Morigny, P. ; Loft, A. ; Klepac, K. ; Maida, A. ; Molocea, C.-E. ; Hass, D, ; Vogl, E.S. ; Alfaro, A.J. ; Sun, W. ; Zitzelsberger, H. ; Unger, K. ; Szendrödi, J. ; Li, Y. ; Diaz, M.B. ; Wolfrum, C. ; Bartelt, A. ; Herzig, S. ; Georgiadi, A.

The TBLR1/TBL1 co-factor complex acts as a transcriptional checkpoint in the brown adipose tissue response to prolonged cold exposure.

Zhou, J. ; He, M. ; Zhao, Q. ; Shi, E. ; Wang, H. ; Ponkshe, V. ; Song, J. ; Wu, Z. ; Ji, D. ; Kranz, G. ; Tscherne, A. ; Schwenk-Zieger, S. ; Razak, N.A. ; Hess J. ; Belka, C. ; Zitzelsberger, H. ; Ourailidis, I. ; Stögbauer, F. ; Boxberg, M. ; Budczies, J. ; Reichel, C.A. ; Canis, M. ; Baumeister, P. ; Unger, K. ; Mock, A. ; Gires, O.

EGFR-mediated local invasiveness and response to Cetuximab in head and neck cancer.

Nieto, A.E. ; Fleischmann, D.F. ; Unger, K. ; Albrecht, V. ; Maas, J. ; Zitzelsberger, H. ; Belka, C. ; Proescholdt, M. ; Lauber, K. ; Niyazi, M. ; Orth, M.

Targeting VEGF-A in an immunocompetent orthotopic mouse model of mesenchymal glioblastoma improves antitumorigenicity and decreases proinflammatory response in normal brain tissue after fractionated radiotherapy.

Marschner, S. ; Maihöfer, C. ; Späth, R. ; Haehl, E. ; Reitz, D. ; Kienlechner, N. ; Schüttrumpf, L. ; Baumeister, P. ; Pflugradt, U. ; Hess J. ; Zitzelsberger, H. ; Unger, K. ; Belka, C. ; Walter, F.

Adjuvant (chemo)radiotherapy for patients with head and neck cancer: Can comorbidity risk scores predict outcome?

Danko, B. ; Hess J. ; Unger, K. ; Samaga, D. ; Walz, C. ; Walch, A.K. ; Sun, N. ; Baumeister, P. ; Zeng, P.Y.F. ; Walter, F. ; Marschner, S. ; Späth, R. ; Gires, O. ; Herkommer, T. ; Dazeh, R. ; Matos, T. ; Kreutzer, L. ; Matschke, J.B. ; Eul, K. ; Klauschen, F. ; Pflugradt, U. ; Canis, M. ; Ganswindt, U. ; Mymryk, J.S. ; Wollenberg, B. ; Nichols, A.C. ; Belka, C. ; Zitzelsberger, H. ; Lauber, K. ; Selmansberger, M.

Metabolic pathway-based subtypes associate glycan biosynthesis and treatment response in head and neck cancer.

Weber, S. ; Unger, K. ; Alunni-Fabbroni, M. ; Hirner-Eppeneder, H. ; Öcal, E. ; Zitzelsberger, H. ; Mayerle, J. ; Malfertheiner, P. ; Ricke, J.

Metabolomic analysis of human cirrhosis and hepatocellular carcinoma: A pilot study.

Burkart, S. ; Weusthof, C. ; Khorani, K. ; Steen, S. ; Stögbauer, F. ; Unger, K. ; Hess J. ; Zitzelsberger, H. ; Belka, C. ; Kurth, I. ; Hess, J.

A novel subgroup of UCHL1-related cancers is associated with genomic instability and sensitivity to DNA-damaging treatment.

Kotsiliti, E. ; Leone, V. ; Schuehle, S. ; Govaere, O. ; Li, H. ; Wolf, M.J. ; Horvatic, H. ; Bierwirth, S. ; Hundertmark, J. ; Inverso, D. ; Zizmare, L. ; Sarusi-Portuguez, A. ; Gupta, R. ; O'Connor, T. ; Giannou, A.D. ; Shiri, A.M. ; Schlesinger, Y. ; Beccaria, M.G. ; Rennert, C. ; Pfister, D. ; Öllinger, R. ; Gadjalova, I. ; Ramadori, P. ; Rahbari, M. ; Rahbari, N. ; Healy, M.E. ; Fernández-Vaquero, M. ; Yahoo, N. ; Janzen, J. ; Singh, I. ; Fan, C. ; Liu, X. ; Rau, M. ; Feuchtenberger, M. ; Schwaneck, E. ; Wallace, S.J. ; Cockell, S. ; Wilson-Kanamori, J. ; Ramachandran, P. ; Kho, C. ; Kendall, T.J. ; Leblond, A.L. ; Keppler, S.J. ; Bielecki, P. ; Steiger, K. ; Hofmann, M. ; Rippe, K. ; Zitzelsberger, H. ; Weber, A. ; Malek, N. ; Luedde, T. ; Vucur, M. ; Augustin, H.G. ; Flavell, R. ; Parnas, O. ; Rad, R. ; Pabst, O. ; Henderson, N.C. ; Huber, S. ; Macpherson, A. ; Knolle, P. ; Claassen, M. ; Geier, A. ; Trautwein, C. ; Unger, K. ; Elinav, E. ; Waisman, A. ; Abdullah, Z. ; Haller, D. ; Tacke, F. ; Anstee, Q.M. ; Heikenwälder, M.

Intestinal B cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signalling.

Unger, K. ; Hess J. ; Link, V. ; Buchner, A. ; Eze, C. ; Li, M. ; Stief, C. ; Kirchner, T. ; Klauschen, F. ; Zitzelsberger, H. ; Niyazi, M. ; Ganswindt, U. ; Schmidt-Hegemann, N.S. ; Belka, C.

DNA-methylation and genomic copy number in primary tumors and corresponding lymph node metastases in prostate cancer from patients with low and high Gleason score.

Prof. Dr. Horst Zitzelsberger

Recent Publications