Molecular Targets and Therapeutics Center Institute of Molecular Toxicology and Pharmacology
We aim at understanding the molecular machines by which our organism responds to bioactive chemicals and how this translates into benefit or harm to us. A key ambition is to generate the knowledge for the development of innovative, efficient and safe drugs.
We aim at understanding the molecular machines by which our organism responds to bioactive chemicals and how this translates into benefit or harm to us. A key ambition is to generate the knowledge for the development of innovative, efficient and safe drugs.
About our Research
Our research targets the interface between biomedicine and chemistry from complementary perspectives. Specific projects may start from:
elicited by a small chemical in mice or man
pathways
for novel chemical matter that could address a promising pharmacologic target
screens to unravel the mechanism behind a physiological response to a chemical challenge
Latest Publications of Our Institute
Read more2024 Review in International Journal of Molecular Sciences
Metabolic derangement of essential transition metals and potential antioxidant therapies.
2024 Scientific Article in Analytical and Bioanalytical Chemistry
Subzero project: Comparing trace element profiles of enriched mitochondria fractions from frozen and fresh liver tissue.
2024 Scientific Article in Metabolism: clinical and experimental
Copper impairs the intestinal barrier integrity in Wilson disease.
2024 Scientific Article in ChemBioChem
Thermal proteome profiling reveals insight to antiproliferative and pro-apoptotic effects of Lagunamide A in the modulation of DNA damage repair.
2024 Scientific Article in Journal of Clinical Investigation
OCaR1 endows exocytic vesicles with autoregulatory competence by preventing uncontrolled Ca2+ release, exocytosis, and pancreatic tissue damage.
2024 Scientific Reports