Molecular Targets and Therapeutics Center
Institute of Molecular Toxicology and Pharmacology
At the Institute of Molecular Toxicology and Pharmacology (TOXI), we explore how the human body responds to bioactive chemicals at the molecular level. Our mission is to uncover the complex molecular mechanism, our body’s molecular machines, that determine whether a chemical compound leads to therapeutic benefits or harmful effects.
A central goal of our research is to generate cutting-edge knowledge that drives the development of innovative, effective, and safe pharmaceuticals. Through our work, we contribute to advancing precision medicine and improving drug safety for the future.
About our Research
Our research targets the interface between biomedicine and chemistry from complementary perspectives. Specific projects may start from:
small molecular screens
small molecular screens
Director of the Institute for Molecular Toxicology and Pharmacology / Group Leader Small Molecule Modulators of Intermediary Metabolism
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Group Leader Oxidative Cell Death
Postdoc Zischka Lab
Latest Publications of Our Institute
Rechtsteiner, M. ; Kröber, S. ; Al-Robaiy, S. ; Zischka, H. ; Simm, A. ; Oliveira, P.J. ; Carvalho, E. ; Weihrauch-Blüher, S.
Stage dependent alterations in PBMC mitochondrial bioenergetics in pediatric obesity: From insulin resistance to type 2 diabetes.Jeltsch, K. ; Hu, D. ; Brenner, S. ; Zöller, J. ; Heinz, G.A. ; Nagel, D. ; Vogel, K.U. ; Rehage, N. ; Warth, S.C. ; Edelmann, S.L. ; Gloury, R. ; Martin, N. ; Lohs, C. ; Lech, M. ; Stehklein, J.E. ; Geerlof, A. ; Kremmer, E. ; Weber, A. ; Anders, H.J. ; Schmitz, I. ; Schmidt-Supprian, M. ; Fu, M. ; Holtmann, H. ; Krappmann, D. ; Ruland, J. ; Kallies, A. ; Heikenwälder, M. ; Heissmeyer, V.
Author Correction: Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote TH17 differentiation.Ramasubramanian, S. ; Öllinger, R. ; Eberhagen, C. ; Zischka, H. ; Schmid, R.M. ; Einwächter, H.
Correction: Mitochondrial superoxide dismutase controls metabolic plasticity in pancreatic cancer.Gu, W. ; Wilkinson, N. ; Fillebeen, C. ; Blackburn, D. ; Sahinyan, K. ; Bonneil, E. ; Zhao, T. ; Luo, Z. ; Soleimani, V. ; Richard, V. ; Borchers, C.H. ; Koulman, A. ; Jenkins, B. ; Michalke, B. ; Zischka, H. ; Sailer, J. ; Venkataramani, V. ; Iliopoulos, O. ; Sweeney, G. ; Pantopoulos, K.
IRP1 deficiency alters mitochondrial metabolism and protects against metabolic syndrome pathologies.Borkowska, A. ; Juhas, U. ; Olszewski, S. ; Reczkowicz, J. ; Wityk, P. ; Akdogan, B. ; Zischka, H. ; Antosiewicz, J.
N-homocysteinylation of ferritin and associated changes in iron metabolism as potential drivers of vascular endothelial dysfunction in hyperhomocysteinemia.Lorenz, S. ; Wahida, A. ; Bostock, M.J. ; Seibt, T. ; Santos Dias Mourão, A. ; Levkina, A. ; Trümbach, D. ; Soudy, M. ; Emler, D. ; Rothammer, N. ; Woo, M.S. ; Sonner, J.K. ; Novikova, M. ; Henkelmann, B. ; Aldrovandi, M. ; Kaemena, D.F. ; Mishima, E. ; Vermonden, P. ; Zong, Z. ; Cheng, D. ; Nakamura, T. ; Ito, J. ; Doll, S. ; Proneth, B. ; Bürkle, E. ; Rizzollo, F. ; Escamilla Ayala, A. ; Napolitano, V. ; Kolonko, M. ; Gaussmann, S. ; Merl-Pham, J. ; Hauck, S.M. ; Pertek, A. ; Orschmann, T. ; Van San, E. ; Vanden Berghe, T. ; Hass, D, ; Maida, A. ; Frenz, J.M. ; Pedrera, L. ; Dolga, A.M. ; Kraiger, M. ; Hrabě de Angelis, M. ; Fuchs, H. ; Ebert, G. ; Lenberg, J. ; Friedman, J. ; Scale, C. ; Agostinis, P. ; Zimprich, A. ; Vogt Weisenhorn, D.M. ; Garrett, L. ; Hölter, S.M. ; Wurst, W. ; Glaab, E. ; Lewerenz, J. ; Popper, B. ; Sieben, C. ; Steinacker, P. ; Zischka, H. ; García-Sáez, A.J. ; Tietze, A. ; Ramesh, S.K. ; Ayton, S. ; Vincendeau, M. ; Friese, M.A. ; Wigby, K. ; Sattler, M. ; Mann, M. ; Ingold, I. ; Jayavelu, A.K. ; Popowicz, G.M. ; Conrad, M.
A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis.Engler, J. ; Kim, E.J. ; Kim, D. ; Shibata, N.M. ; Lynderup, E.M. ; Vendelbo, M.H. ; Akdogan, B. ; Sailer, J. ; Fontes, A. ; Eberhagen, C. ; Rieder, T. ; Reinold, Q. ; Lee, H. ; Park, D. ; Jung, C. ; Im, W. ; Wudy, S.I. ; Kleigrewe, K. ; Engelhardt, S. ; DiSpirito, A.A. ; Sandahl, T.D. ; Medici, V. ; Eun, S.Y. ; Zischka, H.
Rapid transcellular hepatic copper depletion by ARBM-101 rescues severe liver damage in Wilson disease rodents.Ramasubramanian, S. ; Öllinger, R. ; Eberhagen, C. ; Zischka, H. ; Schmid, R.M. ; Einwächter, H.
Mitochondrial superoxide dismutase controls metabolic plasticity in pancreatic cancer.Lynderup, E.M. ; Vendelbo, M.H. ; Kirk, F.T. ; Vase, K.H. ; Alstrup, A.K.O. ; Rieder, T. ; DiSpirito, A.A. ; Semrau, J.D. ; Laursen, T.L. ; Ott, P. ; Zischka, H. ; Sandahl, T.D.
Methanobactin rapidly facilitates biliary copper excretion in a Wilson disease rat model visualised by 64Cu PET/MRI.Cáceres, A. ; Shibata, N.M. ; Davalos-Gutierrez, C.D. ; Sarode, G.V. ; Hussan, H. ; Bettencourt, M. ; Fontes, A. ; Zischka, H. ; Lutsenko, S. ; Heffern, M.C. ; Medici, V.
Inactivation of Atp7b copper transporter in intestinal epithelial cells is associated with altered lipid processing and cell growth machinery independent from hepatic copper accumulation and severity of liver histology.
Expert toxicologist training In Cooperation with Gesellschaft für Toxikologie (GT)
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