Molecular Targets and Therapeutics Center Institute of Molecular Toxicology and Pharmacology
We aim at understanding the molecular machines by which our organism responds to bioactive chemicals and how this translates into benefit or harm to us. A key ambition is to generate the knowledge for the development of innovative, efficient and safe drugs.
We aim at understanding the molecular machines by which our organism responds to bioactive chemicals and how this translates into benefit or harm to us. A key ambition is to generate the knowledge for the development of innovative, efficient and safe drugs.
About our Research
Our research targets the interface between biomedicine and chemistry from complementary perspectives. Specific projects may start from:
elicited by a small chemical in mice or man
pathways
for novel chemical matter that could address a promising pharmacologic target
screens to unravel the mechanism behind a physiological response to a chemical challenge
Latest Publications of Our Institute
Read more2022 Meeting abstract in Journal of Hepatology
Copper accumulation in chronic cholestatic disease augments liver damage by impairment of mitochondrial function.
2022 Scientific Article in Free Radical Biology and Medicine
The decylTPP mitochondria-targeting moiety lowers electron transport chain supercomplex levels in primary human skin fibroblasts.
2022 Scientific Article in Molecular Metabolism
Loss of UCP1 function augments recruitment of futile lipid cycling for thermogenesis in murine brown fat.
2022 Scientific Article in Journal of Cell Science
Lysosomal TRPML1 regulates mitochondrial function in hepatocellular carcinoma cells.
2022 Scientific Article in Cell Reports
IL-6-induced FOXO1 activity determines the dynamics of metabolism in CD8 T cells cross-primed by liver sinusoidal endothelial cells.
2022 Scientific Article in Applied and Environmental Microbiology
MbnC is not required for the formation of the N-terminal oxazolone in the methanobactin from Methylosinus trichosporium OB3b.
2022 Scientific Article in Life Science Alliance