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Molecular Targets and Therapeutics Center Institute of Molecular Toxicology and Pharmacology

We aim at understanding the molecular machines by which our organism responds to bioactive chemicals and how this translates into benefit or harm to us. A key ambition is to generate the knowledge for the development of innovative, efficient and safe drugs. 

We aim at understanding the molecular machines by which our organism responds to bioactive chemicals and how this translates into benefit or harm to us. A key ambition is to generate the knowledge for the development of innovative, efficient and safe drugs. 

About our Research

Our research targets the interface between biomedicine and chemistry from complementary perspectives. Specific projects may start from:

elicited by a small chemical in mice or man

pathways

 for novel chemical matter that could address a promising pharmacologic target

screens to unravel the mechanism behind a physiological response to a chemical challenge

Research Groups

Michael Haggenmueller
Göttlicher Group

Small Molecule Modulators of Intermediary Metabolism

Our research aims at identifying novel targets for small molecules that could modulate intermediary metabolism in order to control body weight or pathologies associated with metabolic disorders such as metabolic syndrome, steatosis hepatis or diabetes.

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©Michael Haggenmueller
Krappmann Unit

Cellular Signal Integration

The Research Unit Cellular Signal Integration (AZS) at the Institute of Molecular Toxicology and Pharmacology (TOXI) conducts research for a better understanding of cellular response pathways. In doing so, it focuses on the interaction of proteins complexes and the effects of posttranslational modifications. The aim of this research is to understand the faulty regulation of the signal complexes in the immune system in case of infectious diseases and the development of lymphoma, and to attack this pharmacologically.

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©Martin Nink
Hadian Group

Cell Signaling and Chemical Biology

In the Hadian Lab, we study the mechanisms of Cell Death Signaling and translate these findings into future drugs using Chemical Biology and Drug Discovery approaches. We are particularly interested in deciphering the cellular mechanisms controlling Ferroptosis and characterizing regulators of Ubiquitin Signaling in Cell Death processes. In addition, we operate the Compound Screening Platform, giving us strong expertise in high-throughput biochemical screening and high-content phenotypic screening to identify disease-relevant small molecule modulators and highly selective probes.

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Kieser Group

Viral Signal Transduction and Therapeutic Intervention Strategies

The viral signal transduction and therapeutic intervention strategies group investigates the molecular basis of cell transformation by the latent membrane protein 1 (LMP1), the primary oncogene of EBV. We focus at elucidating the molecular interactions of LMP1 with cellular signaling pathways to define LMP1’s contribution to chronic disease development by EBV infection.

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Schick Group

Genetics and Cellular Engineering

The Genetics and Cellular Engineering group are experts in genetic interrogation of medically-relevant cellular death pathways.

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Zischka Group

Mitochondrial Toxicology

We focus on Mitochondrial Damage upon diverse aspects of cell-toxic conditions in human disease, e.g. metabolic diseases, neurodegeneration, cancer, organ failure.

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Our Scientists at Molecular Toxicology and Pharmacology

Prof. Dr. med. Martin Göttlicher

Director of the Institute for Molecular Toxicology and Pharmacology / Group Leader Small Molecule Modulators of Intermediary Metabolism View profile

Prof. Dr. Daniel Krappmann

Group Leader Cellular Signal Integration View profile

Dr. rer. nat. Ina Rothenaigner

Postdoc Hadian Lab

Christian Pütz

Technical Assistant, IT Administrator Hadian Lab

Franziska Ober

Doctoral Researcher Krappmann Lab

Dr. rer. nat. Kamyar Hadian

Group Leader Cell Signaling and Chemical Biology

Dr. Banu Akdogan

Postdoc Zischka Lab

Nicole Wimberger

Doctoral Researcher Krappmann Lab

Prof. Dr. Arnd Kieser

Group Leader Viral Signal Transduction and Therapeutic Intervention Strategies

Vera Kühne

Assistent to the Director

Dr. Andreas Gewies

Postdoc Krappmann Lab

Marie Tofaute

Doctoral Researcher Krappmann Lab

Juliane Tschuck

Doctoral Researcher Hadian Lab

Susanne Pfeiffer

Technical Assistant Schick Lab

Dr. Joel Schick

Group Leader Genetics and Cellular Engineering

Iden Jakob

Assistent to the Director

Kristina Herdt

Technical Assistant Krappmann Lab

Stefanie Brandner

Technical Assistant Hadian Lab

Srinark Chanikarn

Doctoral Researcher AG Schick

Carola Eberhagen

Technical Assistant Zischka Lab

Dr. rer. nat. Kenji Schorpp

Postdoc Hadian Lab

Hao Peng

Doctoral Researcher Schick Lab

Dr. Sabine Schmitt

Postdoc Zischka Lab

Prof. Dr. rer. nat. Hans Zischka

Group Leader Oxidative Cell Death

Xin Yang

Doctoral Researcher Schick Lab

Dr. rer. nat. Stefanie Weiss

Postdoc Hadian Lab

Dr. Thomas O´Neill

Postdoc Krappmann Lab

Carina Graß

Doctoral Researcher Krappmann Lab

Yaschar Kabiri

Doctoral Researcher Zischka Lab

Fabian Giehler

Postdoc Kieser Lab

Helmut Kutz

Technical Assistant, Scientific Officer Kieser Lab

Bahareh Nemati Moud

Postdoc Krappmann Lab

Dr. Judith Nagel

Postdoc Zischka Lab

Adriana Filipa da Silva Fontes

Doctoral Researcher Zischka Lab

Tamara Rieder

Technical Assistant Zischka Lab

Katrin Demski

Technical Assistant Krappmann Lab

Reinold Quirin

Technical Assistant Zischka Lab

Judith Sailer

Doctoral Researcher Zischka Lab

Mr. Roboto

The Mysterious Machine

Our Staff in Detail

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Postdocs
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Doctoral Researchers
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Technicians

Latest Publications of Our Institute

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2022 Scientific Article in Journal of Experimental Medicine

Kessler, N. ; Viehmann, S.F. ; Krollmann, C. ; Mai, K. ; Kirschner, K.M. ; Luksch, H. ; Kotagiri, P. ; Böhner, A.M.C. ; Huugen, D. ; de Oliveira Mann, C.C. ; Otten, S. ; Weiss, S.A. ; Zillinger, T. ; Dobrikova, K. ; Jenne, D. ; Behrendt, R. ; Ablasser, A. ; Bartok, E. ; Hartmann, G. ; Hopfner, K.P. ; Lyons, P.A. ; Boor, P. ; Rosen-Wolff, A. ; Teichmann, L.L. ; Heeringa, P. ; Kurts, C. ; Garbi, N.

Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing.

2022 Scientific Article in Nature Biotechnology

Kim, D.-K. ; Weller, B. ; Lin, C.-W. ; Sheykhkarimli, D. ; Knapp, J.J. ; Dugied, G. ; Zanzoni, A. ; Pons, C. ; Tofaute, M.J. ; Maseko, S.B. ; Spirohn, K. ; Laval, F. ; Lambourne, L. ; Kishore, N. ; Rayhan, A. ; Sauer, M. ; Young, V. ; Halder, H. ; Marin De La Rosa, N.A. ; Pogoutse, O. ; Strobel, A. ; Schwehn, P. ; Li, R. ; Rothballer, S.T. ; Altmann, M. ; Cassonnet, P. ; Coté, A.G. ; Elorduy Vergara, L. ; Hazelwood, I. ; Liu, B.B. ; Nguyen, M. ; Pandiarajan, R. ; Dohai, B.S.M. ; Rodriguez, P.A. ; Poirson, J. ; Giuliana, P. ; Willems, L. ; Taipale, M. ; Jacob, Y. ; Hao, T. ; Hill, D.E. ; Brun, C. ; Twizere, J.C. ; Krappmann, D. ; Heinig, M. ; Falter, C. ; Aloy, P. ; Demeret, C. ; Vidal, M. ; Calderwood, M.A. ; Roth, F.B. ; Falter-Braun, P.

A proteome-scale map of the SARS-CoV-2-human contactome.

Contact

Director

Prof. Dr. med. Martin Göttlicher

Director of the Institute for Molecular Toxicology and Pharmacology / Group Leader Small Molecule Modulators of Intermediary Metabolism

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Contact

Office

Vera Kühne

Assistent to the Director

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