TOXI - Helmholtz Munich

We aim at understanding the molecular machines by which our organism responds to bioactive chemicals and how this translates into benefit or harm to us. A key ambition is to generate the knowledge for the development of innovative, efficient and safe drugs.

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About our Research

Our research targets the interface between biomedicine and chemistry from complementary perspectives. Specific projects may start from:

elicited by a small chemical in mice or man

pathways

for novel chemical matter that could address a promising pharmacologic target

screens to unravel the mechanism behind a physiological response to a chemical challenge

Göttlicher Group

Our research aims at identifying novel targets for small molecules that could modulate intermediary metabolism in order to control body weight or pathologies associated with metabolic disorders such as metabolic syndrome, steatosis hepatis or diabetes.

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Krappmann Unit

The Research Unit Cellular Signal Integration (AZS) at the Institute of Molecular Toxicology and Pharmacology (TOXI) conducts research for a better understanding of cellular response pathways. In doing so, it focuses on the interaction of proteins complexes and the effects of posttranslational modifications. The aim of this research is to understand the faulty regulation of the signal complexes in the immune system in case of infectious diseases and the development of lymphoma, and to attack this pharmacologically.

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Core Facility ZWE Assay Development and Screening

Hadian Group

In the Hadian Lab, we study the mechanisms of Cell Death Signaling and translate these findings into future drugs using Chemical Biology and Drug Discovery approaches. We are particularly interested in deciphering the cellular mechanisms controlling Ferroptosis and characterizing regulators of Ubiquitin Signaling in Cell Death processes. In addition, we operate the Compound Screening Platform, giving us strong expertise in high-throughput biochemical screening and high-content phenotypic screening to identify disease-relevant small molecule modulators and highly selective probes.

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Adding samples inside a biosafety cabinet

Kieser Group

The viral signal transduction and therapeutic intervention strategies group investigates the molecular basis of cell transformation by the latent membrane protein 1 (LMP1), the primary oncogene of EBV. We focus at elucidating the molecular interactions of LMP1 with cellular signaling pathways to define LMP1’s contribution to chronic disease development by EBV infection.

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Schick Group

The Genetics and Cellular Engineering group are experts in genetic interrogation of medically-relevant cellular death pathways.

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Zischka Group

We focus on Mitochondrial Damage upon diverse aspects of cell-toxic conditions in human disease, e.g. metabolic diseases, neurodegeneration, cancer, organ failure.

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News from Our Institute

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Molecular Targets and Therapeutics, AZS, TOXI, September 30, 2022

Relaunch of our new TOXI Webpage

Prof. Dr. med. Martin Göttlicher

Director of the Institute for Molecular Toxicology and Pharmacology / Group Leader Small Molecule Modulators of Intermediary Metabolism View profile

Prof. Dr. Daniel Krappmann

Group Leader Cellular Signal Integration View profile

Dr. rer. nat. Ina Rothenaigner

Postdoc Hadian Lab

Christian Pütz

Technical Assistant, IT Administrator Hadian Lab

Franziska Ober

Doctoral Researcher Krappmann Lab

Dr. rer. nat. Kamyar Hadian

Group Leader Cell Signaling and Chemical Biology

Dr. Banu Akdogan

Postdoc Zischka Lab

Nicole Wimberger

Doctoral Researcher Krappmann Lab

Prof. Dr. Arnd Kieser

Group Leader Viral Signal Transduction and Therapeutic Intervention Strategies

Vera Kühne

Assistent to the Director

Dr. Andreas Gewies

Postdoc Krappmann Lab

Marie Tofaute

Doctoral Researcher Krappmann Lab

Juliane Tschuck

Doctoral Researcher Hadian Lab

Susanne Pfeiffer

Technical Assistant Schick Lab

Dr. Joel Schick

Group Leader Genetics and Cellular Engineering

Iden Jakob

Assistent to the Director

Kristina Herdt

Technical Assistant Krappmann Lab

Stefanie Brandner

Technical Assistant Hadian Lab

Srinark Chanikarn

Doctoral Researcher AG Schick

Carola Eberhagen

Technical Assistant Zischka Lab

Dr. rer. nat. Kenji Schorpp

Postdoc Hadian Lab

Hao Peng

Doctoral Researcher Schick Lab

Dr. Sabine Schmitt

Postdoc Zischka Lab

Prof. Dr. rer. nat. Hans Zischka

Group Leader Oxidative Cell Death

Xin Yang

Doctoral Researcher Schick Lab

Dr. rer. nat. Stefanie Weiss

Postdoc Hadian Lab

Dr. Thomas O´Neill

Postdoc Krappmann Lab

Carina Graß

Doctoral Researcher Krappmann Lab

Yaschar Kabiri

Doctoral Researcher Zischka Lab

Fabian Giehler

Postdoc Kieser Lab

Helmut Kutz

Technical Assistant, Scientific Officer Kieser Lab

Bahareh Nemati Moud

Postdoc Krappmann Lab

Dr. Judith Nagel

Postdoc Zischka Lab

Adriana Filipa da Silva Fontes

Doctoral Researcher Zischka Lab

Tamara Rieder

Technical Assistant Zischka Lab

Katrin Demski

Technical Assistant Krappmann Lab

Reinold Quirin

Technical Assistant Zischka Lab

Judith Sailer

Doctoral Researcher Zischka Lab

Mr. Roboto

The Mysterious Machine

A lot of people figures and comment clouds above their heads.

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Technicians

Latest Publications of Our Institute

Unleashing high content screening in hit detection - Benchmarking AI workflows including novelty detection.

2022 Scientific Article in Journal of Experimental Medicine

Kessler, N. ; Viehmann, S.F. ; Krollmann, C. ; Mai, K. ; Kirschner, K.M. ; Luksch, H. ; Kotagiri, P. ; Böhner, A.M.C. ; Huugen, D. ; de Oliveira Mann, C.C. ; Otten, S. ; Weiss, S.A. ; Zillinger, T. ; Dobrikova, K. ; Jenne, D. ; Behrendt, R. ; Ablasser, A. ; Bartok, E. ; Hartmann, G. ; Hopfner, K.P. ; Lyons, P.A. ; Boor, P. ; Rosen-Wolff, A. ; Teichmann, L.L. ; Heeringa, P. ; Kurts, C. ; Garbi, N.

Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing.

2022 Scientific Article in Scientific Reports

Napolitano, V. ; Softley, C. ; Blat, A. ; Kalel, V.C. ; Schorpp, K.K. ; Siebenmorgen, T. ; Hadian, K. ; Erdmann, R. ; Sattler, M. ; Popowicz, G.M. ; Dubin, G.

Small molecule mediated inhibition of protein cargo recognition by peroxisomal transport receptor PEX5 is toxic to Trypanosoma.

2022 Review in Journal for ImmunoTherapy of Cancer

Mempel, T.R. ; Krappmann, D.

Combining precision oncology and immunotherapy by targeting the MALT1 protease.

2022 Scientific Article in Nature Biotechnology

Kim, D.-K. ; Weller, B. ; Lin, C.-W. ; Sheykhkarimli, D. ; Knapp, J.J. ; Dugied, G. ; Zanzoni, A. ; Pons, C. ; Tofaute, M.J. ; Maseko, S.B. ; Spirohn, K. ; Laval, F. ; Lambourne, L. ; Kishore, N. ; Rayhan, A. ; Sauer, M. ; Young, V. ; Halder, H. ; Marin De La Rosa, N.A. ; Pogoutse, O. ; Strobel, A. ; Schwehn, P. ; Li, R. ; Rothballer, S.T. ; Altmann, M. ; Cassonnet, P. ; Coté, A.G. ; Elorduy Vergara, L. ; Hazelwood, I. ; Liu, B.B. ; Nguyen, M. ; Pandiarajan, R. ; Dohai, B.S.M. ; Rodriguez, P.A. ; Poirson, J. ; Giuliana, P. ; Willems, L. ; Taipale, M. ; Jacob, Y. ; Hao, T. ; Hill, D.E. ; Brun, C. ; Twizere, J.C. ; Krappmann, D. ; Heinig, M. ; Falter, C. ; Aloy, P. ; Demeret, C. ; Vidal, M. ; Calderwood, M.A. ; Roth, F.B. ; Falter-Braun, P.

A proteome-scale map of the SARS-CoV-2-human contactome.

2022 Scientific Article in Free Radical Biology and Medicine

Bulthuis, E.P. ; Einer, C. ; Distelmaier, F. ; Groh, L. ; van Emst-de Vries, S.E. ; van de Westerlo, E. ; van de Wal, M. ; Wagenaars, J. ; Rodenburg, R.J. ; Smeitink, J.A.M. ; Riksen, N.P. ; Willems, P.H.G.M. ; Adjobo-Hermans, M.J.W. ; Zischka, H. ; Koopman, W.J.H.

The decylTPP mitochondria-targeting moiety lowers electron transport chain supercomplex levels in primary human skin fibroblasts.

2022 Scientific Article in Bio-Protocol

O'Neill, T.J. ; Krappmann, D. ; Gewies, A.

Optimized CRISPR-Cas9-based strategy for complex gene targeting in murine embryonic stem cells for germline transmission.

2022 Scientific Article in Molecular Metabolism

Oeckl, J. ; Janovska, P. ; Adamcova, K. ; Bardova, K. ; Brunner, S. ; Dieckmann, S. ; Ecker, J. ; Fromme, T. ; Funda, J. ; Gantert, T. ; Giansanti, P. ; Hidrobo, M.S. ; Kuda, O. ; Kuster, B. ; Li, Y. ; Pohl, R. ; Schmitt, S. ; Schweizer, S. ; Zischka, H. ; Zouhar, P. ; Kopecky, J. ; Klingenspor, M.

Molecular Targets and Therapeutics Center Institute of Molecular Toxicology and Pharmacology

exciting phenotypes

essential signaling

small molecular screens

genetics

Research Groups

Small Molecule Modulators of Intermediary Metabolism

Cellular Signal Integration

Cell Signaling and Chemical Biology

Viral Signal Transduction and Therapeutic Intervention Strategies

Genetics and Cellular Engineering

Mitochondrial Toxicology

News from Our Institute

Institute News September 2022

First-in-class Cancer Immunotherapy Drug in Clinical Trial

Our Scientists at Molecular Toxicology and Pharmacology

Prof. Dr. med. Martin Göttlicher

Prof. Dr. Daniel Krappmann

Dr. rer. nat. Ina Rothenaigner

Christian Pütz

Franziska Ober

Dr. rer. nat. Kamyar Hadian

Dr. Banu Akdogan

Nicole Wimberger

Prof. Dr. Arnd Kieser

Vera Kühne

Dr. Andreas Gewies

Marie Tofaute

Juliane Tschuck

Susanne Pfeiffer

Dr. Joel Schick

Iden Jakob

Kristina Herdt

Stefanie Brandner

Srinark Chanikarn

Carola Eberhagen

Dr. rer. nat. Kenji Schorpp

Hao Peng

Dr. Sabine Schmitt

Prof. Dr. rer. nat. Hans Zischka

Xin Yang

Dr. rer. nat. Stefanie Weiss

Dr. Thomas O´Neill

Carina Graß

Yaschar Kabiri

Fabian Giehler

Helmut Kutz

Bahareh Nemati Moud

Dr. Judith Nagel

Adriana Filipa da Silva Fontes

Tamara Rieder

Katrin Demski

Reinold Quirin

Judith Sailer

Mr. Roboto

Our Staff in Detail

Latest Publications of Our Institute

Networks and Affiliations

Expert toxicologist training In Cooperation with Gesellschaft für Toxikologie (GT)

Contact Director

Prof. Dr. med. Martin Göttlicher

Contact Office

Vera Kühne

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