TOXI - Helmholtz Munich

We aim at understanding the molecular machines by which our organism responds to bioactive chemicals and how this translates into benefit or harm to us. A key ambition is to generate the knowledge for the development of innovative, efficient and safe drugs.

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About our Research

Our research targets the interface between biomedicine and chemistry from complementary perspectives. Specific projects may start from:

elicited by a small chemical in mice or man

pathways

for novel chemical matter that could address a promising pharmacologic target

screens to unravel the mechanism behind a physiological response to a chemical challenge

Göttlicher Group

Our research aims at identifying novel targets for small molecules that could modulate intermediary metabolism in order to control body weight or pathologies associated with metabolic disorders such as metabolic syndrome, steatosis hepatis or diabetes.

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Zischka Group

We focus on Mitochondrial Damage upon diverse aspects of cell-toxic conditions in human disease, e.g. metabolic diseases, neurodegeneration, cancer, organ failure.

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Molecular Targets and Therapeutics, AZS, TOXI, September 30, 2022

Relaunch of our new TOXI Webpage

Prof. Martin Göttlicher

Director of the Institute for Molecular Toxicology and Pharmacology / Group Leader Small Molecule Modulators of Intermediary Metabolism View profile

Prof. Dr. rer. nat. Hans Zischka

Group Leader Oxidative Cell Death

Dr. Banu Akdogan

Postdoc Zischka Lab

Carola Eberhagen

Technical Assistant Zischka Lab

Tamara Rieder

Technical Assistant Zischka Lab

Dr. Judith Nagel

Postdoc Zischka Lab

Adriana Filipa da Silva Fontes

Doctoral Researcher Zischka Lab

Quirin Reinold

Technical Assistant Zischka Lab

Judith Sailer

Doctoral Researcher Zischka Lab

Dr. Sabine Schmitt

Postdoc Zischka Lab

Yaschar Kabiri

Doctoral Researcher Zischka Lab

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Employees

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Postdocs

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Doctoral Researchers

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Technicians

Latest Publications of Our Institute

ARBM-101 as a potential therapeutic for wilson disease.

2022 Meeting abstract in Journal of Hepatology

Koob, D. ; Nagel, J. ; Zimny, S. ; Li, J. ; Artmann, R. ; Wimmer, R. ; Denk, G. ; Roderfeld, M. ; Roeb, E. ; Zischka, H. ; Hohenester, S.

Copper accumulation in chronic cholestatic disease augments liver damage by impairment of mitochondrial function.

2022 Scientific Article in Free Radical Biology and Medicine

Bulthuis, E.P. ; Einer, C. ; Distelmaier, F. ; Groh, L. ; van Emst-de Vries, S.E. ; van de Westerlo, E. ; van de Wal, M. ; Wagenaars, J. ; Rodenburg, R.J. ; Smeitink, J.A.M. ; Riksen, N.P. ; Willems, P.H.G.M. ; Adjobo-Hermans, M.J.W. ; Zischka, H. ; Koopman, W.J.H.

The decylTPP mitochondria-targeting moiety lowers electron transport chain supercomplex levels in primary human skin fibroblasts.

2022 Scientific Article in Molecular Metabolism

Oeckl, J. ; Janovska, P. ; Adamcova, K. ; Bardova, K. ; Brunner, S. ; Dieckmann, S. ; Ecker, J. ; Fromme, T. ; Funda, J. ; Gantert, T. ; Giansanti, P. ; Hidrobo, M.S. ; Kuda, O. ; Kuster, B. ; Li, Y. ; Pohl, R. ; Schmitt, S. ; Schweizer, S. ; Zischka, H. ; Zouhar, P. ; Kopecky, J. ; Klingenspor, M.

Loss of UCP1 function augments recruitment of futile lipid cycling for thermogenesis in murine brown fat.

2022 Scientific Article in Journal of Cell Science

Siow, W.X. ; Kabiri, Y. ; Tang, R. ; Chao, Y.K. ; Plesch, E. ; Eberhagen, C. ; Flenkenthaler, F. ; Fröhlich, T. ; Bracher, F. ; Grimm, C. ; Biel, M. ; Zischka, H. ; Vollmar, A.M. ; Bartel, K.

Lysosomal TRPML1 regulates mitochondrial function in hepatocellular carcinoma cells.

2022 Scientific Article in Cell Reports

Dudek, M. ; Lohr, K. ; Donakonda, S. ; Baumann, T. ; Lüdemann, M. ; Hegenbarth, S. ; Dübbel, L. ; Eberhagen, C. ; Michailidou, S. ; Yassin, A. ; Prinz, M. ; Popper, B. ; Rose-John, S. ; Zischka, H. ; Knolle, P.A.

IL-6-induced FOXO1 activity determines the dynamics of metabolism in CD8 T cells cross-primed by liver sinusoidal endothelial cells.

2022 Scientific Article in Applied and Environmental Microbiology

Dershwitz, P. ; Gu, W. ; Roche, J. ; Kang-Yun, C.S. ; Semrau, J.D. ; Bobik, T.A. ; Fulton, B. ; Zischka, H. ; DiSpirito, A.A.

MbnC is not required for the formation of the N-terminal oxazolone in the methanobactin from Methylosinus trichosporium OB3b.

2022 Scientific Article in Life Science Alliance

Borchard, S. ; Raschke, S. ; Zak, K.M. ; Eberhagen, C. ; Einer, C. ; Weber, E. ; Müller, S.M. ; Michalke, B. ; Lichtmannegger, J. ; Wieser, A. ; Rieder, T. ; Popowicz, G.M. ; Adamski, J. ; Klingenspor, M. ; Coles, A.H. ; Viana, R. ; Vendelbo, M.H. ; Sandahl, T.D. ; Schwerdtle, T. ; Plitz, T. ; Zischka, H.

Bis-choline tetrathiomolybdate prevents copper-induced blood-brain barrier damage.

2022 Scientific Article in ISME Journal

Kang-Yun, C.S. ; Liang, X. ; Dershwitz, P. ; Gu, W. ; Schepers, A. ; Flatley, A. ; Lichtmannegger, J. ; Zischka, H. ; Zhang, L. ; Lu, X. ; Gu, B. ; Ledesma, J.C. ; Pelger, D.J. ; DiSpirito, A.A. ; Semrau, J.D.

Evidence for methanobactin "Theft" and novel chalkophore production in methanotrophs: Impact on methanotrophic-mediated methylmercury degradation.

2021 Scientific Article in Advances in Mathematical Sciences and Applications

Efendiyev, M.A. ; Muradova, A. ; Muradov, N. ; Zischka, H.

Molecular Targets and Therapeutics Center Institute of Molecular Toxicology and Pharmacology

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About our Research

Our research targets the interface between biomedicine and chemistry from complementary perspectives. Specific projects may start from:

Research Groups

Small Molecule Modulators of Intermediary Metabolism

Mitochondrial Toxicology

Institute News September 2022

First-in-class Cancer Immunotherapy Drug in Clinical Trial