All Publications of the Institute of Molecular Toxicology and Pharmacology
Publications 2022
Read more2022 Scientific Article in European Journal of Medicinal Chemistry
Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma.
2022 Scientific Article in Computational and Structural Biotechnology Journal
Unleashing high content screening in hit detection - Benchmarking AI workflows including novelty detection.
2022 Scientific Article in Scientific Reports
Small molecule mediated inhibition of protein cargo recognition by peroxisomal transport receptor PEX5 is toxic to Trypanosoma.
2022 Scientific Article in Analytical Cellular Pathology
Comprehensive analysis of the role of SLC2A3 on prognosis and immune infiltration in head and neck squamous cell carcinoma.
2022 Scientific Article in Free Radical Biology and Medicine
The decylTPP mitochondria-targeting moiety lowers electron transport chain supercomplex levels in primary human skin fibroblasts.
2022 Scientific Article in Molecular Metabolism
Loss of UCP1 function augments recruitment of futile lipid cycling for thermogenesis in murine brown fat.
2022 Scientific Article in Current Protocols
Methods to detect small molecule inhibition of RING E3 ligase activity.
2022 Scientific Article in Journal of Cell Science
Lysosomal TRPML1 regulates mitochondrial function in hepatocellular carcinoma cells.
2022 Scientific Article in Science Signaling
Phosphorylation of serine-893 in CARD11 suppresses the formation and activity of the CARD11-BCL10-MALT1 complex in T and B cells.
2022 Scientific Article in ACS Chemical Biology
Machine learning classifies ferroptosis and apoptosis cell death modalities with TfR1 immunostaining.
2022 Scientific Article in Cellular and Molecular Life Sciences - CMLS
A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells.
2022 Scientific Article in Cell Chemical Biology
Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses.
2022 Editorial in Signal transduction and targeted therapy
Vaccination versus SARS-CoV-2 Omicron: Three vaccine doses win the battle.
2022 Scientific Article in Cell Reports
IL-6-induced FOXO1 activity determines the dynamics of metabolism in CD8 T cells cross-primed by liver sinusoidal endothelial cells.
2022 Nature Structural & Molecular Biology
Author Correction: Retinoic acid signaling is critical during the totipotency window in early mammalian development.
2022 Scientific Article in Advanced science
Molecular signature of astrocytes for gene delivery by the synthetic adeno-associated viral vector rAAV9P1.
2022 Scientific Article in American Journal of Respiratory Cell and Molecular Biology
High-content screen identifies cyclosporin A as a novel ABCA3-specific molecular corrector.
2022 Scientific Article in Applied and Environmental Microbiology
MbnC is not required for the formation of the N-terminal oxazolone in the methanobactin from Methylosinus trichosporium OB3b.
2022 Scientific Article in Life Science Alliance
Bis-choline tetrathiomolybdate prevents copper-induced blood-brain barrier damage.
Publications 2021
Read more2021 Scientific Article in Advances in Mathematical Sciences and Applications
Local vs nonlocal models for mitochondria swelling.
2021 Scientific Article in Science Advances
Phenotypic drug screening in a human fibrosis model identified a novel class of antifibrotic therapeutics.
2021 Scientific Article in Journal of Alzheimer's Disease
Inhalational anesthetics do not deteriorate amyloid-β-derived pathophysiology in alzheimer's disease: Investigations on the molecular, neuronal, and behavioral level.
2021 Scientific Article in Science immunology
TRAF6 prevents fatal inflammation by homeostatic suppression of MALT1 protease.
2021 Scientific Article in Molecular Informatics
Highly accurate filters to flag frequent hitters in alphascreen assays by suggesting their mechanism.
2021 Scientific Article in Medicine
The role of CXCL10 in prognosis of patients with colon cancer and tumor microenvironment remodeling.
2021 Scientific Article in Frontiers in cell and developmental biology
Mitochondrial impairment by MitobloCK-6 inhibits liver cancer cell proliferation.
2021 Scientific Article in Cell Reports
Cilium induction triggers differentiation of glioma stem cells.
2021 Review in European Journal of Clinical Investigation
Mushrooms on the plate: Trends towards NAFLD treatment, health improvement and sustainable diets.
2021 Scientific Article in Nature Structural & Molecular Biology
Retinoic acid signaling is critical during the totipotency window in early mammalian development.
2021 Scientific Article in British Journal of Pharmacology
A drug screen with approved compounds identifies amlexanox as a novel Wnt/β-catenin activator inducing lung epithelial organoid formation.
2021 Scientific Article in FASEB Journal
Evolutionary and functional analyses demonstrate conserved ferroptosis protection by Arabidopsis GPXs in mammalian cells.
2021 Scientific Article in Applied and Environmental Microbiology
Oxygen generation via water splitting by a novel biogenic metal ion binding compound.
2021 Scientific Article in Cell Stem Cell
Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3.
2021 Scientific Article in Neuro-Oncology
Cannabidiol converts NFκB into a tumor suppressor in glioblastoma with defined antioxidative properties.
2021 Scientific Article in Plants
Genome-wide analysis of MDHAR gene family in four cotton species provides insights into fiber development via regulating AsA redox homeostasis.
2021 Scientific Article in EMBO Molecular Medicine
Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism.
2021 Scientific Article in Life Sciences
Adipocyte hypertrophy parallels alterations of mitochondrial status in a cell model for adipose tissue dysfunction in obesity.
Publications 2020
Read more2020 Scientific Article in European Journal of Pharmacology
GDF11 replenishment protects against hypoxia-mediated apoptosis in cardiomyocytes by regulating autophagy.
2020 Scientific Article in Antioxidants
Western diet causes obesity-induced nonalcoholic fatty liver disease development by differentially compromising the autophagic response.
2020 Scientific Article in International Journal of Molecular Sciences
IL-18 but not IL-1 signaling is pivotal for the initiation of liver injury in murine non-alcoholic fatty liver disease.
2020 Scientific Article in Nature Communications
Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly.
2020 Scientific Article in Journal of Hepatology
Reduced mitochondrial resilience enables non-canonical induction of apoptosis after TNF receptor signaling in virus-infected hepatocytes.
2020 Scientific Article in Metallomics
LC-ICP-MS method for the determination of "extractable copper" in serum.
2020 Scientific Article in International Journal of Molecular Sciences
JMJD6 regulates splicing of its own gene resulting in alternatively spliced isoforms with different nuclear targets.
2020 Letter to the Editor in Journal of Hepatology
Extending the mode of action of triethylenetetramine (trientine): Autophagy besides copper chelation.
2020 Scientific Article in Radiation Oncology
Transcriptome network of the papillary thyroid carcinoma radiation marker CLIP2.
2020 Scientific Article in FASEB Journal
Metabolic implication of tigecycline as an efficacious second-line treatment for sorafenib-resistant hepatocellular carcinoma.
Publications 2019
Read more2019 Meeting abstract in Neuro-Oncology
RelA-activity is essential for cannabidiol-mediated cytotoxicity in an identified subset of glioblastoma.
2019 Meeting abstract in European Respiratory Journal
Mitochondrial dysfunction activates MHC class I adaptive immune responses in lung aging.
2019 Review in Nutrients
Fat and sugar-a dangerous duet. A comparative review on metabolic remodeling in rodent models of nonalcoholic fatty liver disease.
2019 Review in European Journal of Immunology
Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).
2019 Scientific Article in Lecture Notes in Computer Science
Quantifying structural heterogeneity of healthy and cancerous mitochondria using a combined segmentation and classification USK-net.
2019 Scientific Article in Journal of Cell Science
Mitochondrial Alkbh1 localizes to mtRNA granules and its knockdown induces the mitochondrial UPR in humans and C. elegans.
2019 Review in International Journal of Molecular Sciences
Antioxidant versus pro-apoptotic effects of mushroom-enriched diets on mitochondria in liver disease.
2019 Scientific Article in Cell Communication and Signaling
Connecting lysosomes and mitochondria - a novel role for lipid metabolism in cancer cell death.
2019 Scientific Article in American Journal of Physiology - Endocrinology and Metabolism
Linking bioenergetic function of mitochondria to tissue-specific molecular fingerprints.
2019 Scientific Article in Scientific Reports
Single organelle analysis to characterize mitochondrial function and crosstalk during viral infection.
2019 Meeting abstract in European Journal of Clinical Investigation
Mitochondria are indispensable for liver cancer cell proliferation.
2019 Scientific Article in Frontiers in Genetics
Prognostic and predictive value of three DNA methylation signatures in lung adenocarcinoma.
2019 Scientific Article in Cancer cell international
A novel 4-gene signature for overall survival prediction in lung adenocarcinoma patients with lymph node metastasis.
2019 Meeting abstract in Naunyn-Schmiedeberg's Archives of Pharmacology
Mitochondrial toxicology: Rescuing mitochondria in Wilson disease avoids acute liver failure.
2019 Scientific Article in Cellular and Molecular Gastroenterology and Hepatology
A high caloric diet aggravates mitochondrial dysfunction and triggers severe liver damage in Wilson disease rats.
2019 Scientific Article in EMBO Journal, The