Publications
2024 Scientific Article in EBioMedicine EBioMedicine 110:105438 (2024)
Longitudinal effects of SARS-CoV-2 breakthrough infection on imprinting of neutralizing antibody responses.
2024 Scientific Article in Virology Journal Virol. J. 21:246 (2024)
Adenoviral fiber-knob based vaccination elicits efficient neutralizing antibodies and T cell responses against adenovirus infection.
2024 Scientific Article in Cell Systems Cell Syst. 15, 911-929 (2024)
Protein turnover regulation is critical for influenza A virus infection.
2024 Scientific Article in JHEP Reports JHEP Rep. 6:101128 (2024)
HBV-related HCC development in mice is STAT3 dependent and indicates an oncogenic effect of HBx.
2024 Editorial in The lancet : Gastroenterology & Hepatology Lancet Gastroenterol. Hepatol., DOI: 10.1016/S2468-1253(24)00308-X (2024)
Availability of point-of-care HBV tests in resource-limited settings.
2024 Editorial in Clinical and Molecular Hepatology Clin. Mol. Hepatol., DOI: 10.3350/cmh.2024.0781 (2024)
Correspondence on Editorial regarding "Genetically modified, redirected T cells target hepatitis B surface antigen-positive hepatocytes and hepatocellular carcinoma lesions in a clinical setting".
2024 Scientific Article in Microbes and Infection Microbes Infect.:105412 (2024)
Replication-deficient sendai virus expressing human norovirus capsid protein elicits robust NoV-specific antibody and T-cell responses in mice.
2024 Scientific Article in Infection - A Journal of Infectious Disease Infection, DOI: 10.1007/s15010-024-02384-w (2024)
Evaluation of a host-protein signature score for differentiating between bacterial and viral infections: Real-life evidence from a German tertiary hospital.
2024 Scientific Article in Parasites and Vectors Parasit. Vectors 17:340 (2024)
Humans seropositive for Trypanosoma cruzi co-infected with intestinal helminths have higher infectiousness, parasitaemia and Th2-type response in the Argentine Chaco.
2024 Scientific Article in Nature Communications Nat. Commun. 15:6778 (2024)
Multi-omics characterization of the monkeypox virus infection.
2024 Review in Molecular Neurobiology Mol. Neurobiol., DOI: 10.1007/s12035-024-04421-z (2024)
A disease hidden in plain sight: Pathways and mechanisms of neurological complications of post-acute sequelae of COVID-19 (NC-PASC).
2024 Scientific Article in Nature Communications Nat. Commun. 15:7611 (2024)
Suppression of ferroptosis by vitamin A or radical-trapping antioxidants is essential for neuronal development.
2024 Scientific Article in Medical Microbiology and Immunology Med. Microbiol. Immunol. 213:18 (2024)
Analytical and clinical evaluation of a novel real-time PCR-based detection kit for Mpox virus.
2024 Review in Antiviral Research Antiviral Res. 229:105972 (2024)
Activating adaptive immunity by bispecific, T-cell engager antibodies bridging infected and immune-effector cells is a promising novel therapy for chronic hepatitis B.
Methods in Molecular Biology In: Hepatitis B Virus. 2024. 207-218 (Methods Mol. Biol. ; 2837)
Production and Purification of Adeno-Associated Viral Vectors for the Development of Immune-Competent Mouse Models of Persistent Hepatitis B Virus Replication.
2024 Scientific Article in Microbiology Spectrum Microbiol. Spectr. 12:e0091524 (2024)
Distinct prophage gene profiles of Staphylococcus aureus strains from atopic dermatitis patients and healthy individuals.
2024 Editorial in Frontiers in Immunology Front. Immunol. 15:1454792 (2024)
Editorial: EBV-induced T cell immunity in cancers.
2024 Scientific Article in Communications Chemistry Comm. Chem. 7:149 (2024)
Development of Nurr1 agonists from amodiaquine by scaffold hopping and fragment growing.
2024 Scientific Article in Virology Journal Virol. J. 21:139 (2024)
Evaluation of novel Epstein-Barr virus-derived antigen formulations for monitoring virus-specific T cells in pediatric patients with infectious mononucleosis.
2024 Scientific Article in Nature Nature 631, 867–875 (2024)
A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection.
2024 Scientific Article in Viruses Viruses 16:741 (2024)
Cytokine response of natural killer cells to Hepatitis B virus infection depends on monocyte co-stimulation.
2024 Scientific Article in Clinical and Molecular Hepatology Clin. Mol. Hepatol. 30, 735-755 (2024)
Genetically redirected HBV-specific T cells target HBsAg-positive hepatocytes and primary lesions in HBV-associated HCC.
2024 Scientific Article in ACS applied materials & interfaces ACS Appl. Mater. Interfaces 16, 37275-37287 (2024)
Light-induced transformation of virus-like particles on TiO2.
2024 Scientific Article in Journal of Medical Virology J. Med. Virol. 96:e29739 (2024)
Hybrid immunity by two COVID-19 mRNA vaccinations and one breakthrough infection provides a robust and balanced cellular immune response as basic immunity against severe acute respiratory syndrome coronavirus 2.
2024 Scientific Article in Frontiers in Immunology Front. Immunol. 15:1340619 (2024)
CARs derived from broadly neutralizing, human monoclonal antibodies identified by single B cell sorting target hepatitis B virus-positive cells.
2024 Scientific Article in Journal of Controlled Release J. Control. Release 371, 179-192 (2024)
Mucoadhesive film for oral delivery of vaccines for protection of the respiratory tract.
2024 Scientific Article in ACS applied materials & interfaces ACS Appl. Mater. Interfaces 16, 25836-25842 (2024)
Hepatitis B virus neutralization with DNA origami nanoshells.
2024 Review in Journal of General Virology J. Gen. Virol. 105:001978 (2024)
Highlights from the 2023 international meeting on the molecular biology of hepatitis B virus.
2024 Scientific Article in Viruses Viruses 16:546 (2024)
No remdesivir resistance observed in the phase 3 severe and moderate COVID-19 SIMPLE trials.
2024 Scientific Article in Journal of Personalized Medicine J. Pers. Med. 14:364 (2024)
Longterm outcome of therapeutic vaccination with a third generation Pre-S/S HBV vaccine (PreHevbrioR) of chronically HBV infected patients.
2024 Nature Cell Biology Nat. Cell Biol. 26:1019 (2024)
Author Correction: mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype.
2024 Scientific Article in Nature Communications Nat. Commun. 15:3379 (2024)
Diet changes due to urbanization in South Africa are linked to microbiome and metabolome signatures of Westernization and colorectal cancer.
2024 Scientific Article in Journal of Medicinal Chemistry J. Med. Chem. 67, 7048-7067 (2024)
Structural elucidation and antiviral activity of covalent cathepsin L inhibitors.
2024 Letter to the Editor in Cell Discovery Cell Discov. 10:42 (2024)
Engineered, nucleocytoplasmic shuttling Cas13d enables highly efficient cytosolic RNA targeting.
2024 Scientific Article in Microbiology Spectrum Microbiol. Spectr. 12:e0378823 (2024)
Arsenic trioxide impacts hepatitis B virus core nuclear localization and efficiently interferes with HBV infection.
2024 Scientific Article in Virology Virology 595:110089 (2024)
Major open questions in the hepatitis B and D field – Proceedings of the inaugural International emerging hepatitis B and hepatitis D researchers workshop.
2024 Scientific Article in Antiviral Research Antiviral Res. 226:105896 (2024)
The lack of HBsAg secretion does neither facilitate induction of antiviral T cell responses nor Hepatitis B Virus clearance in mice.
2024 Scientific Article in Vaccines Vaccines 12:308 (2024)
SARS-CoV-2 neutralization capacity in hemodialysis patients with and without a fifth vaccination with the updated comirnaty original/omicron BA.4-5 vaccine.
2024 Scientific Article in Medical Principles and Practice Med. Princ. Pract. 33, 1-9 (2024)
The potential of bacteriophage therapy as an alternative treatment approach for antibiotic-resistant infections.
2024 Scientific Article in Frontiers in Cellular and Infection Microbiology Front. Cell. Infect. Microbiol. 14:1338606 (2024)
CD81 suppresses NF-κB signaling and is downregulated in hepatitis C virus expressing cells.
2024 Scientific Article in Scientific Reports Sci. Rep. 14:5768 (2024)
Viral genome sequencing to decipher in-hospital SARS-CoV-2 transmission events.
2024 Scientific Article in Diagnostics Diagnostics 14:294 (2024)
Postmortem minimally invasive autopsy in critically Ill COVID-19 patients at the bedside: A proof-of-concept study at the ICU.
2024 Review in Cell Reports Cell Rep. 43:113728 (2024)
Bacteriophages, gut bacteria, and microbial pathways interplay in cardiometabolic health.
2024 Scientific Article in Infection - A Journal of Infectious Disease Infection, DOI: 10.1007/s15010-023-02171-z (2024)
Clinical and immunological outcomes of SARS-CoV-2-infected vaccine responders, vaccine non-responders, and unvaccinated patients evaluated for neutralizing monoclonal antibody treatment at a single German tertiary care center: A retrospective cohort study with prospective follow-up.
2024 Scientific Article in JHEP Reports JHEP Rep. 6:100997 (2024)
Introducing adjuvant-loaded particulate hepatitis B core antigen as an alternative therapeutic hepatitis B vaccine component.
2024 Scientific Article in One Health One Health 18:100674 (2024)
Immunisation of pigs with recombinant HEV vaccines does not protect from infection with HEV genotype 3.
2024 Scientific Article in Virology Virology 589:12 (2024)
Murine norovirus infection of macrophages induces intrinsic apoptosis as the major form of programmed cell death.
2024 Scientific Article in Nature Cancer Nat. Cancer 5, 187-208 (2024)
Bacteria and bacteriophage consortia are associated with protective intestinal metabolites in patients receiving stem cell transplantation.
2024 Scientific Article in Journal of Clinical Virology J. Clin. Virol. 170:105622 (2024)
Clinical and immunological benefits of full primary COVID-19 vaccination in individuals with SARS-CoV-2 breakthrough infections: A prospective cohort study in non-hospitalized adults.
In: Molecular Medical Microbiology, Third Edition. 2023. 2641-2658
Human virome in health and disease.
2023 Editorial in Gastroenterology Gastroenterology 18, 50-52 (2023)
SARS-CoV-2-the Pandemic and its Consequences Interview with Prof. Dr. Ulrike Protzer, Director of the Institute of Virology, Technical University of Munich/Helmholtz Center Munich - German Center for Environmental Health.
2023 Scientific Article in Clinical Kidney Journal Clin. Kidney J. 16, 2447-2460 (2023)
Longitudinal SARS-CoV-2 neutralization of Omicron BA.1, BA.5 and BQ.1.1 after four vaccinations and the impact of breakthrough infections in haemodialysis patients.
2023 Letter to the Editor in Nature Nature 621, E7-E26 (2023)
A second update on mapping the human genetic architecture of COVID-19.
2023 Scientific Article in Applied Sciences Appl. Sci. 13:4554 (2023)
COVIX—An index allowing for the assessment of the pandemic situation based on infections and hospitalisation data.
2023 Scientific Article in Human Gene Therapy. Clinical Development Hum. Gene Ther. 34, 1204-1218 (2023)
Vector-mediated delivery of human MHC-I into hepatocytes enables investigation of TCR-redirected HBV-specific T cells in mice and macaque cell cultures.
2023 Scientific Article in Communications Biology Comm. Biol. 6:1058 (2023)
Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections.
2023 Scientific Article in Microbiology Spectrum Microbiol. Spectr. 11:e0176823 (2023)
Improved detection of infection with SARS-CoV-2 Omicron variants of concern in healthcare workers by a second-generation rapid antigen test.
2023 Letter to the Editor in Gut (eGut) Gut, DOI: 10.1136/gutjnl-2023-330362 (2023)
Helicobacter pylori infection alters gut virome by expanding temperate phages linked to increased risk of colorectal cancer.
2023 Scientific Article in Nature Communications Nat. Commun. 14:6908 (2023)
Farnesoid X receptor activation by bile acids suppresses lipid peroxidation and ferroptosis.
2023 Scientific Article in Frontiers in Immunology Front. Immunol. 14:1251593 (2023)
Prevention of CMV/EBV reactivation by double-specific T cells in patients after allogeneic stem cell transplantation: Results from the randomized phase I/IIa MULTIVIR-01 study.
2023 Scientific Article in European Journal of Pharmaceutics and Biopharmaceutics Eur. J. Pharm. Biopharm. 192, 41-55 (2023)
Immunogenicity of a silica nanoparticle-based SARS-CoV-2 vaccine in mice.
2023 Scientific Article in Nature Communications Nat. Commun. 14:6046 (2023)
A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation.
2023 Scientific Article in Gut Microbes Gut Microbes 15:2257291 (2023)
Gut virome profiling identifies an association between temperate phages and colorectal cancer promoted by Helicobacter pylori infection.
2023 Scientific Article in International Journal of Molecular Sciences Int. J. Mol. Sci. 24:14 (2023)
Genetic architecture of ischaemic strokes after COVID-19 shows similarities with large vessel strokes.
2023 Scientific Article in European Journal of Medical Research Eur. J. Med. Res. 28:318 (2023)
Rapid point-of-care detection of SARS-CoV-2 infection in exhaled breath using ion mobility spectrometry: A pilot study.
2023 Scientific Article in Microorganisms Microorganisms 11:1562 (2023)
T-cell-dominated immune response resolves protracted SARS-CoV-2 infection in the absence of neutralizing antibodies in an immunocompromised individual.
2023 Scientific Article in Microbiology Spectrum Microbiol. Spectr. 11:5 (2023)
Targeted single-phage isolation reveals phage-dependent heterogeneous infection dynamics.
2023 Review in Clinical Oral Investigations Clin. Oral Investig. 27, 15-22 (2023)
The role of the oral cavity in SARS-CoV-2- and other viral infections.
2023 Scientific Article in Frontiers in Immunology Front. Immunol. 14:1172477 (2023)
Comparable cellular and humoral immunity upon homologous and heterologous COVID-19 vaccination regimens in kidney transplant recipients.
2023 Scientific Article in Cellular and Molecular Gastroenterology and Hepatology Cell. Mol. Gast. Hept. 16, 201-221 (2023)
Hepatitis B virus targets lipid transport pathways to infect hepatocytes.
2023 Scientific Article in Gut (eGut) Gut 72, 1258-1270 (2023)
Helicobacter pylori promotes colorectal carcinogenesis by deregulating intestinal immunity and inducing a mucus-degrading microbiota signature.
2023 Scientific Article in Gut Microbes Gut Microbes 15:2192522 (2023)
ViroProfiler: A containerized bioinformatics pipeline for viral metagenomic data analysis.
2023 Scientific Article in mBio mBio 14:e0347822 (2023)
Apobec3A deamination functions are involved in antagonizing efficient human adenovirus replication and gene expression.
2023 Scientific Article in Cell Chemical Biology Cell Chem. Bio. 30, 499-512.e5 (2023)
Selective killing of the human gastric pathogen Helicobacter pylori by mitochondrial respiratory complex I inhibitors.
2023 Scientific Article in International Journal of Molecular Sciences Int. J. Mol. Sci. 24:13 (2023)
A multifunctional and highly adaptable reporter system for CRISPR/Cas editing.
2023 Scientific Article in Molecular Metabolism Mol. Metab. 74:101748 (2023)
Depletion of pyruvate kinase (PK) activity causes glycolytic intermediate imbalances and reveals a PK-TXNIP regulatory axis.
2023 Scientific Article in Microbiology Spectrum Microbiol. Spectr. 11:e0044623 (2023)
SUMO modification of hepatitis B virus core mediates nuclear entry, promyelocytic leukemia nuclear body association, and efficient formation of covalently closed circular DNA.
2023 Scientific Article in Clinica Terapeutica Clin. Ter. 174, 266-274 (2023)
Multidimensional analysis of the mother-to-child transmission risk factors in chronic hepatitis B virus infection in pregnant women in Vietnam.
2023 Scientific Article in Molecular Immunology Mol. Immunol. 162, 38-44 (2023)
Modeling of the human interleukin 12:receptor complex allows to engineer attenuated cytokine variants.
2023 Review in Cancers Cancers 15:21 (2023)
Targeted therapy for EWS-FLI1 in ewing sarcoma.
2023 Scientific Article in Journal of Hazardous Materials J. Hazard. Mater. 459:132299 (2023)
Unveiling the hidden role of aquatic viruses in hydrocarbon pollution bioremediation.
2023 Scientific Article in Journal of Medical Virology J. Med. Virol. 95:e29022 (2023)
Implementation and clinical evaluation of an Mpox virus laboratory-developed test on a fully automated random-access platform.
2023 Scientific Article in Medical Microbiology and Immunology Med. Microbiol. Immunol. 212, 307-322 (2023)
Automated antigen assays display a high heterogeneity for the detection of SARS-CoV-2 variants of concern, including several Omicron sublineages.
2023 Scientific Article in Nature Communications Nat. Commun. 14:4564 (2023)
Trimannose-coupled antimiR-21 for macrophage-targeted inhalation treatment of acute inflammatory lung damage.
2023 Review in Viruses Viruses 15:23 (2023)
Phage therapy in Germany-update 2023.
2023 Scientific Article in Vaccines Vaccines 11:17 (2023)
Evaluation of the effect of CD70 co-expression on CD8 T cell response in protein-prime MVA-boost vaccination in mice.
2023 Scientific Article in International Journal of Molecular Sciences Int. J. Mol. Sci. 24:23 (2023)
DeepsmirUD: Prediction of regulatory effects on microRNA expression mediated by small molecules using deep learning.
2023 Scientific Article in ACS applied materials & interfaces ACS Appl. Mater. Interfaces 15, 8770-8782 (2023)
Adsorption and inactivation of SARS-CoV-2 on the surface of anatase TiO2(101).
2023 Other: Opinion in Zeitschrift für Gastroenterologie Z. Gastroenterol. 61, 198-201 (2023)
Strategietreffen: Virushepatitis in Deutschland eliminieren.
2023 Scientific Article in Frontiers in Physiology Front. Physiol. 13:1090732 (2023)
Mutant plasminogen in hereditary angioedema is bypassing FXII/kallikrein to generate bradykinin.
2023 Scientific Article in JHEP Reports JHEP Rep. 5:100603 (2023)
Efficient stabilization of therapeutic hepatitis B vaccine components by amino-acid formulation maintains its potential to break immune tolerance.
2023 Scientific Article in Nature Cancer Nat. Cancer 4, 81–95 (2023)
Potent high-avidity neutralizing antibodies and T cell responses after COVID-19 vaccination in individuals with B cell lymphoma and multiple myeloma.
2023 Scientific Article in Journal of Pathology: Clinical Research J. Pathol. Clin. Res. 9, 73-85 (2023)
Olfactomedin 4 associates with expression of differentiation markers but not with properties of cancer stemness, EMT nor metastatic spread in colorectal cancer.
2023 Scientific Article in Analytical and Bioanalytical Chemistry Anal. Bioanal. Chem. 415, 391-404 (2023)
Automated detection of neutralizing SARS-CoV-2 antibodies in minutes using a competitive chemiluminescence immunoassay.
2022 Scientific Article in Journal of Hepatology J. Hepatol. 78:15 (2022)
Activation of CD4 T cells during prime immunization determines the success of a therapeutic hepatitis B vaccine in HBV-carrier mouse models.
2022 Scientific Article in Journal of Fungi J. Fungi 8:1265 (2022)
Gut microbial disruption in critically Ill patients with COVID-19-associated pulmonary aspergillosis.
2022 Scientific Article in Frontiers in Immunology Front. Immunol. 13:1045498 (2022)
Immune escape pathways from the HBV core18-27 CD8 T cell response are driven by individual HLA class I alleles.
2022 Scientific Article in Frontiers in Immunology Front. Immunol. 13:1029214 (2022)
Activation of distinct antiviral T-cell immunity: A comparison of bi- and trispecific T-cell engager antibodies with a chimeric antigen receptor targeting HBV envelope proteins.
2022 Scientific Article in PLoS Genetics PLoS Genet. 18:e1010367 (2022)
Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative.
2022 Scientific Article in Communications Biology Comm. Biol. 5:1237 (2022)
Multimeric ACE2-IgM fusions as broadly active antivirals that potently neutralize SARS-CoV-2 variants.
2022 Scientific Article in Biochimica et Biophysica Acta - Molecular Basis of Disease Biochim. Biophys. Acta-Mol. Basis Dis. 1869:166592 (2022)
Proteomics reveals antiviral host response and NETosis during acute COVID-19 in high-risk patients.
2022 Scientific Article in Iranian Journal of Immunology Iran. J. Immunol. 19, 278-298 (2022)
Optimization of an efficient cell culture hepatitis B infection system for assessment of hepatitis B virus neutralizing monoclonal antibodies.
2022 Scientific Article in Frontiers in Microbiology Front. Microbiol. 13:953500 (2022)
Insights into the global freshwater virome.
2022 Scientific Article in Veterinary Microbiology Vet. Microbiol. 274:109575 (2022)
Early life dynamics of ARG and MGE associated with intestinal virome in neonatal piglets.
2022 Scientific Article in Frontiers in Immunology Front. Immunol. 13:889836 (2022)
Association between IgG responses against the nucleocapsid proteins of alphacoronaviruses and COVID-19 severity.
2022 Scientific Article in Vaccines Vaccines 10:1328 (2022)
Improved SARS-CoV-2 neutralization of delta and omicron BA.1 variants of concern after fourth vaccination in hemodialysis patients.
2022 Scientific Article in Frontiers in Immunology Front. Immunol. 13:958952 (2022)
A novel monoclonal IgG1 antibody specific for Galactose-alpha-1,3-galactose questions alpha-Gal epitope expression by bacteria.
2022 Scientific Article in Frontiers in Microbiology Front. Microbiol. 13:901762 (2022)
Toxic/bioactive peptide synthesis genes rearranged by insertion sequence elements among the bloom-forming cyanobacteria Planktothrix.
2022 Review in Microbial pathogenesis Microb. Pathog. 170:105704 (2022)
Gut bacteria, bacteriophages, and probiotics: Tripartite mutualism to quench the SARS-CoV2 storm.
2022 Scientific Article in JHEP Reports JHEP Rep. 4:100514 (2022)
Mitosis of hepatitis B virus-infected cells in vitro results in uninfected daughter cells.
2022 Scientific Article in Microbiome Microbiome 10:105 (2022)
Transplantation of bacteriophages from ulcerative colitis patients shifts the gut bacteriome and exacerbates the severity of DSS colitis.
2022 Scientific Article in EBioMedicine EBioMedicine 85:104294 (2022)
Dynamics of humoral and cellular immune responses after homologous and heterologous SARS-CoV-2 vaccination with ChAdOx1 nCoV-19 and BNT162b2.
2022 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 31, 3789-3806 (2022)
Novel genes and sex differences in COVID-19 severity.
2022 Scientific Article in iScience iScience 25:104632 (2022)
Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death.
2022 Review in Current Opinion in Virology Curr. Opin. Virol. 54:101231 (2022)
Emerging technologies in the study of the virome.
2022 Scientific Article in Microbiology Spectrum Microbiol. Spectr. 10:e0078522 (2022)
PML alternative splice products differentially regulate HAdV productive infection.
2022 Mucosal Immunology Mucosal Immunol. 15:798 (2022)
Correction to: Mild COVID-19 imprints a long-term inflammatory eicosanoid- and chemokine memory in monocyte-derived macrophages.
2022 Scientific Article in Frontiers in Microbiology Front. Microbiol. 13:795101 (2022)
Selective maternal seeding and rearing environment from birth to weaning shape the developing piglet gut microbiome.
2022 Scientific Article in Deutsches Ärzteblatt international Dtsch. Arztebl. Int. 119, 546-547 (2022)
Toskana-Virus-Meningoenzephalitis in Oberbayern.
2022 Scientific Article in Aging Aging 14, 5299-5310 (2022)
Cockayne syndrome without UV-sensitivity in Vietnamese siblings with novel ERCC8 variants.
2022 Scientific Article in Viruses Viruses 14:1591 (2022)
Influenza A virus infection reactivates human endogenous retroviruses associated with modulation of antiviral immunity.
2022 Scientific Article in PLoS Pathogens PLoS Pathog. 18:e1010576 (2022)
Hepatitis B virus X protein counteracts high mobility group box 1 protein-mediated epigenetic silencing of covalently closed circular DNA.
2022 Review in Nature Reviews - Gastroenterology & Hepatology Nat. Rev. Gastroenterol. Hepatol. 19, 727-745 (2022)
A roadmap for serum biomarkers for hepatitis B virus: Current status and future outlook.
2022 Scientific Article in STAR Protocols STAR Protoc. 3:101281 (2022)
A protocol for CRISPR-mediated activation and repression of human endogenous retroviruses in human pluripotent stem cells.
2022 Editorial in Frontiers in Immunology Front. Immunol. 13:868616 (2022)
Editorial: Targeting the immune system to treat hepatitis B virus infection.
2022 Scientific Article in Biomolecules Biomolecules 12:470 (2022)
PD-L1 silencing in liver using siRNAs enhances efficacy of therapeutic vaccination for chronic hepatitis B.
2022 Scientific Article in Mucosal Immunology Mucosal Immunol. 15, 515–524 (2022)
Mild COVID-19 imprints a long-term inflammatory eicosanoid- and chemokine memory in monocyte-derived macrophages.
2022 Scientific Article in Nature Communications Nat. Commun. 13:2995 (2022)
Long-term hepatitis B virus infection of rhesus macaques requires suppression of host immunity.
2022 Review in FEMS Microbiology Reviews - Federation of European Microbiological Societies FEMS Microbiol. Rev. 46:fuac027 (2022)
The role of virome in the gastrointestinal tract and beyond.
2022 Scientific Article in Bioinformatics Bioinformatics 38, 2428-2436 (2022)
HAMdetector: A Bayesian regression model that integrates information to detect HLA-associated mutations.
2022 Scientific Article in Gut Microbes Gut Microbes 14:2031840 (2022)
Gut bacterial dysbiosis and instability is associated with the onset of complications and mortality in COVID-19.
2022 Scientific Article in Journal of Molecular Medicine J. Mol. Med. 100, 613-627 (2022)
Early reduction of SARS-CoV-2-replication in bronchial epithelium by kinin B2 receptor antagonism.
2022 Scientific Article in Analytical Chemistry Anal. Chem. 94, 2855-2864 (2022)
Fully automated chemiluminescence microarray analysis platform for rapid and multiplexed. SARS-CoV-2 serodiagnostics.
2022 Scientific Article in Molecular Therapy. Methods & Clinical Development Mol.Ther.-Methods Clin. Dev. 24, 241-254 (2022)
Rapid, accurate mapping of transgene integration in viable rhesus macaque embryos using enhanced-specificity tagmentation-assisted PCR.
2022 Scientific Article in Computational and Structural Biotechnology Journal Comp. Struc. Biotech. J. 20, 799-811 (2022)
Montelukast is a dual-purpose inhibitor of SARS-CoV-2 infection and virus-induced IL-6 expression identified by structure-based drug repurposing.
2022 Review in Internist, Der Internist 63, 118-128 (2022)
Antivirale Medikamente.Potente Wirkstoffe, Hoffnungsträger bei COVID‑19 und therapeutische Grenzen.
Methods in Molecular Biology In: HIV Reservoirs. 2022. 103-114 (Methods Mol. Biol. ; 2407)
Modeling HIV latency in astrocytes with the human neural progenitor cell line HNSC.100.
2022 Scientific Article in Journal of Controlled Release J. Control. Release 345, 661-674 (2022)
Inhibition of SARS-CoV-2 replication in the lung with siRNA/VIPER polyplexes.
2022 Scientific Article in Advanced science Adv. Sci.:e2104979 (2022)
Molecular signature of astrocytes for gene delivery by the synthetic adeno-associated viral vector rAAV9P1.
2022 Nature Genetics Nat. Genet. 54, 358-360 (2022)
EMPReSS: Standardized phenotype screens for functional annotation of the mouse genome (vol 37, pg 1155, 2005).
2022 Nature medicine Nat. Med. 28:600 (2022)
Author Correction: Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer.
2022 Review in Cell Cell 185, 400-400.e1 (2022)
SnapShot: Human endogenous retroviruses.
2022 Scientific Article in Nature medicine Nat. Med. 28, 496–503 (2022)
Three exposures to the spike protein of SARS-CoV-2 by either infection or vaccination elicit superior neutralizing immunity to all variants of concern.
2022 Scientific Article in Nature Communications Nat. Commun. 13:153 (2022)
Dynamics of spike-and nucleocapsid specific immunity during long-term follow-up and vaccination of SARS-CoV-2 convalescents.
2022 Scientific Article in Human Genetics Hum. Genet. 141, 147-173 (2022)
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity.
2022 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 50, 333-349 (2022)
Targeting genomic SARS-CoV-2 RNA with siRNAs allows efficient inhibition of viral replication and spread.
2022 Scientific Article in JMIR Formative Research JMIR Form. Res. 6:e32564 (2022)
A telemedicine-guided self-collection approach for PCR-based SARS-CoV-2 testing: Comparative study.
2022 Review in Molecular Microbiology Mol. Microbiol., DOI: 10.1111/mmi.14849 (2022)
Targeted protein degradation at the host-pathogen interface.
2022 Scientific Article in Alcoholism: Clinical and Experimental Research Alcohol. Clin. Exp. Res. 46, 40-51 (2022)
Ethanol attenuates presentation of cytotoxic T-lymphocyte epitopes on hepatocytes of HBV-infected humanized mice.
2022 Scientific Article in Journal of Investigative Dermatology, The J. Invest. Dermatol. 142, 549-558.e6 (2022)
Immunocompromised patients with therapy-refractory chronic skin diseases show reactivation of latent EBV and CMV infection.
2022 Review in Trends in microbiology Trends Microbiol. 30, 131-142 (2022)
New technologies for developing phage-based tools to manipulate the human microbiome.
2021 Scientific Article in Journal of Voice J. Voice 38, 798.e7-798.e20 (2021)
Reopening the Bavarian state opera safely: Hygiene strategies and incidence of COVID-19 in artistic staff during theater season 2020/2021.
2021 Scientific Article in Nature Nature 600, 472-477 (2021)
Mapping the human genetic architecture of COVID-19.
2021 Scientific Article in Journal of Immunology J. Immunol. 207, 2913-2921 (2021)
Identification and characterization of antigen-specific CD8+ T cells using surface-trapped TNF-α and single-cell sequencing.
2021 Scientific Article in Cells Cells 10:3253 (2021)
Hepatitis-D virus infection is not impaired by innate immunity but increases cytotoxic T-cell activity.
2021 Scientific Article in Antiviral Research Antiviral Res. 196:105197 (2021)
Picomolar inhibition of SARS-CoV-2 variants of concern by an engineered ACE2-IgG4-Fc fusion protein.
2021 Scientific Article in Molecular Therapy. Methods & Clinical Development Mol.Ther.-Methods Clin. Dev. 23, 476-489 (2021)
Characterization of a library of 20 HBV-specific MHC class II-restricted T cell receptors.
2021 Scientific Article in BJPsych Open BJPsych Open 7:e188 (2021)
Interplay between the genetics of personality traits, severe psychiatric disorders and COVID-19 host genetics in the susceptibility to SARS-CoV-2 infection.
2021 Scientific Article in Nature Communications Nat. Commun. 12:6737 (2021)
Mechanistic principles of an ultra-long bovine CDR reveal strategies for antibody design.
2021 Scientific Article in Cellular Microbiology Cell. Microbiol. 23:e13399 (2021)
Hepatitis B virus envelope proteins can serve as therapeutic targets embedded in the host cell plasma membrane.
2021 Scientific Article in JHEP Reports JHEP Rep. 3:100354 (2021)
Control of APOBEC3B induction and cccDNA decay by NF-κB and miR-138-5p.
2021 Scientific Article in American Journal of Physiology - Lung Cellular and Molecular Physiology Am. J. Physiol. Lung Cell Mol. Physiol. 322, L129-L148 (2021)
Validation of in vitro models for smoke exposure of primary human bronchial epithelial cells.
2021 Scientific Article in Faculty of 1000 Research F1000 Res. 9:1130 (2021)
COVID-19 and beyond: A call for action and audacious solidarity to all the citizens and nations, it is humanity’s fight.
2021 Scientific Article in Frontiers in Immunology Front. Immunol. 12:734246 (2021)
Depletion of T cells via inducible caspase 9 increases safety of adoptive T-cell therapy against chronic hepatitis B.
2021 Scientific Article in Scientific Reports Sci. Rep. 11:20143 (2021)
A proof of concept study for the differentiation of SARS-CoV-2, hCoV-NL63, and IAV-H1N1 in vitro cultures using ion mobility spectrometry.
2021 Scientific Article in Scientific Reports Sci. Rep. 11:19799 (2021)
Concentration of Na+-taurocholate-cotransporting polypeptide expressed after in vitro-transcribed mRNA transfection determines susceptibility of hepatoma cells for hepatitis B virus.
2021 Scientific Article in Journal of Clinical Investigation J. Clin. Invest. 131:e152386 (2021)
Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality.
2021 Scientific Article in Frontiers in Immunology Front. Immunol. 12:713351 (2021)
Hepatitis B vaccine non-responders show higher frequencies of CD24highCD38high regulatory B cells and lower levels of IL-10 expression compared to responders.
2021 Letter to the Editor in EBioMedicine EBioMedicine 73:103635 (2021)
SARS-CoV-2 vaccination in multiple sclerosis: A clearer picture for the time point during CD20 depleting therapy.
2021 Scientific Article in BioTechniques / Protocol Guide BioTechniques 71, 534-537 (2021)
A simplified method for bronchoalveolar lavage in mice by orotracheal intubation avoiding tracheotomy.
2021 Scientific Article in Orthopäde, Der Orthopäde, DOI: 10.1007/s00132-021-04148-y (2021)
Behandlung von Knochen- und Protheseninfektionen mit Bakteriophagen.Ein systematisches Review.
2021 Scientific Article in Pan African Medical Journal Pan Afr. Med. J. 39:174 (2021)
Hepatitis B, C and D virus prevalence in children and adults in Mbeya Region, Tanzania: Results from a cohort study 2002-2009.
2021 Scientific Article in Medical Microbiology and Immunology Med. Microbiol. Immunol., DOI: 10.1007/s00430-021-00719-0 (2021)
Comparison of four commercial, automated antigen tests to detect SARS-CoV-2 variants of concern.
2021 Scientific Article in Vaccines Vaccines 9:841 (2021)
Immunogenicity and antiviral response of therapeutic hepatitis B vaccination in a mouse model of hbeag-negative, persistent hbv infection.
2021 Scientific Article in Viruses Viruses 13:1503 (2021)
Rapid and robust continuous purification of high-titer hepatitis B virus for in vitro and in vivo applications.
2021 Scientific Article in Microorganisms Microorganisms 9:1701 (2021)
Differences in gut virome related to barrett esophagus and esophageal adenocarcinoma.
2021 Scientific Article in The Lancet. Infectious diseases Lancet Infect. Dis. 21, 1212-1213 (2021)
Heterologous prime-boost vaccination with ChAdOx1 nCoV-19 and BNT162b2.
Advances in Experimental Medicine and Biology In: Tumor Microenvironment. Gewerbestrasse 11, Cham, Ch-6330, Switzerland: Springer International Publishing Ag, 2021. 1-14 (Adv. Exp. Med. Biol. ; 1302)
CCL2 in the tumor microenvironment.
2021 Scientific Article in Hemasphere Hemasphere 5:e603 (2021)
COVID-19 in Patients Receiving CD20-depleting Immunochemotherapy for B-cell Lymphoma.
2021 Scientific Article in Zeitschrift für Gastroenterologie Z. Gastroenterol. 59, 691-776 (2021)
S3-Leitlinie der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) zur Prophylaxe, Diagnostik und Therapie der Hepatitis-B-Virusinfektion.
2021 Scientific Article in Journal of Hepatology J. Hepatol. 75, 1072-1082 (2021)
Novel function of SART1 in HNF4α transcriptional regulation contributes to its antiviral role during HBV infection.
2021 Scientific Article in Antiviral Research Antiviral Res. 194, 05140:105140 (2021)
Intramolecular recombination enables the formation of hepatitis B virus (HBV) cccDNA in mice after HBV genome transfer using recombinant AAV vectors.
2021 Review in Journal of Clinical and Translational Hepatology J. Clin. Transl. Hepatol. 9, 399-408 (2021)
HBV integration induces complex interactions between host and viral genomic functions at the insertion site.
2021 Scientific Article in Journal of Hazardous Materials J. Hazard. Mater. 419:126205 (2021)
BTEX biodegradation is linked to bacterial community assembly patterns in contaminated groundwater ecosystem.
2021 Scientific Article in Journal of Hepatology J. Hepatol. 75, 1058-1071 (2021)
T-cell engager antibodies enable T cells to control HBV infection and to target HBsAg-positive hepatoma in mice.
2021 Scientific Article in iScience iScience 24, 102802:102802 (2021)
Prolonged norovirus infections correlate to quasispecies evolution resulting in structural changes of surface-exposed epitopes.
2021 Scientific Article in European Journal of Neurology Eur. J. Neurol. 28, 3230-3244 (2021)
Systematic review of cases of acute myelitis in individuals with COVID-19.
2021 Scientific Article in British Journal of Pharmacology Br. J. Pharmacol. 178, 4026-4041 (2021)
A drug screen with approved compounds identifies amlexanox as a novel Wnt/β-catenin activator inducing lung epithelial organoid formation.
2021 Editorial in Signal transduction and targeted therapy Signal Transduct. Target. Ther. 6:193 (2021)
Gut phage database: Phage mining in the cave of wonders.
2021 Scientific Article in Analytical and Bioanalytical Chemistry Anal. Bioanal. Chem. 413, 5619-5632 (2021)
Automated, flow-based chemiluminescence microarray immunoassay for the rapid multiplex detection of IgG antibodies to SARS-CoV-2 in human serum and plasma (CoVRapid CL-MIA).
2021 Scientific Article in Nature materials Nat. Mater. 20, 1281–1289 (2021)
Programmable icosahedral shell system for virus trapping.
2021 Scientific Article in EMBO Reports EMBO Rep. 22:e49568 (2021)
Interferon-induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG20.
2021 Scientific Article in Hepatology Hepatology 74, 1766-1781 (2021)
HIF1α-mediated RelB/APOBEC3B downregulation allows Hepatitis B Virus persistence.
2021 Review in Viruses Viruses 13:766 (2021)
ITN-VIROINF: Understanding (Harmful) virus-host interactions by linking virology and bioinformatics.
2021 Scientific Article in Infection - A Journal of Infectious Disease Infection 49, 927-934 (2021)
Self-sampling versus health care professional-guided swab collection for SARS-CoV-2 testing.
2021 Review in Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids Biochim. Biophys. Acta-Mol. Cell Biol. Lipids 1866:158960 (2021)
Molecular regulation of the hepatic bile acid uptake transporter and HBV entry receptor NTCP.
2021 Scientific Article in BMC Microbiology BMC Microbiol. 21:132 (2021)
Sewage and sewage-contaminated environments are the most prominent sources to isolate phages against Pseudomonas aeruginosa.
2021 Scientific Article in Cells Cells 10:774 (2021)
Increased HERV-K(HML-2) transcript levels correlate with clinical parameters of liver damage in hepatitis C patients.
2021 Scientific Article in Science of the Total Environment, The Sci. Total Environ. 781:146506 (2021)
Thermodynamically favorable reactions shape the archaeal community affecting bacterial community assembly in oil reservoirs.
2021 Scientific Article in Cell Stem Cell Cell Stem Cell 28, 1566-1581.e8 (2021)
Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3.
2021 Scientific Article in Nature Nature 592, 450–456 (2021)
NASH limits anti-tumour surveillance in immunotherapy-treated HCC.
2021 Nature Nature 589, E6 (2021)
Publisher Correction: Inhibition of LTβR signalling activates WNT-induced regeneration in lung (Nature, (2020), 588, 7836, (151-156), 10.1038/s41586-020-2882-8).
2021 Scientific Article in Viruses Viruses 13:334 (2021)
Improving the inhibitory effect of phages against Pseudomonas aeruginosa isolated from a burn patient using a combination of phages and antibiotics.
2021 Scientific Article in Viruses Viruses 13:241 (2021)
Mucosal-associated invariant T (MAIT) cells are highly activated and functionally impaired in COVID-19 patients.
2021 Scientific Article in Journal of Hepatology J. Hepatol. 75, 64-73 (2021)
Hypoxia inducible factors regulate hepatitis B virus replication by activating the basal core promoter.
2021 Scientific Article in The journal of allergy and clinical immunology J. Allergy Clin. Immunol. 148, 1041-1048 (2021)
Novel hereditary angioedema linked with a heparan sulfate 3-O-sulfotransferase 6 gene mutation.
2021 Scientific Article in Medical Microbiology and Immunology Med. Microbiol. Immunol. 210, 65-72 (2021)
Evaluation of two rapid antigen tests to detect SARS-CoV-2 in a hospital setting.
2021 Scientific Article in Virus Research Virus Res. 295:198280 (2021)
Double-edged role of PML nuclear bodies during human adenovirus infection.
2021 Scientific Article in Journal of Hazardous Materials J. Hazard. Mater. 407:124372 (2021)
Stochasticity versus determinism: Microbial community assembly patterns under specific conditions in petrochemical activated sludge.
2021 Scientific Article in Med (N Y) Med. 2, 149-163.e4 (2021)
Public health antibody screening indicates a six-fold higher SARS-CoV-2 exposure rate than reported cases in children.
2021 Review in Microbial Biotechnology Microb. Biotechnol. 14, 45-50 (2021)
Sustainable microbiome: A symphony orchestrated by synthetic phages.
2021 Review in Trends in microbiology Trends Microbiol. 29, 171-181 (2021)
Challenges of studying the human virome – relevant emerging technologies.
2020 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 48, 10397-10412 (2020)
A ribosomal RNA fragment with 2',3'-cyclic phosphate and GTP-binding activity acts as RIG-I ligand.
In: Gut Remediation of Environmental Pollutants. 2020. 199-217
Gut remediation: Back to the future.
In: Gut Remediation of Environmental Pollutants. 2020. 219-245
Current policies and policy implications for environmental pollution.
2020 Scientific Reports Sci. Rep. 10:19332 (2020)
Author Correction: Hypoxic gene expression in chronic hepatitis B virus infected patients is not observed in state-of-the-art in vitro and mouse infection models (Scientific Reports, (2020), 10, 1, (14101), 10.1038/s41598-020-70865-7).
2020 Science of the Total Environment, The Sci. Total Environ. 760:143189 (2020)
Corrigendum to “Using nano-attapulgite clay compounded hydrophilic urethane foams (AT/HUFs) as biofilm support enhances oil-refinery wastewater treatment in a biofilm membrane bioreactor” [Sci. Total Environ., 646 (2019) 606-17/STOTEN-D-18-03954] (Science of the Total Environment (2019) 646 (606–617), (S0048969718326354), (10.1016/j.scitotenv.2018.07.149)).
2020 Scientific Article in Journal of extracellular vesicles J. Extra. Vesicles 10:e12040 (2020)
Efficient and reproducible depletion of hepatitis B virus from plasma derived extracellular vesicles.
2020 Scientific Article in Viruses Viruses 12:1344 (2020)
Global occurrence of clinically relevant hepatitis B virus variants as found by analysis of publicly available sequencing data.
2020 Scientific Article in Scientific Reports Sci. Rep. 10:18625 (2020)
A rigorous assessment and comparison of enumeration methods for environmental viruses.
2020 Scientific Article in Journal of Hepatology J. Hepatol. 73, 1347-1359 (2020)
Reduced mitochondrial resilience enables non-canonical induction of apoptosis after TNF receptor signaling in virus-infected hepatocytes.
2020 Scientific Article in Cells Cells 9:1989 (2020)
A broad-spectrum antiviral peptide blocks infection of viruses by binding to phosphatidylserine in the viral envelope.
2020 Scientific Article in Scientific Reports Sci. Rep. 10:14101 (2020)
Hypoxic gene expression in chronic hepatitis B virus infected patients is not observed in state-of-the-art in vitro and mouse infection models.
2020 Scientific Article in Cellular Microbiology Cell. Microbiol. 22:e13250 (2020)
Synchronised infection identifies early rate-limiting steps in the hepatitis B virus life cycle.
2020 Review in Viruses Viruses 12:828 (2020)
Innovative HBV animal models based on the entry receptor NTCP.
2020 Scientific Article in Journal of Functional Foods J. Funct. Food. 72:104045 (2020)
Bifidobacterium breve ATCC15700 pretreatment prevents alcoholic liver disease through modulating gut microbiota in mice exposed to chronic alcohol intake.
2020 Review in Eurosurveillance Euro Surveill. 25, 2-6 (2020)
Multicentre comparison of quantitative PCR-based assays to detect SARS-CoV-2, Germany, March 2020.
2020 Nature Immunology Nat. Immunol., DOI: 10.1038/s41590-020-0749-7 (2020)
Publisher Correction: Tumor-necrosis factor impairs CD4+ T cell–mediated immunological control in chronic viral infection (Nature Immunology, (2016), 17, 5, (593-603), 10.1038/ni.3399).
2020 Review in World Journal of Gastroenterology World J. Gastroenterol. 26, 2781-2791 (2020)
Innate immune recognition and modulation in hepatitis D virus infection.
2020 Scientific Article in Journal of Translational Medicine J. Transl. Med. 18:242 (2020)
Evaluation of T-activated proteins as recall antigens to monitor Epstein-Barr virus and human cytomegalovirus-specific T cells in a clinical trial setting.
2020 Meeting abstract in Molecular Therapy Mol. Ther. 28, 520-520 (2020)
Characterization of MHC class II-restricted t-cell receptors for t-cell therapy of HBV infection.
2020 Scientific Article in Journal of Hepatology J. Hepatol. 73, 449-451 (2020)
Two-dimensional-cultures of primary human hepatocytes allow efficient HBV infection: Old tricks still work!
2020 Scientific Article in Journal of the Pediatric Infectious Diseases Society J. Pediatr. Infect. Dis. Soc. 9, 362-365 (2020)
Clinical and epidemiological features of a family cluster of symptomatic and asymptomatic severe acute respiratory syndrome coronavirus 2 infection.
2020 Scientific Article in Clinical and translational immunology Clin. Transl. Immunology 9:e1129 (2020)
Dynamic changes in circulating T follicular helper cell composition predict neutralising antibody responses after yellow fever vaccination.
2020 Scientific Article in Journal of Hepatology J. Hepatol. 72, 960-975 (2020)
A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control.
2020 Scientific Article in Nature Immunology Nat. Immunol. 21, 555-566 (2020)
Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal.
2020 Scientific Article in mBio mBio 11:00049-20 (2020)
Viral DNA binding protein SUMOylation promotes PML nuclear body localization next to viral replication centers.
2020 Scientific Article in Cell Host & Microbe Cell Host Microbe 27, 199-212 (2020)
Bacteriophages isolated from stunted children can regulate gut bacterial communities in an age-specific manner.
2020 Scientific Article in Hepatology international Hepatol. Int. 14, 326–337 (2020)
Noninvasive chimeric DNA profiling identifies tumor-originated HBV integrants contributing to viral antigen expression in liver cancer.
2020 Scientific Article in Gastroenterology Gastroenterology 158, 1762-1775 (2020)
Knockdown of virus antigen expression increases therapeutic vaccine efficacy in high-titer hepatitis B virus carrier mice.
2020 Scientific Article in Scientific Reports Sci. Rep. 10:1326 (2020)
Potent inhibition of HIV replication in primary human cells by novel synthetic polyketides inspired by Aureothin.
2020 Scientific Article in Scientific Reports Sci. Rep. 10:1319 (2020)
Advanced identification of global bioactivity hotspots via screening of the metabolic fingerprint of entire ecosystems.
2020 Scientific Article in Advanced science Adv. Sci. 7:1902130 (2020)
ATO (Arsenic Trioxide) effects on promyelocytic leukemia nuclear bodies reveals antiviral intervention capacity.
2020 Scientific Article in Scientific Reports Sci. Rep. 10:2781 (2020)
Chemically labeled toxins or bioactive peptides show a heterogeneous intracellular distribution and low spatial overlap with autofluorescence in bloom-forming cyanobacteria.
2020 Scientific Article in Journal of General Virology J. Gen. Virol. 101, 284-289 (2020)
Differential upregulation of host cell protein kinases by the replication of α-, β- and γ-Herpesviruses provides a signature o virus-specific signalling.
2020 Review in Antiviral Research Antiviral Res. 176:104748 (2020)
Adoptive T-cell therapy for HBV-associated HCC and HBV infection.
2020 Scientific Article in Matters Matters, accepted (2020)
Extracellular vesicles derived from Hepatitis-D Virus infected cells induce a proinflammatory cytokine response in human peripheral blood mononuclear cells and macrophages.
2020 Scientific Article in Environmental Science and Pollution Research Environ. Sci. Pollut. Res. 27, 6637-6648 (2020)
Assessment of German population exposure levels to PM10 based on multiple spatial-temporal data.
2020 Scientific Article in Journal of Infectious Diseases, The J. Infect. Dis. 221, 1448-1461 (2020)
Dynamic, helminth-induced immune modulation influences the outcome of acute and chronic hepatitis B virus infection.
2020 Scientific Article in Journal of Organic Chemistry, The J. Org. Chem. 85, 664-673 (2020)
Discovery of the streptoketides by direct cloning and rapid heterologous expression of a cryptic PKS II gene cluster from streptomyces sp. Tü 6314.
2020 Scientific Article in Hydrobiologia Hydrobiologia 847, 535-548 (2020)
Resilience of planktonic bacterial community structure in response to short-term weather deterioration during the growing season in an alpine lake.
2020 Scientific Article in Brazilian journal of microbiology Braz. J. Microbio. 51, 183-187 (2020)
Quantitation of norovirus-specific IgG before and after infection in immunocompromised patients.
2019 Scientific Article in Journal of General Virology J. Gen. Virol. 102:001373 (2019)
A PCR assay to quantify patterns of HBV transcription.
2019 Meeting abstract in Human Gene Therapy. Clinical Development Hum. Gene Ther. 30, A10-A10 (2019)
Characterization of MHC class II-restricted t-cell receptors for t-cell therapy of HBV infection.
2019 Scientific Article in Nature Communications Nat. Commun. 10:5770 (2019)
SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection.
2019 Scientific Article in ChemBioChem ChemBioChem 21, 492-495 (2019)
Chemoenzymatic total synthesis of sorbicatechol structural analogues and evaluation of their antiviral potential.
2019 Scientific Article in Antimicrobial Agents and Chemotherapy Antimicrob. Agents Chemother. 64:e01440-19 (2019)
A new role for capsid assembly modulators to target mature hepatitis B virus capsids and prevent virus infection.
2019 Meeting abstract in Cancer Research Cancer Res. 79 (2019)
HOXA13 drives hepatocytes proliferation and liver tumorigenesis in mice.
2019 Review in Journal of Virology J. Virol. 93:e01032-19 (2019)
Revisiting hepatitis B virus: Challenges of curative therapies.
2019 Scientific Article in Cancer Cell Cancer Cell 36, 250-267.e9 (2019)
Age-related gliosis promotes central nervous system lymphoma through CCL19-mediated tumor cell retention.
2019 Meeting abstract in Abstracts of Papers of the American Chemical Society Abstr. Pap. Am. Chem. Soc. 257 (2019)
Biological evaluation of molecules of the azaBINOL class as antiviral agents reveals specific inhibition of HIV-1 RNase H activity.
2019 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 116, 18544-18549 (2019)
The uric acid crystal receptor Clec12A potentiates type I interferon responses.
2019 Scientific Article in Nature microbiology Nat. Microbiol. 4, 2192-2203 (2019)
Defining the human gut host-phage network through single-cell viral tagging.
2019 Scientific Article in Scientific Reports Sci. Rep. 9:10808 (2019)
Synergy of therapeutic heterologous prime-boost hepatitis B vaccination with CpG-application to improve immune control of persistent HBV infection.
2019 Scientific Article in Cancers Cancers 11:999 (2019)
An NF-kappaB- and IKK-independent function of NEMO prevents hepatocarcinogenesis by suppressing compensatory liver regeneration.
Advances in Virus Research In:. 525 B Street, Suite 1900, San Diego, Ca 92101-4495 Usa: Elsevier Academic Press Inc, 2019. 313-343 (Adv. Virus Res. ; 104)
Gammaherpesvirus entry and fusion: A tale how two human pathogenic viruses enter their host cells.
2019 Scientific Article in Bioorganic and Medicinal Chemistry Bioorg. Med. Chem. 27, 3595-3604 (2019)
Biological evaluation of molecules of the azaBINOL class as antiviral agents: Inhibition of HIV-1 RNase H activity by 7-isopropoxy-8-(naphth-1-yl) quinoline.
2019 Scientific Article in Frontiers in Microbiology Front. Microbiol. 10:1714 (2019)
Temperature response of planktonic microbiota in remote alpine lakes.
2019 Meeting abstract in Cytotherapy Cytotherapy 21, S10-S10 (2019)
Characterization of MHC class II-restricted t-cell receptors for t-cell therapy of HBV infection.
2019 Meeting abstract in Journal of Hepatology J. Hepatol. 70, E711-E711 (2019)
Approximation of the genotype distribution within global chronic hepatitis B virus infections.
2019 Meeting abstract in Journal of Hepatology J. Hepatol. 70, E456-E456 (2019)
Characterization of a library of CD4+T cells for T-cell therapy of HBV infection.
2019 Meeting abstract in Journal of Hepatology J. Hepatol. 70, E485-E486 (2019)
Exploring TH1/TH2 adjuvants to improve the efficacy of the therapeutic vaccination against chronic hepatitis B.
2019 Meeting abstract in Journal of Hepatology J. Hepatol. 70, E21-E21 (2019)
Viral escape contributes to the failure of hepatitis D virus-specific CD8+T-cells and drives evolution of HDV.
2019 Scientific Article in Journal of Clinical Investigation J. Clin. Invest. 130, 2932-2945 (2019)
T cell receptor grafting allows virological control of hepatitis B virus infection.
2019 Scientific Article in PLoS ONE PLoS ONE 14:e0214882 (2019)
The human adenovirus type 5 E1B 55kDa protein interacts with RNA promoting timely DNA replication and viral late mRNA metabolism.
In: (Proceedings - 2018 13th International Conference on Computer Engineering and Systems, ICCES 2018). 2019. 623-626
VirNet: Deep attention model for viral reads identification.
2019 Scientific Article in Nature medicine Nat. Med. 25, 641-655 (2019)
Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer.
2019 Scientific Article in Life Science Alliance Life Sci. All. 2:e201900355 (2019)
A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesis.
2019 Scientific Article in Journal of Infectious Diseases, The J. Infect. Dis. 220, 567-577 (2019)
Comparative analysis of the antiviral effects mediated by type I and III interferons in hepatitis B virus infected hepatocytes.
2019 Scientific Article in Molecular Therapy Mol. Ther. 27, 947-959 (2019)
Evaluation of a fully human, hepatitis B virus-specific chimeric antigen receptor in an immunocompetent mouse model.
2019 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 47, 4859-4871 (2019)
Modulation of HIV-1 gene expression by binding of a ULM motif in the Rev protein to UHM-containing splicing factors.
2019 Scientific Article in Molecular Cancer Research Mol. Cancer Res. 17, 783-793 (2019)
CCL2 is a vascular permeability factor inducing CCR2-dependent endothelial retraction during lung metastasis.
2019 Scientific Article in Gastroenterology Gastroenterology 156, 1820-1833 (2019)
Mutations in hepatitis D virus allow it to escape detection by CD8+ T cells and evolve at the population level.
2019 Scientific Article in Cell Reports Cell Rep. 26, 1841-1853.e6 (2019)
Release of immunomodulatory Ebola virus glycoprotein-containingmicrovesicles is suppressed by tetherin in a species-specific manner.
2019 Scientific Article in Biochimica et Biophysica Acta - Gene Regulatory Mechanisms Biochim. Biophys. Acta-Gene Regul. Mech. 1862, 557-566 (2019)
Regulatory effect of host miR-101b-3p on parasitism of nematode Angiostrongylus cantonensis via superoxide dismutase 3.
2019 Scientific Article in Zeitschrift für Gastroenterologie Z. Gastroenterol. 57, 61-73 (2019)
Towards curative therapy of chronic viral hepatitis.
2019 Scientific Article in Journal of General Virology J. Gen. Virol. 100, 278-288 (2019)
The antiviral activity of rodent and lagomorph SERINC3 and SERINC5 is counteracted by known viral antagonists.
2019 Scientific Article in Antiviral Research Antiviral Res. 161, 134-143 (2019)
PASylated interferon α efficiently suppresses hepatitis B virus and induces anti-HBs seroconversion in HBV-transgenic mice.
2019 Travel medicine and infectious disease Travel Med. Infect. Dis. 27, 115-115 (2019)
An extra priming dose of hepatitis A vaccine to adult patients with rheumatoid arthritis and drug induced immunosuppression - A prospective, open-label, multi-center study (vol 21, pg 43, 2018).
2019 Scientific Article in Science of the Total Environment, The Sci. Total Environ. 646, 606-617 (2019)
Using nano-attapulgite clay compounded hydrophilic urethane foams (AT/HUFs) as biofilm support enhances oil-refinery wastewater treatment in a biofilm membrane bioreactor.
2018 Meeting abstract in Journal of Hepatology J. Hepatol. 68, S782-S782 (2018)
Statins suppress hepatitis B virus replication and reduce hepatoma cell viability by interfering with Rho-GTPases.
2018 Meeting abstract in Journal of Hepatology J. Hepatol. 68, S121-S122 (2018)
Viral integration profiles in the plasma cell-free DNA from patients with HBV infection well represent tumor clone compositions during HCC development.
2018 Meeting abstract in Journal of Hepatology J. Hepatol. 68, S19-S19 (2018)
T cells grafted with HBV-specific T-cell receptors of high functional avidity achieve functional cure of HBV infection in humanized mice.
2018 Meeting abstract in Journal of Hepatology J. Hepatol. 68, S16-S16 (2018)
Combinatorial RNAi/vaccination therapy for chronic hepatitis B achieves long-term functional cure in preclinical mouse model.
2018 Scientific Article in Journal of Virology J. Virol. 93:01821-18 (2018)
Tetherin inhibits nipah Vvrus but not ebola virus replication in fruit bat cells.
2018 Meeting abstract in Human Gene Therapy. Clinical Development Hum. Gene Ther. 29, A4-A4 (2018)
Evaluation of a fully human car for the treatment of hepatitis B virus infection in an immunocompetent mouse model.
2018 Review in Gastroenterology Gastroenterology 156, 325-337 (2018)
Targeting innate and adaptive immune responses to cure chronic HBV infection.
2018 Scientific Article in Genes Genes 9:495 (2018)
The global hepatitis B virus genotype distribution approximated from available genotyping data.
2018 Scientific Article in Hepatology Hepatology 68, 2089-2105 (2018)
Outcome of antiviral immunity in the liver is shaped by the level of antigen expressed in infected hepatocytes.
2018 Meeting abstract in Journal of Medical Primatology J. Med. Primatol. 47, 324-324 (2018)
A new HIV/HBV co-infection model: Hepatocytic expression of human sodium taurocholate cotransporting polypeptide (NTCP) Enables Hepatitis B Virus Infection of Macaques.
2018 Meeting abstract in Hepatology Hepatology 68, 49A-50A (2018)
Suppression of hepatitis B virus antigens by RNA interference enables therapeutic vaccination to achieve immune control in high-titer virus carriers.
2018 Meeting abstract in Hepatology Hepatology 68, 334A-334A (2018)
Overcoming liver tolerance to clear persistent HBV infection.
2018 Scientific Article in OncoTarget Oncotarget 9, 33947-33960 (2018)
Hepatitis B virus promotes β-catenin-signalling and disassembly of adherens junctions in a Src kinase dependent fashion.
2018 Scientific Article in Journal of Hepatology J. Hepatol. 69, 1231-1241 (2018)
Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels.
2018 Scientific Article in Molecular therapy - Nucleic Acids Mol. Ther. Nucleic Acids 12, 242-253 (2018)
One-vector system for multiplexed CRISPR/Cas9 against hepatitis B virus cccDNA utilizing high-capacity adenoviral vectors.
2018 Scientific Article in Journal of Innate Immunity J. Innate Immun. 10, 339–348 (2018)
Characterization of pattern recognition receptor expression and functionality in liver primary cells and derived cell lines.
2018 Meeting abstract in Journal of Virology J. Virol. 25, 17-17 (2018)
Identification of ISG20 as the nuclease involved in Interferon-induced decline of HBV cccDNA.
2018 Meeting abstract in Journal of Virology J. Virol. 25, 47-47 (2018)
Generating CD4+T cells for the T-cell therapy of HBV infection.
2018 Meeting abstract in Journal of Virology J. Virol. 25, 52-53 (2018)
Altered HBV-specific CD4+T-cell Responses in HBV/HIV-1 Co-versus HBV Mono-infected Patients.
2018 Meeting abstract in Journal of Virology J. Virol. 25, 37-37 (2018)
Establishment and characterization of a novel recombinant reporter HBV utilizing the Cre-lox recombination system.
2018 Scientific Article in Journal of Biological Chemistry, The J. Biol. Chem. 293, 13191-13203 (2018)
Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity.
2018 Scientific Article in Journal of Virology J. Virol. 92:13 e01891-17 (2018)
Amino acid substitutions within HLA-B*27-restricted T cell epitopes prevent recognition by hepatitis delta virus-specific CD8+ T cells.
2018 Scientific Article in Journal of Virology J. Virol. 92:13 e00403-18 (2018)
A GXXXA motif in the transmembrane domain of the Ebola virus glycoprotein is required for tetherin antagonism.
2018 Review in MMW - Fortschritte der Medizin MMW-Fortschr. Med. 160, 35-37 (2018)
Are there strategies against latent infection?
2018 Scientific Article in GigaScience GigaScience 7, 1-8 (2018)
MetaMap: An atlas of metatranscriptomic reads in human disease-related RNA-seq data.
2018 Scientific Article in Science of the Total Environment, The Sci. Total Environ. 637-638, 1400-1412 (2018)
Long-term and high-concentration heavy-metal contamination strongly influences the microbiome and functional genes in Yellow River sediments.
2018 Scientific Article in Journal of Virology J. Virol. 92:e00272-18 (2018)
Common and distinct capsid and surface protein requirements for secretion of complete and genome-free hepatitis B virions.
2018 Scientific Article in Journal of Virology J. Virol. 92:e00342-18 (2018)
Chromatin-remodeling factor SPOC1 acts as a cellular restriction factor against human cytomegalovirus by repressing the major immediate early promoter.
2018 Review in Virus Research Virus Res. 251, 86-90 (2018)
A new era of virus bioinformatics.
2018 Scientific Article in Journal of Virology J. Virol. 92, e00164-18 (2018)
E1B-55K mediated regulation of RNF4 STUbL promotes HAdV gene expression.
2018 Review in Current Opinion in Virology Curr. Opin. Virol. 30, 58-67 (2018)
Overcoming immune tolerance in chronic hepatitis B by therapeutic vaccination.
2018 Scientific Article in Frontiers in Microbiology Front. Microbiol. 9:1110 (2018)
The human virome protein cluster database (HVPC): A human viral metagenomic database for diversity and function annotation.
2018 Scientific Article in Frontiers in Immunology Front. Immunol. 9:1035 (2018)
Impaired immune response to primary but not to booster vaccination against hepatitis B in older adults.
2018 Scientific Article in Frontiers in Physiology Front. Physiol. 9:120 (2018)
Training load, immune status, and clinical outcomes in young athletes: A controlled, prospective, longitudinal study.
2018 Review in Nature Immunology Nat. Immunol. 19, 222-232 (2018)
The immunology of hepatocellular carcinoma.
2018 Scientific Article in Journal of Virology J. Virol. 92:e02232-17 (2018)
Domains of the hepatitis B virus small surface protein S mediating oligomerization.
2018 Editorial in PLoS Pathogens PLoS Pathog. 14:e1006771 (2018)
Virologists-Heroes need weapons.
2018 Scientific Article in Nature Communications Nat. Commun. 9:887 (2018)
Single cell polarity in liquid phase facilitates tumour metastasis.
2018 Meeting abstract in Oncology Research and Treatment Oncol. Res. Treat. 41, 130-130 (2018)
GPR64-specific CAR-trnasgenic T cells selectively kill Ewing sarcoma cells.
2018 Scientific Article in Cancer Immunology, Immunotherapy Cancer Immunol. Immunother. 67, 663-674 (2018)
Epstein-Barr virus strain heterogeneity impairs human T-cell immunity.
2018 Scientific Article in Antiviral Research Antiviral Res. 151, 4-7 (2018)
Lipase inhibitor orlistat prevents hepatitis B virus infection by targeting an early step in the virus life cycle.
2018 Scientific Article in Journal of Virology J. Virol. 92:e01451-17 (2018)
HAdV protein V core protein is targeted by the host SUMOylation machinery to limit essential viral functions.
2018 Scientific Article in Glia Glia 66, 413-427 (2018)
Synthetic AAV/CRISPR vectors for blocking HIV-1 expression in persistently infected astrocytes.
2017 Meeting abstract in European Journal of Immunology Eur. J. Immunol. 47, 83-83 (2017)
Exhaustion of virus-specific CXCR6+liver-resident memory CD8 T cells during persistent liver infection.
2017 Meeting abstract in European Journal of Immunology Eur. J. Immunol. 47, 79-79 (2017)
RIG I senses ribosomal RNA derived degradation products.
2017 Meeting abstract in Human Gene Therapy. Clinical Development Hum. Gene Ther. 28, A30-A30 (2017)
Hepatitis B virus (HBV)-specific T cell receptors with high functional avidity redirect T cells to eliminate HBV.
2017 Meeting abstract in Cancer Immunology Research Cancer Immunol. Res. 5 (2017)
Therapeutic potential of GPR64 specific CAR T cells in pediatric sarcomas.
2017 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 114, 2729-2734 (2017)
Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.
2017 Scientific Article in Gut (eGut) Gut 67, 1663-1673 (2017)
Development of autoimmune pancreatitis is independent of CDKN1A/p21-mediated pancreatic inflammation.
2017 Scientific Article in Journal of Experimental Medicine J. Exp. Med. 214, 905-917 (2017)
Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation.
2017 Scientific Article in Travel medicine and infectious disease Travel Med. Infect. Dis. 21, 43-50 (2017)
An extra priming dose of hepatitis A vaccine to adult patients with rheumatoid arthritis and drug induced immunosuppression - A prospective, open-label, multi-center study.
2017 Scientific Article in Methods in Molecular Biology Methods Mol. Biol. 1540, 59-72 (2017)
Analyses of HBV cccDNA quantification and modification.
2017 Scientific Article in Transplantation Transplantation 101, 904-909 (2017)
Immune reconstitution after HCV clearance with direct antiviral agents: Potential consequences for patients with HCC?
2017 Scientific Article in Nature Communications Nat. Commun. 8:2146 (2017)
Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques.
2017 Review in Frontiers in Microbiology Front. Microbiol. 8, 2192 (2017)
Antagonistic microbial interactions: Contributions and potential applications for controlling pathogens in the aquatic systems.
2017 Scientific Article in Journal of Virology J. Virol. 92:e01154-17 (2017)
Human adenovirus infection causes cellular E3 ubiquitin ligase MKRN1 degradation involving the viral core protein pVII.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:15453 (2017)
Female mice lacking Pald1 exhibit endothelial cell apoptosis and emphysema.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:12715 (2017)
IFN-α-mediated base excision repair pathway correlates with antiviral response against hepatitis B virus infection.
2017 Scientific Article in Leukemia Leukemia 31, 2161-2171 (2017)
Transfer of minimally manipulated CMV-specific T cells from stem cell or third-party donors to treat CMV infection after allo-HSCT.
2017 Scientific Article in Open Biology Open Biol. 7:170115 (2017)
Dual role of the chromatin-binding factor PHF13 in the pre- and post-integration phases of HIV-1 replication.
2017 Scientific Article in Journal of the International AIDS Society J. Int. AIDS Soc. 20:21865 (2017)
T cells with low CD2 levels express reduced restriction factors and are preferentially infected in therapy naïve chronic HIV-1 patients.
2017 Review in Philosophical Transactions of the Royal Society of London. Series B Philos. Trans. R. Soc. B - Biol. Sci. 372:20160274 (2017)
Viral hepatitis and liver cancer.
2017 Scientific Article in Cancer Cell Cancer Cell 32, 342-359.e10 (2017)
A dual role of caspase-8 in triggering and sensing proliferation-associated DNA damage, a key determinant of liver cancer development.
2017 Scientific Article in PLoS ONE PLoS ONE 12:e0182936 (2017)
Isolation and functional characterization of hepatitis B virus-specific T-cell receptors as new tools for experimental and clinical use.
2017 Review in Viruses Viruses 9:193 (2017)
Applicability of metal nanoparticles in the detection and monitoring of hepatitis B virus infection.
2017 Scientific Article in European Journal of Immunology Eur. J. Immunol. 47, 1342-1353 (2017)
Card9-dependent IL-1β regulates IL-22 production from group 3 innate lymphoid cells and promotes colitis-associated cancer.
2017 Editorial in Journal of Immunology Research J. Immunol. Res. 2017:3104719 (2017)
New insights for immune-based diagnosis and therapy for infectious diseases.
2017 Scientific Article in Cellular and Molecular Gastroenterology and Hepatology Cell. Mol. Gast. Hept. 4, 339-363 (2017)
Hepatitis B virus activates signal transducer and activator of transcription 3 supporting hepatocyte survival and virus replication.
2017 Editorial in Journal of Hepatology J. Hepatol. 67, 471–479 (2017)
Visualizing HEV infection in human liver tissue.
2017 Scientific Article in European Journal of Neurology Eur. J. Neurol. 24, 1062-1070 (2017)
The spectrum of aseptic central nervous system infections in southern Germany - demographic, clinical and laboratory findings.
2017 Scientific Article in Antiviral Research Antiviral Res. 144, 153-163 (2017)
Construction of a hepatitis B virus neutralizing chimeric monoclonal antibody recognizing escape mutants of the viral surface antigen (HBsAg).
2017 Review in Viruses Viruses 9:E125 (2017)
A role for the host DNA damage response in Hepatitis B Virus cccDNA formation-and beyond?
2017 Scientific Article in Cancer Research Cancer Res. 77, 3577-3590 (2017)
Chimeric PD-1:28 receptor upgrades low-avidity T cells and restores effector function of tumor-infiltrating lymphocytes for adoptive cell therapy.
2017 Review in Current Opinion in Virology Curr. Opin. Virol. 24, 38-45 (2017)
Novel viral and host targets to cure hepatitis B.
2017 Scientific Article in Gut (eGut) Gut 67, 1124-1134 (2017)
miRNA-132 induces hepatic steatosis and hyperlipidaemia by synergistic multitarget suppression.
2017 Scientific Article in Cancer Cell Cancer Cell 31, 771-789.e6 (2017)
Kupffer cell-derived Tnf triggers cholangiocellular tumorigenesis through JNK due to chronic mitochondrial dysfunction and ROS.
2017 Scientific Article in Nature Reviews - Gastroenterology & Hepatology Nat. Rev. Gastroenterol. Hepatol. 14, 327-328 (2017)
Viral hepatitis: The bumpy road to animal models for HBV infection.
2017 Meeting abstract in Journal of Hepatology J. Hepatol. 66, S112-S112 (2017)
Preclinical study of a combinatorial RNAi/vaccination therapy as a potential cure for chronic hepatitis B.
2017 Meeting abstract in Journal of Hepatology J. Hepatol. 66, S29-S30 (2017)
Hepatitis B virus-specific T cell receptors with high functional avidity redirect T cells to eliminate HBV.
2017 Scientific Article in Clinical Infectious Diseases Clin. Infect. Dis. 64, 513-516 (2017)
Ebola virus persistence in breast milk after no reported illness: A likely source of virus transmission from mother to child.
2017 Scientific Article in PLoS ONE PLoS ONE 12:e0170419 (2017)
N-glycosylation of the Na+-taurocholate cotransporting polypeptide (NTCP) determines its trafficking and stability and is required for hepatitis B Vvrus infection.
2017 Scientific Article in PLoS ONE PLoS ONE 12:e0171035 (2017)
Primary cytomegalovirus infection in seronegative kidney transplant patients is associated with protracted cold ischemic time of seropositive donor organs.
2017 Scientific Article in Journal of Immunology Research J. Immunol. Res. 2017:4828936 (2017)
Secreted interferon-inducible factors restrict hepatitis B and C virus entry in vitro.
In: (Molecular chaperones in cancer, 2-4 May 2017, Madrid). 2017. S. 51
Kupffer cell-derived TNF triggers cholangiocellular tumorigenesis through JNK due to chronic mitochondrial dysfunction and ROS.
2017 Review in Viruses Viruses 9:18 (2017)
Control of hepatitis B virus by cytokines.
2017 Scientific Article in International Journal of Cancer Int. J. Cancer 141, 816-828 (2017)
Genome-wide analysis of somatic copy number alterations and chromosomal breakages in osteosarcoma.
2017 Scientific Article in Hepatology Hepatology 66, 398-415 (2017)
PRMT5 restricts hepatitis B virus replication via epigenetic repression of cccDNA transcription and interference with pgRNA encapsidation.
2017 Scientific Article in Current Opinion in Virology Curr. Opin. Virol. 23, 75-81 (2017)
Therapeutic vaccination for chronic hepatitis B.
2017 Scientific Article in Frontiers in Microbiology Front. Microbiol. 8:219 (2017)
Evolution of anabaenopeptin peptide structural variability in the cyanobacterium planktothrix.
2017 Scientific Article in New journal of chemistry New J. Chem. 41, 212-224 (2017)
Supramolecular combinations of humic polyanions as potent microbicides with polymodal anti-HIV-activities.
2017 Scientific Article in Journal of Hepatology J. Hepatol. 66, 494-503 (2017)
Human stem cell-derived hepatocytes as a model for hepatitis B virus infection, spreading and virus-host interactions.
2016 Meeting abstract in Journal of Hepatology J. Hepatol. 64, S387-S387 (2016)
BI-and trispecific antibodyconstructs mediate specific TCell retargeting towards and elimination of HBV-positive hepatocytes and tumor cells.
2016 Meeting abstract in Journal of Hepatology J. Hepatol. 64, S398-S398 (2016)
Hepatitis B virus infection of human stem cells-derived hepatocyte-like cells.
2016 Meeting abstract in Journal of Hepatology J. Hepatol. 64, S361-S361 (2016)
Correlation of mutations within HDV-protein with HLA Backgrounds of patients leads to identification of novel CD8 T cell epitopes.
2016 Meeting abstract in Journal of Hepatology J. Hepatol. 64, S312-S313 (2016)
Ikkalpha/beta regulate hepatocarcinogenesis and biliary homeostasis by controlling RIPK1 activity.
2016 Meeting abstract in Journal of Hepatology J. Hepatol. 64, S148-S149 (2016)
RNA interference mediated suppression of HBV transcripts restores HBV-specific immunity and enhances the efficacy of therapeutic vaccination.
2016 Meeting abstract in European Journal of Immunology Eur. J. Immunol. 46, 1, 339-339 (2016)
The subcellular localization of viral antigen after infection shapes the antigenic profile and protective capacity of poxvirus-mediated T cell immunity.
2016 Scientific Article in Viruses Viruses 8:325 (2016)
Ion channel activity of Vpu proteins is conserved throughout evolution of HIV-1 and SIV.
2016 Meeting abstract in FEBS Journal, The FEBS J. 283, 24-24 (2016)
A variety of cancer-associated inflammatory reactions.
2016 Editorial in Gastroenterology Gastroenterology 151, 780-783 (2016)
Focal and Local: Ectopic lymphoid structures and aggregates of myeloid and other immune cells in liver.
2016 Scientific Article in Journal of Experimental Medicine J. Exp. Med. 213, 3075-3086 (2016)
Antigen-dependent competition shapes the local repertoire of tissue-resident memory CD8+ T cells.
2016 Scientific Article in Journal of Infectious Diseases, The J. Infect. Dis. 214, 1498-1506 (2016)
Single-dose Hepatitis A immunization: 7.5-year observational pilot study in nicaraguan children to assess protective effectiveness and humoral immune memory response.
2016 Meeting abstract in Hepatology Hepatology 63, 1, 921A-921A (2016)
IFN-alpha-mediated Base Excision Repair Pathway Correlates with Antiviral Response Against Hepatitis B Virus Infection.
2016 Meeting abstract in Hepatology Hepatology 63, 1, 257A-258A (2016)
A new molecular interaction between IKK alpha/beta and RIPK1 regulates biliary homeostasis and hepatocarcinogenesis.
2016 Meeting abstract in Hepatology Hepatology 63, 1, 233A-233A (2016)
Canonical NF-kappa B signaling in hepatocytes acts as a tumor-suppressor in hepatitis B virus surface antigen-driven hepatocellular carcinoma by controlling the unfolded protein response.
2016 Scientific Article in Gene Therapy Gene Ther. 23, 753-759 (2016)
T- and B-cell responses to multivalent prime-boost DNA and viral vectored vaccine combinations against hepatitis C virus in non-human primates.
2016 Scientific Article in Nature Communications Nat. Commun. 7:13171 (2016)
Mitochondrial function controls intestinal epithelial stemness and proliferation.
2016 Scientific Article in MedChemComm MedChemComm 7, 1797-1801 (2016)
Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases.
2016 Scientific Article in Cancer Cell Cancer Cell 30, 533-547 (2016)
Distinct functions of senescence-associated immune responses in liver tumor surveillance and tumor progression.
2016 Scientific Article in Journal of Virology J. Virol. 90, 11075-11086 (2016)
Tetherin antagonism by the Ebola virus glycoprotein requires an intact receptor-binding domain and can be blocked by GP1-specific antibodies.
2016 Editorial in Gastroenterology Gastroenterology 151, 805-806 (2016)
"To be or not to be": Immune tolerance in chronic hepatitis B.
2016 Editorial in Arab journal of gastroenterology Arab. J. Gastroenterol. 17, 111-112 (2016)
Liver research in the International Space Station.
München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2016, 166 S.
Identifizierung transkriptionell aktivierter humaner endogener Retroviren (HERVs) in Tumorerkrankungen.
München, Technische Universität, Fakultät für Medizin, Diss., 2016, 140S.
Therapeutic vaccination using MVA-vectors in a murine model of chronic HBV infection.
München, Technische Universität, Fakultät für Medizin, Diss., 2016, 128 S.
Investigation of environmental and epigenetic etiologies driving cholangiolar and hepatocellular neoplasias.
2016 Scientific Article in Journal of Virology J. Virol. 90, 10558-10573 (2016)
Hepatitis C virus is released via a non-canonical secretory route.
2016 Meeting abstract in Journal of Immunology J. Immunol. 196, 1 (2016)
An optimized IFN-gamma ELISpot assay using T-activated (R) proteins for determination of CMV-specific cell-mediated immunity.
2016 Scientific Article in Journal of Infectious Diseases, The J. Infect. Dis. 214, 1498-1506 (2016)
Single dose hepatitis A immunisation: 7.5 year observational pilot study in Nicaraguan children to assess protective effectiveness and humoral immune memory response.
2016 Scientific Article in Cell Death & Disease Cell Death Dis. 7:e2342 (2016)
Bcl-xL is an oncogenic driver in colorectal cancer.
2016 Scientific Article in Cancer Research Cancer Res. 76, 5550-5561 (2016)
Inducing differentiation of premalignant hepatic cells as a novel therapeutic strategy in hepatocarcinoma.
2016 Scientific Article in Journal of Clinical Investigation J. Clin. Invest. 126, 2919-2932 (2016)
RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis.
2016 Scientific Article in Blood Blood 128, 1829-1833 (2016)
Peripheral blood CD34+ cells efficiently engraft human cytokine knock-in mice.
2016 Scientific Article in Cancer Cell Cancer Cell 30, 308-323 (2016)
Dual role of the adaptive immune system in liver injury and hepatocellular carcinoma development.
2016 Scientific Article in Gastroenterology Gastroenterology 151, 999-1010.e3 (2016)
Inflammation-induced expression and secretion of microRNA 122 leads to reduced blood levels of kidney-derived erythropoietin and anemia.
2016 Scientific Article in EMBO Molecular Medicine EMBO Mol. Med. 8, 1082-1098 (2016)
Blocking sense-strand activity improves potency, safety and specificity of anti-hepatitis B virus short hairpin RNA.
2016 Scientific Article in OncoImmunology OncoImmunology 5:e1175795 (2016)
Transgenic antigen-specific, HLA-A*02:01-allo-restricted cytotoxic T cells recognize tumor-associated target antigen STEAP1 with high specificity.
2016 Scientific Article in EMBO Journal, The EMBO J. 35, 1730-1744 (2016)
Transcriptome-based profiling of yolk sac-derived macrophages reveals a role for Irf8 in macrophage maturation.
2016 Scientific Article in Cancer Cell Cancer Cell 30, 75-91 (2016)
RIPK3 restricts myeloid leukemogenesis by promoting cell death and differentiation of leukemia initiating cells.
2016 Editorial in Cancer Cell Cancer Cell 30, 15-17 (2016)
P(URI)fying novel drivers of NASH and HCC: A feedforward loop of IL17A via white adipose tissue.
2016 Scientific Article in Hepatology Hepatology 64, 1217-1231 (2016)
IκB kinaseα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell-death mediator receptor-interacting protein kinase 1.
2016 Scientific Article in Journal of Virology J. Virol. 90, 8954-8967 (2016)
CD25+ FoxP3+ memory CD4 T cells are frequent targets of HIV infection in vivo.
2016 Scientific Article in Open Biology Open Biol. 6:160046 (2016)
Virion encapsidated HIV-1 Vpr induces NFAT to prime non-activated T cells for productive infection.
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0158557 (2016)
Evidence of an exponential decay pattern of the hepatitis delta virus evolution rate and fluctuations in quasispecies complexity in long-term studies of chronic delta infection.
2016 Scientific Article in Laboratoriumsmedizin Lab. Med. 40, 155-164 (2016)
Der Einfluss der DIN EN ISO 15189 auf die Ergebnissicherheit in der Virusdiagnostik.
2016 Scientific Article in Cell Host & Microbe Cell Host Microbe 20, 36-48 (2016)
Dual-track clearance of circulating bacteria balances rapid restoration of blood sterility with induction of adaptive immunity.
2016 Scientific Article in Hepatology Hepatology 64, 746-759 (2016)
Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection.
2016 Meeting abstract in Cytotherapy Cytotherapy 18, S15-S16 (2016)
Functional characterization of OF HBV-specific T cell receptors for redirection of T cells against HBV-infected hepatocytes.
2016 Scientific Article in Journal of Translational Medicine J. Transl. Med. 14:175 (2016)
Validation of an IFNγ/IL2 FluoroSpot assay for clinical trial monitoring.
2016 Scientific Article in Leukemia Leukemia 30, 1520-1530 (2016)
Re-activation of mitochondrial apoptosis inhibits T-cell lymphoma survival and treatment resistance.
2016 Scientific Article in Gut (eGut) Gut 66, 1369-1381 (2016)
Lymphotoxin β receptor signalling executes Helicobacter pylori-driven gastric inflammation in a T4SS-dependent manner.
2016 Scientific Article in Immunity Immunity 44, 901-912 (2016)
Brain endothelial- and epithelial-specific interferon receptor chain 1 drives virus-induced sickness behavior and cognitive impairment.
2016 Review in Journal of Hepatology J. Hepatol. 64, S49-S59 (2016)
Intracellular transport and egress of hepatitis B virus.
2016 Review in Journal of Hepatology J. Hepatol. 64, S41-S48 (2016)
Attacking hepatitis B virus cccDNA - the holy grail to hepatitis B cure.
2016 Meeting abstract in Oncology Research and Treatment Oncol. Res. Treat. 39, 16 (2016)
Targeting notch for myeloid reprogramming in pancreatic cancer.
2016 Meeting abstract in Oncology Research and Treatment Oncol. Res. Treat. 39, 81 (2016)
Intratumor heterogeneity in hepatocellular carcinoma: Impact on tumor classifications and targeted therapies.
2016 Scientific Article in Nature Immunology Nat. Immunol. 17, 593-603 (2016)
Tumor-necrosis factor impairs CD4+ T cell-mediated immunological control in chronic viral infection.
2016 Scientific Article in Nature Nature 531, 253-257 (2016)
NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis.
2016 Scientific Article in FEBS Journal, The FEBS J. 283, 1669-1688 (2016)
Transcriptional signature induced by a C-terminal c-Src mutant in a human breast cell line.
2016 Scientific Article in Hepatology Hepatology 63, 1888-1899 (2016)
Oncogenic driver genes and the inflammatory microenvironment dictate liver tumor phenotype.
2016 Scientific Article in Nature Communications Nat. Commun. 7:10770 (2016)
Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice.
2016 Scientific Article in Hepatology Hepatology 63, 1592-1607 (2016)
Canonical NF-κB signaling in hepatocytes acts as a tumor-suppressor in HBV surface antigen-driven HCC by controlling the UPR.
2016 Scientific Article in Marine Drugs Mar. Drugs 14:28 (2016)
Alkaloids from the sponge Stylissa carteri present prospective scaffolds for the inhibition of Human Immunodeficiency Virus 1 (HIV-1).
2016 Scientific Article in Journal of Critical Care J. Crit. Care 32, 138-144 (2016)
Herpes simplex virus in bronchoalveolar lavage fluid of medical intensive care unit patients: Association with lung injury and outcome.
2016 Scientific Article in Scientific Reports Sci. Rep. 6:20394 (2016)
Potent in vitro antiviral activity of Cistus incanus extract against HIV and Filoviruses targets viral envelope proteins.
2016 Scientific Article in Neoplasia : An International Journal for Oncology Research Neoplasia 18, 49-59 (2016)
Targeting of CCL2-CCR2-glycosaminoglycan axis using a CCL2 decoy protein attenuates metastasis through inhibition of tumor cell seeding.
2016 Scientific Article in Vaccine Vaccine 34, 923-932 (2016)
Protein-prime/modified vaccinia virus Ankara vector-boost vaccination overcomes tolerance in high-antigenemic HBV-transgenic mice.
2016 Scientific Article in Antiviral Therapy Antivir. Ther. (Lond.) 20, 779-787 (2016)
Entecavir allows an unexpectedly high residual replication of HBV mutants resistant to lamivudine.
2016 Scientific Article in American Journal of Transplantation Am. J. Transplant. 16, 484-496 (2016)
Molecular characterization of acute cellular rejection occurring during intentional immunosuppression withdrawal in liver transplantation.
2016 Scientific Article in Leukemia and Lymphoma Leuk. Lymphoma 57, 623-627 (2016)
Serious outbreak of human metapneumovirus in patients with hematologic malignancies.
2016 Scientific Article in Oncogene Oncogene 35, 69–82 (2016)
PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53.
2016 Scientific Article in Oncogene Oncogene 35, 3125-3138 (2016)
A novel pVHL-independent but NEMO-driven pathway in renal cancer promotes HIF stabilization.
2016 Scientific Article in Oncogene Oncogene 35, 3178-3189 (2016)
Sp100A is a tumor suppressor that activates p53-dependent transcription and counteracts E1A/E1B-55K-mediated transformation.
2016 Scientific Article in Journal of General Virology J. Gen. Virol. 97, 121-127 (2016)