AMIR

Deciphering the molecular mechanisms that control T cell-driven immune responses will create critical knowledge for future therapies against autoimmune diseases or immune cell therapies against cancer

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The Research Unit Molecular Immune Regulation (AMIR) investigates the differentiation of T helper cells with a focus on post-transcriptional gene regulation. T helper cell differentiation enables specific immune responses, however, hyper- or hypofunctional T helper cells critically contribute to inflammatory and autoimmune diseases or to the lack of immune responses during chronic infections and tumor formation, respectively. We analyze molecular interactions and search for diagnostic markers to develop new therapeutic approaches.

AMIR - about our research 1 - centrifuge

New Research Findings, Molecular Targets and Therapeutics, AMIR, July 25, 2022

Researchers gain a fundamental insight for epitranscriptomics and immune response. The research group around Vigo Heissmeyer and Taku Ito-Kureha of Helmholtz Munich and Ludwig-Maximilians-Universität München has revealed the essential function of m6A…

Prof. Vigo Heissmeyer

Head of Molecular Immune Regulation View profile

Dr. Kai Höfig

Senior Scientist

AMIR Portrait Stephanie Edelmann 2000x1800

Dr. Stephanie Edelmann

Postdoc

Sabine Hartig

Technische Assistentin

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Impact factor since 2021

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Reviews since 2021

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Nightshifts per PhD

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Dedication required

Latest Publications of Our Institute

Correction to "The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3'-UTR and promoting Rag1 mRNA expression".

2024 Scientific Article in Life Science Alliance

Bataclan, M. ; Leoni, C. ; Moro, S.G. ; Pecoraro, M. ; Wong, E.H. ; Heissmeyer, V. ; Monticelli, S.

Crosstalk between Regnase-1 and -3 shapes mast cell survival and cytokine expression.

2024 Scientific Article in Nature Communications

Xu, M. ; Ito-Kureha, T. ; Kang, H.-S. ; Chernev, A. ; Raj, T. ; Hoefig, K.P. ; Hohn, C. ; Giesert, F. ; Wang, Y. ; Pan, W. ; Ziętara, N. ; Straub, T. ; Feederle, R. ; Daniel, C. ; Adler, B. ; König, J. ; Feske, S. ; Tsokos, G.C. ; Wurst, W. ; Urlaub, H. ; Sattler, M. ; Kisielow, J. ; Wulczyn, F.G. ; Łyszkiewicz, M. ; Heissmeyer, V.

The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3'-UTR and promoting Rag1 mRNA expression.

2024 Scientific Article in Science immunology

Chang, Y. ; Bach, L. ; Hasiuk, M. ; Wen, L. ; Elmzzahi, T. ; Tsui, C. ; Gutiérrez-Melo, N. ; Steffen, T. ; Utzschneider, D.T. ; Raj, T. ; Jost, P.J. ; Heink, S. ; Cheng, J. ; Burton, O.T. ; Zeiträg, J. ; Alterauge, D. ; Dahlström, F. ; Becker, J.C. ; Kastl, M. ; Symeonidis, K. ; van Uelft, M. ; Becker, M. ; Reschke, S. ; Krebs, S. ; Blum, H. ; Abdullah, Z. ; Paeschke, K. ; Ohnmacht, C. ; Neumann, C. ; Liston, A. ; Meissner, F. ; Korn, T. ; Hasenauer, J. ; Heissmeyer, V. ; Beyer, M. ; Kallies, A. ; Jeker, L.T. ; Baumjohann, D.

TGF-β specifies TFH versus TH17 cell fates in murine CD4+ T cells through c-Maf.

2023 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America

Schmidt, H. ; Raj, T. ; O´Neill, T.J. ; Muschaweckh, A. ; Giesert, F. ; Negraschus, A. ; Hoefig, K.P. ; Behrens, G. ; Esser, L. ; Baumann, Christina ; Feederle, R. ; Plaza-Sirvent, C. ; Geerlof, A. ; Gewies, A. ; Isay, S.E. ; Ruland, J. ; Schmitz, I. ; Wurst, W. ; Korn, T. ; Krappmann, D. ; Heissmeyer, V.

Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity.

2023 Scientific Article in American Journal of Human Genetics, The

Guo, L. ; Salian, S. ; Xue, J.y. ; Rath, N. ; Rousseau, J. ; Kim, H. ; Ehresmann, S. ; Moosa, S. ; Nakagawa, N. ; Kuroda, H. ; Clayton-Smith, J. ; Wang, J. ; Wang, Z. ; Banka, S. ; Jackson, A. ; Zhang, Y.m. ; Wei, Z.j. ; Hüning, I. ; Brunet, T. ; Ohashi, H. ; Thomas, M.F. ; Bupp, C. ; Miyake, N. ; Matsumoto, N. ; Mendoza-Londono, R. ; Costain, G. ; Hahn, G. ; di Donato, N. ; Yigit, G. ; Yamada, T. ; Nishimura, G. ; Ansel, K.M. ; Wollnik, B. ; Hrabě de Angelis, M. ; Megarbane, A. ; Rosenfeld, J.A. ; Heissmeyer, V. ; Ikegawa, S. ; Campeau, P.M.

Null and missense mutations of ERI1 cause a recessive phenotypic dichotomy in humans.

2023 Scientific Article in Nature Communications

Leoni, C. ; Bataclan, M. ; Ito-Kureha, T. ; Heissmeyer, V. ; Monticelli, S.

Molecular Targets and Therapeutics Center Research Unit Molecular Immune Regulation (AMIR)

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About our Research

How Tiny Changes Help T Cells to Survive