Molecular Targets and Therapeutics Center
Research Unit Molecular Immune Regulation (AMIR)
The Research Unit Molecular Immune Regulation (AMIR), which deciphers the molecular mechanisms that control T cell-driven immune responses, will create critical knowledge for future therapies against autoimmune diseases and immune cell therapies against cancer.
The Research Unit Molecular Immune Regulation (AMIR), which deciphers the molecular mechanisms that control T cell-driven immune responses, will create critical knowledge for future therapies against autoimmune diseases and immune cell therapies against cancer.
Our Institute in Numbers
Latest Publications of Our Institute
Kübelbeck, T. ; Wichmann, N. ; Raj, T. ; Raj, C. ; Ohnmacht, C. ; Hövelmeyer, N. ; Kramer, D. ; Heissmeyer, V.
Regulation and function of the atypical IκBs-Bcl-3, IκBNS, and IκBζ-in lymphocytes and autoimmunity.Mishima, E. ; O'Neill, T.J. ; Hoefig, K.P. ; Chen, D. ; Behrens, G. ; Henkelmann, B. ; Ito, J. ; Nakagawa, K. ; Heissmeyer, V. ; Conrad, M. ; Krappmann, D.
MALT1 inhibitor MI-2 induces ferroptosis by direct targeting of GPX4.Wang, Y. ; Rambold, U. ; Fiedler, P. ; Babushku, T. ; Tapken, C.L. ; Hoefig, K.P. ; Hofer, T.P. ; Adler, H. ; Yildirim, A.Ö. ; Strobl, L.J. ; Zimber-Strobl, U.
CD30 influences germinal center B-cell dynamics and the expansion of IgG1-switched B cells.Xu, M. ; Ito-Kureha, T. ; Kang, H.-S. ; Chernev, A. ; Raj, T. ; Hoefig, K.P. ; Hohn, C. ; Giesert, F. ; Wang, Y. ; Pan, W. ; Ziętara, N. ; Straub, T. ; Feederle, R. ; Daniel, C. ; Adler, B. ; König, J. ; Feske, S. ; Tsokos, G.C. ; Wurst, W. ; Urlaub, H. ; Sattler, M. ; Kisielow, J. ; Wulczyn, F.G. ; Łyszkiewicz, M. ; Heissmeyer, V.
Correction to "The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3'-UTR and promoting Rag1 mRNA expression".Bataclan, M. ; Leoni, C. ; Moro, S.G. ; Pecoraro, M. ; Wong, E.H. ; Heissmeyer, V. ; Monticelli, S.
Crosstalk between Regnase-1 and -3 shapes mast cell survival and cytokine expression.Xu, M. ; Ito-Kureha, T. ; Kang, H.-S. ; Chernev, A. ; Raj, T. ; Hoefig, K.P. ; Hohn, C. ; Giesert, F. ; Wang, Y. ; Pan, W. ; Ziętara, N. ; Straub, T. ; Feederle, R. ; Daniel, C. ; Adler, B. ; König, J. ; Feske, S. ; Tsokos, G.C. ; Wurst, W. ; Urlaub, H. ; Sattler, M. ; Kisielow, J. ; Wulczyn, F.G. ; Łyszkiewicz, M. ; Heissmeyer, V.
The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3'-UTR and promoting Rag1 mRNA expression.Chang, Y. ; Bach, L. ; Hasiuk, M. ; Wen, L. ; Elmzzahi, T. ; Tsui, C. ; Gutiérrez-Melo, N. ; Steffen, T. ; Utzschneider, D.T. ; Raj, T. ; Jost, P.J. ; Heink, S. ; Cheng, J. ; Burton, O.T. ; Zeiträg, J. ; Alterauge, D. ; Dahlström, F. ; Becker, J.C. ; Kastl, M. ; Symeonidis, K. ; van Uelft, M. ; Becker, M. ; Reschke, S. ; Krebs, S. ; Blum, H. ; Abdullah, Z. ; Paeschke, K. ; Ohnmacht, C. ; Neumann, C. ; Liston, A. ; Meissner, F. ; Korn, T. ; Hasenauer, J. ; Heissmeyer, V. ; Beyer, M. ; Kallies, A. ; Jeker, L.T. ; Baumjohann, D.
TGF-β specifies TFH versus TH17 cell fates in murine CD4+ T cells through c-Maf.