AMIR - Helmholtz Munich

Deciphering the molecular mechanisms that control T cell-driven immune responses will create critical knowledge for future therapies against autoimmune diseases or immune cell therapies against cancer

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The Research Unit Molecular Immune Regulation (AMIR) investigates the differentiation of T helper cells with a focus on post-transcriptional gene regulation. T helper cell differentiation enables specific immune responses, however, hyper- or hypofunctional T helper cells critically contribute to inflammatory and autoimmune diseases or to the lack of immune responses during chronic infections and tumor formation, respectively. We analyze molecular interactions and search for diagnostic markers to develop new therapeutic approaches.

AMIR - about our research 1 - centrifuge

News from Our Institute

New Research Findings, Molecular Targets and Therapeutics, AMIR, July 25, 2022

Researchers gain a fundamental insight for epitranscriptomics and immune response. The research group around Vigo Heissmeyer and Taku Ito-Kureha of Helmholtz Munich and Ludwig-Maximilians-Universität München has revealed the essential function of m6A…

Prof. Vigo Heissmeyer

Leiter der Abteilung Molekulare Immunregulation View profile

Dr. Kai Höfig

Senior Scientist

Dr. Stephanie Edelmann

Postdoc

Dr. Meng Xu

Postdoc

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Impact factor since 2020

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Billon T cells per publication

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Nightshifts per PhD

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Dedication required

Latest Publications of Our Institute

Critical functions of N6-adenosine methylation of mRNAs in T cells.

2022 Scientific Article in Nature Immunology

Ito-Kureha, T. ; Leoni, C. ; Borland, K. ; Cantini, G. ; Bataclan, M. ; Metzger, R.N. ; Ammann, G. ; Krug, A.B. ; Marsico, A. ; Kaiser, S. ; Canzar, S. ; Feske, S. ; Monticelli, S. ; König, J. ; Heissmeyer, V.

The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells.

2022 Scientific Article in Immunology Letters

Krueger, A. ; Łyszkiewicz, M. ; Heissmeyer, V.

Post-transcriptional control of T-cell development in the thymus.

2022 Review in Frontiers in Immunology

Behrens, G. ; Heissmeyer, V.

Cooperation of RNA-binding proteins - a focus on roquin function in T cells.

2022 Scientific Article in Nature

Mohanta, S.K. ; Peng, L. ; Li, Y. ; Lu, S. ; Sun, T. ; Carnevale, L. ; Perrotta, M. ; Ma, Z. ; Foerstera, B. ; Stanic, K. ; Zhang, C. ; Zhang, X. ; Szczepaniak, P. ; Bianchini, M. ; Saeed, B.R. ; Carnevale, R. ; Hu, D. ; Nosalski, R. ; Pallante, F. ; Beer, M. ; Santovito, D. ; Ertürk, A. ; Mettenleiter, T.C. ; Klupp, B.G. ; Megens, R.T.A. ; Steffens, S. ; Pelisek, J. ; Eckstein, H.H. ; Kleemann, R. ; Habenicht, L. ; Mallat, Z. ; Michel, J. ; Bernhagen, J. ; Dichgans, M. ; D'Agostino, G. ; Guzik, T.J. ; Olofsson, P.S. ; Yin, C. ; Weber, C. ; Lembo, G. ; Carnevale, D. ; Habenicht, A.J.R.

Neuroimmune cardiovascular interfaces control atherosclerosis.

2022 Scientific Article in Nature Communications

Günsel, G.G. ; Conlon, T.M. ; Jeridi, A. ; Kim, R. ; Ertüz, Z. ; Lang, N.J. ; Ansari, M. ; Novikova, M. ; Jiang, D. ; Strunz, M. ; Gaianova, M. ; Hollauer, C. ; Gabriel, C. ; Angelidis, I. ; Doll, S. ; Pestoni, J. ; Edelmann, S.L. ; Kohlhepp, M.S. ; Guillot, A. ; Bassler, K. ; Van Eeckhoutte, H.P. ; Kayalar, Ö. ; Konyalilar, N. ; Kanashova, T. ; Rodius, S. ; Ballester-Lopez, C. ; Genes Robles, C.M. ; Smirnova, N.F. ; Rehberg, M. ; Agarwal, C. ; Krikki, I. ; Piavaux, B. ; Verleden, S.E. ; Vanaudenaerde, B. ; Königshoff, M. ; Dittmar, G. ; Bracke, K.R. ; Schultze, J.L. ; Watz, H. ; Eickelberg, O. ; Stöger, T. ; Burgstaller, G. ; Tacke, F. ; Heissmeyer, V. ; Rinkevich, Y. ; Bayram, H. ; Schiller, H. B. ; Conrad, M. ; Schneider, R. ; Yildirim, A.Ö.

The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD.

2021 Scientific Article in Nature Immunology

Behrens, G. ; Edelmann, S.L. ; Raj, T. ; Kronbeck, N. ; Monecke, T. ; Davydova, E.-O. ; Wong, E.H. ; Kifinger, L. ; Giesert, F. ; Kirmaier, M.E. ; Hohn, C. ; de Jonge, L.S. ; Pisfil, M.G. ; Fu, M. ; Theurich, S. ; Feske, S. ; Kawakami, N. ; Wurst, W. ; Niessing, D. ; Heissmeyer, V.

Molecular Targets and Therapeutics Center Research Unit Molecular Immune Regulation (AMIR)

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About our Research

News from Our Institute

How Tiny Changes Help T Cells to Survive