Institute of Asthma and Allergy Prevention, IAP, Environmental Health Center, Helmholtz Munich | Helmholtz Munich

ASTHME DESSIN

Asthma is an inflammatory disease of the airways of the lung. It is not one disease but a syndrome consisting of many so far not well characterized and delineated genetic and environmental determinants. The focus of our work is to develop novel strategies of asthma and allergy prevention and to characterize in depth asthma phenotypes.

Asthma is an inflammatory disease of the airways of the lung. It is not one disease but a syndrome consisting of many so far not well characterized and delineated genetic and environmental determinants. The focus of our work is to develop novel strategies of asthma and allergy prevention and to characterize in depth asthma phenotypes.

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Un bambino con cappellino si occupa delle vacche giocando con loro e portandogli il fieno nelle mangiatoie

Why and how are children growing up on traditional farms protected from asthma. And what role is playing the microbiome in the gut or bacteria on skin and in the nose? Scientists at IAP try to disentangle microorganisms or their interactions which are associated with allergic diseases.

child using inhaler for asthma outside in a park with his father

Our studies on the farm effect show how relevant microbiome-derived functional agents are to protect children from asthma. But how can we translate these findings to children and their families? With ongoing both experimental and human population-based studies and projects we aim to develop innovative and effective prevention strategies to stop asthma and allergies.

Alliance_Logo_IAP

What are the different forms of asthma and how can we identify biomarkers (signal transducers) that will make it possible to identify these subtypes as early as possible? To answer this question is the aim of the ALL AGE ASTHMA COHORT (ALLIANCE) of the German Center for Lung Research (DZL). The large-scale study has been running since 2011 with now more than 1200 patients throughout Germany.

Giulia Pagani

Awards & Grants, IAP, October 13, 2022

For pioneering research into the development of allergic diseases, Giulia Pagani has received a grant of 61,400 euros from the German Research Foundation (DFG).

Erika von Mutius / 2022

Environmental Health, IAP, July 14, 2022

Erika von Mutius, Director of the Environmental Health Center, and her team receive an Advanced ERC Grant for their research on prevention strategies to curb asthma and allergies in children. ERC Advanced Grants are endowed with up to 2.5 million…

Intestinal bacteria, Gut microbiome helps control intestinal digestion and the immune system, Probiotics are beneficial bacteria used to help the growth of healthy gut flora

New Research Findings, IAP, November 02, 2020

Asthma impacts millions of children already at a young age. Children growing up on a farm have a lower risk of developing asthma than children not living on a farm. The mechanisms behind this protective farm effect on childhood asthma are largely…

Christine Strunz-Lehner

Christine Strunz-Lehner

Studienkoordinatorin MARTHA

Prof. Dr. med. Dr. h.c Erika von Mutius

Prof. Dr. med. Dr. h.c Erika von Mutius

Director and Head of Research Group View profile

Dr. rer. med. Sabina Illi

Dr. rer. med. Sabina Illi

Statistikerin, stellv. Leitung

Prof. Dr. Heiko Adler

Prof. Dr. Heiko Adler

Wissenschaftlicher Mitarbeiter

Dr. rer. biol. hum. Martin Depner

Dr. rer. biol. hum. Martin Depner

Biostatistiker

Prof. Dr. Markus Ege

Prof. Dr. Markus Ege

Wissenschaftlicher Mitarbeiter

Professor Jonathan Grigg

Professor Jonathan Grigg

Gastwissenschaftler, MD, FRCPCH, FFPH, Professor of Paediatric Respiratory and Environmental Medicine, Queen Mary University of London

Birgit Langer

Birgit Langer

Datenmanagerin

Dr. med. Nicole Maison

Dr. med. Nicole Maison

Ärztin/Wissenschaftl. Mitarbeiterin

Dr. Jimmy Omony

Dr. Jimmy Omony

Biostatistiker

Dr. Giulia Pagani

Dr. Giulia Pagani

Bioinformatikerin

PD Dr. sc. hum. Sonali Pechlivanis

PD Dr. sc. hum. Sonali Pechlivanis

Epidemiologin

Ursula Rambold

Ursula Rambold

Doktorandin

Bettina Rankl

Bettina Rankl

Koordinatorin Arzneimittelentwicklung

Elisabeth Schmaußer-Hechfellner

Elisabeth Schmaußer-Hechfellner

Datenmanagerin

2021 Am J Respir Crit Care Med DOI: 10.1164/rccm.202106-1458OC (2022)

Illi S et al.

Immune Responsiveness to LPS Determines Risk of Childhood Wheeze and Asthma in 17q21 Risk Allele Carriers.

2020 Acta Med Acad doi: 10.5644/ama2006-124.293

Pechlivanis S, von Mutius E

Effect of Farming on Asthma

2017 Allergy DOI: 10.1111/all.13002

Birzele LT et al.

Environmental and mucosal microbiota and their role in childhood asthma

2015 Science doi: 10.1126/science.aac6623

Schuijs S al.

Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells

2013 J Allergy Clin Immunol. DOI:https://doi.org/10.1016/j.jaci.2012.11.048

Depner M et al.

Atopic sensitization in the first year of life

2012 J Allergy Clin Immunol doi: 10.1016/j.jaci.2012.03.013

Illi S et al.

Protection from childhood asthma and allergy in Alpine farm environments

2012 J Allergy Clin Immunol. DOI:https://doi.org/10.1016/j.jaci.2012.04.049

Fuchs O et al.

Farming environments and childhood atopy, wheeze, lung function, and exhaled nitric oxide

2011 N Engl J Med. 2011 DOI: 10.1056/NEJMoa1007302

Ege MJ

Exposure to environmental microorganisms and childhood asthma

2010 Nat Rev Immunol doi: 10.1038/nri2871

von Mutius E et al.

Farm living: effects on childhood asthma and allergy

2002 N Engl J Med DOI: 10.1056/NEJMoa020057

Braun-Fahrländer C et al.

Environmental exposure to endotoxin and its relation to asthma in school-age children

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DZL - Deutsches Zentrum für Lungenforschung

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