Teddy Study
The Teddy consortium comprises six clinical centers located in the USA and Europe: Washington (Seattle), Colorado (Denver), and Georgia (Augusta), Finland (Turku), Sweden (Malmo), and Germany (Munich).
The primary objective is the identification of environmental factors like infectious agents, dietary factors, or psychosocial factors that predispose to or protect from autoimmunity and type 1 diabetes. Identification of such factors will lead to a better understanding of disease pathogenesis and result in new strategies to prevent, delay, or reverse type 1 diabetes.
The Teddy study has recruited 8,668 children (7,751 from the general population, and 917 with a first degree relative with type 1 diabetes), including 595 children from Germany. Newborns were eligible for Teddy if they were younger than 4.5 months of age and had HLA DR, DQ type 1 diabetes risk genotypes.
Participants are seen every 3 months up to 4 years of age, with subsequent visits every 6 months until the subject is 15 years of age. Blood samples are collected at each visit for detection of islet autoantibodies, candidate infectious agents and nutritional biomarkers; monthly stool samples are collected for infectious agents. Demographic data, information about child's diet, illnesses, vaccination, allergies and psychosocial factors are obtained by interviews and questionnaires. Recruitment began in 2004 and ended in 2010.
The Teddy study has a central repository of data and biologic samples for subsequent hypothesis-based research.
The Teddy consortium comprises six clinical centers located in the USA and Europe: Washington (Seattle), Colorado (Denver), and Georgia (Augusta), Finland (Turku), Sweden (Malmo), and Germany (Munich).
The primary objective is the identification of environmental factors like infectious agents, dietary factors, or psychosocial factors that predispose to or protect from autoimmunity and type 1 diabetes. Identification of such factors will lead to a better understanding of disease pathogenesis and result in new strategies to prevent, delay, or reverse type 1 diabetes.
The Teddy study has recruited 8,668 children (7,751 from the general population, and 917 with a first degree relative with type 1 diabetes), including 595 children from Germany. Newborns were eligible for Teddy if they were younger than 4.5 months of age and had HLA DR, DQ type 1 diabetes risk genotypes.
Participants are seen every 3 months up to 4 years of age, with subsequent visits every 6 months until the subject is 15 years of age. Blood samples are collected at each visit for detection of islet autoantibodies, candidate infectious agents and nutritional biomarkers; monthly stool samples are collected for infectious agents. Demographic data, information about child's diet, illnesses, vaccination, allergies and psychosocial factors are obtained by interviews and questionnaires. Recruitment began in 2004 and ended in 2010.
The Teddy study has a central repository of data and biologic samples for subsequent hypothesis-based research.
