Helmholtz Diabetes Center

Institute of Diabetes Research

The Institute of Diabetes Research (IDF) is dedicated to studying the natural history of type 1 diabetes, identifying mechanisms and predictive markers of the disease, investigating the pathology of the human pancreas, and implementing novel treatment approaches in clinical trials to prevent type 1 diabetes.

Institute Director Deputy Director Your Contribution

The Institute of Diabetes Research (IDF) is dedicated to studying the natural history of type 1 diabetes, identifying mechanisms and predictive markers of the disease, investigating the pathology of the human pancreas, and implementing novel treatment approaches in clinical trials to prevent type 1 diabetes.

Institute Director Deputy Director Your Contribution

Doctor diagnose pancreas .
EDENT1FI_Logo_final

Research Platforms

EDENT1FI

EDENT1FI is a global consortium comprised of 28 partners spanning 12 countries. These partners have come together with a shared mission: to identify T1D at its pre-clinical stage in children in the general population. The project is funded through the Horizon Europe program and is set to run over five years.


EDENT1FI website

Press release

Pre-T1D Logo Transparent

European pre-T1D Registry 

European pre-T1D Registry is a network of investigators who register children and adults diagnosed with early-stage type 1 diabetes to inform about monitoring, trials, and treatment to delay or prevent disease progression. European pre-T1D Registry is operated by Helmholtz Munich under the umbrella of GPPAD & INNODIA.

pre-T1D Registry website

pre-T1D Registry dashboard

HHZ_Newsild_IDF_715x550px

Campaigns

K1DS ARE HEROES

The K1DS ARE HEROES campaign spots type 1 diabetes heroes around the world! The campaign aims to raise awareness for type 1 diabetes, early detection and prevention of type 1 diabetes. The campaign is run by GPPAD together with the Institute of Diabetes Research (IDF) at Helmholtz Munich.

Read more

News

See all
Institut für Diabetesforschung Studienzentrum

New Research Findings, Diabetes, IDF,

Early Detection of Type 1 Diabetes in Children Is Broadly Feasible

For ten years, the Fr1da study, coordinated by Helmholtz Munich, has been investigating whether early stages of type 1 diabetes in children can be detected in routine pediatric care. The latest evaluation shows that the screening program is…

Screenshot pancreas für research area "type 1 diabetes pathology" (Teresa Rodgriguez-Calvo)

Awards & Grants, Diabetes, IDF,

New Funding Supports Research into Causes and Treatment of Type 1 Diabetes

Dr. Teresa Rodriguez-Calvo from Helmholtz Munich has been awarded two prestigious grants from Breakthrough T1D, the leading global type 1 diabetes (T1D) research and advocacy organization. The funding will support two innovative projects at the…

Institut für Diabetesforschung Studienzentrum

Diabetes, IDF,

Fr1da Study Expands Early Diabetes Detection to 12 German Federal States

As part of the Fr1da study, “Early detection and early treatment of type 1 diabetes”, led by researchers at the Institute of Diabetes Research at Helmholtz Munich, families can have their children aged two to ten tested for an early stage of type 1…

Portrait Anette Gabriele Ziegler, Querformat;

Awards & Grants, Diabetes, IDF,

Anette-Gabriele Ziegler Receives Claude Bernard Prize for Diabetes Research

Prof. Anette-Gabriele Ziegler from Helmholtz Munich has been named the recipient of the 58th Claude Bernard Prize, the highest honor awarded by the European Association for the Study of Diabetes (EASD). The prize recognizes her outstanding leadership…

Doctor drawing man's blood sample in clinic, closeup  AdobeStock_1937412501

Diabetes, IDF, Environmental Health, EPI,

Rethinking Early Detection: Type 1 Diabetes in Young Adults

A population-based cohort study provides new data on the prevalence of early-stage type 1 diabetes in young adults, addressing a gap in epidemiological research. Using samples from the LISA and GINIplus cohorts and methodologies established in the…

Blood Screening for Type 1 Diabetes

New Research Findings, Diabetes, IDF,

100,000 Participants Screened for Early-Stage Type 1 Diabetes in the EDENT1FI Project

EDENT1FI (“European action for the Diagnosis of Early Non-clinical Type 1 diabetes For disease Interception”), a research project led by Prof. Anette-Gabriele Ziegler from Helmholtz Munich and Prof. Chantal Mathieu from the KU Leuven, has reached an…

Currently Recruiting

Publications

Winkler, C. ; Friedl, N. ; Abt, R. ; Ackermann, K. ; Bently, J. ; Braig, S. ; Brämswig, S. ; Dunstheimer, D. ; Ermer, U. ; Ewald, D. ; Gerstl, E.M. ; Hammersen, J. ; Haupt, F. ; Hergl, M. ; Hubmann, M. ; Hummel, S. ; Jochem, B. ; Knopff, A. ; Lange, K. ; Lwowsky, D. ; Nellen-Hellmuth, N. ; Prey, B. ; Rettner, D. ; Schill, S. ; Schmidt, S. ; Scholz, M. ; Sindichakis, M. ; Stock, J. ; Stricker, D. ; Völkl, T.M.K. ; Warncke, K. ; Weber, L. ; Weiss, A. ; Bonifacio, E. ; Achenbach, P. ; Ziegler, A.-G.

Screening children for early-stage type 1 diabetes.
Diabetologia, DOI: 10.1007/s00125-026-06717-2 (2026)

Quinn, L.M. ; Stanley, D. ; Milano, F. ; Perego, G. ; Randell, M.J. ; Gatti, F. ; Catarinella, A. ; Dettori, L.B. ; Sheldon, R. ; Abid, M. ; Ziegler, A.-G. ; Bonifacio, E. ; Mathieu, C. ; Peakman, M. ; Dunne, J.L. ; Hurtado del Pozo, C. ; Vercauteren, J. ; Overbergh, L. ; Bosi, E. ; Di Mattei, V.E. ; Barnard, K. ; Lange, K. ; Dias, R.P. ; Litchfield, I. ; Greenfield, S.M. ; Boardman, F.K. ; Boiko, O. ; Narendran, P. ; EDENT1FI consortium (Achenbach, P. ; Haupt, F. ; Hummel, S.) ; EDENT1FI consortium (Winkler, C.)

Psychosocial implications, acceptability and ethics of screening for paediatric type 1 diabetes: A systematic review and mixed methods evidence synthesis.
Nat. Commun. 17:4414 (2026)

Becker, M. ; Kälin, S. ; Neubig, A.H. ; Lauber, M. ; Opaleva, D. ; Hipp, H. ; Salb, V.K. ; Ott, V. ; Legutko, B. ; Kälin, R.E. ; Hippich, M. ; Scherm, M.G. ; Nascimento, L.F.R. ; Serr, I. ; Hosp, F. ; Nikolaev, A. ; Mohebiany, A. ; Krueger, M. ; Flachmeyer, B. ; Pfaffl, M.W. ; Haase, B. ; Yi, C. ; Dietzen, S. ; Bopp, T. ; Woods, S.C. ; Waisman, A. ; Weigmann, B. ; Mann, M. ; Tschöp, M.H. ; Daniel, C.

Author Correction: Regulatory T cells in the mouse hypothalamus control immune activation and ameliorate metabolic impairments in high-calorie environments.
Lancet Diabet. Endocrinol. 14, 371-373 (2026)

Standl, M. ; Scholz, M. ; Thiering, E. ; Gappa, M. ; Schikowski, T. ; Achenbach, P. ; Ziegler, A.-G.

Prevalence of early-stage type 1 diabetes in young adults: A population-based cohort study.

Networks & Affiliations

Logo Deutsches Zentrum für Diabetesforschung

DZD

Read more
INNODIA Logo

INNODIA

Read more
Type 1 Diabetes TrialNet Logo

TrialNet

Read more

GPPAD

Read more
Fr1da plex Logo mit Untertitel

Fr1da plex

Read more
Logo Teddy Studie

Teddy consortium

Read more
nPOD_Logo1

nPOD

Read more
diabinfo Logo

diabinfo

Read more
Pre-T1D Logo Transparent

pre-T1D registry

Read more

EDENT1FI_Logo_final

EDENT1FI

Read more

Team

See all
[Translate to German:]
Univ.-Prof. Dr. med. Anette-Gabriele Ziegler

Institutsdirektorin, Lehrstuhl für Diabetes und Gestationsdiabetes, Klinikum rechts der Isar und Technische Universität München, Direktorin Globale Plattform zur Prävention des Autoimmunen Diabetes (GPPAD)

View profile
Portrait Peter Achenbach
Prof. Dr. med. Peter Achenbach

Deputy Director, Lead Scientist Research Area: Study Center for Childhood Diabetes

View profile
Sandra Hummel 2
Prof. Dr. oec. troph. Sandra Hummel

Lead Scientist Research Area: Lifestyle, Obesity, and Epigenetic Programming in Type 1 and Gestational Diabetes

View profile
Christiane Winkler_31
Dr. rer. biol. hum. Christiane Winkler

Lead Scientist Research Area: Early Diagnosis & Staging of Type 1 Diabetes, and Phenotyping

View profile
Porträt Raffael Ott
Dr. Raffael Ott

Lead Scientist Research Area: Computational Biology and Immune Response Trajectories of Type 1 Diabetes Development

View profile
Porträt Florian Haupt
Dr. rer. nat. Florian Haupt

Lead Scientist Research Area: Digital Networking for Type 1 Diabetes Research

View profile
Porträt Teresa Rodriguez; IDF; Hintergrund: grau
Dr. Teresa Rodriguez-Calvo

Lead Scientist Research Group: Type 1 Diabetes Pathology

View profile

Contact

[Translate to German:]
Univ.-Prof. Dr. med. Anette-Gabriele Ziegler

Institutsdirektorin, Lehrstuhl für Diabetes und Gestationsdiabetes, Klinikum rechts der Isar und Technische Universität München, Direktorin Globale Plattform zur Prävention des Autoimmunen Diabetes (GPPAD)

Heidemannstraße 1, 80939 München

View profile

Portrait Peter Achenbach
Prof. Dr. med. Peter Achenbach

Deputy Director, Lead Scientist Research Area: Study Center for Childhood Diabetes

Heidemannstraße 1, 80939 München

View profile