Functional Genetics

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About Our Group

The characterization of mutants represents a valuable instrument for functional genome analysis. Novel mouse models for metabolic diseases are in the center of our projects. By unraveling the molecular pathways and pathophysiological events leading, in particular, to diabetes we also transfer the basic research results into the development of novel strategies for diagnosis, prevention and therapy.
As a service platform we offer to interested scientific groups the ENU DNA F1 Archive with 16,800 paralleled DNA and sperm samples of ENU mutagenesis derived F1 mice for the screening of genes of interest.

Prof. Dr. Dr. h.c. Martin Hrabě De Angelis

Research Director Helmholtz Munich, Full Professor and Chair of Experimental Genetics Technical University Munich, Director of the Institute of Experimental Genetics Helmholtz Munich View profile

Dr. Gerhard Przemeck

Group Leader, Research Group ‘Functional Genetics’ View profile

Aliona Harten

Maximilian Schmidtke

Andreas Mayer

Michael Schulz

Selected Publications

2023 Scientific Article in Kidney International

Riedhammer, K.M. ; Nguyen, T.T. ; Koşukcu, C. ; Calzada-Wack, J. ; Li, Y. ; ... ; Kraiger, M. ; Sanz-Moreno, A. ; Amarie, O.V. ; Rathkolb, B. ; Klein-Rodewald, T. ; Garrett, L. ; Hölter, S.M. ; Seisenberger, C. ; Marschall, S. ; Wurst, W. ; Fuchs, H. ; Gailus-Durner, V. ; Hrabě de Angelis, M. ; Hoefele, J.

Implication of transcription factor FOXD2 dysfunction in syndromic congenital anomalies of the kidney and urinary tract (CAKUT).

2023 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America

Correa, D. ; Scheuber, M.I. ; Shan, H. ; Weinmann, O.W. ; ... ; Harten, A. ; Schwab, M.E.

Intranasal delivery of full-length anti-Nogo-A antibody: A potential alternative route for therapeutic antibodies to central nervous system targets.

2022 Scientific Article in Cell Death Discovery

Kandaswamy, S. ; Zobel, L. ; John, B. ; Santhiya, S.T. ; ... ; Przemeck, G.K.H. ; Gailus-Durner, V. ; Fuchs, H. ; Hrabě de Angelis, M. ; Graw, J. ; Michalakis, S. ; Amarie, O.V.

Mutations within the cGMP-binding domain of CNGA1 causing autosomal recessive retinitis pigmentosa in human and animal model.

2022 Scientific Article in Radiation Research

Pawliczek, D. ; Fuchs, H. ; Gailus-Durner, V. ; Hrabě de Angelis, M. ; Quinlan, R. ; Graw, J. ; Dalke, C.

On the nature of murine radiation-induced subcapsular cataracts: Optical coherence tomography-based fine classification, in vivo dynamics and impact on visual acuity.

2021 Scientific Article in EMBO Molecular Medicine

Vidali, S. ; Gerlini, R. ; Thompson, K. ; Urquhart, J.E. ; Meisterknecht, J. ; Aguilar-Pimentel, J.A. ; Amarie, O.V. ; Becker, L. ; Breen, C. ; Calzada-Wack, J. ; Chhabra, N.F. ; Cho, Y.-L. ; da Silva Buttkus, P. ; ... ; Gampe, K. ; Garrett, L. ; Hoefig, K.P. ; Hölter, S.M. ; Klein-Rodewald, T. ; Leuchtenberger, S. ; Marschall, S. ; Mayer-Kuckuk, P. ; Miller, G. ; Oestereicher, M.A. ; Pfannes, K. ; Rathkolb, B. ; Rozman, J. ; Spielmann, N. ; Stoeger, C. ; Treise, I. ; Wurst, W. ; Fuchs, H. ; Prokisch, H. ; Gailus-Durner, V. ; Hrabě de Angelis, M.

Characterising a homozygous two-exon deletion in UQCRH: Comparing human and mouse phenotypes.

2021 Scientific Article in Nature Communications

Jacobsen, H. ; Walendy-Gnirß, K. ; Tekin-Bubenheim, N. ; Kouassi, N.M. ; ... ; Jeridi, A. ; Yildirim, A.Ö. ; Fuchs, H. ; Gailus-Durner, V. ; Stoeger, C. ; Hrabě de Angelis, M. ; Gabriel, G.

Offspring born to influenza A virus infected pregnant mice have increased susceptibility to viral and bacterial infections in early life.

2021 Review in Mammalian Genome

Ehlich, H. ; Cater, H.L. ; Flenniken, A.M. ; Goncalves Da Cruz, I. ; ... ; Stoeger, C. ; Hrabě de Angelis, M. ; Rozman, J. ; Sorg, T.

INFRAFRONTIER quality principles in systemic phenotyping.

2021 Scientific Article in Molecular Metabolism

Chhabra, N.F. ; Amend, A.-L. ; Bastidas-Ponce, A. ; Sabrautzki, S. ; Tarquis Medina, M. ; Sachs, S. ; Rubey, M. ; Lorenz-Depiereux, B. ; Feuchtinger, A. ; Bakhti, M. ; Lickert, H. ; Przemeck, G.K.H. ; Hrabě de Angelis, M.

Functional Genetics

Click and view

About Our Group

Group Members

Prof. Dr. Dr. h.c. Martin Hrabě De Angelis

Dr. Gerhard Przemeck

Aliona Harten

Maximilian Schmidtke

Andreas Mayer

Michael Schulz

Selected Publications

Implication of transcription factor FOXD2 dysfunction in syndromic congenital anomalies of the kidney and urinary tract (CAKUT).

Intranasal delivery of full-length anti-Nogo-A antibody: A potential alternative route for therapeutic antibodies to central nervous system targets.

Mutations within the cGMP-binding domain of CNGA1 causing autosomal recessive retinitis pigmentosa in human and animal model.

On the nature of murine radiation-induced subcapsular cataracts: Optical coherence tomography-based fine classification, in vivo dynamics and impact on visual acuity.

Characterising a homozygous two-exon deletion in UQCRH: Comparing human and mouse phenotypes.

Offspring born to influenza A virus infected pregnant mice have increased susceptibility to viral and bacterial infections in early life.

INFRAFRONTIER quality principles in systemic phenotyping.

A point mutation in the Pdia6 gene results in loss of pancreatic β-cell identity causing overt diabetes.

Contact

Dr. Gerhard Przemeck

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