Molecular Targets and Therapeutics Center Institute of Medicinal Chemistry
The Institute of Medicinal Chemistry develops chemical tool compounds for the discovery of mechanisms of pathogenesis and deals with identification and optimisation of innovative drugs. The Institute of Medicinal Chemistry is a satellite institute of the Helmholtz Zentrum München, located at the Leibniz University of Hanover. It focusses on providing chemical compound tools to explain mechanisms of pathogenesis as well as identifying and optimizing innovative drug substances.
The Institute of Medicinal Chemistry develops chemical tool compounds for the discovery of mechanisms of pathogenesis and deals with identification and optimisation of innovative drugs. The Institute of Medicinal Chemistry is a satellite institute of the Helmholtz Zentrum München, located at the Leibniz University of Hanover. It focusses on providing chemical compound tools to explain mechanisms of pathogenesis as well as identifying and optimizing innovative drug substances.
Publications
Read more2022 Scientific Article in European Journal of Medicinal Chemistry
Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma.
2022 Scientific Article in Cell Metabolism
Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes.
2022 Scientific Article in Nanophotonics
Multifunctional croconaine nanoparticles for efficient optoacoustic imaging of deep tumors and photothermal therapy.
2022 Scientific Article in Cellular and Molecular Life Sciences - CMLS
A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells.
2022 Scientific Article in Cell Chemical Biology
Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses.
2021 Scientific Article in Science Advances
Phenotypic drug screening in a human fibrosis model identified a novel class of antifibrotic therapeutics.
2021 Scientific Article in Science immunology
TRAF6 prevents fatal inflammation by homeostatic suppression of MALT1 protease.
2021 Scientific Article in Journal of Chemical Information and Modeling
Computer-aided design and synthesis of a new class of PEX14 inhibitors: substituted 2,3,4,5-tetrahydrobenzo[F][1,4]oxazepines as potential new trypanocidal agents.
2021 Review in Expert Opinion on Therapeutic Patents
A patent review of MALT1 inhibitors (2013-present).
2021 Scientific Article in International Journal of Molecular Sciences
Structural and biochemical characterization of a dye-decolorizing peroxidase from Dictyostelium discoideum.
2021 Scientific Article in Nanomaterials
Diamond nanoparticles-porphyrin mthpp conjugate as photosensitizing platform: Cytotoxicity and antibacterial activity.
Affiliations & Networks
