Helmholtz Diabetes Center
Institute for Pancreatic Islet Research
The mission of the Institute for Pancreatic Islet Research (IPI) is to protect and restore the insulin-producing beta cells of the pancreas to prevent and cure diabetes mellitus.
The mission of the Institute for Pancreatic Islet Research (IPI) is to protect and restore the insulin-producing beta cells of the pancreas to prevent and cure diabetes mellitus.
About our Research
The research at the IPI focuses on the pancreatic islets, in which the insulin-producing beta cells, which are damaged or even destroyed in type-1 and type-2 diabetes, are located. The study of the underlying mechanisms and their better understanding helps scientists to develop new therapeutic approaches.
Since January 2016, the IPI has been part of Helmholtz Munich as a satellite institute and forms the core of the previously founded Paul Langerhans Institute Dresden (PLID) of the German Center for Diabetes Research (DZD e.V.).
Currently, the IPI comprises 16 research groups dealing with various aspects of diabetes. The scientists are working on deciphering the mechanisms that lead to the destruction and/or functional impairment of beta cells and are also trying to develop new approaches to replace damaged or destroyed beta cells.
Therefore, our mission is to protect and restore the insulin-producing beta cells of the pancreas to prevent and cure diabetes mellitus.
Over the past years, an international team of scientists from a wide variety of disciplines has been recruited to perform their research in Dresden, making IPI to one of the leading diabetes research locations in Germany. The interdisciplinary cooperation and the close connection of experts from different disciplines such as genetics, immunology, cell and developmental biology with the clinical departments of internal medicine and visceral, thoracic and vascular surgery or stem cell experts guarantee a translational orientation of the research. The excellent research infrastructure in Dresden provides moreover the basis for future scientific excellence.
Our Research Groups
Group leader at Paul Langerhans Institute Dresden of Helmholtz Munich at at the University Hospital and the Carl Gustav Carus Medical Faculty of the Technical University of Dresden
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Postdoc
Postdoc
Technical Assistant
Technical Assistant
Technical Assistant
Administrative Coordination
Group Leader
Postdoc
Technical Assistant
Group Leader
Technical Assistant
Group Leader
Postdoc
Technical Assistant
Administration
Scientific Coordination
Scientific Coordinator
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Predoc
Postdoc / Lab Manage
Technical Assistant
Technical Assistant
Postdoc
Postdoc
Technical Assistant
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Publications
Bahra, O. ; Grzybek, M. ; Coskun, Ü.
Characterization of human Akt1-lipid interactions by label-free differential scanning fluorimetry.Sandforth, A. ; Arreola, E.V. ; Hanson, R.L. ; Wewer Albrechtsen, N.J. ; Holst, J.J. ; Ahrends, R. ; Coman, C. ; Gerst, F. ; Lorza-Gil, E. ; Cheng, Y. ; Sandforth, L. ; Katzenstein, S. ; Ganslmeier, M. ; Seissler, J. ; Hauner, H. ; Perakakis, N. ; Wagner, R. ; Machann, J. ; Schick, F. ; Peter, A. ; Lehmann, R. ; Weigert, C. ; Maurer, J. ; Preissl, H. ; Heni, M. ; Szendrödi, J. ; Kopf, S. ; Solimena, M. ; Schwarz, P. ; Blüher, M. ; Häring, H.-U. ; Hrabě de Angelis, M. ; Schürmann, A. ; Kabisch, S. ; Mai, K. ; Pfeiffer, A.F.H. ; Bornstein, S. ; Stumvoll, M. ; Roden, M. ; Stefan, N. ; Fritsche, A. ; Birkenfeld, A.L. ; Jumpertz von Schwartzenberg, R.
Prevention of type 2 diabetes through prediabetes remission without weight loss.Mund, C. ; Sinha, A. ; Aderhold, A. ; Mateska, I. ; Hagag, E. ; Traikov, S. ; Gercken, B. ; Soto, A. ; Pollock, J. ; Arndt, L. ; Wölk, M. ; Werner, N. ; Fodelianaki, G. ; Subramanian, P. ; Chung, K.J. ; Grossklaus, S. ; Langner, M. ; Elgendy, M. ; Grinenko, T. ; Wielockx, B. ; Dahl, A. ; Gericke, M. ; Blüher, M. ; Coskun, Ü. ; Voehringer, D. ; Fedorova, M. ; Peitzsch, M. ; Murray, P.J. ; Chavakis, T. ; Alexaki, V.I.
A key role of polyamine metabolism in adipose tissue homeostasis that regulates obesity.Quezada, E. ; Knoch, K.-P. ; Vasiljevic, J. ; Seiler, A. ; Pal, A. ; Gunasekaran, A. ; Münster, C. ; Friedland, D. ; Schöniger, E. ; Sönmez, A. ; Roch, P. ; Wegbrod, C. ; Ganß, K. ; Kipke, N. ; Alberti, S. ; Nano, R. ; Piemonti, L. ; Aust, D. ; Weitz, J. ; Distler, M. ; Solimena, M.
Aldolase-regulated G3BP1/2+ condensates control insulin mRNA storage in beta cells.Zhu, X. ; Bennett, T.J.D. ; Zouboulis, K.C. ; Soulias, D. ; Grzybek, M. ; Benesch, J.L.P. ; El-Sagheer, A.H. ; Coskun, Ü. ; Krishnan, M.
Measurements of molecular size and shape on a chip.Kalandarishvili, M. ; Oehme, F. ; Radulova-Mauersberger, O. ; Kipke, N. ; Solimena, M. ; Teske, C. ; Mibelli, N. ; Weitz, J. ; Distler, M. ; Hempel, S.
Glucose metabolism after distal pancreatectomy - deterioration of beta cell function becomes noticeable at an early stage: A retrospective cohort study.Nilsson, C.I. ; Dumral, Ö. ; Sánchez, G. ; Xie, B. ; Müller, A. ; Solimena, M. ; Ren, H. ; Idevall-Hagren, O.
Somatostatin triggers local cAMP and Ca2+ signaling in primary cilia to modulate pancreatic β-cell function.Barovic, M. ; Hahn, J.J. ; Heinrich, A. ; Adhikari, T. ; Schwarz, P.E. ; Mirtschink, P. ; Funk, A. ; Kabisch, S. ; Pfeiffer, A.F.H. ; Blüher, M. ; Seissler, J. ; Stefan, N. ; Wagner, R. ; Fritsche, A. ; Jumpertz von Schwartzenberg, R. ; Chlamydas, S. ; Harb, H. ; Mantzoros, C.S. ; Chavakis, T. ; Schürmann, A. ; Birkenfeld, A.L. ; Roden, M. ; Solimena, M. ; Bornstein, S.R. ; Perakakis, N.
Proteomic and metabolomic signatures in prediabetes progressing to diabetes or reversing to normoglycemia within 1 Year.Kopaliani, I. ; Elsaid, B. ; Speier, S. ; Deussen, A.
Immune and metabolic mechanisms of endothelial dysfunction.Siehler, J. ; Bilekova, S. ; Chapouton, P. ; Dema, A. ; Albanese, P. ; Tamara, S. ; Jain, C. ; Sterr, M. ; Enos, S.J. ; Chen, C. ; Malhotra, C. ; Villalba, A. ; Schomann, L. ; Bhattacharya, S. ; Feng, J. ; Akgün, M. ; Ribaudo, F. ; Ansarullah ; Burtscher, I. ; Ahlbrecht, C. ; Plettenburg, O. ; Kurth, T. ; Scharfmann, R. ; Speier, S. ; Scheltema, R.A. ; Lickert, H.
Inceptor binds to and directs insulin towards lysosomal degradation in β cells.
German Center for Diabetes Research
University Hospital and Faculty of Medicine Carl Gustav Carus at TU Dresden
Center for Regenerative Therapies Dresden (CRTD)
Technische Universität Dresden
Max Planck Institute for Molecular Cell Biology and Genetics
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