Computational Health Center
Institute of Translational Genomics
We generate insights from big biomedical data to improve human health.
At the Institute of Translational Genomics (ITG) we generate insights from big biomedical data to improve human health.
Scientific Focus
Our research leverages big data in genetics and genomics for medically important human traits. We aim to translate insights from genomics into mechanisms of disease development and progression, shortening the path to translation and empowering precision medicine.
Our overarching aims are to
- Characterise the genetic architecture of common complex diseases of high public health burden;
- Generate insights into the biological mechanisms underpinning chronic disease development and progression;
- Develop robust methods for integrating big data to address key biomedical challenges;
- Catalyse pathways to translation for disease prognosis, management and treatment.
Our Institute in Numbers
Recent Publications
Arruda, A.L. ; Bocher, O. ; Taylor, H.J. ; Cammann, D. ; Yoshiji, S. ; Yin, X. ; Zhao, C. ; Chen, J. ; Wood, A.C. ; Suzuki, K. ; Mercader, J.M. ; Spracklen, C.N. ; Meigs, J.B. ; Vujkovic, M.R. ; Smith, G.D. ; Rotter, J.I. ; Voight, B.F. ; Morris, A.P. ; Zeggini, E.
The effect of type 2 diabetes genetic predisposition on non-cardiovascular comorbidities.Chen, S. ; Zhang, Y. ; Fan, T. ; Zeng, M. ; Yang, Q. ; Yang, H. ; Fang, X. ; Jin, X. ; Cao, P. ; Wang, Z. ; Hunter, D.J. ; Zhou, Y. ; Ding, C. ; Zhu, Z.
Associations of healthy lifestyle and genetic susceptibility with risks of osteoarthritis: A prospective cohort study.Han, S. ; Yu, S. ; Shi, M. ; Harada, M. ; Ge, J. ; Lin, J. ; Prehn, C. ; Petrera, A. ; Li, Y. ; Sam, F. ; Matullo, G. ; Adamski, J. ; Suhre, K. ; Gieger, C. ; Hauck, S.M. ; Herder, C. ; Roden, M. ; Casale, F.P. ; Cai, N. ; Peters, A. ; Wang-Sattler, R.
LEOPARD: Missing view completion for multi-timepoint omics data via representation disentanglement and temporal knowledge transfer.
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