Identification of a previously unknown function of adipose tissue in insulin secretion.
Scientists at Helmholtz Munich and the University of Augsburg have made an important breakthrough in better understanding early processes in the development of…
Type 2 diabetes disease progression and successful intervention depend on individual’s unique clinical, genetic, genomic, and environmental information partly represented by gene expression patterns. An international team of researchers around…
Non-alcoholic fatty liver disease (NAFLD) is an important risk factor for type 2 diabetes and cardiovascular diseases. In a Perspective in Cell Metabolism, Norbert Stefan from Helmholtz Munich, the German Center for Diabetes Research and the…
Modern cancer therapy aims to tailor treatment to each individual patient's needs by identifying specific molecular targets with essential functions in the tumor of these patients. Leukemia, or blood cancer, is a common tumor in children and occurs…
How can the clinical translation of research findings be accelerated to improve human health? What role does bioengineering play in driving the development of medicine and biology solutions? Matthias Tschöp, CEO at Helmholtz Munich and Alexander von…
The renal phosphate wasting disease X-linked hypophosphatemia (XLH) is a rare metabolic disorder of the bones associated with severe renal phosphate loss. The first symptoms of the genetic defect appear in childhood and adolescence and can…
Which factors drive non-communicable inflammatory skin diseases? A research team led by Stefanie Eyerich, Michael Menden, as well as Kilian Eyerich have investigated this question and applied a new spatial transcriptomics technology, that gives…
A research team from Helmholtz Munich and the Leipzig University’s Faculty of Medicine has discovered a new mechanism that is associated with severe obesity in children. This genetic rearrangement leads to an unusual expression of a gene that can…
Three approaches with a reputation for slowing aging processes have proven largely ineffective. For their study, researchers developed a new method to measure aging, which accounts for the complexity of aging in organisms.
It is well known that genes and environmental factors such as air pollutants, bacteria and also diet can influence the development of allergies or asthma. Researchers at Helmholtz Munich have now examined the role of food in more detail. Their…
How is a muscle protein related to energy production in brown adipose tissue (BAT)? And could this be a possible starting point in the fight against obesity? A team of researchers led by John Heiker from the Helmholtz Institute for Metabolic, Obesity…
The discovery of gut hormone dual and triple co-agonist drug classes by Matthias Tschöp and Richard DiMarchi has led to a series of new therapeutics in clinical development. The first co-agonist at the receptors for GLP-1 and GIP has recently been…
Through the course of the last several decades, the rate of obesity has progressively increased and is now one of the leading causes of death worldwide – according to the World Health Organization (WHO) 650 million adults are classified as obese. The…
Does exercise help against diabetes and obesity? Researchers around PD Dr Stephanie Kullmann from Helmholtz Munich and DZD have investigated this question in a clinical study. The results show that just eight weeks of exercise can help restore the…
More than three percent of the world’s population (around 300 million people) are living with a chronic hepatitis B virus (HBV) infection. Having chronic hepatitis B increases the risk for patients to develop liver failure, liver cancer or cirrhosis…
Helmholtz Munich researcher Kristian Unger, head of Translational Bioinformatics at the Department of Radiation Cytogenetics (ZYTO), together with scientists from the LMU Radiation Clinic and the LMU Medical Physics, has developed the AI method…
Surface molecules EGFR and Integrin beta 4 play a key role in this process
Frequently, cancer patients do not die because of their “initial tumor” in a specific organ. Only when individual cells of the primary tumor transform, migrate or colonize…
New Publication of Ali Doryab and Otmar Schmid (Schmid Lab, Institute of Lung Health and Immunity) in Advanced Materials
Parkinson's disease, formerly known as shaking palsy, is the second most common neurodegenerative disease in Germany after Alzheimer's disease. It affects about 400,000 people in Germany alone and can neither be cured nor can its progression be…
The use of artificial intelligence (AI) in the field of pathology, especially in the early detection of diseases, has increased rapidly in the past decade. However, despite an ever-growing number of publications in the field, only few methods are…
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