Prediabetes is a precursor to type 2 diabetes with an increased risk of heart attacks, kidney and eye diseases, and various types of cancer. In Germany, there is no approved medication for prediabetes. Scientists from the German Center for Diabetes…
An in vitro roadmap guiding vascularization in tissue engineering
With the dilemma of the need for organ transplants by far surpassing available donor organs, the number of patients dying while waiting for a suitable transplant will inevitably…
A collaborative endeavor between computer scientists and diabetes researchers at Helmholtz Munich has yielded novel insights into the mechanisms underlying type 1 and type 2 diabetes. This collaboration has resulted in the creation of the first mouse…
A recent discovery led by Dr. Anika Seel and Dr. Kurt Schmoller at the Institute for Functional Epigenetics (IFE) at Helmholtz Munich has uncovered a fascinating link between cell size and mitochondrial DNA regulation, shedding light on a previously…
Researchers from Helmholtz Munich have reached a significant milestone in precision medicine with their new publication on the 'Oncology Biomarker Discovery (OncoBird)' framework. This innovative approach aims to systematically identify actionable…
DNA origami structures fitted with antibodies help immune system to target cancer cells
Immunotherapy is viewed as an exceptionally promising weapon in the fight against cancer. In essence, the aim is to activate the body’s immune system in such a…
Why “Eating Your Greens” Represents a Major Aspect of Lifestyle Driven Obesity Treatment
The coexistence of multiple chronic diseases in a single individual, defined as multimorbidity, poses a significant challenge in healthcare as the global population ages. In a collaborative effort, researchers investigated the link between type 2…
Over the past decades, epidemiological studies have clearly demonstrated the effects of air pollution on health. There are now explicit recommendations from the World Health Organization regarding guidelines for particulate matter, especially PM2.5…
Diagnosis of type 1 diabetes (T1D) can come with serious complications for families: too often, the autoimmune disease is only detected after severe symptoms develop. In Germany, more than 20 percent of all children and adolescents diagnosed with T1D…
Human health is closely connected to the health of our environment. So far, the complex ways in which they influence each other are not fully understood. The concept of One Health recognizes this interconnectedness of human, animal, and environmental…
CAMPA, a new deep-learning framework, that allows for analysis of subcellular organization in healthy and perturbed cells using high-resolution fluorescence microscopy data has now been introduced in Nature Methods. This tool can facilitate the…
New algorithm six times more reliable at predicting defective RNA
So far, it has not been possible to explain the causes of around half of all rare hereditary diseases. A Munich research team has developed an algorithm that predicts the effects of…
Predicting the effects of drugs regarding dosage, timing, possible drug combinations and other types of intervention such as gene knockouts can be experimentally difficult and very time-consuming. Nonetheless, this is one of the most important tasks…
Inflammatory fatty liver disease (NASH, nonalcoholic steatohepatitis) and the resulting liver cancer are driven by autoaggressive T cells. Scientists from the German Cancer Research Center (DKFZ), Helmholtz Munich and the Technical University Munich…
It is commonly known that DNA assembles into heterochromatin, a densely composed structure, thereby preventing access to the information encoded by the DNA and gene expression. Until now it is not completely understood how this structure forms during…
Triose phosphates (TPs) are the primary products of photosynthetic CO2 fixation in chloroplasts, which need to be exported into the cytosol across the chloroplast inner envelope (IE) and outer envelope (OE) membranes to sustain plant growth.
A team…
Lean, metabolically unhealthy, people have a risk of cardiovascular disease (CVD) that is higher than the risk observed in obese, metabolically healthy people. Recently, novel cluster analyses (computer-based grouping of people) also identified a…
Genetically encoded nano-barcodes
How do the nerve cells in our brain communicate with each other? What processes take place when T cells render cancer cells harmless? Details of the mechanisms at the cellular level remain hidden from view. Now,…
Identification of a previously unknown function of adipose tissue in insulin secretion.
Scientists at Helmholtz Munich and the University of Augsburg have made an important breakthrough in better understanding early processes in the development of…
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