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Comprehensive Separation

+49 (0)89 3187-4554Email meBuilding/Room: 107 / 232

"Comprehensive Separation" represents the interface between the main research areas "Enabling Analytical Technologies" and "Aerosols and Health". New and state-of-the-art analytical instruments and methods are developed and applied in "Aerosols and Health" and in other areas of environmental health.

"Comprehensive Separation" represents the interface between the main research areas "Enabling Analytical Technologies" and "Aerosols and Health". New and state-of-the-art analytical instruments and methods are developed and applied in "Aerosols and Health" and in other areas of environmental health.

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About our research

"Comprehensive Separation" conducts research at the interface of the JMSC's two main research areas, "Enabling Analytical Technologies" and "Aerosols and Health". The scientific goals are to develop and implement new and state-of-the-art analytical tools and methods for their application in the fields of environmental health. Key techniques are comprehensive two-dimensional gas chromatography (GC×GC) in combination with highly selective spectroscopic and mass spectrometric detection systems. In addition, thermal sample insertion techniques such as direct insertion probe (DIP) and various thermal analysis (TA) approaches in combination with soft ionization techniques are also established and used to extend the applied interfaces of gas phase ionization to less and non-volatile matrices. Another focus is the comprehensive and state-of-the-art data processing and data analysis of the generated multidimensional data.

"Comprehensive Separation" offers a broad spectrum of projects with a clear focus on the priorities of Helmholtz Munich and the JMSC. Internal and third-party funded projects in recent years have focused on diabetes research, allergy research, and aerosols and health. These interdisciplinary studies have always aimed at bridging the gap between chemical analysis and biological response. In this context, the close interaction with other institutes on the HMGU campus, as well as the JMSC topics "Aerosol Toxicology" and "Aerosol Mutagenesis" are becoming increasingly important.

The goal is the subsequent application of the developed techniques for aerosol and health research. An example of such successful collaboration and subsequent transfer of scope is the establishment of an analytical platform for the study of less volatile and highly complex petroleum products. The platform allows the simultaneous application of different thermal methods such as Direct Inlet Probe (DIP), Thermal Analysis (TA) or high temperature GC×GC coupled with a high resolution time-of-flight mass spectrometer.

This successfully established platform is being used in a new project to study pharmaceutical raw materials and identify pharmacologically active ingredients with similar complexity to petroleum-based matrices (Paper Käfer, Tiemann?). In this context, collaboration with analytical system manufacturers is instrumental in maintaining the analytical technical level and availability of state-of-the-art analytical platforms at the JMSC and HMGU. However, a unifying feature of all these projects is the methodological approach of non-targeted and comprehensive chemical analysis.

Scientists at Comprehensive Chromatographic Separation

Thomas Gröger

Head of Comprehensive Chromatographic Separation

Ramona Brejcha

Technician/ Engineer

Dr. Nadine Gawlitta

Postdoc

Barbara Giocastro

PhD Student

Elena Hartner

PhD Student

Dr. Uwe Kaefer

Scientist

Lukas Schwalb

PhD Student

Publications

2022 Scientific Article in ACS Earth and Space Chemistry ACS Earth Space Chem. 6, 1358-1374 (2022)

Hartner, E. ; Paul, A. ; Käfer, U. ; Czech, H. ; Hohaus, T. ; Gröger, T.M. ; Sklorz, M. ; Jakobi, G. ; Orasche, J. ; Jeong, S. ; Brejcha, R. ; Ziehm, T. ; Zhang, Z.H. ; Schnelle-Kreis, J. ; Adam, T. ; Rudich, Y. ; Kiendler-Scharr, A. ; Zimmermann, R.

On the complementarity and informative value of different electron ionization mass spectrometric techniques for the chemical analysis of secondary Organic aerosols.

2022 Scientific Article in Environment International Environ. Int. 166:107366 (2022)

Pardo, M. ; Offer, S. ; Hartner, E. ; Di Bucchianico, S. ; Bisig, B. ; Bauer, S. ; Pantzke, J. ; Zimmermann, E. ; Cao, X. ; Binder, S. ; Kuhn, E. ; Huber, A. ; Jeong, S. ; Käfer, U. ; Schneider, E. ; Mesceriakovas, A. ; Bendl, J. ; Brejcha, R. ; Buchholz, A. ; Gat, D. ; Hohaus, T. ; Rastak, N. ; Karg, E.W. ; Jakobi, G. ; Kalberer, M. ; Kanashova, T. ; Hu, Y. ; Ogris, C. ; Marsico, A. ; Theis, F.J. ; Shalit, T. ; Gröger, T.M. ; Rüger, C.P. ; Oeder, S. ; Orasche, J. ; Paul, A. ; Ziehm, T. ; Zhang, Z.H. ; Adam, T. ; Sippula, O. ; Sklorz, M. ; Schnelle-Kreis, J. ; Czech, H. ; Kiendler-Scharr, A. ; Zimmermann, R. ; Rudich, Y.

Exposure to naphthalene and β-pinene-derived secondary organic aerosol induced divergent changes in transcript levels of BEAS-2B cells.

2022 Scientific Article in Environmental Health Perspectives Environ. Health Perspect. 130:27003 (2022)

Offer, S. ; Hartner, E. ; Di Bucchianico, S. ; Bisig, B. ; Bauer, S. ; Pantzke, J. ; Zimmermann, E. ; Cao, X. ; Binder, S. ; Kuhn, E. ; Huber, A. ; Jeong, S. ; Käfer, U. ; Martens, P. ; Mesceriakovas, A. ; Bendl, J. ; Brejcha, R. ; Buchholz, A. ; Gat, D. ; Hohaus, T. ; Rastak, N. ; Jakobi, G. ; Kalberer, M. ; Kanashova, T. ; Hu, Y. ; Ogris, C. ; Marsico, A. ; Theis, F.J. ; Pardo, M. ; Gröger, T.M. ; Oeder, S. ; Orasche, J. ; Paul, A. ; Ziehm, T. ; Zhang, Z.H. ; Adam, T. ; Sippula, O. ; Sklorz, M. ; Schnelle-Kreis, J. ; Czech, H. ; Kiendler-Scharr, A. ; Rudich, Y. ; Zimmermann, R.

Effect of atmospheric aging on soot particle toxicity in lung cell models at the air-liquid interface: Differential toxicological impacts of biogenic and anthropogenic Secondary Organic Aerosols (SOAs).

2022 Scientific Article in Atmospheric Chemistry and Physics Atmos. Chem. Phys. 22, 1793-1809 (2022)

Zhang, Z.H. ; Hartner, E. ; Utinger, B. ; Gfeller, B. ; Paul, A. ; Sklorz, M. ; Czech, H. ; Yang, B.X. ; Su, X.Y. ; Jakobi, G. ; Orasche, J. ; Schnelle-Kreis, J. ; Jeong, S. ; Gröger, T.M. ; Pardo, M. ; Hohaus, T. ; Adam, T. ; Kiendler-Scharr, A. ; Rudich, Y. ; Zimmermann, R. ; Kalberer, M.

Are reactive oxygen species (ROS) a suitable metric to predict toxicity of carbonaceous aerosol particles?

2021 Scientific Article in Aerosol Science and Technology Aerosol Sci. Technol. 5, 292–306 (2021)

Koch, A. ; Bergelt, P. ; Fiala, P. ; Käfer, U. ; Orasche, J. ; Bauer, S. ; Di Bucchianico, S. ; Stintz, M. ; Gröger, T.M. ; Streibel, T. ; Zimmermann, R.

Investigation of chemical composition and fiber-occurrence in inhalable particulate matter obtained from dry cutting processes of carbon fiber reinforced concrete composite, concrete and the carbon fiber reinforcement materials.

2016 Scientific Article in PLoS ONE PLoS ONE 11:e0157964 (2016)

Sapcariu, S.C. ; Kanashova, T. ; Dilger, M. ; Diabaté, S. ; Oeder, S. ; Passig, J. ; Radischat, C. ; Buters, J.T.M. ; Sippula, O. ; Streibel, T. ; Paur, H.R. ; Schläger, C. ; Mülhopt, S. ; Stengel, B. ; Rabe, R. ; Harndorf, H. ; Krebs, T. ; Karg, E.W. ; Gröger, T.M. ; Weiss, C. ; Dittmar, G. ; Hiller, K. ; Zimmermann, R.

Metabolic profiling as well as stable isotope assisted metabolic and proteomic analysis of RAW 264.7 macrophages exposed to ship engine aerosol emissions: Different effects of heavy fuel oil and refined diesel fuel.

2015 Scientific Article in PLoS ONE PLoS ONE 10:e0126536 (2015)

Oeder, S. ; Kanashova, T. ; Sippula, O. ; Sapcariu, S.C. ; Streibel, T. ; Arteaga-Salas, J.M. ; Passig, J. ; Dilger, M. ; Paur, H.R. ; Schläger, C. ; Mülhopt, S. ; Diabaté, S. ; Weiss, C. ; Stengel, B. ; Rabe, R. ; Harndorf, H. ; Torvela, T. ; Jokiniemi, J.K. ; Hirvonen, M.R. ; Schmidt-Weber, C.B. ; Traidl-Hoffmann, C. ; BéruBé, K.A. ; Wlodarczyk, A.J. ; Prytherch, Z. ; Michalke, B. ; Krebs, T. ; Prévôt, A.S. ; Kelbg, M. ; Tiggesbäumker, J. ; Karg, E.W. ; Jakobi, G. ; Scholtes, S. ; Schnelle-Kreis, J. ; Lintelmann, J. ; Matuschek, G. ; Sklorz, M. ; Klingbeil, S. ; Orasche, J. ; Richthammer, P. ; Müller, L. ; Elsasser, M. ; Reda, A. ; Gröger, T.M. ; Weggler, B.A. ; Schwemer, T. ; Czech, H. ; Rüger, C.P. ; Abbaszade, G. ; Radischat, C. ; Hiller, K. ; Buters, J.T.M. ; Dittmar, G. ; Zimmermann, R.

Particulate matter from both heavy fuel oil and diesel fuel shipping emissions show strong biological effects on human lung cells at realistic and comparable in vitro exposure conditions.

2009 Scientific Article in Analytical Chemistry Anal. Chem. 81, 6038-6048 (2009)

Geissler, R. ; Saraji-Bozorgzad, M.R. ; Gröger, T.M. ; Fendt, A. ; Streibel, T. ; Sklorz, M. ; Krooss, B.M. ; Fuhrer, K. ; Gonin, M. ; Kaisersberger, E. ; Denner, T. ; Zimmermann, R.

Single photon ionization orthogonal acceleration time-of-flight mass spectrometry and resonance enhanced multiphoton ionization time-of-flight mass spectrometry for evolved gas analysis in thermogravimetry: Comparative analysis of crude oils.

Head of Comprehensive Chromatographic Separation

Contact

Thomas Gröger

Head of Comprehensive Chromatographic Separation

107/ 232