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narbenbildende Fibroblasten grün in Mausembryo_Simon Christ
Helmholtz Munich | Simon Christ

Environmental Health Center Institute of Regenerative Biology and Medicine

With the intent to move towards a scarless world with targeted clinical therapy

With the intent to move towards a scarless world with targeted clinical therapy

Regenerative medicine is considered the next evolution of medicine and medical treatments. It encompasses interdisciplinary biological and translational areas and aims to understand human disease, trauma and aging.

The IRBM brings together basic research and applied research under one roof. Scientific topics and tasks include:

(1) Tissue repair and regeneration in animal models (Bikram Dasgupta, Aydan Sardogan, Ruoxuan Dai)

(2) Repair and regeneration mechanisms at the cellular and molecular level (Donovan-Correa Gallegos, Yue Lin)

(3) Processes involved in fibrotic disease mechanisms including scars, fibrosis, sclerosis, adhesions and chronic wounds (Shaoping Hu, Christoph Diesenhofer)



People at IRBM

Latest publications



Correa-Gallegos D.*, Ye H.*, Dasgupta B.*, Sardogan A., Kadri S., Kandi R., Dai R., Lin Y., Kopplin R., Shantaram D.S., Wannemacher J., Ichijo R., Jiang D., Strunz M., Ansari M., Angelidis I., Schiller H.B., Voltz T., Machens H.-G., Rinkevich Y. (2023). CD201+ fascia progenitors choreograph injury repair. Nature


Kalgudde GS, Dai R, Stefanska AM, Ansari M, Zhao J, Ramesh P, Bagnoli JW, Correa-Gallegos D, Lin Y, Christ S, Angelidis I, Lupperger V, Marr C, Davies LC, Enard W, Machens HG, Schiller HB, Jiang D, Rinkevich Y (2023). Wound infiltrating adipocytes are not myofibroblasts. Nat Commun 14, Article number: 3020 (2023)


Qarri A, Kültz D, Gardell A. M, Rinkevich B, Rinkevich Y (2023) Improved Media Formulations for Primary Cell Cultures Derived from a Colonial Urochordate, Cells 2023, 12(13), 1709


Fischer A, Correa-Gallegos D, Wannemacher J, Christ S, Rinkevich Y , (2023) In vivo fluorescent labeling and tracking of Extracellular Matrix, Nat Protocols 18, 2876–2890 (2023)


Ye H, Rinkevich Y (2023) Fascia layer - a novel target for the application of biomaterials in skin wound healing; International Journal of Molecular Sciences 2023, 24(3), 2936


Bajwa P, Kordylewicz K, Bilecz A, Lastra RR, Wroblewski K, Rinkevich Y, Lengyel E, Kenny HA, (2023) Cancer-associated mesothelial cell-derived ANGPTL4 and STC1 promote the early steps of ovarian cancer metastasis, JCI Insight 2023 Mar 22; 8(6): e163019




Qarri A, Rinkevich B, Rinkevich Y (2022) Improving the Yields of Blood Cell Extractions from Botryllus schlosseri Vasculature, Advances in aquatic invertebrate stem cell research

Correa-Gallegos D, Machens HG, Rinkevich Y (2022) States and Fates of Skin Fibroblasts Revealed through Chromatin Accessibility, J Invest Dermatol. 142 (7): 1767-1770

Jiang D, Guo R, Machens HG, Rinkevich Y (2022) Diversity of Fibroblasts and Their Roles in Wound Healing, Cold Spring Harb Perspect Biol. 2023 Mar 1;15(3):a041222.

Ramesh P, Ye H, Dasgupta B, Machens HG, Rinkevich Y (2022) Visualizing Scar Development Using SCAD Assay – An Ex-situ Skin Scarring Assay, J Vis Exp. (182)

Hyams Y, Panov J,  Rosner A, Brodsky L, Rinkevich Y, Rinkevich B (2022) Transcriptome landscapes that signify Botrylloides leachi torpor states, Developmental Dynamics 490: 22-36

Wu M, Matar DY, Yu Z, Chen Z, Knoedler S, Ng B, Darwish OA, Sohrabi S, Friedman L, Haug V, Murphy GF, Rinkevich Y, Orgill DP, Panayi AC (2022) Continuous NPWT Regulates Fibrosis in Murine Diabetic Wound Healing, Pharmaceutics 14 (10):2125




PhD Students

Networks and Affiliations

Herr Rinkevich, Yuval, Dr.

Dr. Yuval Rinkevich

Institute Director

Building 092, Room C3.11