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Helmholtz Munich | Simon Christ

Environmental Health Center Institute of Regenerative Biology and Medicine

With the intent to move towards a scarless world with targeted clinical therapy

With the intent to move towards a scarless world with targeted clinical therapy

Wellcome to IRBM

Scientific focus

 

Tissue Regeneration:

The Rinkevich lab wishes to identify fundamental cellular and molecular principles of tissue/organ regeneration and to develop a basis for therapeutic strategies in clinical use. 

Helmholtz Munich | IRBM

 

Applied Techniques:

Our lab combines state-of-the-art flow cytometry techniques, multi-color mouse models, mouse genetics, single cell analysis, in-silico approaches and live imaging.
Helmholtz Munich | © IRBM

 

Lung Fibrosis:

The lab is interessted in the identification of embryonic origins of the fibroblasts. In order to approach it, the live in-vivo imaging of fibroblast lineages and the wound healing models in fetal and adult mice are undertaken.

Helmholtz Munich / ©Donovan Correa-Gallegos

 

Studies on Mesothelium:

The lab is studying regeneration of methotelium of the organs. For that aim the single cell analysis and the molecular characterization of the mesothelium are applied.

IRBM@

 

Tissue Patterning:

Generation of in-vitro organoid assays from single stem cells. In-vivo clonal analysis and lineage tracing of stem cells during tissue development and  regeneration. Functional studies of gene perturbations in stem cell lineages using mouse models of organ injury.
Helmholtz Munich | © IRBM

People at IRBM

Latest publications

 

2023

 

Kalgudde GS, Dai R, Stefanska AM, Ansari M, Zhao J, Ramesh P, Bagnoli JW, Correa-Gallegos D, Lin Y, Christ S, Angelidis I, Lupperger V, Marr C, Davies LC, Enard W, Machens HG, Schiller HB, Jiang D, Rinkevich Y (2023). Wound infiltrating adipocytes are not myofibroblasts. Nat Commun In press.

 

Qarri A, Kültz D, Gardell A. M, Rinkevich B, Rinkevich Y (2023) Improved Media Formulations for Primary Cell Cultures Derived from a Colonial Urochordate, Cells 2023, 12(13), 1709

https://www.mdpi.com/2073-4409/12/13/1709

 

Fischer A, Correa-GallegosD, Wannemacher J, Christ S, RinkevichY , (2023) In vivo fluorescent labeling and tracking of Extracellular Matrix, Nat Protocols in press 

 

Ye H, Rinkevich Y (2023) Fascia layer - a novel target for the application of biomaterials in skin wound healing; International Journal of Molecular Sciences

https://www.mdpi.com/1422-0067/24/3/2936

 

Bajwa P, Kordylewicz K, Bilecz A, Lastra RR, Wroblewski K, Rinkevich Y, Lengyel E, Kenny HA, (2023) Cancer-associated mesothelial cell-derived ANGPTL4 and STC1 promote the early steps of ovarian cancer metastasis, JCI Insight

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070116/

 

2022

 

Qarri A, Rinkevich B, Rinkevich Y (2022) Improving the Yields of Blood Cell Extractions from Botryllus schlosseri Vasculature, Advances in aquatic invertebrate stem cell research

https://www.mdpi.com/books/edition/5071

 

Correa-Gallegos D, Machens HG, Rinkevich Y (2022) States and Fates of Skin Fibroblasts Revealed through Chromatin Accessibility, J Invest Dermatol. 142 (7): 1767-1770

https://pubmed.ncbi.nlm.nih.gov/35715155/

 

Jiang D, Guo R, Machens HG, Rinkevich Y (2022) Diversity of Fibroblasts and Their Roles in Wound Healing, Cold Spring Harb Perspect Biol. 2023 Mar 1;15(3):a041222.

https://cshperspectives.cshlp.org/content/15/3/a041222.long

 

Ramesh P, Ye H, Dasgupta B, Machens HG, Rinkevich Y (2022) Visualizing Scar Development Using SCAD Assay – An Ex-situ Skin Scarring Assay, J Vis Exp. (182)

https://www.jove.com/de/t/63808/visualizing-scar-development-using-scad-assay-an-ex-situ-skin

 

Hyams Y, Panov J,  Rosner A, Brodsky L, Rinkevich Y, Rinkevich B (2022) Transcriptome landscapes that signify Botrylloides leachi torpor states, Developmental Dynamics 490: 22-36

https://www.sciencedirect.com/science/article/abs/pii/S0012160622001208

 

Wu M, Matar DY, Yu Z, Chen Z, Knoedler S, Ng B, Darwish OA, Sohrabi S, Friedman L, Haug V, Murphy GF, Rinkevich Y, Orgill DP, Panayi AC (2022) Continuous NPWT Regulates Fibrosis in Murine Diabetic Wound Healing, Pharmaceutics 14 (10):2125

https://www.mdpi.com/1999-4923/14/10/2125

 

 

IRBM,

Adrian Fischer Wins the Best Paper Award

Adrian Fischer, PostDoc at IRBM, received the Helmholtz Munich Best Paper Award (Q2, 2022). He took first place as co-first author of the paper "Neutrophils direct preexisting matrix to initiate repair in damaged tissues" published in Nature…

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Networks and Affiliations

SaxoCell Cluster

Tel Aviv University

Dr. Yuval Rinkevich

Institute Director

Building 092, Room C3.11

Natalja S. Ring

Lab Manager, Technician

Building 092, Room B.301