Institute of Synthetic Biomedicine (ISBM)

The Institute for Synthetic Biomedicine (ISBM) develops and deploys next-generation biotechniques for molecular sensing and actuation of distributed cellular processes to reverse engineer cell-circuit function and guide future cell therapies.

The research of ISBM focuses on three synergistic areas:

Sigmund+_ACS_NANO_credit_Barth_van_Rossum

Until now, studying the genetic processes in cells required destroying them - making it impossible to observe these processes over extended periods of time. A team from Helmholtz Munich and the Technical University of Munich (TUM) has developed a new…

Genetic engineering, GMO and Gene manipulation, DNA gene editing, CRISPR-Cas9 gene editing tool

A research team from Helmholtz Munich and the Technical University of Munich has developed an advanced delivery system that transports gene-editing tools based on the CRISPR/Cas9 gene-editing system into living cells with significantly greater…

New method makes room for DNA insertions

Sporadic Parkinson's Disease (sPD) is a progressive neurodegenerative disorder influenced by both genetic and environmental factors. While mitochondrial dysfunction contributes to this condition, its role across disease progression remains unclear.…

Please see these new gene reporters for Electron Microscopy

Genetically encoded nano-barcodes

How do the nerve cells in our brain communicate with each other? What processes take place when T cells render cancer cells harmless? Details of the mechanisms at the cellular level remain hidden from view. Now,…

Prof. Dr. Gil Gregor Westmeyer

Director of the Institute for Synthetic Biomedicine, ISBM

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Dr. Felix Sigmund

Group Leader

Dr. Dong-Jiunn Jeffery Truong

Group Leader

MD Silviu-Vasile Bodea

Group Leader

Anja Ammer

Laboratory manager

Armbrust, N. ; Grosshauser, M. ; Geilenkeuser, J. ; Stroppel, L. ; Jozinovic, M. ; Levermann, H. ; Panne, T. ; Wißmann, J. ; Goelitz, L. ; Schmidt, S. ; Orschmann, T. ; Rusha, E. ; Steinmaßl, E. ; Widenmeyer, F. ; Warsing, N. ; Sabry, M. ; Sultanbai, A. ; Santl, T. ; Geerlof, A. ; Berezin, O. ; Bodea, S.V. ; Moretti, A. ; Schneider, S. ; Theis, F.J. ; Gagneur, J. ; Truong, D.J.J. ; Westmeyer, G.G.

Non-destructive transcriptomics via vesicular export.

Erenoglu, Z.I. ; Hiendlmeier, L. ; Del Duca, F. ; Kopic, I. ; Schmidt, S. ; Weiss, L.J.K. ; Al Boustani, G. ; Teshima, T.F. ; Westmeyer, G.G. ; Wolfrum, B.

Rapid prototyping of a 3D well-shaped, porous, microelectrode array for extracellular recordings from cardiac cell layers and cortical organoids.

Berezin, O. ; Piovesan, A. ; Graf, R. ; Samara, E. ; Sigmund, F. ; Westmeyer, G.G.

Multiplexed genetic tags for electron and fluorescence microscopy.

Hołubowicz, R. ; Gao, F. ; Du, S.W. ; Menezes, C.R. ; Zhang, J. ; Hołubowicz, M.W. ; Chen, P.Z. ; Armbrust, N. ; Geilenkeuser, J. ; Liu, D.R. ; Truong, D.J.J. ; Westmeyer, G.G. ; Palczewska, G. ; Palczewski, K.

Scalable purification enables high-quality virus-like particles for therapeutic translation.

Kopic, I. ; Peng, H. ; Schmidt, S. ; Berezin, O. ; Wang, S. ; Westmeyer, G.G. ; Wolfrum, B.

Inkjet-printed 3D sensor arrays with FIB-induced electrode refinement for low-noise amperometric recordings in hiPSC-derived brain organoids.

Institute for Synthetic Biomedicine

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About our Research

Our Scientific Areas

Biomolecular Engineering of Sensors and Actuators

Genetic and Cellular Engineering of Model Systems

Multiscale Interrogation of Cell-circuit Function

Our Highlights

Reading Genetic Activity from Living Cells without Destroying Them

Engineering Smart Delivery for Gene Editors

Expanding the gene editing toolbox

Breakthrough Discovery Unravels Metabolic Mysteries in Sporadic Parkinson’s Disease Etiology

GFPs for Electron Microscopy

Electron microscopy: Nano-reporter proteins make invisible processes visible

Scientists at ISBM

Latest Publications

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