Bioengineering Center Institute for Synthetic Biomedicine

Please see these new gene reporters for Electron Microscopy

We introduce a new gene reporter system (INSPECT) that encode reporter or effector proteins from intronic information.

New biological tool for tracking cellular processes

This work describes the cell-free production, transient protein-modification, and time-resolved proteomics analysis of bacteriophages targeted against clinically relevant bacteria.

We have generated a suite of gene reporters, EXSISERS, that self-excise themselves out of the native amino-acid chain of a protein of interest to report on the translation of specific protein isoforms from alternatively spliced mRNA.

Our proteome is much bigger than our genome because one gene produces several variants of proteins called protein isoforms, whose disbalance is implicated in many diseases. A new bioengineered reporter system developed at Helmholtz Zentrum München…

To sequester multi-component enzymatic processes inside living mammalian cells, we introduce heterologously expressed encapsulins as a versatile platform to generate self-assembling ompartments which can serve as nano-reaction chambers.

We have synthesized a calcium sensor for photoacoustics, which changes its absorbance and thus photoacoustic spectrum upon selective binding to Ca2+ for future use in organoids or in vivo models.

To increase the multiplexing capabilities of gene reporters for multispectral optoacoustic tomography (MSOT), we have introduced the concept of discriminating optoacoustic contrast agents not by color but by time-varying photocontrolled signal…