Institute of Synthetic Biomedicine (ISBM)

The Institute for Synthetic Biomedicine (ISBM) develops and deploys next-generation biotechniques for molecular sensing and actuation of distributed cellular processes to reverse engineer cell-circuit function and guide future cell therapies.

The research of ISBM focuses on three synergistic areas:

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A research team from Helmholtz Munich and the Technical University of Munich has developed an advanced delivery system that transports gene-editing tools based on the CRISPR/Cas9 gene-editing system into living cells with significantly greater…

New method makes room for DNA insertions

Sporadic Parkinson's Disease (sPD) is a progressive neurodegenerative disorder influenced by both genetic and environmental factors. While mitochondrial dysfunction contributes to this condition, its role across disease progression remains unclear.…

Please see these new gene reporters for Electron Microscopy

Genetically encoded nano-barcodes

How do the nerve cells in our brain communicate with each other? What processes take place when T cells render cancer cells harmless? Details of the mechanisms at the cellular level remain hidden from view. Now,…

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We introduce a new gene reporter system (INSPECT) that encode reporter or effector proteins from intronic information.

Prof. Dr. Gil Gregor Westmeyer

Director

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Dr. Felix Sigmund

Group Leader

Dr. Dong-Jiunn Jeffery Truong

Group Leader

MD Silviu-Vasile Bodea

Group Leader

Filipa Goncalves

Ph.D. student

Anja Ammer

Laboratory manager

Oleksandr Berezin

Ph.D. student

Zohra Mohammadi

Technical Assistant

Niklas Armbrust

Ph.D. student

Stefanie Winkler

Technical Assistant

Martin Grosshauser

Ph.D. student

Julian Geilenkeuser

Ph.D. student

Berezin, O. ; Piovesan, A. ; Graf, R. ; Samara, E. ; Sigmund, F. ; Westmeyer, G.G.

Multiplexed genetic tags for electron and fluorescence microscopy.

Hołubowicz, R. ; Gao, F. ; Du, S.W. ; Menezes, C.R. ; Zhang, J. ; Hołubowicz, M.W. ; Chen, P.Z. ; Armbrust, N. ; Geilenkeuser, J. ; Liu, D.R. ; Truong, D.J.J. ; Westmeyer, G.G. ; Palczewska, G. ; Palczewski, K.

Scalable purification enables high-quality virus-like particles for therapeutic translation.

Kopic, I. ; Peng, H. ; Schmidt, S. ; Berezin, O. ; Wang, S. ; Westmeyer, G.G. ; Wolfrum, B.

Inkjet-printed 3D sensor arrays with FIB-induced electrode refinement for low-noise amperometric recordings in hiPSC-derived brain organoids.

Phlairaharn, T. ; Shannon, A.E. ; Zeng, X. ; Truong, D.J.J. ; Schoof, E.M. ; Ye, Z. ; Searle, B.C.

Improving proteomic dynamic range with Multiple Accumulation Precursor Mass Spectrometry.

Jäkel, A.C. ; Truong, D.J.J. ; Simmel, F.C.

Genetic manipulation of mammalian cells in microphysiological hydrogels.

Institute for Synthetic Biomedicine

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About our Research

Biomolecular Engineering of Sensors and Actuators

Genetic and Cellular Engineering of Model Systems

Multiscale Interrogation of Cell-circuit Function

Our Highlights

Engineering Smart Delivery for Gene Editors

Expanding the gene editing toolbox

Breakthrough Discovery Unravels Metabolic Mysteries in Sporadic Parkinson’s Disease Etiology

GFPs for Electron Microscopy

Electron microscopy: Nano-reporter proteins make invisible processes visible

Non-invasive monitoring of non-coding RNA | how to encode proteins from intronic information?

Scientists at ISBM

Latest Publications

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