Research Group Signaling and Immunity
Krappmann GroupThe research aims to unravel cellular signaling pathways controlling immunity and inflammation. The main research focuses are on the interaction of signaling mediators in supra-molecular protein clusters and how these complexes shape immune activating and suppressive depending on the cellular and molecular context. We are translating our findings on the exact function of these signaling mediators into novel therapeutic approaches to treat aggressive lymphomas and to boost anti-tumor immunity. In addition, we design biomarkers to allow patient stratification and monitoring therapeutic responses to novel treatments.
The research aims to unravel cellular signaling pathways controlling immunity and inflammation. The main research focuses are on the interaction of signaling mediators in supra-molecular protein clusters and how these complexes shape immune activating and suppressive depending on the cellular and molecular context. We are translating our findings on the exact function of these signaling mediators into novel therapeutic approaches to treat aggressive lymphomas and to boost anti-tumor immunity. In addition, we design biomarkers to allow patient stratification and monitoring therapeutic responses to novel treatments.