Institute of Molecular Epidemiology, AME, Environmental Health Center, Helmholtz Munich

The Research Unit of Molecular Epidemiology (AME) analyses population-based cohorts and case studies for specific diseases, using genomics, epigenomics, transcriptomics, proteomics, metabolomics, and functional analyses. The aim of this research unit is to decipher the molecular mechanisms of complex diseases like type 2 diabetes or obesity. The unit administers the biological specimen repository of the Department of Epidemiology and stores the samples for national and international projects.

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Molecular Epidemiology

The main objective is to decipher the molecular causes and mechanisms of complex diseases like type 2 diabetes, cardiovascular diseases, atopic eczema, lung cancer, or obesity.

Genome Analysis Center

The Research Unit is located in the Genome Analysis Center of Helmholtz Munich where methods and systems for genomics, epigenomics, transcriptomics, proteomics, metabolomics and functional analyses have been established.

Cohorts

We apply these methods on our population based children and adult cohorts (KORA, GINIplus, LISA) as well as on case populations of interest.

Biological Specimen Repository

Additionally the Biological Specimen Repository of the Department of Epidemiology including DNA, RNA, serum, plasma, urine, and immortalized cell lines is administered by our unit. Moreover we are responsible for sample preparation and sample storage of the German National Cohort participants.

The working group deals with topics regarding biobanking, ELSI questions and biodata management as basis for molecular epidemiology.

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Dr. Melanie Waldenberger

The working group aims to decipher the molecular underpinnings of complex traits and the effect of environment and lifestyle on (epi-)genomic regulation.

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Medicine doctor touching electronic medical record on tablet. DNA

Dr. Harald Grallert

The working group aims to elucidate molecular mechanisms of metabolic diseases, using this information to refine subtype definitions for precision medicine.

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Awards & Grants, EPI, September 23, 2022

Helmholtz Munich has been participating in the DigiMed Bayern project of the Bavarian State Ministry of Health and Care (STMGP) since the end of 2018. The goal of the project is to advance digitized medicine in Bavaria. The project has now been…