Stem Cell Center
Epigenetics and Stem Cells
At the Institute of Epigenetics and Stem Cells (IES), we aim to unlock a cell's full potential by understanding how a single cell can give rise to all the cells in our body at the beginning of life.
At the Institute of Epigenetics and Stem Cells (IES), we aim to unlock a cell's full potential by understanding how a single cell can give rise to all the cells in our body at the beginning of life.
IES Members
Director of the Stem Cell Center (rotating), Director of the Institute for Epigenetics and Stem Cells, Group Leader, IES
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Group Leader, IES
Deputy Head of Institute for Epigenetics and Stem Cells
Head of Microscopy Core
Senior Computational Biologist
Postdoc
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Postdoc
Doctoral Researcher, IES/HPC
Doctoral Researcher
Doctoral Researcher
Doctoral Researcher
Doctoral Researcher, Torres-Padilla lab
Doctoral Researcher
Research Assistant – Bioinformatics
Lab Manager
Lab Manager
Intern
Masters Students
Doctoral Researcher
Doctoral Researcher
Masters Student
Postdoc
Administrative Assistant
Team Assistant, Institute of Epigenetics and Stem Cells
Our Institute in Numbers
Latest Publications
Rodriguez-Terrones, D. ; Oomen, M.E. ; Torres-Padilla, M.E.
Protocol for simultaneous profiling of transcription start sites and full-length transcripts from low-input samples using Smart-seq+5'.Uruci, S. ; Lalonde, M. ; Luijsterburg, M.S. ; Hamperl, S.
Polymerase face-off: Emerging concepts in transcription-replication coordination.Hermant, C. ; Mourra-Díaz, D.M. ; Oomen, M.E. ; Jansz, N. ; Noll, C. ; Canat, A. ; Pal, M. ; Nakatani, T. ; Schauer, T. ; Torres-Padilla, M.E.
TBP regulates transposable element expression in early mouse embryos.Shapira, Y. ; Noack, F. ; Vangelisti, S. ; Chong, F. ; Lifshitz, A. ; Tanay, A. ; Bonev, B.
Neural stem cell epigenomes and fate bias are temporally coordinated during mouse cortical development.Marmolejo, C.O. ; Sanchez, C. ; Helms, E. ; McEvoy, M.J. ; Lee, J. ; Werner, M. ; Roberts, P. ; Hamperl, S. ; Saldivar, J.C.
Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability.Uruci, S. ; Boer, D.E.C. ; Chrystal, P. ; Lalonde, M. ; Panagopoulos, A. ; Yakoub, G. ; Kirdök, I. ; Lint, K.d. ; Woude, M.v.d. ; Wendel, T.J. ; Brussee, S. ; Wondergem, A.P. ; Overbeek, N.v. ; Schotman, N. ; Lingeman, J. ; Ljungman, M. ; Vidal, M. ; Attikum, H.v. ; Vertegaal, A.C.O. ; Noordermeer, S.M. ; Wolthuis, R.M.F. ; Altmeyer, M. ; Hamperl, S. ; Tropepe, V. ; Berg, J.v.d. ; Heuvel, D.v.d. ; Luijsterburg, M.S.
CFAP20 salvages arrested RNAPII from the path of co-directional replisomes.Nitsch, S. ; Coraor, A.E. ; Schauer, T. ; Wu, Y. ; Sun, J. ; Möritz, N. ; Funke, J.J. ; Nagpal, H. ; Chua, G.N.L. ; Battistini, F. ; Lauberth, S.M. ; Richard, E.M. ; Orozco, M. ; Liu, S. ; Desviat, L.R. ; Fierz, B. ; Dietz, H. ; Roeder, R.G. ; de Pablo, J.J. ; Schneider, R.
H4K16 acylations destabilize chromatin architecture and facilitate transcriptional response during metabolic perturbations.Oak, M.S. ; Stock, M. ; Janeva, A. ; Mezes, M. ; Hynes-Allen, A.M. ; Straub, T. ; Forné, I. ; Ettinger, A. ; Hamperl, S. ; Imhof, A. ; van den Ameele, J. ; Scialdone, A. ; Hörmanseder, E.
Pre-marking chromatin with H3K4 methylation is required for accurate zygotic genome activation and development.Ummethum, H. ; Murriello, A.C. ; Werner, M. ; Márquez-Gómez, E. ; König, A.-C. ; Kruse, E. ; Lalonde, M. ; Trauner, M. ; Chanou, A. ; Weiß, M. ; Lee, C.S.K. ; Ettinger, A. ; Erhard, F. ; Hauck, S.M. ; Hamperl, S.
The CGG triplet repeat binding protein 1 counteracts R-loop induced transcription-replication stress.Wagner, C.B. ; Longaretti, M. ; Sergi, S.G. ; Singh, N. ; Tsirkas, I. ; Bento, F. ; Wong, R.P. ; Wilkens, M. ; Hamperl, S. ; Butter, F. ; Aharoni, A. ; Ulrich, H.D. ; Luke, B.
Rad53 regulates RNase H1, which promotes DNA replication through sites of transcription-replication conflict.Apostolou, Z. ; Venkatasubramani, A.V. ; Kopp, L.C. ; Kars, G. ; Scacchetti, A. ; Campos-Sparr, A. ; Schauer, T. ; Imhof, A. ; Becker, P.B.
The Tip60 acetylome is a hallmark of the proliferative state in Drosophila.Ewe, C.K. ; Farnworth, M.S. ; Miller, A. ; Navajas Acedo, J. ; Oomen, M.E. ; Paci, G. ; Widen, S.A. ; Yamada, T.
Pathway to Independence: A forecast for the future of developmental biology.Stock, M.
Incorporation of prior knowledge to improve gene regulatory network inference from single-cell transcriptomics data.
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