Stem Cell Center Epigenetics and Stem Cells
At the Institute of Epigenetics and Stem Cells (IES), we aim to unlock a cell's full potential by understanding how a single cell can give rise to all the cells in our body at the beginning of life.
At the Institute of Epigenetics and Stem Cells (IES), we aim to unlock a cell's full potential by understanding how a single cell can give rise to all the cells in our body at the beginning of life.
IES members
Latest Publications
Read more2024 Scientific Article in Genome Biology
Multi-omics approaches reveal that diffuse midline gliomas present altered DNA replication and are susceptible to replication stress therapy.
2024 Scientific Article in PLoS ONE
In vivo monitoring of leukemia-niche interactions in a zebrafish xenograft model.
2024 Editorial in Developmental Cell
Understanding how cells and organisms keep time during development.
2024 Scientific Article in Nature Neuroscience
Direct neuronal reprogramming of mouse astrocytes is associated with multiscale epigenome remodeling and requires Yy1.
2024 Scientific Article in Nature Cell Biology
Mapping putative enhancers in mouse oocytes and early embryos reveals TCF3/12 as key folliculogenesis regulators.
2024 Scientific Article in Developmental Cell
An integrated approach identifies the molecular underpinnings of murine anterior visceral endoderm migration.
2024 Scientific Article in Bioinformatics
Topological benchmarking of algorithms to infer Gene Regulatory Networks from Single-Cell RNA-seq Data.
2024 Scientific Article in Journal of Cell Biology, The
Determinants of minor satellite RNA function in chromosome segregation in mouse embryonic stem cells.
2024 Editorial in Molecular Cell
A quick restart: RNA polymerase jumping onto post-replicative chromatin.
2023 Scientific Article in Nature
Emergence of replication timing during early mammalian development.
2023 Scientific Article in Genes and Development
Reorganization of lamina-associated domains in early mouse embryos is regulated by RNA polymerase II activity.
2023 Scientific Article in Nucleic Acids Research
Single molecule MATAC-seq reveals key determinants of DNA replication origin efficiency.
2023 Scientific Article in Journal of Visualized Experiments
Single-copy gene locus chromatin purification in Saccharomyces cerevisiae.
2023 Scientific Article in Nature Methods
Multiplex-GAM: genome-wide identification of chromatin contacts yields insights overlooked by Hi-C.
2023 Scientific Article in Cell Reports
Transient suppression of SUMOylation in embryonic stem cells generates embryo-like structures.
2023 Review in Developmental Cell
Dynamics of nuclear architecture during early embryonic development and lessons from liveimaging.
2023 Scientific Article in Genes and Development
A change in biophysical properties accompanies heterochromatin formation in mouse embryos.
2023 Scientific Article in Blood
A noncanonical enzymatic function of PIWIL4 maintains genomic integrity and leukemic growth in AML.
2023 Scientific Article in Development / Company of Biologists
CIARA: A cluster-independent algorithm for identifying markers of rare cell types from single-cell sequencing data.
2023 Scientific Article in Physical Review E
Emergent statistical laws in single-cell transcriptomic data.
2023 Review in Nucleus
Where and when to start: Regulating DNA replication origin activity in eukaryotic genomes.
2023 Scientific Article in EMBO Reports
Hyperosmotic stress induces 2-cell-like cells through ROS and ATR signaling.
2023 Review in Current Opinion in Genetics & Development
Regulation of mammalian totipotency: A molecular perspective from in vivo and in vitro studies.
2023 Review in Nature Protocols
Measuring DNA modifications with the comet assay: A compendium of protocols.
2023 Scientific Article in Cell Reports
Single-copy locus proteomics of early- and late-firing DNA replication origins identifies a role of Ask1/DASH complex in replication timing control.
2022 Scientific Article in Cell Reports