Helmholtz Diabetes Center Institute of Diabetes and Regeneration Research
The primary objective of the Institute of Diabetes and Regeneration Research (IDR) at the Helmholtz Diabetes Center Munich is to develop regenerative therapeutic approaches to treat diabetes mellitus. Therefore, the aim is to improve current strategies for functional β-cell production in vitro to provide alternative sources of β-cells for cell replacement therapy in diabetes. Additionally, we analyze and characterize the embryonic and adult pancreatic progenitor cells to understand β-cell development, homeostasis, and function for in vivo regeneration. Triggering endogenous β-cell regeneration is a promising approach to restore beta cell mass and normoglycemia in diabetic patients.
The primary objective of the Institute of Diabetes and Regeneration Research (IDR) at the Helmholtz Diabetes Center Munich is to develop regenerative therapeutic approaches to treat diabetes mellitus. Therefore, the aim is to improve current strategies for functional β-cell production in vitro to provide alternative sources of β-cells for cell replacement therapy in diabetes. Additionally, we analyze and characterize the embryonic and adult pancreatic progenitor cells to understand β-cell development, homeostasis, and function for in vivo regeneration. Triggering endogenous β-cell regeneration is a promising approach to restore beta cell mass and normoglycemia in diabetic patients.
Our latest Publications
Read more2025 Editorial in Nature Reviews - Endocrinology
mTORC1 is the central regulator in pancreatic β-cells.
2025 Position paper in Diabetologie, Die
Geschlechtersensible Aspekte von Diabetes mellitus Typ 2.Präzisionsmedizin der Zukunft in der Diabetologie.
2025 Scientific Article in Stem Cell Research
Generation of ARX-T2A-H2B-CFP x C-PEP-mCherry-hiPSC double reporter line for monitoring of pancreatic differentiation.
2025 Review in Nature Chemical Biology
Mechanistic insights and approaches for beta cell regeneration.
2025 Scientific Article in Cell Reports
Chronic intermittent fasting impairs β cell maturation and function in adolescent mice.
2025 Scientific Article in Nature Communications
Pantothenate kinase 4 controls skeletal muscle substrate metabolism.
2024 Scientific Article in Current Biology
Doublecortin reinforces microtubules to promote growth cone advance in soft environments.
2024 Scientific Article in Nature metabolism
Inceptor binds to and directs insulin towards lysosomal degradation in β cells.
2024 Scientific Article in Diabetologia
Transcriptomic heterogeneity of non-beta islet cells is associated with type 2 diabetes development in mouse models.
2024 Scientific Article in JMIR Medical Informatics
Personalized prediction of long-term renal function prognosis following nUsing interpretable machine learning algorithms: Case-control study.
2024 Cardiovascular Diabetology
Correction: GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease.
2024 Scientific Article in Life Science Alliance
Examining the liver-pancreas crosstalk reveals a role for the molybdenum cofactor in β-cell regeneration.
2024 Scientific Article in Photoacoustics
Non-invasive optoacoustic imaging of dermal microcirculatory revascularization in diet-induced obese mice undergoing exercise intervention.
2024 Scientific Article in Studies in Higher Education
Behind the scenes of doctoral success: A mixed methods approach to exploring PhD supervision courses in Swedish higher education institutions.
2024 Scientific Article in Postepy Biochemii
Space-time dynamics of genome replication studied with super-resolved microscopy.
2024 Review in Zeitschrift für Medizinische Ethik
Leitbilder und Forschung in der Geschlechtersensiblen Medizin.
2024 Editorial in Frontiers in Endocrinology