Molecular Targets and Therapeutics Center Institute of Network Biology

At INET we systematically generate molecular interactome maps by our well established AI informed and robotics supported protein-protein interaction pipeline integrating latest experimental and theoretical approaches.

Regulatory network mapping will identify transcription factors (TFs) regulating the genes and pathways that enable either regulation processes within an organism or elucidate regulation of molecular host pathways by microbes.

The contactome, the sum of physical contacts between viral and host macromolecules, affects cellular perturbations that enable viral replication and cause disease manifestations. Because co-complex assays predominantly detect indirect

The presence of secretion systems by which the so-called ‘effector-proteins’ can be injected into the host’s cytosol to interact with host proteins and modulate molecular pathways is a unique feature of proteobacteria.

For our comparative viral-human protein-protein interaction network we screened all 7 human corona viruses against each other and against the human ORFEome in order to get better insights to