Molecular Targets and Therapeutics Center
Institute of Network Biology
Molecular interactions form the basis of almost all biological processes in any living organism. Perturbations in these molecular networks result in dysfunctions that manifest themselves in disease, up to fatal outcomes. Our aim at the Institute of Network Biology (INET) is to understand how these molecular interactions and network changes caused by genetic variants or also by environmental influences like viruses or bacteria, lead to pathological processes. A deep understanding of the interplay of all the different layers of molecular networks may lead to new strategies for disease prevention and pharmacological interventions.
Molecular interactions form the basis of almost all biological processes in any living organism. Perturbations in these molecular networks result in dysfunctions that manifest themselves in disease, up to fatal outcomes. Our aim at the Institute of Network Biology (INET) is to understand how these molecular interactions and network changes caused by genetic variants or also by environmental influences like viruses or bacteria, lead to pathological processes. A deep understanding of the interplay of all the different layers of molecular networks may lead to new strategies for disease prevention and pharmacological interventions.
Doctoral researcher
Senior Scientist & Scientific Coordination
Doctoral researcher
Doctoral researcher
Lab Assitant
Doctoral researcher
Senior-Postdoc
Doctoral researcher
Technician (Dipl. Biol.)
Doctoral researcher
Research Student
Senior Scientist
INET Core Publications
Lambourne, L. ; Yadav, A. ; Wang, Y. ; Desbuleux, A. ; Kim, D.K. ; Laval, F. ; Spirohn-Fitzgerald, K. ; Cafarelli, T. ; Pons, C. ; Kovács, I.A. ; Jailkhani, N. ; Schlabach, S. ; De Ridder, D. ; Luck, K. ; Botchkarev, V.V. ; Debnath, O. ; Bian, W. ; Shen, Y. ; Yang, Z. ; Mee, M.W. ; Helmy, M. ; Jacob, Y. ; Lemmens, I. ; Rolland, T. ; McClain, G.G. ; Coté, A.G. ; Gebbia, M. ; Kishore, N. ; Knapp, J.J. ; Mellor, J.C. ; Memisoglu, G. ; Reimand, J. ; Tavernier, J. ; Cusick, M.E. ; Zhong, Q. ; Aloy, P. ; Hao, T. ; Charloteaux, B. ; Roth, F.P. ; De Las Rivas, J. ; Falter-Braun, P. ; Hill, D.E. ; Calderwood, M.A. ; Twizere, J.C. ; Vidal, M.
Experimental assessment of AI-based interactome mapping.Weller, B. ; Lin, C.-W. ; Rothballer, S.T. ; Calderwood, M.A. ; Falter-Braun, P. ; Falter, C.
NeuroViOme: A viral orfeome collection for studies of neurodegenerative disease.Dragunas, G. ; Klotz, M. ; Chen, S. ; Ertüz, Z. ; Tan, X. ; Korkmaz, R.Ü. ; Shankhwar, S. ; Rankl, B. ; Dhakad, D. ; Omony, J. ; Mayr, C.H. ; Chen, Y. ; Agami, A. ; Lin, C.-W. ; Müller, C. ; Lunding, L. ; Wegmann, M. ; Berner, J. ; Popovic, J. ; Schraml, B.U. ; Adler, H. ; Falter-Braun, P. ; Schiller, H.B. ; Watz, H. ; Conlon, T.M. ; Jeridi, A. ; Kapellos, T. ; von Mutius, E. ; Yildirim, A.Ö.
A beneficial environment promotes immune resilience through epigenetic regulation.Young, V. ; Dohai, B.S.M. ; Halder, H. ; Fernandez-Macgregor, J. ; van Heusden, N.S. ; Hitch, T.C.A. ; Weller, B. ; Hyden, P. ; Saha, D. ; Pieren, D.K.J. ; Rittchen, S. ; Lambourne, L. ; Maseko, S.B. ; Lin, C.-W. ; Tun, Y.M. ; Bibus, J. ; Pletschacher, L. ; Boujeant, M. ; Choteau, S.A. ; Bergogne, L. ; Perrin, J. ; Ober, F. ; Schwehn, P. ; Rothballer, S.T. ; Altmann, M. ; Altmann, S. ; Strobel, A. ; Rothballer, M. ; Tofaute, M.J. ; Kotlarz, D.M. ; Heinig, M. ; Clavel, T. ; Calderwood, M.A. ; Vidal, M. ; Twizere, J.C. ; Vincentelli, R. ; Krappmann, D. ; Boes, M. ; Falter, C. ; Rattei, T. ; Brun, C. ; Zanzoni, A. ; Falter-Braun, P.
Effector-host interactome map links type III secretion systems in healthy gut microbiomes to immune modulation.Padovani, F. ; Stegmaier, T. ; Mairhörmann, B. ; Schmoller, K.M.
Analysis of multidimensional microscopy data using cell-ACDC.Ratajczak, F. ; Heinig, M. ; Falter-Braun, P.
Exploring the omnigenic architecture of selected complex traits.Dugied, G. ; Laurent, E.M. ; Attia, M. ; Gimeno, J.P. ; Bachiri, K. ; Samavarchi-Tehrani, P. ; Donati, F. ; Rahou, Y. ; Munier, S. ; Amara, F. ; Dos Santos, M. ; Soler, N. ; Volant, S. ; Pietrosemoli, N. ; Gingras, A.C. ; Pavlopoulos, G.A. ; van der Werf, S. ; Falter-Braun, P. ; Aloy, P. ; Jacob, Y. ; Komarova, A. ; Sofianatos, Y. ; Coyaud, E. ; Demeret, C.
Multimodal SARS-CoV-2 interactome sketches the virus-host spatial organization.Zhou, J. ; Ridderbeek, K. ; Zou, P. ; Naden, A.B. ; Gaussmann, S. ; Song, F. ; Falter-Braun, P. ; Kay, E.R. ; Sattler, M. ; Cui, J.
Modular nanoparticle platform for solution-phase optical sensing of protein-protein interactions.Schwehn, P. ; Falter-Braun, P.
Inferring protein from transcript abundances using convolutional neural networks.Bohn, L. ; Huang, J. ; Weidig, S. ; Yang, Z. ; Heidersberger, C. ; Genty, B. ; Falter-Braun, P. ; Christmann, A. ; Grill, E.
The temperature sensor TWA1 is required for thermotolerance in Arabidopsis.Wiese, C. ; Abele, M. ; Al, B. ; Altmann, M. ; Steiner, A. ; Kalbfuß, N. ; Strohmayr, A. ; Ravikumar, R. ; Park, C.H. ; Brunschweiger, B. ; Meng, C. ; Facher, E. ; Ehrhardt, D.W. ; Falter-Braun, P. ; Wang, Z.Y. ; Ludwig, C. ; Assaad, F.F.
Regulation of adaptive growth decisions via phosphorylation of the TRAPPII complex in Arabidopsis.Tofaute, M.J. ; Weller, B. ; Grass, C. ; Halder, H. ; Dohai, B.S.M. ; Falter-Braun, P. ; Krappmann, D.
SARS-CoV-2 NSP14 MTase activity is critical for inducing canonical NF-κB activation.Boes, M. ; Falter-Braun, P.
Long-COVID-19: The persisting imprint of SARS-CoV-2 infections on the innate immune system.Mairhörmann, B. ; Castelblanco, A. ; Häfner, F. ; Koliogiannis, V. ; Haist, L. ; Winter, D. ; Flemmer, A.W. ; Ehrhardt, H. ; Stöcklein, S. ; Dietrich, O. ; Förster, K. ; Hilgendorff, A. ; Schubert, B.
Automated MRI lung segmentation and 3D morphologic features for quantification of neonatal lung disease.Mairhörmann, B. ; Padovani, F. ; Schmoller, K.M.
Zugängliche KI-Algorithmen für bessere Zellmikroskopie.Ratajczak, F. ; Joblin, M. ; Hildebrandt, M. ; Ringsquandl, M. ; Falter-Braun, P. ; Heinig, M.
Speos: An ensemble graph representation learning framework to predict core gene candidates for complex diseases.Weller, B. ; Lin, C.-W. ; Pogoutse, O. ; Sauer, M. ; Marin De La Rosa, N.A. ; Strobel, A. ; Young, V. ; Knapp, J.J. ; Rayhan, A. ; Falter, C. ; Kim, D.K. ; Roth, F.P. ; Falter-Braun, P.
A resource of human coronavirus protein-coding sequences in a flexible, multipurpose Gateway Entry clone collection.Osborne, R. ; Rehneke, L. ; Lehmann, S. ; Roberts, J. ; Altmann, M. ; Altmann, S. ; Zhang, Y. ; Köpff, E. ; Dominguez-Ferreras, A. ; Okechukwu, E. ; Sergaki, C. ; Rich-Griffin, C. ; Ntoukakis, V. ; Eichmann, R. ; Shan, W. ; Falter-Braun, P. ; Schäfer, P.
Symbiont-host interactome mapping reveals effector-targeted modulation of hormone networks and activation of growth promotion.Kim, D.-K. ; Weller, B. ; Lin, C.-W. ; Sheykhkarimli, D. ; Knapp, J.J. ; Dugied, G. ; Zanzoni, A. ; Pons, C. ; Tofaute, M.J. ; Maseko, S.B. ; Spirohn, K. ; Laval, F. ; Lambourne, L. ; Kishore, N. ; Rayhan, A. ; Sauer, M. ; Young, V. ; Halder, H. ; Marin De La Rosa, N.A. ; Pogoutse, O. ; Strobel, A. ; Schwehn, P. ; Li, R. ; Rothballer, S.T. ; Altmann, M. ; Cassonnet, P. ; Coté, A.G. ; Elorduy Vergara, L. ; Hazelwood, I. ; Liu, B.B. ; Nguyen, M. ; Pandiarajan, R. ; Dohai, B.S.M. ; Rodriguez, P.A. ; Poirson, J. ; Giuliana, P. ; Willems, L. ; Taipale, M. ; Jacob, Y. ; Hao, T. ; Hill, D.E. ; Brun, C. ; Twizere, J.C. ; Krappmann, D. ; Heinig, M. ; Falter, C. ; Aloy, P. ; Demeret, C. ; Vidal, M. ; Calderwood, M.A. ; Roth, F.B. ; Falter-Braun, P.
A proteome-scale map of the SARS-CoV-2-human contactome.McLellan, H. ; Harvey, S.E. ; Steinbrenner, J. ; Armstrong, M.R. ; He, Q. ; Clewes, R. ; Pritchard, L. ; Wang, W. ; Wang, S. ; Nussbaumer, T. ; Dohai, B.S.M. ; Luo, Q. ; Kumari, P. ; Duan, H. ; Roberts, A. ; Boevink, P.C. ; Neumann, C. ; Champouret, N. ; Hein, I. ; Falter-Braun, P. ; Beynon, J. ; Denby, K. ; Birch, P.R.J.
Exploiting breakdown in nonhost effector-target interactions to boost host disease resistance.Padovani, F. ; Mairhörmann, B. ; Falter-Braun, P. ; Lengefeld, J. ; Schmoller, K.M.
Segmentation, tracking and cell cycle analysis of live-cell imaging data with Cell-ACDC.Kuhl-Nagel, T. ; Rodriguez, P.A. ; Gantner, I. ; Chowdhury, S.P. ; Schwehn, P. ; Rosenkranz, M. ; Schnitzler, J.-P. ; Kublik, S. ; Schloter, M. ; Rothballer, M. ; Falter-Braun, P.
Novel Pseudomonas sp. SCA7 promotes plant growth in two plant families and induces systemic resistance in Arabidopsis thaliana.Gruner, K. ; Leissing, F. ; Sinitski, D. ; Thieron, H. ; Axstmann, C. ; Baumgarten, K. ; Reinstädler, A. ; Winkler, P. ; Altmann, M. ; Flatley, A. ; Jaouannet, M. ; Zienkiewicz, K. ; Feussner, I. ; Keller, H. ; Coustau, C. ; Falter-Braun, P. ; Feederle, R. ; Bernhagen, J. ; Panstruga, R.
Chemokine-like MDL proteins modulate flowering time and innate immunity in plants.Parry, G. ; Provart, N.J. ; Brady, S.M. ; Uzilday, B. ; Multinational Arabidopsis Steering Committee (Falter-Braun, P.) ; Multinational Arabidopsis Steering Committee (Mayer, K.F.X.)
Current status of the multinational Arabidopsis community.Kulich, I. ; Vogler, F. ; Bleckmann, A. ; Cyprys, P. ; Lindemeier, M. ; Fuchs, I. ; Krassini, L. ; Schubert, T. ; Steinbrenner, J. ; Beynon, J. ; Falter-Braun, P. ; Längst, G. ; Dresselhaus, T. ; Sprunck, S.
ARMADILLO REPEAT ONLY proteins confine Rho GTPase signalling to polar growth sites.Garcia, V.J. ; Xu, S. ; Ravikumar, R. ; Wang, W. ; Elliott, L. ; Gonzalez, E. ; Fesenko, M. ; Altmann, M. ; Brunschweiger, B. ; Falter-Braun, P. ; Moore, I. ; Burlingame, A. ; Assaad, F.F. ; Wang, Z.
TRIPP is a plant-specific component of the Arabidopsis TRAPPII membrane trafficking complex with important roles in plant development.Altmann, M. ; Altmann, S. ; Rodriguez, P.A. ; Weller, B. ; Elorduy Vergara, L. ; Palme, J. ; Marin De La Rosa, N.A. ; Sauer, M. ; Wenig, M. ; Villaécija-Aguilar, J.A. ; Sales, J. ; Lin, C.-W. ; Pandiarajan, R. ; Young, V. ; Strobel, A. ; Gross, L. ; Carbonnel, S. ; Kugler, K.G. ; Garcia-Molina ; Bassel, G.W. ; Falter, C. ; Mayer, K.F.X. ; Gutjahr, C. ; Vlot, A.C. ; Grill, E. ; Falter-Braun, P.
Extensive signal integration by the phytohormone protein network.Wierbowski, S.D. ; Vo, T.V. ; Falter-Braun, P. ; Jobe, T.O. ; Kruse, L.H. ; Wei, X. ; Liang, J. ; Meyer, M.J. ; Akturk, N. ; Rivera-Erick, C.A. ; Cordero, N.A. ; Paramo, M.I. ; Shayhidin, E.E. ; Bertolotti, M. ; Tippens, N.D. ; Akther, K. ; Sharma, R. ; Katayose, Y. ; Salehi-Ashtiani, K. ; Hao, T. ; Ronald, P.C. ; Ecker, J.R. ; Schweitzer, P.A. ; Kikuchi, S. ; Mizuno, H. ; Hill, D.E. ; Vidal, M. ; Moghe, G.D. ; McCouch, S.R. ; Yu, H.
A massively parallel barcoded sequencing pipeline enables generation of the first ORFeome and interactome map for rice.Lantzouni, O. ; Alkofer, A. ; Falter-Braun, P. ; Schwechheimer, C.
Growth-regulating factors interact with DELLAs and regulate growth in cold stress.Mergner, J. ; Frejno, M. ; List, M. ; Papacek, M. ; Chen, X. ; Chaudhary, A. ; Samaras, P. ; Richter, S. ; Shikata, H. ; Messerer, M. ; Lang, D. ; Altmann, S. ; Cyprys, P. ; Zolg, D.P. ; Mathieson, T. ; Bantscheff, M. ; Hazarika, R.R. ; Schmidt, T. ; Dawid, C. ; Dunkel, A. ; Hofmann, T. ; Sprunck, S. ; Falter-Braun, P. ; Johannes, F. ; Mayer, K.F.X. ; Jürgens, G. ; Wilhelm, M. ; Baumbach, J. ; Grill, E. ; Schneitz, K. ; Schwechheimer, C. ; Kuster, B.
Mass-spectrometry-based draft of the Arabidopsis proteome.Kalde, M. ; Elliott, L. ; Ravikumar, R. ; Rybak, K. ; Altmann, M. ; Klaeger, S. ; Wiese, C. ; Abele, M. ; Al, B. ; Kalbfuß, N. ; Qi, X. ; Steiner, A. ; Meng, C. ; Zheng, H. ; Kuster, B. ; Falter-Braun, P. ; Ludwig, C. ; Moore, I. ; Assaad, F.F.
Interactions between Transport Protein Particle (TRAPP) complexes and Rab GTPases in Arabidopsis.Rodriguez, P.A. ; Rothballer, M. ; Chowdhury, S.P. ; Nussbaumer, T. ; Gutjahr, C. ; Falter-Braun, P.
Systems biology of plant-microbiome interactions.Falter-Braun, P. ; Brady, S. ; Gutiérrez, R.A. ; Coruzzi, G. ; Krouk, G.
iPlant Systems Biology (iPSB): An international network hub in the plant community.Marin De La Rosa, N.A. ; Lin, C.-W. ; Kang, Y.J. ; Dhondt, S. ; Gonzalez, N. ; Inzé, D. ; Falter-Braun, P.
Drought resistance is mediated by divergent strategies in closely related Brassicaceae.Ravikumar, R. ; Kalbfuß, N. ; Gendre, D. ; Steiner, A. ; Altmann, M. ; Altmann, S. ; Rybak, K. ; Edelmann, H. ; Stephan, F. ; Lampe, M. ; Facher, E. ; Wanner, G. ; Falter-Braun, P. ; Bhalerao, R.P. ; Assaad, F.F.
Independent yet overlapping pathways ensure the robustness and responsiveness of trans-Golgi network functions in Arabidopsis.Altmann, M. ; Altmann, S. ; Falter, C. ; Falter-Braun, P.
High-quality yeast-2-hybrid interaction network mapping.Friesner, J. ; Assmann, S.M. ; Bastow, R. ; Bailey-Serres, J. ; Beynon, J. ; Brendel, V. ; Buell, C.R. ; Bucksch, A. ; Busch, W. ; Demura, T. ; Dinneny, J.R. ; Doherty, C.J. ; Eveland, A.L. ; Falter-Braun, P. ; Gehan, M.A. ; Gonzales, M. ; Grotewold, E. ; Gutiérrez, R.A. ; Krämer, U. ; Krouk, G. ; Ma, S.L. ; Markelz, R.J.C. ; Megraw, M. ; Meyers, B.C. ; Murray, J.A.H. ; Provart, N.J. ; Rhee, S. ; Smith, R. ; Spalding, E.P. ; Taylor, C. ; Teal, T.K. ; Torii, K.U. ; Town, C. ; Vaughn, M. ; Vierstra, R. ; Ware, D. ; Wilkins, O. ; Williams, C. ; Brady, S.M.
The next generation of training for arabidopsis researchers: Bioinformatics and quantitative biology.Garcia-Molina, A. ; Altmann, M. ; Alkofer, A. ; Epple, P.M. ; Dangl, J.L. ; Falter-Braun, P.
LSU network hubs integrate abiotic and biotic stress responses via interaction with the superoxide dismutase FSD2.Falter-Braun, P. ; Calderwood, M.A.
Big data biology - just the next big hype?
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