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Helmholtz Munich | ©Dr. Claudie Falter
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Molecular Targets and Therapeutics Center Institute of Network Biology

Molecular interactions form the basis of almost all biological processes in any living organism. Perturbations in these molecular networks result in dysfunctions which manifest themselves in disease up to fatal outcomes. Our aim at INET is to understand how these molecular interactions network changes caused by genetic variants or also by environmental influences like viruses or bacteria, lead to pathological processes. A deep understanding of the interplay of all the different layers of molecular networks may lead to new strategies for disease prevention and pharmacological interventions.

 

Molecular interactions form the basis of almost all biological processes in any living organism. Perturbations in these molecular networks result in dysfunctions which manifest themselves in disease up to fatal outcomes. Our aim at INET is to understand how these molecular interactions network changes caused by genetic variants or also by environmental influences like viruses or bacteria, lead to pathological processes. A deep understanding of the interplay of all the different layers of molecular networks may lead to new strategies for disease prevention and pharmacological interventions.

 

Our Networks

Helmholtz Munich | ©Dr. Claudie Falter

Interactomics

At INET we systematically generate molecular interactome maps by our well established AI informed and robotics supported protein-protein interaction pipeline integrating latest experimental and theoretical approaches.

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Helmholtz Munich | ©Dr. Claudie Falter

Regulomics

Regulatory network mapping will identify transcription factors (TFs) regulating the genes and pathways that enable either regulation processes within an organism or elucidate regulation of molecular host pathways by microbes.

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Helmholtz Munich | ©Dr. Claudie Falter

Contactomics

The contactome, the sum of physical contacts between viral and host macromolecules, affects cellular perturbations that enable viral replication and cause disease manifestations. Because co-complex assays predominantly detect indirect

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Helmholtz Munich | ©Dr. Claudie Falter

Effectoromics

The presence of secretion systems by which the so-called ‘effector-proteins’ can be injected into the host’s cytosol to interact with host proteins and modulate molecular pathways is a unique feature of proteobacteria.

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Helmholtz Munich | ©Dr. Claudie Falter

PAN-VIRUS-HOST INTERACTOMICS

PAN-VIRUS-HOST INTERACTOMICS For our comparative viral-human protein-protein interaction network we screened all 7 human corona viruses against each other and against the human ORFEome in order to get better insights to

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Our Scientists at Network Biology

Prof. Dr. Pascal Falter-Braun

Director of Network Biology View profile

Dr. Claudia Falter

Scientific Coordinator

Dr. Melina Altmann

Postdoc on maternity leave

Dr. Chung-Wen Lin

Postdoc

Lena Elorduy Vergara

PhD Student

Patrick Schwehn

PhD Student

Dr. Benjamin Weller

Postdoc

Sophia Klink

PhD Student

Ramakrishnan Pandiarajan

PhD Student

Veronika Young

PhD Student

Simin Rothballer

Technician

Dr. Michael Rothballer

Group Leader

Arsin Sabunchi

Technician

Mayra Sauer

PhD Student

Hridi Halder

MSc Student

Benedikt Mairhörmann

PhD Student

Hatice Karabudak

Lab Assitant

Bushra Dohai

PhD Student

Florin Ratajczak

PhD Student

Latest Publications of Our Institute

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2022 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America

McLellan, H. ; Harvey, S.E. ; Steinbrenner, J. ; Armstrong, M.R. ; He, Q. ; Clewes, R. ; Pritchard, L. ; Wang, W. ; Wang, S. ; Nussbaumer, T. ; Dohai, B.S.M. ; Luo, Q. ; Kumari, P. ; Duan, H. ; Roberts, A. ; Boevink, P.C. ; Neumann, C. ; Champouret, N. ; Hein, I. ; Falter-Braun, P. ; Beynon, J. ; Denby, K. ; Birch, P.R.J.

Exploiting breakdown in nonhost effector-target interactions to boost host disease resistance.

Networks and Affiliations

Contact


Dr. Claudia Falter

Scientific Coordinator