Helmholtz Diabetes Center Institute of Experimental Genetics
The Institute of Experimental Genetics (IEG) aims to further the understanding of mechanisms underlying human diseases' etiology. Metabolic diseases with a focus on diabetes are key areas of research. Experimental set-ups are centered on the mouse as a pre-clinical model organism with direct translation of results to humans. Besides studying the effects of genotypes, the institute identifies and characterizes environmental and epigenetic factors and the mechanisms by which these act on the etiology of diseases.
The Institute of Experimental Genetics (IEG) aims to further the understanding of mechanisms underlying human diseases' etiology. Metabolic diseases with a focus on diabetes are key areas of research. Experimental set-ups are centered on the mouse as a pre-clinical model organism with direct translation of results to humans. Besides studying the effects of genotypes, the institute identifies and characterizes environmental and epigenetic factors and the mechanisms by which these act on the etiology of diseases.
Aim of our Research
The aim of the Institute of Experimental Genetics (IEG) is to further the understanding of mechanisms that underlie the etiology of human diseases. Metabolic diseases with focus on diabetes are key areas of research. Experimental set-ups are centered on the mouse as pre-clinical model organism with direct translation of results to humans. Besides studying the effects of genotypes, the institute identifies and characterizes environmental and epigenetic factors and the mechanisms by which these act on the etiology of diseases.
Selected Publications of the IEG
Read more2024 Scientific Article in Scientific Data
The Journey to a FAIR CORE DATA SET for Diabetes Research in Germany.
2024 Scientific Article in Metabolomics
Infants with biliary atresia exhibit an altered amino acid profile in their newborn screening.
2024 Scientific Article in Advanced science
The eATP/P2×7R axis drives quantum dot-nanoparticle induced neutrophil recruitment in the pulmonary microcirculation.
2024 Scientific Article in Molecular Metabolism
HDAC5 controls a hypothalamic STAT5b-TH axis, the sympathetic activation of ATP-consuming futile cycles and adult-onset obesity in male mice.
2024 Scientific Article in Science Advances
Loss of atrial natriuretic peptide signaling causes insulin resistance, mitochondrial dysfunction, and low endurance capacity.
2024 Scientific Article in Diabetologia