IEG

The Institute of Experimental Genetics (IEG) aims to further the understanding of mechanisms underlying human diseases' etiology. Metabolic diseases with a focus on diabetes are key areas of research. Experimental set-ups are centered on the mouse as a pre-clinical model organism with direct translation of results to humans. Besides studying the effects of genotypes, the institute identifies and characterizes environmental and epigenetic factors and the mechanisms by which these act on the etiology of diseases.

The characterization of mutants represents a valuable instrument for functional genome analysis. Novel mouse models for metabolic diseases are in the center of our projects. By unraveling the molecular pathways and pathophysiological events leading, in particular, to diabetes we also transfer the basic research results into the development of novel strategies for diagnosis, prevention and therapy.

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Our research focuses on the epigenetic inheritance of metabolic diseases such as obesity and diabetes mostly using the mouse as functional model system. We aim to understand how metabolic phenotypes that are acquired during life - for example, by malnutrition - are inherited from one generation to the next. We want to contribute to a better understanding of this inter-generational epigenetic inheritance and its implications for the observed pandemic of obesity and diabetes in man.

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Diabetes and Obesity affect almost 400 million people worldwide and forecasts anticipate an increase of at least 20% by 2030.
Epidemiological studies have shown a high degree of genetic predisposition and familial aggregation in both diabetes and obesity. Nevertheless, lifestyle interventions have proven valuable in disease prevention and management.
We study physiological and pathological aspects of gene-environment interaction and epigenetic control of inheritance and aim to find novel targets and/or mechanisms towards effective strategies for disease prevention.

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German Mouse Clinic

The German Mouse Clinic (GMC) as an open access phenotyping platform offers comprehensive phenotyping of mouse models in a systemic primary screen. Scientists with expert knowlegde from various fields of mouse physiology and pathology work together on evaluating numerous physiological pathways.

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The European Mouse Mutant Archive is an INFRAFRONTIER core service for collection, archiving and distribution of mutant mice valuable for scientific and medical research. The IEG is one INFRAFRONTIER partner operating the German EMMA node with a main focus on cryopreservation and in vitro fertilization.

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Advances in medical research revealed that a disease phenotype is the result of pathobiological processes that interact in complex networks. A large body of information generated in decades of experimental research is hidden in the scientific literature.
Our aim is to generate high-quality databases that describe experimentally validated interactions between molecules and processes involved in the development of diseases.

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Data funnel abstract technology background

We initiate and take lead in projects that use artificial intelligence methods on large mouse phenotyping datasets from the German Mouse Clinic (GMC) or from external sources.
We develop and maintain highly customised IT infrastructure and solutions for our institute. Such as the in-house developed application "MausDB" , a modular laboratory information management system (LIMS).
And we support IEG research projects internally with our IT expertise and tools.

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Selected Publications of the IEG

Frontiers in Steroid Research: Steroid Congress 2023.

2025 Scientific Article in ACS Chemical Biology

Lechner, S. ; Sha, S. ; Sethiya, J.P. ; Szczupak, P. ; Dolot, R. ; Lomada, S. ; Sakhteman, A. ; Tüshaus, J. ; Prokofeva, P. ; Krauss, M. ; Breu, F. ; Voegerl, K. ; Morgenstern, M. ; German Mouse Clinic Consortium (Hrabě de Angelis, M. ; Amarie, O.V. ; Becker, L. ; Calzada-Wack, J. ; Dámek, F. ; Dragano, N.R.V. ; Garrett, L. ; Hölter, S. ; Kraiger, M. ; Leuchtenberger, S. ; Marschall, S. ; Östereicher, M.A. ; Rathkolb, B. ; Sanz-Moreno, A. ; Seisenberger, C. ; Spielmann, N. ; Stoeger, C. ; Wurst, W. ; Zimprich, A. ; Fuchs, H. ; Gailus-Durner, V.) ; Haucke, V. ; Wieland, T. ; Wagner, C. ; Médard, G. ; Bracher, F. ; Kuster, B. ; German Mouse Clinic Consortium (da Silva Buttkus, P.)

Serendipitous and systematic chemoproteomic discovery of MBLAC2, HINT1, and NME1-4 inhibitors from histone deacetylase-targeting pharmacophores.

2025 Scientific Article in International Journal of Molecular Sciences

Krüger, P. ; Schroll, M. ; Fenzl, F. ; Hartinger, R. ; Lederer, E. ; Görlach, A. ; Gordon, L.B. ; Cavalcante, P. ; Iacomino, N. ; Rathkolb, B. ; Aguilar-Pimentel, J.A. ; Östereicher, M.A. ; Spielmann, N. ; Wolf, C.M. ; Hrabě de Angelis, M. ; Djabali, K.

Baricitinib and lonafarnib synergistically target Progerin and inflammation, improving lifespan and health in progeria mice.

2025 Scientific Article in European Journal of Human Genetics

Luo, S. ; Gailus-Durner, V. ; McGivern, B. ; Li, Q. ; Kottmeier, J. ; Ho, M.L. ; Mor-Shaked, H. ; Elpeleg, O. ; Aref-Eshghi, E. ; Brodeur, A.C. ; Schmitz-Abe, K. ; Genetti, C.A. ; Picker, J. ; Shi, J. ; Bux, R.I. ; Ben-Omran, T. ; Fuchs, H. ; Harel, T. ; Hrabě de Angelis, M. ; German Mouse Clinic Consortium (Garrett, L. ; Amarie, O.V. ; Spielmann, N. ; Sanz-Moreno, A. ; da Silva Buttkus, P. ; Becker, L. ; Hölter, S. ; Seisenberger, C. ; Marschall, S.) ; German Mouse Clinic Consortium (Dragano, N.R.V.) ; German Mouse Clinic Consortium (Aguilar-Pimentel, J.A.)

Recessive variants in WSB2 encoding a substrate receptor of E3 ubiquitin ligase underlie a neurodevelopmental syndrome.

2025 Scientific Article in Investigative Ophthalmology & Visual Science, IOVS

Briere, A. ; Vo, P. ; Yang, B. ; Adams, D. ; Amano, T. ; Amarie, O.V. ; Berberovic, Z. ; Bower, L. ; Brown, S.D.M. ; Burrill, S. ; Cho, S.Y. ; Clementson-Mobbs, S. ; D'Souza, A.R. ; Eskandarian, M. ; Flenniken, A.M. ; Fuchs, H. ; Gailus-Durner, V. ; Hérault, Y. ; Hrabě de Angelis, M. ; Jin, S. ; Joynson, R. ; Kang, Y.K. ; Kim, H. ; Masuya, H. ; Meziane, H. ; Nam, K.H. ; Noh, H. ; Nutter, L.M.J. ; Palkova, M. ; Prochazka, J. ; Raishbrook, M.J. ; Riet, F. ; Salazar, J. ; Sedlacek, R. ; Selloum, M. ; Seo, K.Y. ; Seong, J.K. ; Shin, H.S. ; Shiroishi, T. ; Stewart, M. ; Svenson, K.L. ; Tamura, M. ; Tolentino, H. ; Wells, S. ; Wurst, W. ; Yoshiki, A. ; Lanoue, L. ; Lloyd, K.C.K. ; Leonard, B.C. ; Roux, M.J. ; McKerlie, C. ; Moshiri, A.

Systematic ocular phenotyping of knockout mouse lines identifies genes associated with age-related corneal dystrophies.

2025 Scientific Article in Molecular Metabolism

Prudente de Mello, N. ; Berger, M. ; Lagerborg, K.A. ; Yan, Y. ; Wettmarshausen, J. ; Keipert, S. ; Weidner, L. ; Tokarz, J. ; Möller, G. ; Ciciliot, S. ; Walia, S.R. ; Cheng, Y. ; Chudenkova, M. ; Artati, A. ; Weisenhorn, D.M. ; Wurst, W. ; Adamski, J. ; Nilsson, R.H. ; Cossu, G. ; Boon, A.J.W. ; Kievit, A.J.A. ; Mandemakers, W. ; Bonifati, V. ; Jain, M. ; Jastroch, M. ; Schmitt-Kopplin, P. ; Perocchi, F. ; Dyar, K.A.

Dr. Juan Antonio Aguilar Pimentel

Dr. Lore Becker

Prof. Dr. Johannes Beckers

Prof. Dr. rer. nat. Johannes Beckers, Executive MBA (TUM) View profile

Barbara Brauner

Silvia Crowley

Dr. Patricia da Silva-Buttkus

Dr. Nathalia Dragano

Head of Metabolism Research - German Mouse Clinic - Institute of Experimental Genetics

Ann-Elisabeth Engelniederhammer

Daniel Feeser

Marion Fisch

Anna Fischer

Ralf Fischer

Dr. Gisela Fobo

Dr. Goar Frischmann

Dr. Helmut Fuchs

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Dr. Valérie Gailus-Durner

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Isabella Galter

Doctoral Candidate

Cindy Gonda

Sandra Hoffmann

Martin Hrabe de Angelis _ Portrait NEU_freigestellt

Prof. Dr. Dr. h.c. Martin Hrabě De Angelis

Research Director Helmholtz Munich, Full Professor and Chair of Experimental Genetics Technical University Munich, Director of the Institute of Experimental Genetics Helmholtz Munich View profile