Induced Pluripotent Stem Cells

microscope of human stem cells, 3d rendering.

Core Facility Induced pluripotent stem cells (CF-iPSC) provides know-how, training, and hands-on support for researchers interested in working with human pluripotent stem cells (hPSCs). Our primary goal is to aid the Helmholtz Munich scientific community, external academic and industry clients to establish high-quality iPSCs-based disease models.

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Welcome to CF-iPSC

Over the past ten years, we developed an extensive toolbox of reprogramming services. We advise users on sample acceptance criteria, quality control and experimental strategies for differentiation modalities.

We will guide you to find the most suitable tissue of origin for a disease model and perform pilot experiments to ensure its suitability for your specific application.

Our Achivements

CF-iPSC has successfully reprogrammed more than 90% of the submitted patient samples from various disease backgrounds (e.g. PURA Syndrome, Bohring Opitz Syndrome, IRF 2 BPL-related disorders, MPAN disorders).

We have established clinically relevant differentiation modalities for the three embryonic lineages.

Our Control iPSC lines

The CF-iPSC provides control iPSCs for internal distribution. They can be shared with third-party non-Helmholtz Munich collaborators under Material Transfer Agreement.

Our neonatal control lines are part of the Human Pluripotent Stem Cell Registry (hPSCreg) and have been distributed into more then 50 labs internationally.

Ejona Rusha

The CF-iPSC team is committed to help establishing robust hPSC disease models using integration-free reprogramming, Crispr Cas toolbox and 2D/3D differentiation modalities.

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