Stem Cell Center
Stammzellen sind einzigartig in ihrer Fähigkeit, sich zu vermehren und Zellen zu ersetzen - oft lebenslang. Viele erwachsene Organe, wie das Gehirn oder die Bauchspeicheldrüse, haben jedoch keine oder nur wenige Stammzellen. Die Mission unseres Departments stützt sich in solchen Organen auf unseren bahnbrechenden Ansatz zur Umprogrammierung lokaler Zellen in Richtung der verlorenen Zelltyp-Identität sowie auf unsere bahnbrechenden Entdeckungen zu epigenetischen Mechanismen der Umprogrammierung. Für alle Schlüsselproteine, die eine solche Umwandlung des Zellschicksals ermöglichen, wurden die Rollen während der Entwicklung zur Bildung von relevanten Zelltypen identifiziert. Unser Department vereint daher Fachwissen in einer weltweit einzigartigen Kombination über Stammzellen, Entwicklungsmechanismen der Schicksalsspezifikation und Plastizität, einschließlich einer starken epigenetischen Expertise mit Verletzungsmodellen und direkter Reprogrammierung.
Stem Cell Center
Replacing lost or damaged cells is the cornerstone of regenerative medicine. To achieve this, we need to understand not only how cells acquire their specific identity but also how cell plasticity is regulated. Helmholtz Munich’s Stem Cell Center is unique worldwide in combining leading expertise in cell plasticity, epigenetics, and direct reprogramming.
![[Translate to German:]](/fileadmin/_processed_/9/2/csm_image003_b100537688.png "[Translate to German:]")
![[Translate to German:] Prof. Maria-Elena Torres-Padilla im Interview](https://images.admiralcloud.com/v3/deliverEmbed/a6bafa43-ca29-4eb8-bb9c-dedcfb2331b5/image/cropperjsfocus/759/480/0,0,3840,2555,0,1,1/1920,1277.5?poc=true "Torres-Padilla; Portrait standing at HDC")
![[Translate to German:]](https://images.admiralcloud.com/v3/deliverEmbed/6acb4df0-c30a-4bf6-a7ce-b03aa66a2cfb/image/cropperjsfocus/759/480/170.80920934813753,83.19138386461314,1536,592.0000000000001,0,1,1/768,296?poc=true "[Translate to German:]")
![[Translate to German:]](https://images.admiralcloud.com/v3/deliverEmbed/0a1b6b43-c4f0-4e62-98ee-25dd1aceda6e/image/cropperjsfocus/759/480/0,0,1280,894,0,1,1/640,447?poc=true "[Translate to German:]")
![[Translate to German:]](https://images.admiralcloud.com/v3/deliverEmbed/640d83f9-7249-4955-85a5-b787b6dd8261/image/cropperjsfocus/759/480/6,141.79999999999995,1274,1134.4,0,1,1/637,567?poc=true "[Translate to German:]")
![[Translate to German:]](https://images.admiralcloud.com/v3/deliverEmbed/724c7108-2d13-4224-8647-a8ac94749ab0/image/cropperjsfocus/759/480/0,0,3840,2381,0,1,1/1920,1190.5?poc=true "[Translate to German:]")
![[Translate to German:]](https://images.admiralcloud.com/v3/deliverEmbed/037c245f-d2ac-4878-a48c-c222214b312a/image/cropperjsfocus/759/480/0,0,1280,1688,0,1,1/639.9999999999999,844?poc=true "[Translate to German:]")
Unsere Stammzellexperten
![[Translate to German:]](https://images.admiralcloud.com/v3/deliverEmbed/fa361b86-9801-4f95-b5d4-4013a6763792/image/cropperjsfocus/400/400/83.79856115107908,42.35971223021578,1731.68345323741,1738.589928057554,0,1,1/865.5,869?poc=true "Prof. Dr. Maria-Elena Torres-Padilla")
![[Translate to German:]](https://images.admiralcloud.com/v3/deliverEmbed/b86aa9e2-23d9-413f-9424-8d1ab6ac473a/image/cropperjsfocus/400/400/276.3033573141486,85.29999999999998,676.2541966426859,682.4000000000001,0,1,1/338,341?poc=true "Prof. Dr. Wolfgang Wurst")
![[Translate to German:]](https://images.admiralcloud.com/v3/deliverEmbed/457cebf5-7279-46db-9aa3-3599e6235e19/image/cropperjsfocus/400/400/192.00000000000003,579.0755395683451,1536,1443.1918465227816,0,1,1/768,721.5?poc=true "Prof. Dr. Magdalena Götz")
![[Translate to German:]](/fileadmin/_processed_/9/2/csm_image003_eb38256f00.png "[Translate to German:]")
![[Translate to German:]](https://images.admiralcloud.com/v3/deliverEmbed/7e858521-0816-4753-87c0-bf1b0340d626/image/cropperjsfocus/250/250/21.00074239049732,45.04231625835177,3339.973273942094,2352.0831477357096,0,1,1/1669.5,1176?poc=true "[Translate to German:]")
Neuste Publikationen
See all2024 Nat Neurosci. 2024 Jul 2.
2024 Cell Discovery volume 10, Article number: 42 (2024)
Engineered, nucleocytoplasmic shuttling Cas13d enables highly efficient cytosolic RNA targeting
2024 Neuron P1117-1132.e9, April 03, 2024
2024 Nature Communication 15(1):2866
2024 Nature 625, pages 401–409 (2024)
Emergence of replication timing during early mammalian development
2023 Nature Medicine 29, 3149-3161
Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain
2023 Nature Communications 14, Article number: 7674 (2023)
A reversible state of hypometabolism in a human cellular model of sporadic Parkinson’s disease
2023 Mol Cancer. 2023 Jul 8;22(1)
Combined proteomics and CRISPR‒Cas9 screens in PDX identify ADAM10 as essential for leukemia in vivo
2023 Blood. 2023 Feb 23;141(8):955-960
WT1 and DNMT3A play essential roles in the growth of certain patient AML cells in mice
